 Besides the nucleolus , the nucleus contains a number of other non @-@ membrane @-@ delineated bodies . These include Cajal bodies , Gemini of coiled bodies , polymorphic interphase karyosomal association ( PIKA ) , promyelocytic leukaemia ( PML ) bodies , paraspeckles , and splicing speckles . Although little is known about a number of these domains , they are significant in that they show that the nucleoplasm is not a uniform mixture , but rather contains organized functional subdomains . 
 Besides the nucleolus , the nucleus <a href='uninflect' title='1'><mark>contains</mark></a> a number of other non @-@ membrane @-@ delineated bodies . These include Cajal bodies , Gemini of coiled bodies , polymorphic interphase karyosomal association ( PIKA ) , promyelocytic leukaemia ( PML ) bodies , paraspeckles , and splicing speckles . Although little is known about a number of these domains , they <a href='drop_aux' title='2'><mark>are</mark></a>significant in that they show that the nucleoplasm <a href='negative_concord' title='3'><mark>is</mark></a> <a href='negative_concord' title='4'><mark>not</mark></a>a uniform mixture , but rather <a href='uninflect' title='5'><mark>contains</mark></a> organized functional subdomains . 
Besides the nucleolus , the nucleus contain a number of other non @-@ membrane @-@ delineated bodies . These include Cajal bodies , Gemini of coiled bodies , polymorphic interphase karyosomal association ( PIKA ) , promyelocytic leukaemia ( PML ) bodies , paraspeckles , and splicing speckles . Although little is known bout a number of dese domains , they significant in dat they show tdatda nucleoplasm ain't a uniform mixture , but rather contain organized functional subdomains .