 There have been a few instances of general population poisoning as the result of long @-@ term exposure to cadmium in contaminated food and water , and research into an estrogen mimicry that may induce breast cancer is ongoing . In the decades leading up to World War II , mining operations contaminated the Jinzū River in Japan with cadmium and traces of other toxic metals . As a consequence , cadmium accumulated in the rice crops along the riverbanks downstream of the mines . Some members of the local agricultural communities consumed the contaminated rice and developed itai @-@ itai disease and renal abnormalities , including proteinuria and glucosuria . 
 <a href='dey_it' title='1'><mark>There</mark></a> have been a few instances of general population poisoning as the result of long @-@ term exposure to cadmium in contaminated food and water , and research into an estrogen mimicry <a href='null_relcl' title='2'><mark>that</mark></a>may induce breast cancer is ongoing . In the decades leading up to World War II , mining operations contaminated the Jinzū River in Japan with cadmium and traces of other toxic metals . As a consequence , cadmium accumulated in the rice crops along the riverbanks downstream of the mines . Some members of the local agricultural communities consumed the contaminated rice and developed itai @-@ itai disease and renal abnormalities , including proteinuria and glucosuria . 
It have been a few instances of general population poisoning as the result of long @-@ term exposure to cadmium in contaminated food and water , and research into an estrogen mimicry may induce breast cancer is ongoing . In the decades leading up to World War II , mining operations contaminated the Jinzū River in Japan wit cadmium and traces of other toxic metals . As a consequence , cadmium accumulated in da rice crops along the riverbanks downstream of tdamines . Some members of thdaocal agricultural communities consumed thedantaminated rice and developed itai @-@ itai disease and renal abnormalities , including proteinuria and glucosuria .