Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation . Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades . Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes . Probably plays a role in regulating protein degradation via its interaction with NEDD4 . May also contribute to the regulation of gene expression in the nucleus (, ). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines . May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (, ).
Subcellular locations: Cytoplasm, Nucleus, Lysosome membrane, Early endosome membrane, Late endosome membrane, Endosome membrane, Cell membrane, Golgi apparatus membrane
Associated with membranes of lysosomes, early and late endosomes ( ). Can translocate from the cytoplasm into the nucleus . Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).
Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.