Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation ( ). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation . Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 . Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity . Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm . Phosphorylates ATF2 which activates its transcriptional activity .
Subcellular locations: Nucleus, Cytoplasm
Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Widely expressed. Highly expressed in fetal liver, testis and thymus.