n up by the finding that inhibition of RNA Polymerase II leads to a burst of transposon activity in Arabidopsis and rice, providing.
Researchers at the University of Texas at Austin examined the epigenomic signatures of domestication traits during cotton evolution, which may have contributed to the crop’s worldwide cultivation.
In the world of mammalian epigenomes, were given the mouse epigenetic clock, which will be invaluable for understanding the biology of aging and will provide avenues for manipulating (and possibly resetting) its speed in vivo.
Using the diagnostic potential of cell-free DNA, researchers from UCLA created a probabilistic method for not only detecting tumors, but also their location. CancerLocator has been accessed over 19,000 times so far and created quite a buzz in the news!
We got a step closer to unlocking the full potential of metagenomic data with DESMAN, which identifies variants in core genes and links them into haplotypes and abundance profiles, allowing species-level identification.
Easi-CRISPR, a new method for animal genome editing, addresses the problem of inefficiency of targeted DNA casette insertion. In the development of the method, the authors produced correctly targeted alleles in 100% of live offspring.
We also saw the first application of the CRISPR/Cas9 system in cattle. Researchers from China targeted the NRAMP1 gene with reduced off-target effects, creating transgenic cattle with increased resistance to tuberculosis. This is among our most talked-about articles of the year!
Single-cell analysis got a bit of lasting power with a method for sample preservation that maintains transcripts in viable single cells, disconnecting the logistics of sampling from the subsequent processing and analysis steps.
A microbiome profile of 531 Finnish men identified links between gut microbiome composition and circulating metabolites, teasing apart more of the story in the human-microbiome relationship.
The first methicillin-resistant Staphylococcus aureus isolates, preserved since the 1960s, showed us that antibiotic resistance can predate the widespread use of an antibiotic, demonstrating that new drugs could be rendered ineffective by previous adaptations to bacterial genomes. Listen to Scientific American cover the article in their 60-second Science podcast!
Thank you to all our authors and reviewers in 2017. We look forward to a lot of great research to come in 2018!