#Smoking and #Pathogenic #Germline Variants (PGVs) in #Patients w/ #LungCancer
14,000 #patients
12% PGV rate for smokers
12% PGV rate for non-smokers
(controlled for age, family history, personal history of other cancers)
PGVs in #DDR genes #BRCA2 (2.2%), #CHEK2 (2.0%), #ATM (1.6%), #SPINK1 (1.6%), and #BRCA1 (1.2%)

Time to consider #universal #germline #genetictesting in all #patients w/ #lungcancer@Invitae @Labcorp @GeneticsSociety #ASHG24 

#access #reducedisparities #germlinetesting #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention #AI #precisioninterpretation
#smoking
#Smoking #Pathogenic #Germline #Patients #LungCancer #patients #DDR #BRCA2 #CHEK2 #ATM