Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids including estradiol-17beta-D-glucuronide (or 17beta-estradiol 17-O-(beta-D-glucuronate)), androstanediol glucuronide (or 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), and estrone 3-sulfate, as well as bile acids taurocholate and glycocholate, driven by an outward gradient of dicarboxylates such as glutarate or succinate.
Similar uptake function as Isoform 1.
Lack of transporter activity.
Subcellular locations: Cell membrane
Subcellular locations: Cell membrane
Localized to the kidney . Highly specific expression pattern in the nephron, localized to segment 3 of the proximal tubule .
Localized to the kidney . Highly specific expression pattern in the nephron, localized to segment 3 of the proximal tubule .