The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland .
Subcellular locations: Mitochondrion inner membrane
Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.