be aimed at understanding how statins turn on the atrogin-1 response in muscle, and in ascertaining what transpires in muscle following atrogin-1 activation that leads to muscle damage and atrophy. The hope is that eventually patients will be able to glean statins' positive benefits to cholesterol metabolism and reduction of cardiovascular events while being spared accompanying muscle toxicities."
Study coauthors include BIDMC investigators Jun-Ichi Hanai and Peirang Cao (lead authors) and Preeti Tanksale; Shintaro Imamura, Eriko Koshimizu and Shuji Kishi of Schepens Eye Research Institute; Michiaki Yamashita, of the National Research Institute of Fisheries Science, Yokohama, Japan; and Paul Phillips of Scripps Mercy Hospital, San Diego, California.
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