Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
Subcellular locations: Cell membrane, Cytoplasm, Cytoplasmic vesicle
Expressed in kidney, lung, pancreas and spleen.