UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward 3-hydroxyandrogens. It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.
Subcellular locations: Microsome membrane, Endoplasmic reticulum membrane
Expressed in liver, prostate, kidney, testis, adrenal, bile duct, bladder, colon, small intestine, cerebellum and pancreas.