 The malignant cell in AML is the myeloblast . In normal hematopoiesis , the myeloblast is an immature precursor of myeloid white blood cells ; a normal myeloblast will gradually mature into a mature white blood cell . In AML , though , a single myeloblast accumulates genetic changes which " freeze " the cell in its immature state and prevent differentiation . Such a mutation alone does not cause leukemia ; however , when such a " differentiation arrest " is combined with other mutations which disrupt genes controlling proliferation , the result is the uncontrolled growth of an immature clone of cells , leading to the clinical entity of AML . 
 The malignant cell in AML <a href='drop_aux' title='1'><mark>is</mark></a>the myeloblast . In normal hematopoiesis , the myeloblast is an immature precursor of myeloid white blood cells ; a normal myeloblast will gradually mature into a mature white blood cell . In AML , though , a single myeloblast <a href='uninflect' title='2'><mark>accumulates</mark></a> genetic changes which " freeze " the cell in its immature state and prevent differentiation . Such a mutation alone <a href='uninflect' title='3'><mark>does</mark></a> not cause <a href='negative_concord' title='4'><mark>leukemia</mark></a> ; however , when such a " differentiation arrest " is combined with other mutations which disrupt genes controlling proliferation , the result is the uncontrolled growth of an immature clone of cells , leading to the clinical entity of AML . 
Da malignant cell in AML tdamyeloblast . In normal hematopoiesis , the myeloblast is an immature precursor of myeloid white blood cells ; a normal myeloblast will gradually mature into a mature white blood cell . In AML , tho , a single myeloblast accumulate genetic changes which " freeze " thdaell in its petty state and prevent differentiation . Such a mutation alone do not cuz no leukemia ; however , when such a " differentiation arrest " is combined with other mutations which disrupt genes controlling proliferation , the result is the uncontrolled growth of an immpettyone of cells , leading to the clinical entity of AML .