Transcription factor (, ). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts . May control the differentiation, survival and proliferation of lymphoid cells . May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (, ).
Acts as a dominant-negative for isoform c-ETS-1A.
Subcellular locations: Nucleus, Cytoplasm
Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.