S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA . Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity . Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity . Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors . Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements . Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro .
Subcellular locations: Nucleus, Nucleus, Nucleoplasm, Cytoplasm, Perinuclear region, Cytoplasm
Localized diffusely throughout the nucleus and the cytoplasm . Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes . Localization is not affected by glucocorticoid treatment .
Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level). Tends to be down-regulated in lungs affected by inflammatory diseases or neoplasia (at protein level). Expressed in immune cells, including B and T lymphocytes and macrophages.