Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases . Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication .
Subcellular locations: Cytoplasm, Cell cortex, Endomembrane system, Cell projection, Lamellipodium
Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.
Ubiquitously expressed in all tissues examined with high levels in the testis.