General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites ( , ). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress . Down-regulates expression of target genes in response to oxidative stress . Overexpression protects cells against apoptosis in response to oxidative stress .
Subcellular locations: Nucleus