RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses . Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity). Also required for immunity against some bacteria, such as mycobacteria .
Subcellular locations: Mitochondrion outer membrane, Cytoplasm, Stress granule
Widely expressed.