What ever the potion was that Antonin offered Hermione after their son left to return to Hogwarts wasn't nearly as potent as the one she took the first night she was back home in Hogsmeade. It calmed her down immediately after imbibing and though she felt her eyes grow heavy with exhaustion, she only slept for several hours instead of more than a day. She knew she was being contradictory about her feelings when it came to her husband giving her potions. Not trusting him to make her tea when she first arrived out of fear that he would potion her was a valid concern. She didn't want to be fuzzy-headed for their first meeting, especially if he suddenly flipped the concerned husband routine to attack her in anger.