 RAFA domains , or polymorphic interphase karyosomal associations , were first described in microscopy studies in 1991 . Their function remains unclear , though they were not thought to be associated with active DNA replication , transcription , or RNA processing . They have been found to often associate with discrete domains defined by dense localization of the transcription factor PTF , which promotes transcription of small nuclear RNA ( snRNA ) . 
 RAFA domains , or polymorphic interphase karyosomal associations , <a href='uninflect' title='1'><mark>were</mark></a> first described in microscopy studies in 1991 . Their function <a href='uninflect' title='2'><mark>remains</mark></a> unclear , though they <a href='uninflect' title='3'><mark>were</mark></a> not thought to be associated with active DNA replication , transcription , or RNA processing . They <a href='been_done' title='4'><mark>have</mark></a> been found to often associate with discrete domains defined by dense localization of the transcription factor PTF , which <a href='uninflect' title='5'><mark>promotes</mark></a> transcription of small nuclear RNA ( snRNA ) . 
RAFA domains , or polymorphic interphase karyosomal associations , was first described in microscopy studies in 1991 . Their function remain unclear , tho they was not thought to be associated with active DNA replication , transcription , or RNA processing . They done been found to often associate with discrete domains defined by dense localization of the transcription factor PTF , which promote transcription of small nuclear RNA ( snRNA ) .