Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization.
Subcellular locations: Postsynaptic cell membrane
Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).
Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).