If he altered her memories or rooted around in her brain at all during his training, the effects would've been felt much sooner than they were. She wished she could blame her husband for the moments in time that the world swirled around her and she felt like she was doomed to spin for all eternity. Or when she forgot Harry was dead. Her greatest fear had always been that something would happen to her mind. Years into her service to the Dark Lord, her nightmares began to come into fruition. No, her confusion was never Antonin's fault. She only resented him because he was there when they happened more often than not. He wanted to seek out help to discover the underlying cause and how they could be prevented or eliminated entirely. Her paranoia that he was searching out a weakness to bring her down kept her from trusting that the potions he fed her were actually just there to help. In his warped way, her husband cared very much for her.