 Antibodies to certain types of chromatin organization , in particular , nucleosomes , have been associated with a number of autoimmune diseases , such as systemic lupus erythematosus . These are known as anti @-@ nuclear antibodies ( ANA ) and have also been observed in concert with multiple sclerosis as part of general immune system dysfunction . As in the case of progeria , the role played by the antibodies in inducing the symptoms of autoimmune diseases is not obvious . 
 Antibodies to certain types of chromatin organization , in particular , nucleosomes , <a href='been_done' title='1'><mark>have</mark></a> been associated with a number of autoimmune diseases , such as systemic lupus erythematosus . These are known as anti @-@ nuclear antibodies ( ANA ) and <a href='been_done' title='2'><mark>have</mark></a> also been observed in concert with multiple sclerosis as part of general immune system dysfunction . As in the case of progeria , the role played by the antibodies in inducing the symptoms of autoimmune diseases <a href='negative_concord' title='3'><mark>is</mark></a> <a href='negative_concord' title='4'><mark>not</mark></a>obvious . 
Antibodies to certain types of chromatin organization , in particular , nucleosomes , done been associated with a number of autoimmune diseases , such as systemic lupus erythematosus . These are known as anti @-@ nuclear antibodies ( ANA ) and done also been observed in concert wid multiple sclerosis as part of general immune system dysfunction . As in the case of progeria , the role played by the antibodies in inducing the symptoms of autoimmune diseases ain't obvious .