GTPase activator for RAN ( ). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (, ). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export .
Subcellular locations: Cytoplasm, Nucleus, Nucleoplasm, Nucleus envelope, Chromosome, Centromere, Kinetochore, Cytoplasm, Cytoskeleton, Spindle
Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (, ). Targeted to the nuclear pores after sumoylation . During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (, ). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase . Mitotic location also requires sumoylation .
Highly expressed in brain, thymus and testis.