Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
Subcellular locations: Endoplasmic reticulum
Found in the cytoplasm, which could include the endoplasmic reticulum.
Expressed in the lung, in the ciliated cells of the airway epithelium . Expression increased with differentiation of airway epithelial cells . Not detected in the mucous cells . Expressed in ciliated cells in the oviduct . Also detected in stomach, colon, prostate and liver . Expressed in breast, ovary, prostate and liver cancer . Expression is associated with the level of differentiation of breast cancer (at protein level) .