Uh, hell yeah it would! But logistically it would be difficult to pull off, as Pompeo quickly points out. Why? "Some of them were killed on the show,” she says with a matter-of-fact shrug, obviously talking about one of the original five Grey’s interns, George (T.R. Knight) who was killed off in season 5 after Knight asked to be released from his contract. Izzie and Cristina, played by Katherine Heigl and Sandra Oh , have since moved on to other projects.