Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Subcellular locations: Nucleus
Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs.
Widely expressed. Expressed in tumor cell lines.