 Paraspeckles are dynamic structures that are altered in response to changes in cellular metabolic activity . They are transcription dependent and in the absence of RNA Pol II transcription , the paraspeckle disappears and all of its associated protein components ( PSP1 , p54nrb , PSP2 , CFI ( m ) 68 , and PSF ) form a crescent shaped perinucleolar cap in the nucleolus . This phenomenon is demonstrated during the cell cycle . In the cell cycle , paraspeckles are present during interphase and during all of mitosis except for telophase . During telophase , when the two daughter nuclei are formed , there is no RNA Pol II transcription so the protein components instead form a perinucleolar cap . 
 Paraspeckles <a href='drop_aux' title='1'><mark>are</mark></a>dynamic structures <a href='null_relcl' title='2'><mark>that</mark></a>are altered in response to changes in cellular metabolic activity . They are transcription dependent and in the absence of RNA Pol II transcription , the paraspeckle <a href='uninflect' title='3'><mark>disappears</mark></a> and all of its associated protein components ( PSP1 , p54nrb , PSP2 , CFI ( m ) 68 , and PSF ) form a crescent shaped perinucleolar cap in the nucleolus . This phenomenon is demonstrated during the cell cycle . In the cell cycle , paraspeckles <a href='drop_aux' title='4'><mark>are</mark></a>present during interphase and during all of mitosis except for telophase . During telophase , when the two daughter nuclei are formed , <a href='dey_it' title='5'><mark>there</mark></a> is no RNA Pol II transcription so the protein components instead form a perinucleolar cap . 
Paraspeckles dynamic structures r altered in response to changes in cellular metabolic activity . They arrranscription dependent and in da absence of RNA Pol II transcription , tdaparaspeckle disappear and alll of its associated protein components ( PSP1 , p54nrb , PSP2 , CFI ( m ) 68 , and PSF ) form a crescent shaped perinucleolar cap in the nucleolus . This phenomenon is demonstrated during thdaell cycle . In thedall cycle , paraspeckles present durin interphase and during all of mitosis except fir telophase . During telophase , when the da daughter nuclei are formed , it ain't no RNA Pol II transcription soo the protein components instead form a perinucleolar cap .