Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (, ). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (, ). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (, ). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (, ). Participates in IFNB promoter activation via TICAM1 .
Subcellular locations: Cytoplasm
Widely expressed . Abundant expression seen in the pancreas and testis .