Acts as a component of the STAGA transcription coactivator-HAT complex (, ). Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation (, ). Necessary for microtubule cytoskeleton stabilization .
Subcellular locations: Nucleus, Nucleus, Nucleolus, Nucleus matrix, Cytoplasm, Cytoskeleton
In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus . It is able to shuttle between the nucleus and cytoplasm .
Subcellular locations: Cytoplasm
Isoform a is expressed in CNS, but is expressed predominantly in the peripherical tissues.
Isoform b is expressed in CNS . Also highly expressed in the frontal lobe, skeletal muscle and spinal cord and is expressed at a lower level in the lung, lymphoblast and intestine .