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SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3
Cell Reports Volume 11, Issue 11, p1694–1702, 23 June 2015 DOI: http://dx.doi.org/10.1016/j.celrep.2015.04.061
Kandel et al
The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton
Cell Reports, Vol. 11, Issue 11, p1772–1785 DOI: http://dx.doi.org/10.1016/j.celrep.2015.04.060
Ferdinando Fiumara, Priyamvada Rajasethupathy, Igor Antonov, Stylianos Kosmidis, Wayne S. Sossin, Eric R. Kandel
MicroRNA-22 Gates Long-Term Heterosynaptic Plasticity in Aplysia through Presynaptic Regulation of CPEB and Downstream Targets
Cell Reports Volume 11, Issue 12, p1866–1875, 30 June 2015 DOI: http://dx.doi.org/10.1016/j.celrep.2015.05.034
Illustration: Memories are stored for the long-term with the help of prion-like proteins called CPEB. CPEB prions aggregate and maintain synapses that recorded the memory [“spines” in the bottom image]. When CPEB prions are not present or are inactivated, the synapses collapse and the memory fades [see upper image]. Credit: Lab of David Sulzer, Ph.D., Columbia University Medical Center