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Diabetes Care (1)
The Malaysian Journal of Medical Sciences : MJMS (1)
Wan Bebakar, Wan Mohamad (2)
Al-Mahmood, Abu Kholdun (1)
Ali, Osman (1)
Isa, Siti Harnida Md (1)
Ismail, Ab Aziz (1)
Ismail, Aziz Al-Safi (1)
Ismail, Ikram Shah (1)
Kadir, Khalid Abdul (1)
Kamarudin, Nor Azmi (1)
Khir, Amir Sharifuddin (1)
Musa, Kamarul Imran (1)
Mustafa, Norlaila (1)
Rashid, Faridah Abdul (1)
Yaacob, Nor Azwany (1)
wan Mohamud, Wan Nazaimoon (1)
Year of Publication
Prevalence of Abnormal Glucose Tolerance and Risk Factors in Urban and Rural Malaysia
Kamarudin, Nor Azmi
Ismail, Ab Aziz
Khir, Amir Sharifuddin
Ismail, Ikram Shah
Musa, Kamarul Imran
Kadir, Khalid Abdul
Yaacob, Nor Azwany
Isa, Siti Harnida Md
wan Mohamud, Wan Nazaimoon
To determine the prevalence of prediabetes and diabetes among rural and urban Malaysians.
RESEARCH DESIGN AND METHODS
This cross-sectional survey was conducted among 3,879 Malaysian adults (1,335 men and 2,544 women). All subjects underwent the 75-g oral glucose tolerance test (OGTT).
The overall prevalence of prediabetes was 22.1% (30.2% in men and 69.8% in women). Isolated impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) were found in 3.4 and 16.1% of the study population, respectively, whereas 2.6% of the subjects had both IFG and IGT. Based on an OGTT, the prevalence of newly diagnosed type 2 diabetes was 12.6% (31.0% in men and 69.0% in women). The prediabetic subjects also had an increased prevalence of cardiovascular disease risk factors.
The large proportion of undiagnosed cases of prediabetes and diabetes reflects the lack of public awareness of the disease.
Insulin Sensitivity and Secretory Status of a Healthy Malay Population
Al-Mahmood, Abu Kholdun
Ismail, Aziz Al-Safi
Rashid, Faridah Abdul
The Malaysian Journal of Medical Sciences : MJMS
Insulin insensitivity is a common finding in several metabolic disorders including glucose intolerance, dyslipidemia, hyperuricemia and hypertension. Most of the previous studies on insulin sensitivity were performed on diabetic or obese population. So our knowledge about insulin sensitivity of healthy population remains limited. Rising prevalence of obesity, diabetes and metabolic syndrome is a serious issue in Malaysia and some other rapidly developing countries. So it is important to look at the insulin sensitivity status of healthy Malaysian subjects and to compare it in future with those of diabetic, obese or metabolic syndrome patients. In this study we sampled subjects who were independent of confounding factors such as obesity (including abdominal obesity), hypertension and glucose intolerance (diabetes, IGT or IFG) which may influence insulin sensitivity. Fasting plasma glucose, fasting insulin and lipid profile were determined. Insulin sensitivity and secretory status were calculated using the homeostasis model assessment (HOMA) software (HOMA%S, HOMA%B and HOMA-IR). The insulin sensitivity (HOMA%S) of healthy Malay subjects aged between 30–60 years was 155.17%, HOMA-IR was 1.05 and HOMA%B was 116.65% (values adjusted for age, sex, BMI and waist circumference). It was seen that non-obese Malaysians can prevent age related lowering of insulin sensitivity if they can retain their BMI within limit.
insulin sensitivity; homeostasis model assessment
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