Sodium-dependent and purine-selective transporter (, ). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) ( ). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues . May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable).
Subcellular locations: Membrane, Apicolateral cell membrane
Localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells in testis.
Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain . Weak expression in lung . In testis, primarily localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells, and weakly expressed in Leydig cells, peritubular myoid cells and germ cells .