Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation ( ). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Subcellular locations: Cell membrane
Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus . Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon . Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells ( ).