Wilson, Barnabas and Samanta, Malay K. and Santhi, Kumaraswamy and Kumar, K. P. Sampath and Ramasamy, Muthu and Suresh, Bhojraj (2010) Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine. Nanomedicine: Nanotechnology, Biology and Medicine, 6 (1). 144 - 152.
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://www.sciencedirect.com/science/article/B7MDB...
Tacrine-loaded chitosan nanoparticles were prepared by spontaneous emulsification. The particle size and zeta potential was determined by scanning probe microscopy and Zetasizer, respectively. The prepared particles showed good drug-loading capacity. The in vitro release studies showed that after the initial burst, all the drug-loaded batches provided a continuous and slow release of the drug. Coating of nanoparticles with Polysorbate 80 slightly reduced the drug release from the nanoparticles. Release kinetics studies showed that the release of drug from nanoparticles was diffusion-controlled, and the mechanism of drug release was Fickian. The biodistribution of these particles after intravenous injection in rats showed that of nanoparticles coated with 1% Polysorbate 80 altered the biodistribution pattern of nanoparticles.
|Uncontrolled Keywords:||Tacrine; Chitosan nanoparticles; Alzheimer's disease; Biodistribution|
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited On:||22 Apr 2010 11:01|
|Last Modified:||22 Apr 2010 11:01|
Repository Staff Only: item control page