Regulates cellular transport and efflux of cholesterol . Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol .
Subcellular locations: Cytoplasm, Cytosol, Endoplasmic reticulum membrane, Nucleus envelope, Cell membrane, Endosome membrane
Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum.
Expressed in brain and striated muscle (at protein level) . Widely expressed . Expressed in skeletal muscle .