Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R ( , ). May also play a role in cell adhesion (By similarity).
Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R.
Binds only to the receptor EDA2R.
Subcellular locations: Cell membrane
Subcellular locations: Secreted
Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.