Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (  ). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 . Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin . Catalyzes ubiquitination of Salmonella type III secreted protein sopA . Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N . Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses . Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy .
Subcellular locations: Cell membrane, Mitochondrion membrane, Endoplasmic reticulum membrane
Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
Widely expressed.