Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity).
Subcellular locations: Endoplasmic reticulum membrane, Lysosome membrane, Cytoplasmic vesicle, Autophagosome membrane, Cell projection, Dendritic spine membrane, Cell projection, Axon, Endosome membrane, Cytoplasmic vesicle, Clathrin-coated vesicle membrane, Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane