 indicated less atrophy in MAGENTA-treated mice and suggested increases in pathways that promote muscle growth.
“While untreated muscles and muscles treated with the device, but not significantly stimulated, atrophied during this time, actively stimulated muscles showed reduced muscle wasting. Our approach may also promote recovery from muscle mass that had already been lost during a three-week immobilization period,” said Sungmin Nam, PhD, a Harvard researcher and co-author of the study.
These anti-atrophy effects were not observed with a different mechanical stimulation device applied to the skin of mice. “This highlights the effectiveness of MAGENTA despite the required implantation procedure,” the researchers wrote. Other results suggest that the implanted device does not induce substantial inflammation.
“MAGENTA’s general capabilities and the fact that its assembly can be easily scaled from a few millimeters to several centimeters could make it interesting as a centerpiece of future mechanotherapy not only to treat atrophy, but perhaps- also be to accelerate the regeneration of the skin, heart and other places that could benefit from this form of [mechanic stimulation]”Nam said.
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