E. Behavioral state instability in orexin knock-out mice. J Neurosci 2004; 24:6291–300.
- Foutz AS, Delashaw JB Jr., Guilleminault C, Dement WC. Monoaminergic mechanisms and experimental cataplexy. Ann Neurol 1981; 10:369–76.
- Oishi Y, Williams RH, Agostinelli L, Arrigoni E, Fuller PM, Mochizuki T, Saper CB, Scammell TE. Role of the medial prefrontal cortex in cataplexy. J Neurosci 2013; 33:9743–51.
- Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27:469–74.
- Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 6:991–7.
- Crocker A, Espana RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology 2005; 65:1184–8.
- Mignot E, Lammers G, Ripley B, Okun M, Nevsimalova S, Overeem S, Vankova J, Black J, Harsh J, Bassetti C, Schrader H, Nishino S. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002; 59:1553–62.
- Thannickal TC, Nienhuis R, Siegel JM. Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy. Sleep 2009; 32:993–8.
- Andlauer O, Moore H 4th, Hong SC, Dauvilliers Y, Kanbayashi T, Nishino S, Han F, Silber MH, Rico T, Einen M, Kornum BR, Jennum P, Knudsen S, Nevsimalova S, Poli F, Plazzi G, Mignot E. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep 2012; 35:1247–55F.
- Latorre D, et al. T cells in patients with narcolepsy target self-antigens of hypocretin neurons. Nature. 2018; 562:63-8.
- Kornum BR, et al. Absence of autoreactive CD4_ T cells targeting HLA-DQA1*:02/DQB1*06:02 restricted hypocretin/orexin eipitopes in narcolepsy type 1 when detected by EliSpot. J Neuroimmunol. 2017; 309:7-11.
- Luo G, et al. Absence of anti-hypocretin receptor 2 autoantibodies in post Pandemrix narcolepsy cases. PLoS One. 2017;12:e0187305.
- Cogswell AC, et al. Children with narcolepsy type 1 have increased T-cell responses to orexins. Ann Clin Transl Neurol. 2019; 6:2566-72.
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