Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (  ). Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning . Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis ( , ). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts ( ).
Subcellular locations: Cytoplasm, Secreted
Mainly localizes in the cytoplasm . Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion .
Preferentially expressed in endothelial cells (, ). Highly expressed in fetal organs . Expressed in brain and placenta, and at lower level in heart and kidney . Highly detected in microvessels endothelial cells of atherosclerotic lesions .