 The major toxins involved in A. muscaria poisoning are muscimol ( 3 @-@ hydroxy @-@ 5 @-@ aminomethyl @-@ 1 @-@ isoxazole , an unsaturated cyclic hydroxamic acid ) and the related amino acid ibotenic acid . Muscimol is the product of the decarboxylation ( usually by drying ) of ibotenic acid . Muscimol and ibotenic acid were discovered in the mid @-@ 20th century . Researchers in England , Japan , and Switzerland showed that the effects produced were due mainly to ibotenic acid and muscimol , not muscarine . These toxins are not distributed uniformly in the mushroom . Most are detected in the cap of the fruit , a moderate amount in the base , with the smallest amount in the stalk . Quite rapidly , between 20 and 90 minutes after ingestion , a substantial fraction of ibotenic acid is excreted unmetabolised in the urine of the consumer . Almost no muscimol is excreted when pure ibotenic acid is eaten , but muscimol is detectable in the urine after eating A. muscaria , which contains both ibotenic acid and muscimol . 
 The major toxins involved in A. muscaria poisoning <a href='drop_aux' title='1'><mark>are</mark></a>muscimol ( 3 @-@ hydroxy @-@ 5 @-@ aminomethyl @-@ 1 @-@ isoxazole , an unsaturated cyclic hydroxamic acid ) and the related amino acid ibotenic acid . Muscimol <a href='drop_aux' title='2'><mark>is</mark></a>the product of the decarboxylation ( usually by drying ) of ibotenic acid . Muscimol and ibotenic acid <a href='uninflect' title='3'><mark>were</mark></a> discovered in the mid @-@ 20th century . Researchers in England , Japan , and Switzerland showed that the effects produced <a href='uninflect' title='4'><mark>were</mark></a> due mainly to ibotenic acid and muscimol , not muscarine . These toxins are not distributed uniformly in <a href='None' title='5'><mark>the</mark></a><a href='negative_concord' title='6'><mark>mushroom</mark></a> . Most are detected in the cap of the fruit , a moderate amount in the base , with the smallest amount in the stalk . Quite rapidly , between 20 and 90 minutes after ingestion , a substantial fraction of ibotenic acid is excreted unmetabolised in the urine of the consumer . Almost no muscimol is excreted when pure ibotenic acid is eaten , but muscimol <a href='drop_aux' title='7'><mark>is</mark></a>detectable in the urine after eating A. muscaria , which <a href='uninflect' title='8'><mark>contains</mark></a> both ibotenic acid and muscimol . 
The major toxins involved in A. muscaria poisoning muscimol ( 3 @-@ hydroxy @-@ 5 @-@ aminomethyl @-@ 1 @-@ isoxazole , an unsaturated cyclic hydroxamic acid ) and da related amino acid ibotenic acid . Muscimol the product of the decarboxylation ( usually by drying ) of ibotenic acid . Muscimol and ibotenic acid was discovered in tdamid @-@ 20th century . Researchers in England , Japan , and Switzerland showed that thdaffects produced was due mainly to ibotenic acid and muscimol , not muscarine . These toxins ain't distributed uniformly in no mushroom . Most r detected in thedap of the fruit , a moderate amount in the base , with the dallest amount in the stalk . Quite rapidly , between 20 and 90 minutes after ingestion , a substantial fraction of ibotenic acid is excreted unmetabolised in the urine of the consumer . Almost no muscimol is excreted when pure ibotenic acid is eaten , but muscimol detectable in the urine after eatting A. muscaria , which contain both ibotenic acid and muscimol .