Meridian is located in the North Central Hills region of Mississippi in Lauderdale County . According to the United States Census Bureau , the city has a total area of 45 @.@ 9 sq mi ( 119 km2 ) , of which 45 @.@ 1 sq mi ( 117 km2 ) is land and 0 @.@ 8 sq mi ( 2 @.@ 1 km2 ) is water . Along major highways , the city is 93 mi ( 150 km ) east of Jackson , Mississippi ; 154 mi ( 248 km ) west of Birmingham , Alabama ; 202 mi ( 325 km ) northeast of New Orleans , Louisiana ; 231 mi ( 372 km ) southeast of Memphis , Tennessee ; and 297 mi ( 478 km ) west of Atlanta , Georgia . The area surrounding the city is covered with cotton and corn fields along with oak and pine forests , and its topography consists of clay hills and the bottom lands of the head waters of the Chickasawhay River .