Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 .
Does not catalyze guanine nucleotide exchange on CDC42 .
Subcellular locations: Cytoplasm, Cell membrane
Subcellular locations: Cytoplasm, Endomembrane system
Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain.
Subcellular locations: Cytoplasm, Cell membrane