Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling . May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 .
Subcellular locations: Cytoplasm, Cytoskeleton, Nucleus, Cell projection, Lamellipodium
Colocalizes with F-actin . Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover .
Expressed in keratinocytes (at protein level) . Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain.