 Ibotenic acid and muscimol are structurally related to each other and to two major neurotransmitters of the central nervous system : glutamic acid and GABA respectively . Ibotenic acid and muscimol act like these neurotransmitters , muscimol being a potent GABAA agonist , while ibotenic acid is an agonist of NMDA glutamate receptors and certain metabotropic glutamate receptors which are involved in the control of neuronal activity . It is these interactions which are thought to cause the psychoactive effects found in intoxication . Muscimol is the agent responsible for the majority of the psychoactivity . 
 Ibotenic acid and muscimol <a href='drop_aux' title='1'><mark>are</mark></a>structurally related to each other and to two major neurotransmitters of the central nervous system : glutamic acid and GABA respectively . Ibotenic acid and muscimol act like these neurotransmitters , muscimol being a potent GABAA agonist , while ibotenic acid <a href='drop_aux' title='2'><mark>is</mark></a>an agonist of NMDA glutamate receptors and certain metabotropic glutamate receptors which are involved in the control of neuronal activity . It <a href='drop_aux' title='3'><mark>is</mark></a>these interactions which are thought to cause the psychoactive effects found in intoxication . Muscimol <a href='drop_aux' title='4'><mark>is</mark></a>the agent responsible for the majority of the psychoactivity . 
Ibotenic acid and muscimol structurally related to each other and to two major neurotransmitters of the central nervous system : glutamic acid and GABA respectively . Ibotenic acid and muscimol act like these neurotransmitters , muscimol being a potent GABAA agonist , while ibotenic acid an agonist of NMDA glutamate receptors and certain metabotropic glutamate receptors which are involved in the control of neuronal activity . It these interactions which are thought to cause the psychoactive effects found in intoxication . Muscimol the agent responsible for the majority of the psychoactivity .