Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (, ). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development ( ). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis .
Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process .
Cytoplasmic form induces gene transcription inhibition.
Subcellular locations: Cell membrane, Cytoplasmic vesicle lumen, Lysosome lumen
Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination . Colocalizes with the SPPL2A protease at the cell membrane .
Subcellular locations: Secreted
May be released into the extracellular fluid by cleavage from the cell surface.
Subcellular locations: Nucleus
The FasL ICD cytoplasmic form is translocated into the nucleus.