 The clinical manifestations of Chagas disease are due to cell death in the target tissues that occurs during the infective cycle , by sequentially inducing an inflammatory response , cellular lesions , and fibrosis . For example , intracellular amastigotes destroy the intramural neurons of the autonomic nervous system in the intestine and heart , leading to megaintestine and heart aneurysms , respectively . If left untreated , Chagas disease can be fatal , in most cases due to heart muscle damage . 
 The clinical manifestations of Chagas disease <a href='drop_aux' title='1'><mark>are</mark></a>due to cell death in the target tissues <a href='null_relcl' title='2'><mark>that</mark></a><a href='uninflect' title='3'><mark>occurs</mark></a> during the infective cycle , by sequentially inducing an inflammatory response , cellular lesions , and fibrosis . For example , intracellular amastigotes destroy the intramural neurons of the autonomic nervous system in the intestine and heart , leading to megaintestine and heart aneurysms , respectively . If left untreated , Chagas disease can be fatal , in most cases due to heart muscle damage . 
Da clinical manifestations of Chagas disease due to cell death in tdatarget tissues occur during thdanfective cycle , by sequentially inducing an inflammatory response , cellular lesions , and fibrosis . For example , intracellular amastigotes destroy thedatramural neurons of the autonomic nervous system in the daestine and heart , leading to megaintestine and heart aneurysms , respectively . If left untreated , Chagas disease can be fatal , in most cases due to heart muscle damage .