May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.
Subcellular locations: Nucleus, Cytoplasm
Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta.