 RNA biology that will be of interest to advanced undergraduate students and graduate students. Some of the material taught in this course will necessarily be taught in entry-level biochemistry courses at both the undergraduate level but because of the breadth of subject matter in these courses, in-depth coverage of RNA-related topics is not possible. This course will provide a panoramic view of the fast-evolving RNA research field and cover the field in a systematic way.
- Hayes, R., Xiao, Y., Ding, F., & Ke, A. (2016). Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature.
- Johnson, C. M., Chen, Y., Lee, H., Ke, A., Weaver, K. E., & Dunny, G. M. (2014). Identification of a conserved branched RNA structure that functions as a factor-independent terminator. PNAS: Proceedings of the National Academy of Sciences of the United States of America. 111:3573-3578.
- Huo, Y., Nam, K., Ding, F. F., Lee, H., Wu, L., Xiao, Y., Farchione , M. D., Zhou, S., Rajashankar , K., Kourinov, I., Zhang, R., Ailong, K., & , (2014). Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation. Nature Structural & Molecular Biology. 10.1038:2875.
- Liu, J. J., Bratkowski, M. A., Liu, X., Niu, C. Y., Ke, A., & Wang, H. W. (2014). Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM. Nature Structural & Molecular Biology. 21:95-102. .
- Grigg, J. C., Chen, Y., Grundy, F. J., Henkin, T. M., Pollack, L., & Ke, A. (2013). T box RNA decodes both the information content and geometry of tRNA to affect gene expression. PNAS: Proceedings of the National Academy of Sciences of the United States of America. 110:7240-5.
- Nam, K., Kurinov, I., & Ke, A. (2012). Crystal structure of clustered regularly interspaced short palindromic repeats (CRISPR)-associated Csn2 protein revealed Ca2+-dependent double-stranded DNA binding activity. JBC: Journal of Biological Chemistry. 286:30759-68.
- Wang, H. -., Wang, J., Ding, F., Kevin, C., Butler, J. S., Nogales, E., & Ke, A. (2007). Architecture of the Yeast Rrp44-Exosome Complex Suggests Routes of RNA Recruitment for 3’-end Processing. PNAS: Proceedings of the National Academy of Sciences of the United States of America. 104:16844-16849.
- Ke, A., & Doudna, J. A. (2005). Catalytic strategies of self-cleaving ribozymes: Relics of an RNA world? The RNA World.