 Apoptosis is a controlled process in which the cell 's structural components are destroyed , resulting in death of the cell . Changes associated with apoptosis directly affect the nucleus and its contents , for example , in the condensation of chromatin and the disintegration of the nuclear envelope and lamina . The destruction of the lamin networks is controlled by specialized apoptotic proteases called caspases , which cleave the lamin proteins and , thus , degrade the nucleus ' structural integrity . Lamin cleavage is sometimes used as a laboratory indicator of caspase activity in assays for early apoptotic activity . Cells that express mutant caspase @-@ resistant lamins are deficient in nuclear changes related to apoptosis , suggesting that lamins play a role in initiating the events that lead to apoptotic degradation of the nucleus . Inhibition of lamin assembly itself is an inducer of apoptosis . 
 Apoptosis <a href='drop_aux' title='1'><mark>is</mark></a>a controlled process in which the cell <a href='null_genetive' title='2'><mark>'s</mark></a>structural components are destroyed , resulting in death of the cell . Changes associated with apoptosis directly affect the nucleus and its contents , for example , in the condensation of chromatin and the disintegration of the nuclear envelope and lamina . The destruction of the lamin networks is controlled by specialized apoptotic proteases called caspases , which cleave the lamin proteins and , thus , degrade the nucleus <a href='null_genetive' title='3'><mark>'</mark></a>structural integrity . Lamin cleavage is sometimes used as a laboratory indicator of caspase activity in assays for early apoptotic activity . Cells <a href='null_relcl' title='4'><mark>that</mark></a>express mutant caspase @-@ resistant lamins <a href='drop_aux' title='5'><mark>are</mark></a>deficient in nuclear changes related to apoptosis , suggesting that lamins play a role in initiating the events <a href='null_relcl' title='6'><mark>that</mark></a>lead to apoptotic degradation of the nucleus . Inhibition of lamin assembly itself <a href='drop_aux' title='7'><mark>is</mark></a>an inducer of apoptosis . 
Apoptosis a controlled process in which da cell  structural components are destroyed , resulting in death of tdacell . Changes associated with apoptosis directly affect the nucleus and its contents , for example , in the condensation of chromatin and thdaisintegration of thedaclear envelope and lamina . The datruction of the lamin networks is controlled by specialized apoptotic proteases called caspases , which cleave the lamin proteins and , thus , degrade the ndaeus  structural integrity . Lamin cleavage is sometimes used as a laboratory indicator of caspase activity in assays for early apoptotic activity . Cells express mutant caspase @-@ resistant lamins deficient in nuclear changes related to apoptosis , suggesting that lamins play a role in initiating the events lead to apoptotic degradation of the nucleus . Inhibition of lamin assembly itself an inducer of apoptosis .