 Other possibilities exist , as well . For example , immunohistochemistry usually utilizes an antibody to one or more proteins of interest that are conjugated to enzymes yielding either luminescent or chromogenic signals that can be compared between samples , allowing for localization information . Another applicable technique is cofractionation in sucrose ( or other material ) gradients using isopycnic centrifugation . While this technique does not prove colocalization of a compartment of known density and the protein of interest , it does increase the likelihood , and is more amenable to large @-@ scale studies . 
 Other possibilities exist , as well . For example , immunohistochemistry usually <a href='uninflect' title='1'><mark>utilizes</mark></a> an antibody to one or more proteins of interest <a href='null_relcl' title='2'><mark>that</mark></a>are conjugated to enzymes yielding either luminescent or chromogenic signals <a href='null_relcl' title='3'><mark>that</mark></a>can be compared between samples , allowing for localization information . Another applicable technique <a href='drop_aux' title='4'><mark>is</mark></a>cofractionation in sucrose ( or other material ) gradients using isopycnic centrifugation . While this technique <a href='uninflect' title='5'><mark>does</mark></a> not prove <a href='negative_concord' title='6'><mark>colocalization</mark></a> of a compartment of known density and the protein of interest , it <a href='uninflect' title='7'><mark>does</mark></a> increase the likelihood , and <a href='drop_aux' title='8'><mark>is</mark></a>more amenable to large @-@ scale studies . 
Other possibilities exist , as well . For example , immunohistochemistry usually utilize an antibody to one or more proteins of interest are conjugated to enzymes yielding either luminescent or chromogenic signals can be compared between samples , allowing for localization information . anotha applicable technique cofractionation in sucrose ( or other material ) gradients using isopycnic centrifugation . While this technique do not prove no colocalization of a compartment of known density and da protein of interest , it do increase the likelihood , and more amenable to bigass @-@ scale studies .