Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (, ). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (, ). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors .
Subcellular locations: Cell junction, Adherens junction, Cytoplasm, Nucleus, Cell membrane
Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (, ). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm . CDH1 enhances cell membrane localization . Isoforms 4A and 1AB are excluded from the nucleus .
Subcellular locations: Nucleus
Subcellular locations: Nucleus
Subcellular locations: Nucleus
Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.