Catalyzes several different glutathione-dependent reactions (  ). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (, ). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (, ). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (, ). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells .
Subcellular locations: Endoplasmic reticulum membrane, Microsome membrane
Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow . Abundantly expressed in human umbilical vein endothelial cells (at protein level) .