Receptor for MSH (alpha, beta and gamma) and ACTH (  ). The activity of this receptor is mediated by G proteins which activate adenylate cyclase ( , ). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes .
Subcellular locations: Cell membrane
Expressed in melanocytes (, ). Expressed in corticoadrenal tissue .