Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
Subcellular locations: Chromosome, Centromere, Kinetochore, Nucleus, Cytoplasm, Cytoskeleton, Spindle
Enriched at the nuclear periphery and around the nucleolus . In mitotic cells, localizes to kinetochores from prometaphase to metaphase . At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis .