Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin ( ). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels . Contributes to transcriptional repression by BCL6 .
Subcellular locations: Nucleus, Cytoplasm
Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.