Participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes . Protective against the mitochondrial apoptotic cascade .
Subcellular locations: Peroxisome membrane
Isoform 1 is detected in the kidney (at protein level). Isoform 1 and isoform 2 are expressed in the kidney, heart, liver, lung, pancreas and skeletal muscle.