Amtrak 's Crescent line connects Meridian with the cities of New York , New York ; Philadelphia , Pennsylvania ; Baltimore , Maryland ; Washington , D.C. ; Charlotte , North Carolina ; Atlanta , Georgia ; Birmingham , Alabama ; and New Orleans , Louisiana . The Union Station Multi @-@ Modal Transportation Center ( MMTC ) is located at 1901 Front Street , part of the Meridian Downtown Historic District , which is listed on the National Register of Historic Places . Originally built in 1906 , but later demolished in 1966 then rebuilt in 1997 , the station includes several modes of transportation including the Meridian Transit System , Amtrak , Norfolk Southern rail corridor , Greyhound buses , Trailways and other providers of transit services . The number of passengers on Amtrak trains , Greyhound buses , and Meridian Transit System buses averages 242 @,@ 360 per year .