Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
Subcellular locations: Cell membrane, Cytoplasm
During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones.
Subcellular locations: Endoplasmic reticulum
Transmembrane localization is essential for Wnt signaling inhibition.
Subcellular locations: Cytoplasm
Scattered throughout the cytoplasm in small-sized punctate structures.
Expressed in thymocytes.