Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Subcellular locations: Cell membrane, Early endosome, Endoplasmic reticulum, Cytoplasm, Cytoplasm, Cytoskeleton, Spindle, Nucleus
And mitotic spindle.
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.