Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly (, ). Able to hydrolyze ATP, GTP, UTP and CTP . Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits (, ). Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota) (, ). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway . Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA . As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy . RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL . Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway ( ).
(Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly.
(Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Subcellular locations: Cytoplasm, Mitochondrion