Hermione had taken the hunters’ advice and had an anti-possession symbol tattooed onto her shoulder blade and, without her consent, Cas had also placed Enochian symbols on her ribs to hide her from angels. He told her that she was a target due to being a witch and to helping Sam and Dean. The angels weren’t happy with her interference. Hermione had told Cas that they could take their irritation and shove it where the sun didn’t shine, she didn’t care. She protected those she considered friends and family from all who would bring them harm. One of the first things Hermione had done was to help Dean deal with his time in Hell. She knew he had spent several months there and couldn’t imagine what all he had been through. She hadn’t asked and he hadn’t volunteered but she knew a few spells to help him dull the memories and, with his permission, had cast them on him. To her amazement, Castiel had thanked her.