Scholes International Airport at Galveston ( IATA : GLS , ICAO : KGLS ) is a two @-@ runway airport in Galveston ; the airport is primarily used for general aviation , offshore energy transportation , and some limited military operations . The nearest commercial airline service for the city is operated out of Houston through William P. Hobby Airport and George Bush Intercontinental Airport . The University of Texas Medical Branch have two heliports , one for Ewing Hall and one for its emergency room .