Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium . Binds beta-tubulin via its basic region . Required for ciliogenesis . Essential for flagellogenesis during spermatogenesis .
Subcellular locations: Cell projection, Cilium, Cytoplasmic vesicle, Cell projection, Cilium, Flagellum, Cytoplasmic vesicle, Secretory vesicle, Acrosome
Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis . In male germ cells, strongly expressed in the vesicles of spermatocytes and round spermatids and also in the acrosome and centrosome regions of elongating spermatids and in developing sperm tails (By similarity).
Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen . Detected in sperm (at protein level) .