Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer . Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes . Involved in lipid droplet formation, which is important for HCV virion assembly .
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Cytoplasmic vesicle membrane, Early endosome, Recycling endosome membrane, Cell projection, Ruffle membrane, Cell membrane, Cell projection, Membrane, Caveola
Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Widely expressed.