 At temperatures greater than 44 ° C ( 111 ° F ) , proteins begin losing their three @-@ dimensional shape and start breaking down . This results in cell and tissue damage . Many of the direct health effects of a burn are secondary to disruption in the normal functioning of the skin . They include disruption of the skin 's sensation , ability to prevent water loss through evaporation , and ability to control body temperature . Disruption of cell membranes causes cells to lose potassium to the spaces outside the cell and to take up water and sodium . 
 At temperatures greater than 44 ° C ( 111 ° F ) , proteins begin losing their three @-@ dimensional shape and start breaking down . This <a href='uninflect' title='1'><mark>results</mark></a> in cell and tissue damage . Many of the direct health effects of a burn <a href='drop_aux' title='2'><mark>are</mark></a>secondary to disruption in the normal functioning of the skin . They include disruption of the skin <a href='null_genetive' title='3'><mark>'s</mark></a>sensation , ability to prevent water loss through evaporation , and ability to control body temperature . Disruption of cell membranes <a href='uninflect' title='4'><mark>causes</mark></a> cells to lose potassium to the spaces outside the cell and to take up water and sodium . 
At temperatures greater than 44 ° C ( 111 ° fuc ) , proteins begin losing their three @-@ dimensional shape and start breaking dwn . This result in cell and tissue damage . Many of the direct health effects of a burn secondary to disruption in da normal functioning of tdaskin . They include disruption of the skin  sensation , ability to prevent water loss through evaporation , and ability to control body temperature . Disruption of cell membranes cause cells to lose potassium to the spaces outside the cell and to take up water and sodium .