Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns . Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion . Involved in the regulation of innate immune response . Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (, ). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (, ).
Subcellular locations: Nucleus, Cytoplasm, Cytosol
Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.