Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation . Regulates TRAF6 and MAP3K7 ubiquitination . Involved in the regulation of cell mobility ( ). Regulates lipolysaccharide (LPS)-induced endothelial cell migration . Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis .
Subcellular locations: Cytoplasm
Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes (, ).