Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes ( , ). Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
Subcellular locations: Cell membrane, Basolateral cell membrane
Restricted to the basolateral membrane in various portions of the urothelium.
Detected in erythrocytes (at protein level) . Expressed in spleen erythroblasts and tumoral kidney .