Serine protease ( ). Cleaves the proform of PRSS8/prostasin to form the active protein . Cleaves the proform of HGF to form the active protein which promotes MAPK signaling . Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (By similarity).
Subcellular locations: Cell membrane, Secreted, Cytoplasm
The non-phosphorylated, inactive full length protein localizes intracellularly . N-glycosylation and phosphorylation is required for trafficking to the cell surface ( ). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (, ). Proteolytic cleavage is required for secretion .
Expressed in placenta.
Predominantly expressed in lung, placenta, pancreas, and prostate.
Expressed in lung, placenta, pancreas, and prostate . Weakly expressed in testis and peripheral blood lymphocytes .