Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (, ). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding . Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis .
Subcellular locations: Cytoplasm, Cytoplasm, Perinuclear region, Endoplasmic reticulum
Expressed in endothelial cells (at protein level) . Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon .