The University of the City of Manila ( Pamantasan ng Lungsod ng Maynila ) located at Intramuros , and Universidad de Manila located just outside the walled city , are both owned and operated by the Manila city government . The national government controls the University of the Philippines Manila , the oldest of the University of the Philippines constituent universities and the center of health sciences education in the country . The city is also the site of the Polytechnic University of the Philippines , the largest university in the country in terms of student population .