Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate ( ). Its function seems to be partially redundant with that of CNOT8 . Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation ( ). During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation . Additional complex functions may be a consequence of its influence on mRNA expression (, ). Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity (, ).
Subcellular locations: Nucleus, Cytoplasm, P-body, Cytoplasm, Cytoplasmic ribonucleoprotein granule
NANOS2 promotes its localization to P-body (By similarity). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs .