d polio vaccines, called Quadrigen, was developed in 1954 and approved in 1959. Quadrigen was later removed from the market in 1968 after a series of lawsuits pertaining to adverse effects in vaccinated children. Parke-Davis also produced the broad-spectrum antibiotic chloramphenicol, which was a blockbuster product before discovery of its association with aplastic anemia.
In the case of Franklin v. Parke-Davis (2002) the company was accused of illegal marketing practices, including the promotion of off-label uses of its anticonvulsant medication Neurontin. The drug had only been approved for use in patients with epilepsy, but in 2001 over 80% of its $1.8 billion in sales were for indications unapproved by the United States Food and Drug Administration. In 2004, Pfizer "admitted that Parke-Davis aggressively marketed Neurontin by illicit means for unrelated conditions including bipolar disorder, pain, migraine headaches, and drug and alcohol withdrawal", and consented to $430 million in penalties although it claimed the violations originated in 1996, well before Pfizer's acquisition of Warner-Lambert.
As announced on January 22, 2007, Pfizer closed its research facilities in Ann Arbor, MI.
- Exploring Our History: 2000 - Pfizer acquires Warner-Lambert. from Pfizer corporate website. Accessed May 19, 2006.
- Bennett, Joan and Yamomoto, Yutaka. Dr. Jokichi Takamine: Japanese father of American Biotechnology. Deerland Enzymes.
- Kevin Brown (December 2005). Penicillin Man: Alexander Fleming and the Antibiotic Revolution. The History Press. ISBN 978-0750931533.
- Sutin, Lawrence (2000). Do What Thou Wilt: a life of Aleister Crowley. Macmillan. p. 253. ISBN 978-0312252434.
- A Flaw in the System. remarkablemedicine.com Accessed May 16, 2006.
- Bayly, M. Beddow. The Story of the Salk Anti-Poliomyelitis Vaccine. 1956.
- Suit: Neurontin Marketed Illegally for Bipolar Disorder. About.com. May 16, 2004.
- Huge penalty in drug fraud Pfizer settles felony case in Neurontin off-label promotion. San Francisco Chronicle. Friday, May 14, 2004.
- At Pfizer, Brutal Cuts And Big Changes
- A picture of a Parke Davis & Co. Cocaine injection kit from 1885(discontinued)
- 2002 NPR broadcast of the Neurontin lawsuit story on the show All Things Considered