A 62-year-old man with no medical history presents with a spontaneous deep hematoma of the psoas muscle. the nfs shows hemoglobin at 90 g/l and platelets at 170 g/l. its hemostasis assessment is as follows: tca ratio at 2.1, tp at 78% and fibrinogen at 3.1g/l. mixing the patient's plasma with normal plasma does not allow the TCA to be corrected (Rosner index at 28 for normal < 15). the dosage of endogenous pathway factors reveals a factor viii at 4%. what diagnostic hypothesis(s) do you retain? (one or more possible answers)
The presence of a lupus-type anticoagulant
Constitutional hemophilia
The presence of an anti-factor VIII antibody
Willebrand disease type 1
Acquired hemophilia b