Cell Commitment and Differentiation
First published in 1987, this book is about how cells differentiate; that is it describes the way in which cells in animal and plant bodies take on their specialised fates. It has long been recognised that since all such cells retain copies of all genes, the genetic explanation for tissue differences lies in the controlled expression of restricted sets of genes. But how is the choice made and how are such restricted groups of genes activated and regulated? This book discusses these questions and describes both determination and differentiation. The mechanisms that underlie the processes are described for the embryo and in the adult. Determination may occur in adult life during regeneration, wound healing, cancer formation and in the immune and blood systems, and the possible genetic basis for the events is explored. The influence of the cell environment, the cell surface and the pericellular-extracellular matrix as mediators of external signals is discussed.
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adult amphibian animal antibody antigen cartilage cell commitment cell differentiation cell division cell fate cell lineage cell surface cell types cell-specific cellular Chapter chick chromatin chromosomes cloned coding collagen culture cytoplasm decondensation determination differen differentiated cells discussed DNA methylation DNase Drosophila ectoderm embryos endoderm enzyme epithelial cells epithelium erythrocytes eukaryotic evidence example factors fibroblasts function gap junctions gene activity gene expression gene regulation gene regulatory gene sequences genetic genome germ cells gland globin gradient growth histone homeotic genes hormones imaginal discs induced initial injected interactions involved larvae limb bud lymphocytes mechanism mesenchyme mesoderm mitosis molecular morphogen morphogenesis mouse mRNA muscle mutation neural crest cells normal nuclear nuclei nucleosomes occurs oncogenes oocyte organism pattern plant plasma membrane posterior protein receptors regeneration regions regulatory molecules ribosomal RNA polymerase role specific gene stage stem cells structure synthesis tion tissue totipotency transcription transdetermination vertebrates vesicles vitro Xenopus
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