Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) ( , ). It is degraded during the mitotic phase of the cell cycle ( ). Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle ( ). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing . Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control .
Subcellular locations: Cytoplasm, Nucleus
Mainly cytoplasmic but can be relocalized to the nucleus.