May play a role in cholesterol transfer to late endosomes . May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation .
Subcellular locations: Membrane, Late endosome membrane, Membrane raft, Cell membrane, Cytoplasmic vesicle
Ubiquitously expressed at low levels. Expression is highest in brain.