Desperate Housewives focus on the lives of several residents living on Wisteria Lane . In recent episodes , Susan ( Teri Hatcher ) and Mike Delfino ( James Denton ) celebrate the birth of their son . Bree Hodge ( Marcia Cross ) choose to raise her grandson while her daughter , Danielle ( Joy Lauren ) , attend college . She also issue an ultimatum , telling her husband , Orson ( Kyle MacLachlan ) , that she will leave him if he do not turn himself into the police after committing a hit @-@ and @-@ run . Gabrielle Solis ( Eva Longoria ) struggle with Carlos ' ( Ricardo Antonio Chavira ) permanent blindness . Also , Edie Britt ( Nicollette Sheridan ) leave Wisteria Lane after the other residents shun her for her malice .