Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (, ). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (, ). Catalyzes in the oxidative direction with higher efficiency . Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal .
Subcellular locations: Cytoplasm