Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta . Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).
Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry . Induces phosphorylation of MAPT/tau .
Subcellular locations: Cytoplasm, Nucleus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosomes during metaphase .
Subcellular locations: Nucleus
Subcellular locations: Nucleus, Nucleolus
Expressed in placenta, including the invasive extravillus trophoblast cells.