 α @-@ Hydroxyketones , or acyloins , are an important synthetic motifs present in many natural products. α @-@ Hydroxyketones have been synthesized in many ways , including reduction of α @-@ diketones , substitution of a hydroxyl for a leaving group and direct oxidation of an enolate . Oxodiperoxymolybdenum ( pyridine ) - ( hexamethylphosphoric triamide ) ( MoOPH ) and N @-@ sulfonyloxaziridines are the most common electrophilic sources of oxygen implemented in this process . One advantage of using N @-@ sulfonyloxaziridines is that higher chiral induction is almost invariably observed relative to MoOPH and other oxidants . High yield ( 77 @-@ 91 % ) and dr ( 95 : 5 - 99 : 1 ) are reported for α @-@ hydroxylation with the Evans ' chiral auxiliary with N @-@ sulfonyloxaziridine as the electrophile . Chiral induction has been demonstrated with many other chiral ketones and ketones with chiral auxiliaries , including SAMP and RAMP . 
 α @-@ Hydroxyketones , or acyloins , <a href='drop_aux' title='1'><mark>are</mark></a>an important synthetic motifs present in many natural products. α @-@ Hydroxyketones <a href='been_done' title='2'><mark>have</mark></a> been synthesized in many ways , including reduction of α @-@ diketones , substitution of a hydroxyl for a leaving group and direct oxidation of an enolate . Oxodiperoxymolybdenum ( pyridine ) - ( hexamethylphosphoric triamide ) ( MoOPH ) and N @-@ sulfonyloxaziridines <a href='drop_aux' title='3'><mark>are</mark></a>the most common electrophilic sources of oxygen implemented in this process . One advantage of using N @-@ sulfonyloxaziridines is that higher chiral induction is almost invariably observed relative to MoOPH and other oxidants . High yield ( 77 @-@ 91 % ) and dr ( 95 : 5 - 99 : 1 ) are reported for α @-@ hydroxylation with the Evans <a href='null_genetive' title='4'><mark>'</mark></a>chiral auxiliary with N @-@ sulfonyloxaziridine as the electrophile . Chiral induction <a href='been_done' title='5'><mark>has</mark></a> been demonstrated with many other chiral ketones and ketones with chiral auxiliaries , including SAMP and RAMP . 
Α @-@ Hydroxyketones , or acyloins , an important synthetic motifs present in many natural products. α @-@ Hydroxyketones done been synthesized in many ways , including reduction of α @-@ diketones , substitution of a hydroxyl fa a leavin group and direct oxidation of an enolate . Oxodiperoxymolybdenum ( pyridine ) - ( hexamethylphosphoric triamide ) ( MoOPH ) and N @-@ sulfonyloxaziridines the most common electrophilic sources of oxygen implemented in dis process . One advantage of using N @-@ sulfonyloxaziridines is that higher chiral induction is almost invariably observed relative to MoOPH and other oxidants . High yield ( 77 @-@ 91 % ) and dr ( 95 : 5 - 99 : 1 ) r reported for α @-@ hydroxylation with da Evans  chiral auxiliary w/ N @-@ sulfonyloxaziridine as tdaelectrophile . Chiral induction done been demonstrated with many other chiral ketones and ketones with chiral auxiliaries , including SAMP and RAMP .