opment of new ones for these purposes. Investigations of family dynamics are essential for understanding the impact of both the disorder and the different modalities of therapy.
- Diet --Further dietary research is needed with improved study design, including particular attention to certain features such as adequate sample size, explicit criteria for selection of subjects, ensuring and monitoring compliance, precise definition of the diet or dietary agent being tested, and consideration of synergistic effects of simultaneous exposure to additional dietary and/or other agents. Randomized, double-blind trials with checks on the adequacy of the blinding and repetitive evaluations are needed. Moreover, studies are also needed of the possible adverse effects of dietary intervention, on both the patient and the family, and of both a biologic and a psychosocial nature. These types of studies are essential for risk-benefit assessments that should also be carried out for other nondietary options of therapy.
- Animal studies --These studies offer an obvious opportunity for obtaining relevant biologic information. However, such studies should be conducted with particular attention to dosages of specific test substances, standardization of rigorously defined synthetic diets, routes of administration, and genetic factors. These studies should provide important information regarding the absorption, distribution, metabolism, and mechanism of action of the agents being tested and may be particularly relevant for human populations if appropriate behavioral endpoints in the animal model can be developed.
Consensus Development Panel
Floyd W. Denny, M.D.
Professor of Pediatrics
University of North Carolina School of Medicine
Chapel Hill, North Carolina
Leon Gordis, M.D., Dr.P.H.
Professor and Chairman
Department of Epidemiology
Johns Hopkins University School of Hygiene and Public Health
Morris Green, M.D.
Perry W. Lesh Professor and Chairman
Department of Pediatrics
Indiana University School of Medicine
Samuel W. Greenhouse, Ph.D.
Visiting Professor of Biostatistics
Department of Biostatistics
Harvard School of Public Health
Ileana Collado Herrell, Ph.D.
Hispanic Affairs Advisor for the Chief Administrative Officer
Elizabeth Jean-Marie Jameson, J.D.
Attorney at Law
Youth Law Center
San Francisco, California
Michael M. Kaback, M.D.
Professor, Departments of Pediatrics and Medicine
University of California at Los Angeles School of Medicine
Associate Chief, Division of Medical Genetics
Harbor-UCLA Medical Center
Jeanne M. Manson, Ph.D.
Associate Professor of Environmental Health, Division of Toxicology
University of Cincinnati College of Medicine
Kristen W. McNutt, Ph.D.
Assistant Professor, Nutrition
University of Illinois
School of Public Health
Former President, Kentucky Parent/Teachers Association
E. Richard Stiehm, M.D.
Professor, Head, Division of Pediatric Immunology/Allergy
Department of Pediatrics
University of California School of Medicine
University of California at Los Angeles
Center for Interdisciplinary Research and Immunologic Diseases
Los Angeles, California
Glen L. Stimmel, Pharm.D.
Associate Professor of Clinical Pharmacy and Psychiatry
University of Southern California
Schools of Pharmacy and Medicine
Los Angeles, California
Charles B. Wilkinson, M.D.
Greater Kansas City Mental Health Foundation
University of Missouri School of Medicine
Kansas City, Missouri
C. Keith Conners, Ph.D.
Director of Research
Department of Psychiatry
Children's Hospital National Medical Center
Ben F. Feingold, M.D.
Emeritus, Department of Allergy
Kaiser Permanente Medical Center
San Francisco, California
Rachel Gittelman, Ph.D.
Director of Psychology
The New York State Psychiatric Institute
Professor of Clinical Psychology
Columbia University College of Physicians and Surgeons
New York, New York
Albert C. Kolbye, Jr., M.D., M.P.H., J.D.
Associate Bureau Director for Toxicological Sciences
Bureau of Foods
Food and Drug Administration
Richard B. Mailman, Ph.D.
Associate Professor of Psychiatry and Pharmacology
University of North Carolina
Chapel Hil