Functions as a component of the nuclear pore complex (NPC) and the COPII coat . At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles . Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity).
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (  ). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex ( , ). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex ( ). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex .
Subcellular locations: Cytoplasmic vesicle, COPII-coated vesicle membrane, Endoplasmic reticulum membrane, Nucleus, Nuclear pore complex, Lysosome membrane
In interphase, localizes at both sides of the NPC.