Receptor for transcobalamin saturated with cobalamin (TCbl) . Plays an important role in cobalamin uptake (, ). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells . Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (, ). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) . CD320 augments the proliferation of PC precursors generated by IL-10 .
Subcellular locations: Cell membrane
Detected in the germinal center (GC) of lymphoid follicles (at protein level) . Expressed abundantly on follicular dendritic cells (FDCs) .