Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker . In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning . During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure . Has been proposed to play a role in CEP170 recruitment to centrosomes . However, this function could not be confirmed . Plays a non-essential role in ciliogenesis (, ).
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriolar satellite, Cytoplasm, Cytoskeleton, Cilium basal body
Localization at the centriolar satellite is dependent on intact microtubule network . Localizes at the centriole subdistal appendages and proximal ends . Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2 .