Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis . Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production . WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 .
Subcellular locations: Cytoplasm, Cytoskeleton, Cilium basal body, Cytoplasm, Nucleus, Cytoplasm, Cytoskeleton, Cilium axoneme, Cytoplasmic vesicle, Golgi apparatus, Trans-Golgi network
Shuttles from the cilium to the nucleus in response to Hh signaling . Might be shuttling between the nucleus and the cytoplasm .
Ubiquitous.