Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) . May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles . Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes .
Subcellular locations: Cytoplasm, Golgi apparatus, Trans-Golgi network membrane, Cytoplasm, Perinuclear region, Cytoplasmic vesicle, Clathrin-coated vesicle
Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin . Associates with membranes via the adapter protein complex AP-1 (By similarity). Colocalizes with AP1G1 (By similarity).