Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (  ). Uses the proton gradient/membrane potential to extrude sodium . Contributes to the regulation of intracellular pH and sodium homeostasis (By similarity). Also able to mediate Na(+)/Li(+) antiporter activity in kidney . May play a physiological role in renal tubular function and blood pressure homeostasis (By similarity). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).
Subcellular locations: Cell membrane, Mitochondrion membrane, Endosome membrane, Recycling endosome membrane, Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane, Cell projection, Cilium, Flagellum membrane, Basolateral cell membrane, Apical cell membrane
Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts.
Widely expressed . High levels detected in the distal tubules of the kidney nephron . Detected in red blood cells (at protein level) (, ).