 In order to control which genes are being transcribed , the cell separates some transcription factor proteins responsible for regulating gene expression from physical access to the DNA until they are activated by other signaling pathways . This prevents even low levels of inappropriate gene expression . For example , in the case of NF @-@ κB @-@ controlled genes , which are involved in most inflammatory responses , transcription is induced in response to a signal pathway such as that initiated by the signaling molecule TNF @-@ α , binds to a cell membrane receptor , resulting in the recruitment of signalling proteins , and eventually activating the transcription factor NF @-@ κB . A nuclear localisation signal on the NF @-@ κB protein allows it to be transported through the nuclear pore and into the nucleus , where it stimulates the transcription of the target genes . 
 In order to control which genes are being transcribed , the cell <a href='uninflect' title='1'><mark>separates</mark></a> some transcription factor proteins responsible for regulating gene expression from physical access to the DNA until they are activated by other signaling pathways . This <a href='uninflect' title='2'><mark>prevents</mark></a> even low levels of inappropriate gene expression . For example , in the case of NF @-@ κB @-@ controlled genes , which are involved in most inflammatory responses , transcription is induced in response to a signal pathway such as that initiated by the signaling molecule TNF @-@ α , <a href='uninflect' title='3'><mark>binds</mark></a> to a cell membrane receptor , resulting in the recruitment of signalling proteins , and eventually activating the transcription factor NF @-@ κB . A nuclear localisation signal on the NF @-@ κB protein <a href='uninflect' title='4'><mark>allows</mark></a> it to be transported through the nuclear pore and into the nucleus , where it <a href='uninflect' title='5'><mark>stimulates</mark></a> the transcription of the target genes . 
In order to control which genes r bein transcribed , the cell separate some transcription factor proteins responsible for regulating gene expression from physical access to da DNA untill they are activated by other signaling pathways . dis prevent even low levels of inappropriate gene expression . For example , in tdacase of NF @-@ κB @-@ controlled genes , which are involved in most inflammatory responses , transcription is induced in response to a signal pathway such as that initiated by thdaignaling molecule TNF @-@ α , bind to a cell membrane receptor , resulting in the recruitment of signalling proteins , and eventually activating thedaanscription factor NF @-@ κB . A nuclear localisation signal on the NF @-@ κB protein allow it to be transported through the nuclear pore and into the nucleus , where it stimulate the transcription of the daget genes .