Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress.
Subcellular locations: Endoplasmic reticulum, Endoplasmic reticulum-Golgi intermediate compartment, Endosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Nucleus, Endosome, Multivesicular body, Cytoplasmic vesicle