Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling ( , ). Plays an essential role in stress granule formation ( , ). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress ( ). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity).
Subcellular locations: Cytoplasm, Cytoplasm, Stress granule