Even if someone wants to help in general, it’s not uncommon for them to back away when the real, damaging symptoms appear. Depression is depressing. Who wants to be depressed?“I can’t have this conversation anymore. It just cycles,” one of my best friends said. And she was right; cycling thoughts — the inability to roll an idea around in your head until you come to a logical conclusion — is a hallmark of depression (as well as many anxiety disorders). “I need to surround myself with positive people,” proclaimed another close, intimate friend, who had recently become pregnant. When I tried win her back, she told me to stop being “so emo.”But I’m not talking about just “feeling sad.” Sadness is spending a weekend in your pajamas watching Netflix amidst a sea of your own junk food wrappers, or a couple of weeks of tear-soaked blues after a bad breakup. “Everyone gets the blues,” Dr. Serani says. “But if you’re feeling sad, irritable, or depressed for more than two weeks, that’s the defining line for a clinical disorder.”The exact symptoms of clinical depression may be different for different people. But for me, true depression means I can’t get out of bed, literally, for days. And when I do, it’s because I’ve mustered all the energy inside me just to relocate to the couch. I can’t remember the last time I showered or brushed my teeth, because my mind is consumed with doomsday scenarios: No one understands me. There’s no hope for me. Nothing means anything, and my life is over. I’m fighting against a "reality" that isn't real — and depression usually wins.In a moment I’m not proud of, I reacted to a third friend’s engagement with snark, instead of joy — which was unusual for me. This friend had worked hard for her happiness. She's a warrior who battled cancer six years ago at age 24. Though she was understandably absent from my life during this period, I did everything I could to support her, including raising money for the Leukemia & Lymphoma Foundation and running the New York City Half Marathon in support of her fight (she finished the race before me — a testament to her strength).But after I crapped on her happy news — and quickly apologized profusely, reminding her I was not in a healthy state of mind — she wrote me off completely. I even tried to educate her about depression’s stranglehold on a person’s emotions and actions, to no avail. “Many [people suffering bouts of clinical depression] say things they normally would not say,” says Melinda Gallagher, PhD, a psychologist in New York City. "It’s important that loved ones understand this as a symptom of the disorder and that with treatment and time, she will feel better and more like herself.”So, if it’s the sufferer’s job to seek help during a serious case of clinical depression, what’s the role of friends, family, and other loved ones who feel helpless, drained, or overwhelmed? It's simple. Dr. Gallagher says the simple gesture of acting with compassion can go a long way toward healing. That means doing your best to understand the emotional state of this person you love and what they’re going through, even — especially — if doesn’t make sense to you.You don’t have to fix someone with depression. That's not your job. You don’t even have to interact with that person if it’s too much for you. But if you truly do love the person and you want to maintain a relationship in the long run, listen with compassion, that desire to understand, and help in the ways you actually can. Communicate your boundaries with compassion. Don’t take the illness as a personal affront and certainly don't abandon them; that's probably the worst way to react.