Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle ( , ). Plays a role in insulin homeostasis (, ). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Subcellular locations: Mitochondrion, Endoplasmic reticulum
Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum.