Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex . Slows down the rate of inactivation of KCNC3 channels . Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
Subcellular locations: Mitochondrion matrix, Endoplasmic reticulum, Nucleus membrane, Cytoplasmic vesicle, Cytoplasm, Cell cortex, Cell membrane, Sarcoplasmic reticulum, Cytoplasm, P-body
Subcellular locations: Cytoplasm, Nucleus
Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited, and in response to cellular stress caused by arsenite (in vitro).
Subcellular locations: Cytoplasm, Nucleus
Predominantly cytoplasmic. Also detected in the nucleus when nuclear export is inhibited (in vitro).
Subcellular locations: Cytoplasm, Nucleus
Shuttles between nucleus and cytoplasm.
Subcellular locations: Cytoplasm
Predominantly cytoplasmic.
Ubiquitous. Up-regulated in oral cancers.