Oxidizes medium and long chain saturated and unsaturated aldehydes (, ). Metabolizes also benzaldehyde . Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (, ). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor . May have a protective role against the cytotoxicity induced by lipid peroxidation .
Subcellular locations: Cell membrane
Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
Highest expression in kidney and lung.