Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular locations: Cell membrane, Endoplasmic reticulum, Secreted
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.