Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity . Seems to be capable of activating ENaC (By similarity).
(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.
Subcellular locations: Cell membrane
Subcellular locations: Secreted
Activated by cleavage and secreted.
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract . Coexpressed with ACE2 within mature enterocytes .