DNA helicase that plays a role in DNA damage repair and genome stability (  ). Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction ( ). Plays a role in restoring regressed replication forks . Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions . May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens (, ).
Subcellular locations: Nucleus
High expression in heart, lung, skeletal muscle and kidney, low expression in brain.