Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (   ). In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides ( ). Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (  ). Can completely deacylate triacylglycerols . When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (  ). Hydrolyzes medium- and long-chain fatty acyls in galactolipids (, ). May act together with LIPF to hydrolyze partially digested triglycerides . Hydrolyzes long-chain monoglycerides with high efficiency ( ). In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity (, ). In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity).
Subcellular locations: Secreted, Zymogen granule membrane, Cell projection, Neuron projection
Localizes to neurite tips in neuronal cells.
Pancreas.