vidence in humans.
There are mixed reports that IGF-1 signaling modulates the aging process in humans and about whether the direction of its effect is positive or negative.
Therapeutic administration of neurotrophic proteins (IGF-1) is associated with potential reversal of degeneration of spinal cord motor neuron axons in certain peripheral neuropathies.
The IGF signaling pathway is implicated in some cancers. People with Laron syndrome have a lessened risk of developing cancer. Dietary interventions and modifications such as vegan diets shown to downregulate IGF-1 activity, has been associated with lower risk of cancer. However, despite considerable research, perturbations specific to cancer are incompletely delineated and clinical drug trials have been unsuccessful.
IGF-1 has also been shown to be effective in animal models of stroke when combined with erythropoietin. Both behavioural and cellular improvements were found.
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