The Chapel of the Immaculate Conception ( Spanish : Capilla de la Inmaculada Concepción ) was built between 1642 and 1648 . It have a churrigueresque altarpiece which , due to the lack of columns , most likely dates from the 18th century . The altar is framed with molding — instead of columns — and a painting of the Immaculate Conception preside over it . The altar is surrounded by paintings by José de Ibarra relating to the Passion of Christ and various saints . The chapel also contain a canvas of Saint Christopher painted by Simon Pereyns in 1588 , and the Flagellation by Baltasar de Echave Orio , painted in 1618 . The altarpiece on the right side is also dedicated to the Immaculate Conception and was donated by the College of Saints Peter and Paul . This chapel hold the remains of Franciscan friar Antonio Margil de Jesús who was evangelized in what is now the north of Mexico .