What is St. John’s wort? St. John’s wort is a flowering yellow herb that has been used in traditional European medicine dating back to the Greeks. Its botanical name is Hypericum perforatum. Native to Europe and parts of Asia, it is called St John’s wort because it flowers at the time of the summer solstice in late June, which is also around the Feast of St. John the Baptist. It is thought that the plant genus is named Hypericum from the Greek words hyper (above) and eikon (picture) because during the Feast of St. John people would hang plants over their religious icons at home.
What does St. John’s wort treat? This herb has been used for centuries to treat a wide variety of ailments, including sleep disorders, poor appetite, and hemorrhoids. Today it is best known, and has significant support, for its use in the treatment of mild to moderate depression. It has mixed reviews as a treatment for pre-menstrual syndrome, some limited support for relieving menopause-related symptoms and weak evidence in the treatment of Seasonal Affective Disorder.
How is St. John’s wort prepared and how does it work? St. John’s wort can be consumed in the form of teas, tablets, capsules, and liquid extracts. The yellow star-shaped flowers and buds can be dried and made into capsules or teas or pressed for use in oils and liquids. It appears that St. John’s wort works like prescription antidepressant medications. Also, like prescription medications, exactly how it works is not fully understood. The active ingredients of St. John’s wort are hypericin, hyperforin, and adhyperforin, which are thought to increase serotonin, dopamine, and noradrenaline – the chemical messengers in the brain. These are the chemicals understood to improve and regulate mood.
How does St. John’s wort compare to prescription antidepressants? Numerous clinical trials demonstrate that St. John’s wort is more effective than placebo in treating mild and moderate depression. It is comparable to prescription antidepressants such as fluoxetine and sertraline for mild and moderate depression. It also has fewer adverse side effects than prescription antidepressants. However, and importantly, St John’s wort does not appear to be effective in treating severe depression.