Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility . NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation . Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells . Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells . In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells .
Subcellular locations: Cell membrane, Endomembrane system
Localizes to cytoplasmic membrane in tumor cells.