 Exposure to anticancer chemotherapy , in particular alkylating agents , can increase the risk of subsequently developing AML . The risk is highest about three to five years after chemotherapy . Other chemotherapy agents , specifically epipodophyllotoxins and anthracyclines , have also been associated with treatment @-@ related leukemias , which are often associated with specific chromosomal abnormalities in the leukemic cells . 
 Exposure to anticancer chemotherapy , in particular alkylating agents , can increase the risk of subsequently developing AML . The risk <a href='drop_aux' title='1'><mark>is</mark></a>highest about three to five years after chemotherapy . Other chemotherapy agents , specifically epipodophyllotoxins and anthracyclines , <a href='been_done' title='2'><mark>have</mark></a> also been associated with treatment @-@ related leukemias , which are often associated with specific chromosomal abnormalities in the leukemic cells . 
Exposure to anticancer chemotherapy , in particular alkylating agents , can increase the risk of subsequently developing AML . The risk highest about three to five yrs after chemotherapy . Other chemotherapy agents , specifically epipodophyllotoxins and anthracyclines , done also been associated with treatment @-@ related leukemias , which are often associated wit specific chromosomal abnormalities in da leukemic cells .