 Mutations in lamin genes leading to defects in filament assembly cause a group of rare genetic disorders known as laminopathies . The most notable laminopathy is the family of diseases known as progeria , which causes the appearance of premature aging in its sufferers . The exact mechanism by which the associated biochemical changes give rise to the aged phenotype is not well understood . 
 Mutations in lamin genes leading to defects in filament assembly cause a group of rare genetic disorders known as laminopathies . The most notable laminopathy <a href='drop_aux' title='1'><mark>is</mark></a>the family of diseases known as progeria , which <a href='uninflect' title='2'><mark>causes</mark></a> the appearance of premature aging in its sufferers . The exact mechanism by which the associated biochemical changes give rise to the aged phenotype <a href='negative_concord' title='3'><mark>is</mark></a> <a href='negative_concord' title='4'><mark>not</mark></a>well understood . 
Mutations in lamin genes leading to defects in filament assembly cause a group of rare genetic disorders known as laminopathies . The most notable laminopathy the family of diseases known as progeria , which cause the appearance of premature aging in its sufferers . The exact mechanism by which the associated biochemical changes give rise to da aged phenotype ain't well understood .