Nobel prize winners prove that success can be cloned October 9 2012 853pm EDT Author Justin St John Professor and Director Centre for Genetic Diseases Monash Institute of Medical Research Monash University Disclosure statement Justin St John holds a patent on cloning He receives funding from the NHMRC and Australian Pork Limited and received funding from the MRC in the UK He reviews license applications for the Human Fertilisation and Embryology Authority in the UK and held a license to make human stem cells using crossspecies cloning technology Partners Monash University provides funding as a founding partner of The Conversation AU Victoria State Government provides funding as a strategic partner of The Conversation AU View all partners Republish this article Republish our articles for free online or in print under Creative Commons license Shinya Yamanaka and John Gurdon have received the 2012 Nobel prize for Physiology or Medicine AAP The 2012 Nobel Prize for Medicine and Physiology has been awarded to John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent A pluripotent cell is capable of becoming any of the cells in the body just as the cells of an early embryo can When they are derived from an embryo these cells are referred to as embryonic stem cells and they have the potential to differentiate into all cell types of the body John Gurdons contribution to this field was his foresight in 1958 to predict that the egg which is normally fertilised to produce an embryo contains powerful factors that regulate the way genes are expressed during very early development Gurdon used nuclei from mature frog cells to show that these nuclei were capable of being reprogrammed to a naïve state by frog eggs so much so that they gave rise to a live offspring What had actually happened was that the egg managed to wipe off specific marks present in the cells nuclei that enable them to perform specific functions making the cell pluripotent and able to differentiate into all cell types of the body Gurdons work opened up a whole new field in developmental biology which we call epigenetics This involves the study of how the expression of genes is regulated Some epigenetic factors silence genes so that they are not expressed while others promote the expression of genes It enabled us to start understanding the importance of the timing of the expression of certain genes during development and the whole sequence of gene expression which determines how we develop We now apply this knowledge to differentiating embryonic and induced pluripotent stem cells to understand when a mutation might have its first effect on an individual during development and how it might predispose people to certain diseases Dolly the Sheep became a worldwide sensation and popularised the term cloning Toni BarrosWikimedia Commons But it wasnt until 1997 that one of the major advances resulted from Gurdons work This was the cloning of Dolly the Sheep Here Keith Campbell and Ian Wilmut took a cell from a sheep mammary gland breast tissue and introduced the cell into a sheep egg This resulted in Dolly the first mammalian clone Since then multiple species have been cloned and the cloning industry has expanded to produce specialised livestock for agricultural purposes Scientists also wanted to know whether it was possible to derive human embryonic stem cells using this approach where the cell to be reprogrammed would for example contain mutations associated with specific human diseases This was considered to be a holy grail for scientists as it would provide human models of disease that are so desperately required for medical research Sadly this has proven to be elusive to date Although this is exciting work cloning opened up a whole world of controversy Research governance bodies such as the Human Fertilisation and Embryology Authority in the United Kingdom and the NHMRC in Australia had to rethink whether they should allow people to do this sort of work using human cells and human eggs Nevertheless a major breakthrough came when Shinya Yamanaka deciphered which of the key factors present in the egg conferred pluripotency He chose four genes that when packaged appropriately and then incubated with cells such as skin cells had the potential to reprogram or dedifferentiate these cells into pluripotent stem cells Remarkably this technique did not require the use of an egg to generate these embryoniclike stem cells and became known as induced pluripotency Yamanaka then showed that these cells could be differentiated into many of the cell types of the body such as nerve and heart cells Since then others have made induced pluripotent stem cell lines of various diseases including Parkinsons disease The modification of DNA and how genes are expressed is not just limited to developmental biology These scientists have allowed us to think differently about how for example cancers arise Some of the factors involved in inducing pluripotency are similar to the factors involved in cancers And this work has been instrumental for getting researchers from different disciplines to work together to find common ground and answer significant scientific questions Stem cells derived from human embryonic cells can be manipulated to create other cells Nissim BenvenistyWikimedia Commons This is not the first Nobel prize associated stem cell research either Martin J Evans Mario Capecchi and Oliver Smithies were awarded the prize in 2007 for the discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells Their work led to more efficient mechanisms for generating transgenic mice that may be deficient of a specific gene or have one that is overexpressed Such mice are invaluable in medical research as they are instrumental in studying disease and for drug discovery Theres still the potential for stem cells to be used for therapeutic purposes but they are equally important for helping us understand developmental biology processes and for designing therapeutics based on what we learn from them But this award shows how basic science is fundamentally important for opening the doors of translational research As we drive towards translational research we need to remember that early fundamental science is integral and we cant do translational work without it Science also needs young intellects to step forward to drive tomorrows research programs Giving people like John Gurdon and Shinya Yamanaka the Nobel prize for their inventiveness will hopefully switch young people on and encourage them to think into the unknown Its also worth remembering that John Gurdon was told by his teacher that he was not cut out for science Stem cell research Stem cells Nobel Prize Embryonic stem cells Nobel Prize 2012 Share Get newsletter

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South Africas Blombos cave is home to the earliest drawing by a human September 12 2018 105pm EDT Authors Christopher Henshilwood Professor of Evolutionary Studies Professor of African Prehistory University of Bergen Karen Loise van Niekerk Principal Investigator SapienCE Centre for Early Sapiens Behaviour University of Bergen Disclosure statement Christopher Henshilwood receives funding from his DSTNRF SARChI Chair at Wits University as well as through a Research Council of Norway Centre of Excellence grant Centre for Early Sapiens Behaviour SapienCE at the University of Bergen Norway Karen Loise van Niekerk does not work for consult own shares in or receive funding from any company or organization that would benefit from this article and has disclosed no relevant affiliations beyond their academic appointment Partners View all partners Republish this article Republish our articles for free online or in print under Creative Commons license The drawing found on silcrete stone in Blombos Cave Craig Foster Scientists working in Blombos Cave in South Africas southern Cape region have made a discovery that changes our understanding of when our human ancestors started expressing themselves through drawings Theyve found a 73 000yearold crosshatched drawing on a silcrete stone flake It was made with an ochre crayon The Conversation Africa asked Professor Christopher Henshilwood who leads the team that made the discovery about its significance What does the drawing your team found look like It consists of a set of six straight subparallel lines crossed obliquely by three slightly curved lines One line partially overlaps the edge of a flake scar This suggests it was made after that flake became detached The abrupt termination of all lines on the fragment edges indicates that the pattern originally extended over a larger surface So the pattern was probably more complex and structured in its entirety than in this truncated form This has shifted our thinking about when human ancestors started drawing What was the earliest known drawing found before this The earliest known engraving a zigzag pattern incised on a fresh water shell from Trinil Java was found in layers dated to 540 000 years ago In terms of drawings a recent article proposed that painted representations in three caves of the Iberian Peninsula were 64000 years old this would mean they were produced by Neanderthals So the drawing on the Blombos silcrete flake is the oldest drawing by Homo sapiens ever found You describe it as a drawing how can you be sure it wasnt just a random series of scratches The presence of similar crosshatched patterns engraved on ochre fragments found in the same archaeological level and older levels suggests the pattern in question was reproduced with different techniques on different media This is what we would expect to find in a society with a symbolic system embedded in different categories of artefacts Its also worth noting that patterns drawn on a stone are less durable than those engraved on an ochre fragment and may not survive transport This may indicate that comparable signs were produced in different contexts possibly for different purposes Is there any reason to think the pattern is an artwork We would be hesitant to call it art It is definitely an abstract design it almost certainly had some meaning to the maker and probably formed a part of the common symbolic system understood by other people in this group Its also evidence of early humans ability to store information outside of the human brain Does it tell us anything else about the people who made it And do we know which group they belonged to on our ancestral tree The drawing was made by Homo sapiens people like us who were our ancient direct ancestors They were huntergatherers who lived in groups of between 20 and 40 people The discovery adds to our existing understanding of Homo sapiens in Africa They were behaviourally modern they behaved essentially like us They were able to produce and use symbolic material culture to mediate their behaviour just like we do now They also had syntactic language essential for conveying symbolic meaning within and across groups of hunter gatherers who were present in southern Africa at that time Blombos Cave is a really significant archaeological site Can you explain why The outside of Blombos Cave where the drawing was discovered Magnus Haaland Blombos Cave is situated 50 m from the Indian Ocean elevated at 35 m above sea level and 300 km east of Cape Town Its very small just 55m It was used as a temporary living site by hunter gatherer groups theyd spend a week or two there at a time before moving on The archaeological layer in which the Blombos drawing was discovered has also yielded other indicators of symbolic thinking These include shell beads covered with ochre and more importantly pieces of ochres engraved with abstract patterns Some of these engravings closely resemble the one drawn on the silcrete flake In older layers at Blombos Cave dated at 100 000 years they also discovered a complete toolkit consisting of two abalone shells filled with an ochre rich substance a red paint and all the artefacts associated with making it including seal bone used to add fat to the mixture This discovery proves that our early ancestors could also make paint by 100 000 years ago Engraved ochre slabs with various designs including crosshatched patterns were also found in these older layers Homo sapiens Drawing Caves ochre Human ancestors Share Get newsletter

O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O O B I O O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


Stuck on Young Dissecting Our Obsession with Youth Beauty Culture October 21 2015 It was the eve of my birthday I was supposed to be celebrating but instead I was on my bed dreading the idea of getting older My best friend was with me for support trying to convince me I was not old and I was overreacting I wasnt listening and when the clock turned 12 midnight I let out a highpitched agonizing scream that reverberated across the room You wouldve thought I was being tortured But I wasnt I was in my college dorm I was 19 Even then on some level I knew I was being completely ridiculous But I couldnt shake off my perception of what it meant to be older Im not sure I had the words to adequately articulate what I was responding to at that time but I member feeling like I was losing my childhood my youth and moving closer to the unknown abyss of the aged insert creepy horror movie music here I had internalized the cultures obsession with youth and beauty so wholeheartedly that I wanted to be stuck in a youth time capsule yet still live a full Many many ahem years later I still struggle with getting older but Im much better at it now thanks to a little psychological training some divine wisdom and learning from others experiences with aging Its not surprising that a lot of young women already feel old and living are under the impression that no one will care about them as they get older Lets face it our culture doesnt do a great job at valuing the elderly Look at any number of glossy images in magazines newspapers television or online Older people are noticeably absent from them translation they dont exist Or when we do see them theyre often presented in unfavorable ways How difficult is it to conjure up images of the elderly sickly gentleman in a nursing home with a walker who is dependent upon others for his daytoday needs Or the elderly woman with missing teeth and poor coordination who forgets things easily and feels lonely They dont exactly make The Contradiction No matter how old I get youll always be older than me said my lovely teenage niece Its as if my age relative to hers was some sort of salvation that prevented her from having to face her own anxieties about aging Because when she was with me shed always be young er And to be young is everything Its the epitome of beauty vitality and the most exciting time of our lives We think to be young is everything That its the epitome of beauty vitality and the most exciting time of our lives Its when we dream big dreams and fantasize about the great life ahead Only we dont want to move too far ahead because then wed no longer be young fantasizing about the great life ahead Its kind of like Christmas Everyones excited about the day leading up to it but once it arrives the excitement is over and many people feel depressed It seems that the hope and excitement of what is to come is so much better than when it comes This may be why we romanticize the beginning of life but rarely the end and there are few So we try to stop the aging process a process thats been happening since birth Only its biologically impossible to do So instead we disassociate ourselves from all things old Theres a reason why the beauty industry which entices us with the hope of eternal youth is a booming business I love beauty products as much as the next person but it can be problematic when we are consuming products as a way to cope with the fear of aging Fear is never beautiful and we can become so preoccupied with staying young that we spend much of our time and energy running away from a normal developmental process and ironically miss our youth Thats the problem with fear It strips us of our lives Thats the problem with fear It strips us of our lives Live your life in such a way that your older self will thank you All too many of us have looked back and wondered where the time went where life went because we spent it in fear While the challenges inherent in growing older can feel isolating its something we must all deal with Either we get older or we die young and Id say the former is a better alternative So one way to cope with this dilemma is to choose to live the best life at the age you are right now Five ten even twentyyears from now you can either look back with regret that you did not live your life The Myth of Them As children we tend to glorify adulthood Oh to have the freedom to be able to stay up late eat as much candy as you like and wear anything you want Theres the idea that when you become a grownup you know what youre doing you have the answers and you have this life thing all worked out But these idealizations are not limited to childhood As an adult before I became a parent I can recall having very rigid views of what it meant to be a mother It felt so distinct and unme yet I thought I would Thankfully Ive matured a lot since I was 19 but many parts of me then are still me and my 19yearold self would certainly recognize my idiosyncrasies And yes Im a mother now but I didnt miraculously turn into the overly understanding person I imagined I still get frustrated when my child asks for the same thing umpteen times God bless him And if all of that is true then I am my 65yearold self just younger and less experienced Nevertheless our culture certainly does its share to promote the perception that older people are a distinct population completely different As our fear grows our sympathy declines and we look at aging as something to avoid dismiss and even obliterate Thus we are inclined to feel less valued with each age and can not enjoy the process of growing Lets not buy into the concept of them so we can more fully appreciate ourselves now and in the future A Balanced Perspective of Beauty Youth is beautiful But no one age group has the monopoly on beauty Ive come across some very beautiful older women And clearly it wasnt their youth that made them beautiful It was them their features and the way they carried themselves Im all for enhancing and preserving our looks for as long as we can but our physical appearance has been changing since the day we were born and while we can slow down the aging process we can not stop it Holding onto our youth is much like a baby holding on to her bottle Shes bound to get disappointed So It becomes problematic when we place so much value on something thats ever changing Age is not all we are and beauty is much more than looks A person in their 20s may feel unattractive while someone in their 40s may feel quite the opposite The difference between the two perspectives may not be a discrepancy in their looks but in their selfimage Unlike the aging process our selfimage and selfperception are things we can change We can enhance the way we see ourselves by living fully and creating meaningful experiences And in doing so we make ourselves look better Yes being young is a valuable asset but remaining stuck is not Misery starts I certainly dont have this age dilemma all worked out but I know that as we develop a more balanced perspective of growing older one that allows us to be more open to the changes life brings then we can be free to be And thats always beautiful Tweet Pin Show Comments Firefox Chrome Internet Explorer 11 Safari Juley Le Casually Chic by Monique Casually Chic by Monique Perfectly Rachel httpperfectlyrachelblog sanja Lady Beatrix Copy by Sarah SeungMcFarland Photography By Sweetwater Portraits Shopbopcom Take 15 Off First Order with Shopbop App Use Code APP15 JUST ARRIVED SHOP BELT BAG SHOP TIE Shop Tassel Earrings Heeled Sandals White One Piece Swimsuit Fashion Jackets and more Get this widget

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Floor Plans The Glades may not be situated in a conventionally rich area like Holland Village or Orchard Road but it is in a very high traffic well connected part of the island While there are no truly close amenities within a couple of minutes of walking it is within proximity by bus or train to several malls supermarkets and food courts as well as schools Bedok Interchange and its two shopping malls is one train stop down while Tampines Expo Changi Airport and Pasir Ris are readily reached from Tanah Merah MRT station which is next to the development The bus stop in front of the station goes toward downtown and Marine Parade New Upper Changi Road links all the way to Bugis Junction along Victoria Street and past the Esplanade along the way to Jurong That and with its lavish landscaping real marble floors and generous layouts contribute to a higher cost The Glades has the some of the pricier units out of all the condominiums in the area around Tanah Merah The good thing about The Glades is definitely its layout The spaciousness of even little units adds to that feeling of luxury Bigger units are certainly with the capacity of handling larger families while a 1bedroom unit can meet most of a working professionals demands Obviously squeezing two individuals in a common bedroom wot create the best of experiences but if theyre children its doable when they modest Its location is unequivocally great and the extreme convenience of the MRT station next to it will make this an excellent buy for professionals that work along the EastWest line or nearby at Changi Business Park However its higher price means individuals buying to rent may choose some of the other condominiums There are cheaper alternatives around while The Glades is aesthetically pleasant

B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B O O O O O O O O O O O B O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


About Us From humble beginnings in a homebased environment to elevating to new heights in a shopping centre The Grillfather has since established a lasting mark on the grillhouse map Inspired by the owners passion for serving good food as well as his love of the Godfather trilogy The Grillfather has become a fusion of your delicious backyard braai only without the wait Whether its a tasty Don Corleone steak youre after or chicken wings marinated in sheer barbeque heaven rest assured that The Grillfather has just what youre after With ample parking you and the family are guaranteed to be in Chicken Wings Burgers Steaks All our food is Halaal Friendly We also do call and collect BURGERS OUR VK TSEK BURGER R 9000 2 x 100 Beef Patties 2 x Slices of Cheese 1 x Boerewors 2 x Slices of Pineapple Braised Onions and topped with our Famous Mushroom Sauce Served with Chips BIG BOSS CHICKEN BURGER R 5000 Grilled Chicken fillet served on a sesame seed bun with chips BIG BOSS BEEF BURGER R 5000 180g 100 Beef Burger served on a sesame seed bun with chips DOUBLE BIG BOSS BEEF BURGER R 7000 2 x 180g 100 Beef Burger served on a sesame seed bun with chips BOSS IT UP CHEESE SLICE R 700 MUSHROOM SAUCE R 1000 PEPPER SAUCE R 1000 SWEET PEPPADEW CHUTNEY R 1000 BRAISED ONIONS R 700 GRILLED PINEAPPLE RING R 700 CHILLI RELISH R 1000 STEAKS 200G DON CORLEONE STEAK R 7000 200g Sirloin steak served with chips coleslaw Grilled either Rare Medium Rare Medium Medium to well or Well done 500G DON CORLEONE STEAK R 14000 500g Rump steak served with chips coleslaw Grilled either Rare Medium Rare Medium Medium to well or Well done BOEREWORS FOOTLONG BOEREWORS R 4700 Served with onions chips BBQ chilli chutney tomato sauce mustard or sweet chilli WINGS FIVE FINGER WINGS R 5500 5 Full wings served with chips coleslaw Grilled either BBQ or Periperi CHICKEN SOLOZZO DEAL R 5500 Grilled Chicken Breast served with chips coleslaw Grilled either BBQ or Periperi KIDDIES BAMBINO MEAL R 3500 2 Drumsticks served with chips EXTRAS ONION RINGS R 3500 CHILLI CHEESE NUGGETS R 4000 SWEET POTATO CHIPS R 2000 BOSSY CHEESE STICKS R 3500 SMALL CHIPS R 800 JALEPENO POPPERS R 4000 4 Jalepeno peppers stuffed with 3 cheeses PEPPADEW BALLS R 2500 4 Peppadew Balls stuffed with 3 cheeses DESSERTS JELLY CUSTARD R 1200 PEPPERMINT DESSERT R 2000 STRAWBERRY DESSERT R 2000 CHEESECAKE R 2700 I wont sell food I wont eat food that I would serve at home is what comes out of the kitchen Shane Owner

O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


The Handmaids Tale Concordances Monday August 30 2010 Pen Is Envy Aunt Lydia would say 186 Here Atwood uses a play on words Pen Is Envy spells p envy when the spaces and capital letters are removed to show how the women in The Handmaids Tale even the Aunts secretly envy the mens privileges of being able to read and write freely and have other freedoms that men have The Aunts are not allowed to express how they feel openly so this is likely their way of saying it to themselves so that no one else catches on This also shows how oblivious the Handmaids are to their own treatment even Offred does not understand the true meaning of the Aunts slogan The capital letter of the I makes this a clever hidden note in the book for anyone observant enough to notice and analyze Posted by Kayleigh at 602 PM BlogThis 1 comment Jamie Corbett June 21 2017 at 253 AM Also Penis Envy is a Freudian theory which states that women are jealous of mens outward and protruding genitalia Atwood could be reducing the power of sexuality or uniting sexuality and language as two dangerous concepts to the Gilead Subscribe to Post Comments Atom Followers About Me Kayleigh I stood on the corner and pretended I was a tree View my complete profile

O O O O O O O O B I I O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


iRip Transfer songs from your iPod or iPhone to your Mac or PC End User License Agreement Free Download for Mac What customers think about iRip OneClick Recovery Recover your music movies playlists and more If youve lost the media collection on your computer you can copy the contents of your iPod or iPhone to your Mac or PC with a single click Videos Playlists and More iRip lets you copy not only music but also movies TV shows audiobooks podcasts and playlists Transfer individual songs or videos to your computer from your device or entire playlists at a time Friends with iTunes iRip was designed with convenience in mind Music and movies are transferred directly into iTunes without the need to manually drag or import files Playlists are seamlessly rebuilt with a click

B O O O O O O O O O O O O O O O O O O O O O O O O B O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


Shakes Made by Designers Out of this World Shakes Now Designing Victoria Gardens Mall Food Court 12434 N Main St Ranchocucamonga ca 91739 9096095889

B O O B O O O O B O O O O O O O O O O O O O O O


Added on November 14 2017 The News Wheel 50 Shades of Grey Cars 2018 Vehicles Available in Sexy Silver Hues Are you in the mood for something scandalous Refined yet harboring a dark side that wants to thrill you Give into temptation and feast your eyes on these sensual bodies Were talking about cars obviously Get your mind out of the gutter Do You Like Leather Pros and cons to leather vs cloth seats List of 2018 Model Vehicles Offered in Shades of Grey Acura Modern Steel Metallic Lunar Silver Metallic pictured on the MDX left Alfa Romeo Vesuvio Gray Metallic pictured on the Stelvio left Stromboli Gray Metallic Audi Tornado Gray Metallic pictured on the A6 left Florett Silver Metallic Buick Satin Steel Metallic pictured on the Enclave left Quicksilver Metallic BMW Space Gray Metallic pictured on the 640i left Glacier Silver Metallic Cadillac Radiant Silver Metallic pictured on the CT6 left Satin Steel Metallic Chevrolet Silver Ice Metallic pictured on the Spark left Nightfall Gray Metallic Chrysler Billet Silver Metallic Granite Crystal Metallic pictured on the Pacifica left Dodge Bruiser Grey pictured on the Journey left Granite Pearl Ford Ingot Silver Magnetic pictured on the Flex left Genesis San Simeon Gray pictured on the G90 left Himalayan Gray Honda Lunar Silver pictured on the Odyssey left Modern Steel Hyundai Gray pictured on the Elantra left Silver INFINITI Graphite Shadow pictured on the Q60 left Liquid Platinum Kia Silky Silver pictured on the Niro left Metal Stream Lexus Nebula Gray Pearl pictured on the IS left Atomic Silver Maserati Grigio Maratea Grigio pictured on the Ghibli left Mazda Sonic Silver Metallic Machine Grey Metallic pictured on the Mazda3 left MercedesBenz Selenite Grey Magno matte pictured on the E400 left Iridium Silver Metallic Mitsubishi Mercury Gray Metallic pictured on the Outlander Sport left Alloy Silver Metallic Nissan Gun Metallic Brilliant Silver pictured on the Maxima left Subaru Ice Silver Metallic Dark Gray Metallic pictured on the WRX left Toyota Classic Silver Metallic Magnetic Gray Metallic pictured on the Yaris left Volkswagen Platinum Gray Metallic pictured on the Jetta left White Silver Metallic Volvo Osmium Grey Metallic Pine Grey Metallic pictured on the XC60 left Model Research Find out which models retain their value the best

O O O O O O O O O B I I B O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B O O O O O O O O O O O O O O O O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


The Oakleaf Group Home About Us Expertise Condition Surveys Fire Safety Space Management Legionella Management Energy Management Access Consultancy Health Consultancy Building Consultancy Health and Safety Engineering Consultancy Sectors Health Sector Local Authorities Emergency Services Education Sector Commercial Sector Case Studies News Health Consultancy Six Facet Survey Condition Surveys Legionella Management Health Consultancy Architectural Services HTM Reviews Infection Control Audit CQC Audit Functional Suitability Review Estates Strategy Condition Survey Health Sector Six Facet Survey GP Premesis Survey Fire Safety Energy Management Building Consultancy Space Management Access Consultancy Health and Safety Engineering Consultancy Six Facet Survey The 6 Facet Survey forms the core estates information required by HBN 0008 NHS EstateCODE Historically this has always been regarded as the minimum data set of information necessary on which to base intelligent decisions about the future of an estate It provides good baseline information for an Estates Strategy and can assist property transfer and is consistent with the updated NHS Premises Assurance Model PAM and the updated ERIC Returns and the Carter and Naylor Reviews The Review Oakleafs 6 Facet Survey comprises a combination of six separate surveys and reviews which are carried out by separate specialised facet survey teams and auditors each experienced in their own field Oakleaf have been providing 6 Facet Surveys since their inception and are in touch with NHSi to provide our Six Facet Survey clients with the most up to date relevant and accurate data The resultant 6 Facet Survey will allow Condition Categories to be allocated to properties on a facet by facet basis together with a summary of remedial costs to bring each facet up to a safe and sound condition Data is gathered using hand held electronic gathering tools that provide data consistency between surveyors and have inbuilt checking and productivity functionality The tools mirror a standard proforma style and are used to record the condition of each elementsub element A risk assessment is undertaken as required by NHS which gives a score for Severity and Probability allowing the Risk Scored Backlog to be calculated The Content Oakleaf have extensive experience in working with differing Government Organisations and the Survey can be adapted to suit individual clients needs The Six Facets are as follows Facet 1 Physical Condition Survey Fabric ME Facet 2 Statutory Compliance Audit inc Fire Facet 3 Space Utilisation Audit Facet 4 Functional Suitability Review Facet 5 Quality Audit Facet 6 Environmental Management Audit We commonly add extra facets to the surveys which provides you with efficiencies and costs savings these would typically be Asset Registers Space Utilisation New ERIC departmental requirements Carter Review and Disabled Access Audit The Report Ranking A rating is identified for each survey aspect and other reviews are compared and rated as applicable Risk Assessments We have included a Risk Assessment so that hazardous issues can be prioritised Budget Costs We also provide full budget costs so that you can program any necessary remedial work Digital Photographs We take photographs showing selected non compliant items so that the problems can be more easily understood Extra Efficiencies Oakleaf are at the cutting edge of technology in this sector and use efficient and time served methodologies when implementing 6 Facet Surveys More than 50 of our NHS clients use the Six Facet Survey as an opportunity to pick up other essential estates data whilst our surveyors engineers and auditors are on site This partnership working saves our NHS clients s compared to our competitors Data Presentation All data can be input into all software packages we are experienced in working with all leading brands As an independent surveying consultancy we can advise on the best solution for your Trust We specialise in graphical summaries for board presentation as well as detailed Excel data for out of software planning and work packages Keep the data Live Oakleaf want you to get the most from your 6 Facet Survey We have cost efficient methods to update your data ranging from desk top reviews to 3 5 year refresh survey contracts We also can supply consultancy to assist you demonstrate the value of the investments made and the projects that you manage Carter and Naylor Reviews Oakleaf are at the forefront in providing data as highlighted in the Carter and Naylor Reviews The Carter Review is challenging the productivity and the space use is a key measure now Oakleaf can provide your NHS organisation with the validated data to ensure accurate ERIC Returns and the data and recommendations to make change as the Carter Review suggests We believe that creating the room use data your organisation will be future proofing itself against changing NHS Space Definitions The Naylor review to develop the new NHS strategy to release 2bn of asset relies on accurate backlog figures so Frameworks Oakleaf have won several frameworks for your convenience and efficient procurement this will enable you to purchase the surveys at pretender rates without the expensive and timeconsuming procurement processes whilst complying with your SFIs For more information please or call Tim Cooper on 0845 293 7571 6 facet survey 6 facet survey 6 facet surveys 6 facet surveys 6 facet surveys 6 facet surveys 6 facet survey Contact Us 0845 293 7571 Business Development Team Call us today for an informal conversation or use the contact form and well be in touch

O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B I I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O


Scenarios Medical Simulation Scenarios are text documents outlining the various details of a simulation everything from patient simulator settings to debriefing notes Below is a collection of donated scenarios for you to use or modify If you have any scenarios you would be willing to share with the simulation community please forward them to me Topic Abdominal Trauma Title Motorcycle Crash Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Adrenal Crisis Target Senior Emergency Residents Trauma Team Author Institution Anon click here to download Topic Anaphylaxis Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Anaphylaxis Title Anaphylaxis In An Inpatient Target PGY1 Author Institution Alison Rodger Babar Haroon Dalhousie University click here to download Topic Anaphylaxis Title Bee Sting In An 8 Month Old Author Institution Katie Gordon University of Maryland School of Medicine click here to download Topic Apnea Title Drowning In A 3 Year Old Author Institution Katie Gordon University of Maryland School of Medicine click here to download Topic Asthmatic Protocol for ED Title Branching Scenario 3 Treatment Routine ER Pediatric Patient Targets Emergency Department Staff and Respiratory Therapy Students Author Instituation Carl Rod MS RRT RCP Rose State College RT Clinical Simulation Lab click here to download Topic Atrial Fibrillation Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download plus chart documents here Topic Bidirectional Ventricular Tachycardia from Digoxin Toxicity Target Senior Emergency Residents Trauma Team Author Institution Anon click here to download Topic Bradicadia Title Bradycardic Arrest Carotid Sinus Mass Target PGY1 Author Institution Babar Haroon Dalhousie University click here to download Topic Burn Title Cigarette Fire Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Burn Title Meth Lab Explosion Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Cardiac Arrest Target Interprofessional Team Training Author Institution Devin Sydor click here to download Topic Chest and Abdominal Trauma Title Auto Accident Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic CHF Congestive Heart Failure Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Communication Interpersonal Skills Mediating Conflict Title Managing Family Members with Different Views Target ICU Fellows Author Institution Ryan Fink Miko Enomoto OHSU click here to download Topic Crohns Flare Title Complicated Crohns Target PGY1 Author Institution Allen Tran Dalhousie University click here to download Topic Delirious Combative Violent Patient Management Title Delirium Target ICU Fellows Author Institution Ryan Fink Miko Enomoto OHSU click here to download Topic Delivering Bad News Title Delivering Bad News after a Stroke Target ICU Fellows Author Institution Ryan Fink Miko Enomoto OHSU click here to download Topic Difficult Airway Title Ace Inhibitor Angioedema Target Mid Senior Emergency Residents Author Institution Anon click here to download Topic Difficult Airway Title Difficult Failed Airway Target Mid Senior Emergency Residents Author Institution Anon click here to download Topic Disclosure of an Adverse Event Title Retained Guidewire from a Central Line Target ICU Fellows Author Institution Ryan Fink OHSU click here to download Topic DKA Diabetic Ketoacidosis Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic DKA Target PGY1 Author Institution Allen Tran Babar Haroon Dalhousie University click here to download Topic Dyspnea Shortness of Breath Title Acute Pulmonary Edema requiring intubation Target Senior Emergency Residents Author Institution Anon click here to download Topic Dyspnea Shortness of Breath Title Severe Asthma requiring intubation Target Senior Emergency Residents Author Institution Anon click here to download Topic Electrical Storm Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download plus chart documents here Topic Emergent MedSurg Response Title METRRT Response Targets Response Teams House Staff and Respiratory Therapy Students Author Instituation Carl Rod MS RRT RCP Rose State College RT Clinical Simulation Lab click here to download Topic EtOH Withdrawal Title EtOH Withdrawal Siezure Target PGY1 Author Institution Allen Tran Babar Haroon Dalhousie University click here to download Topic Febrile Neutropenia Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Head Trauma Title Four Storey Fall Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Head Trauma Title Hit by Motorboat Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Hypertension Title Aortic Dissection Target Senior Emergency Residents Author Institution Anon click here to download Topic Hypertension Title Autonomic Dysreflexia Target Senior Emergency Residents Author Institution Anon click here to download Topic Hypertensive Emergency Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Hypertensive Emergency Title Diastolic Danger Hypertensive Urgency Emergency Target PGY1 Author Institution Hailey Hobbs Babar Haroon Dalhousie University click here to download Topic Hypoxia Target Interprofessional Team Training Author Institution Devin Sydor click here to download Topic Inferior Stemi Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Labor and delivery postpartum hemorrhage Title Normal Delivery with PPH Target Maternal Child Course Nursing Education Author Institution Kelly McMunn click here to download Topic PEA Arrest pulseless electrical activity Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Pelvic Fracture Target Senior Emergency Residents Trauma Team Author Institution Anon click here to download Topic Penetrating Thoracic Trauma Target Senior Emergency Residents Trauma Team Author Institution Anon click here to download Topic Pneumonia Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Pneumonia Title Community Acquired Pneumonia Target PGY1 Author Institution Iain Arseneau Babar Haroon Dalhousie University click here to download Topic Pulmonary Embolism Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Ruptured Ectopic Pregnancy Target Senior Emergency Residents Trauma Team Author Institution Anon click here to download Topic Sepsis Target PGY1 Author Institution Allen Tran Dalhousie University click here to download Topic Sepsis Title Sepsis Crohns Intraabdominal Target Mid Senior Emergency Residents Author Institution Anon click here to download Topic Sepsis Title Sepsis DKA and Pneumonia Target Mid Senior Emergency Residents Author Institution Anon click here to download Topic Sepsis Title Sepsis Febrile Neutropenia Target Mid Senior Emergency Residents Author Institution Anon click here to download Topic Shock Title Blunt Trauma Causing a High Spinal Cord Injury with Neurogenic Shock Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Shock Title Hemorrhagic Shock in an Elderly Pedestrian stuck by a Vehicle Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Shock Title Penetrating Chest Trauma Causing Obstructive Shock Target Senior Emergency Residents Trauma Team Author Institution Tim Chaplin Alison Archibald click here to download Topic Snake Bite Target ER residents Author Institution Katie Gordon University of Maryland School of Medicine click here to download Topic Status Asthmaticus Target PGY1 Author Institution Unknown click here to download Topic Status Epilepticus Apnea PostBenzodiazepines Title Seven month old with Status Epilepticus Target Pediatric Residents Author Institution Keith Gregoire click here to download Topic Stroke Target PGY1 Author Institution Allen Tran Dalhousie University click here to download Topic Subdural Hemorrhage Title SDH and DOAC Target PGY1 Author Institution Allen Tran Dalhousie University click here to download Topic Syncope Torsades Title Syncope Torsades in the setting of acquired prolonged QT Target PGY1 Author Institution Tasha Kulai Babar Haroon Dalhousie University click here to download Topic Tachycardia Rapid AF Target PGY1 Author Institution Allen Tran Babar Haroon Dalhousie University click here to download Topic Toxic Shock Syndrome Target Senior Emergency Residents Trauma Team Author Institution Anon click here to download Topic Toxicology Bupivicaine Overdose Target Senior Emergency Residents Author Institution Queens University click here to download Topic Toxicology Hydrofluoric Acid Burns Target Senior Emergency Residents Author Institution Queens University click here to download Topic Toxicology Organophosphates Target Senior Emergency Residents Author Institution Queens University click here to download Topic Upper GastrointestinalI Bleed Target Internal Medicine Author Institute Jim Boseovski Queens University click here to download Topic Upper Gastrointestinal Bleeding Title GI Bleed Target PGY1 Author Institution Babar Haroon Dalhousie University click here to download Topic Viral bronchiolitis in infants requiring intubation Title Apnea in the infant with RSV bronchiolitis Target Pediatric Residents Author Institution Mike Storr click here to download

O B I I O O O O O O O O O O O O B I O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O

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