Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (   , ). Channel properties are modulated by subunit assembly . Mediates IK(NI) current in myoblasts . Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) .
Subcellular locations: Cell membrane, Nucleus inner membrane, Cell projection, Dendrite, Cell projection, Axon, Presynaptic cell membrane, Perikaryon, Postsynaptic density membrane, Early endosome membrane
Perinuclear KCNH1 is located to NPC-free islands.
Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.