Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (, ). Does not act on PRDX5 or PRDX6 (, ). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (, ).
Subcellular locations: Cytoplasm
Widely expressed with highest levels in kidney, lung, spleen and thymus.