Human bone marrow megakaryocyte in the process of forming two small platelets via proplatelet extensions. Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. During megakaryocyte maturation the cell grows in size and replicates its DNA without cytokinesis, a process called endomitosis. As a result, the nucleus of the megakaryocyte is polyploid and may contain up to 32 copies of the normal complement of DNA in a human cell. Thrombocytes or platelets are necessary for normal blood clotting. Megakaryocytes release mature platelets in a complex process which begins with the extension of large pseudopodia from their cell surface that form thin tube-like cytoplasmic extensions with bulbous thickenings called proplatelets. Each megakaryocyte produces and releases hundreds of platelets into the circulatory system and nearly a trill
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