Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses . Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease . Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair .
(Microbial infection) Acts as a receptor for Hepatitis A virus.
(Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane . Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP .
(Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane . TIM1 and Dengue virus are co-internalized during virus entry .
(Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E.
(Microbial infection) Plays a positive role in Chikungunya virus cell entry.
Subcellular locations: Cell membrane
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.