Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.
Subcellular locations: Cell membrane, Peroxisome membrane
Imported in peroxisomes through the PEX5 receptor pathway.
Subcellular locations: Secreted
Detected in the blood of individuals subjected to endurance exercise.
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.