Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.
Subcellular locations: Cell membrane, Cytoplasm
Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.