 A hereditary risk for AML appears to exist . Multiple cases of AML developing in a family at a rate higher than predicted by chance alone have been reported . Several congenital conditions may increase the risk of leukemia ; the most common is probably Down syndrome , which is associated with a 10- to 18 @-@ fold increase in the risk of AML . 
 A hereditary risk for AML <a href='uninflect' title='1'><mark>appears</mark></a> to exist . Multiple cases of AML developing in a family at a rate higher than predicted by chance alone <a href='been_done' title='2'><mark>have</mark></a> been reported . Several congenital conditions may increase the risk of leukemia ; the most common is probably Down syndrome , which is associated with a 10- to 18 @-@ fold increase in the risk of AML . 
A hereditary risk for AML appear to exist . Multiple cases of AML developing in a family at a rate higher den predicted by chance alone done been reported . Several congenital conditions may increase the risk of leukemia ; da most common is probably Down syndrome , which is associated w a 10- to 18 @-@ fold increase in the risk of AML .