Promotes DNA damage repair through both homologous recombination repair (HRR) and post-replication repair (PRR) mechanisms . Enhances the retention of DNA damage response protein RAD18 at sites of DNA damage . This allows for HRR via association of RAD18 with RAD51C and for PRR via RAD18-mediated promotion of PCNA monoubiquitination .
Subcellular locations: Nucleus, Chromosome
Forms DNA damage-induced foci.