Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response . Involved in JNK signaling pathway (By similarity).
Subcellular locations: Cytoplasm, Nucleus, Cytoplasm, Cytoskeleton, Spindle pole
Not detected in the cilium. Localized around the poles of the mitotic spindle from prophase to anaphase in mitotic cells.
Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes . Expressed in kidney .