Organisms are evolving and changing every day, creating, molding, and even deleting genetic diversity. Meanwhile, next-generation sequencing is reinventing evolutionary biology and our ability to track and probe evolutionary processes. Our researchers use cutting-edge tools to understand evolutionary processes within whole genomes that lead to differences in organismal function. We also use evolutionary differences to detect species in nature and predict their responses to environmental change. We study the evolution in many organisms, mostly in wild populations, including human diseases and their hosts.