Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP . Regulates inflammatory responses (By similarity).
(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (, ). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP . This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release .
Subcellular locations: Cell membrane
Highly expressed in bone marrow with lower levels in synovium, lung and bronchus . Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins . Expression is down-regulated when monocytes differentiate into dendritic cells .