Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (, ). Plays an important role in osteoclast differentiation and function . Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).
Subcellular locations: Apical cell membrane, Basolateral cell membrane
Subcellular locations: Apical cell membrane, Basolateral cell membrane
Subcellular locations: Apical cell membrane, Basolateral cell membrane
Expressed in the liver, stomach, kidney, prostate, thyroid and rectum.
Expressed in the liver and kidney.
Expressed in the liver and kidney.