FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen.
May act as an autocrine hepatotrophic growth factor promoting liver regeneration.
Subcellular locations: Mitochondrion intermembrane space, Mitochondrion
Subcellular locations: Cytoplasm, Secreted
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.