y fetal development. Affected people typically have no history of the disorder in their family.
Some affected individuals inherit a chromosome 11 with a deleted segment from an unaffected parent. In these cases, the parent carries a chromosomal rearrangement called a balanced translocation, in which no genetic material is gained or lost. Balanced translocations usually do not cause any health problems; however, they can become unbalanced as they are passed to the next generation. Children who inherit an unbalanced translocation can have a chromosomal rearrangement with extra or missing genetic material. Individuals with WAGR syndrome who inherit an unbalanced translocation are missing genetic material from the short arm of chromosome 11, which results in an increased risk of Wilms tumor, aniridia, genitourinary anomalies, and intellectual disability.
- 11p deletion syndrome
- 11p partial monosomy syndrome
- WAGR complex
- WAGR contiguous gene syndrome
- Wilms tumor-aniridia-genital anomalies-retardation syndrome
- Wilms tumor-aniridia-genitourinary anomalies-MR syndrome
- Wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome
- Atlas of Genetics and Cytogenetics in Oncology and Haematology: WAGR syndrome
- Boston Children's Hospital: Wilms Tumor in Children
- Centers for Disease Control and Prevention: Intellectual Disability (PDF)
- Cincinnati Children's Hospital: Wilms Tumor
- Great Ormond Street Hospital for Children (UK): Kidney Failure
- MalaCards: wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome
- March of Dimes: Chromosomal Conditions
- Merck Manual Consumer Version: Wilms' Tumor
- My46 Trait Profile
- Orphanet: WAGR syndrome
- Swedish Information Center for Rare Diseases
- Aniridia Foundation International
- Chromosome Disorder Outreach
- International WAGR Syndrome Association
- Kidney Cancer Association
- National Organization for Rare Disorders (NORD)
- Unique: Rare Chromosome Disorder Support Group (UK)
- University of Kansas Medical Center Resource List: Sexuality and Sexual Differentiation Syndromes