 Chronic Chagas disease remains a major health problem in many Latin American countries , despite the effectiveness of hygienic and preventive measures , such as eliminating the transmitting insects . However , several landmarks have been achieved in the fight against it in Latin America , including a reduction by 72 % of the incidence of human infection in children and young adults in the countries of the Southern Cone Initiative , and at least three countries ( Uruguay , in 1997 , and Chile , in 1999 , and Brazil in 2006 ) have been certified free of vectorial and transfusional transmission . In Argentina , vectorial transmission has been interrupted in 13 of the 19 endemic provinces , and major progress toward this goal has also been made in both Paraguay and Bolivia . 
 Chronic Chagas disease <a href='uninflect' title='1'><mark>remains</mark></a> a major health problem in many Latin American countries , despite the effectiveness of hygienic and preventive measures , such as eliminating the transmitting insects . However , several landmarks <a href='been_done' title='2'><mark>have</mark></a> been achieved in the fight against it in Latin America , including a reduction by 72 % of the incidence of human infection in children and young adults in the countries of the Southern Cone Initiative , and at least three countries ( Uruguay , in 1997 , and Chile , in 1999 , and Brazil in 2006 ) <a href='been_done' title='3'><mark>have</mark></a> been certified free of vectorial and transfusional transmission . In Argentina , vectorial transmission <a href='been_done' title='4'><mark>has</mark></a> been interrupted in 13 of the 19 endemic provinces , and major progress toward this goal <a href='been_done' title='5'><mark>has</mark></a> also been made in both Paraguay and Bolivia . 
Chronic Chagas disease remain a major health problem in many Latin American countries , despite the effectiveness of hygienic and preventive measures , such as eliminating the transmitting insects . However , several landmarks done been achieved in da fight against it in Latin America , including a reduction by 72 % of the incidence of human infection in children and young adults in the countries of the Southern Cone Initiative , and at least three countries ( Uruguay , in 1997 , and Chile , in 1999 , and Brazil in 2006 ) done been certified free of vectorial and transfusional transmission . In Argentina , vectorial transmission done been interrupted in 13 of tda19 endemic provinces , and major progress toward this goal done also been made in both Paraguay and Bolivia .