Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling ( ). It also catalyzes N-terminal palmitoylation of DHH . Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs . It is an essential factor for proper embryonic development and testicular organogenesis .
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane
Co-localizes with SHH in the ER and Golgi membrane.
Widely expressed. Expressed in fetal ovary and testis, with high levels of expression observed in Sertoli cells .