Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.
Subcellular locations: Recycling endosome, Early endosome membrane, Golgi apparatus membrane, Golgi apparatus, Trans-Golgi network membrane, Cytoplasmic vesicle, Phagosome
Recruited to recycling endosomes by DENND6A . Recruited to phagosomes containing S.aureus or M.tuberculosis .