 The first clue to a diagnosis of AML is typically an abnormal result on a complete blood count . While an excess of abnormal white blood cells ( leukocytosis ) is a common finding , and leukemic blasts are sometimes seen , AML can also present with isolated decreases in platelets , red blood cells , or even with a low white blood cell count ( leukopenia ) . While a presumptive diagnosis of AML can be made by examination of the peripheral blood smear when there are circulating leukemic blasts , a definitive diagnosis usually requires an adequate bone marrow aspiration and biopsy . 
 The first clue to a diagnosis of AML <a href='drop_aux' title='1'><mark>is</mark></a>typically an abnormal result on a complete blood count . While an excess of abnormal white blood cells ( leukocytosis ) <a href='drop_aux' title='2'><mark>is</mark></a>a common finding , and leukemic blasts are sometimes seen , AML can also present with isolated decreases in platelets , red blood cells , or even with a low white blood cell count ( leukopenia ) . While a presumptive diagnosis of AML can be made by examination of the peripheral blood smear when <a href='dey_it' title='3'><mark>there</mark></a> are circulating leukemic blasts , a definitive diagnosis usually <a href='uninflect' title='4'><mark>requires</mark></a> an adequate bone marrow aspiration and biopsy . 
The first clue to a diagnosis of AML typically an abnormal result on a complete blood count . While an excess of abnormal white blood cells ( leukocytosis ) a common finding , and leukemic blasts are sometimes seen , AML can also present witt isolated decreases in platelets , red blood cells , or even with a low white blood cell count ( leukopenia ) . While a presumptive diagnosis of AML can be made by examination of the peripheral blood smear when it is circulating leukemic blasts , a definitive diagnosis usually require an adequate bone marrow aspiration and biopsy .