Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (, ). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 .
Subcellular locations: Cytoplasm, Nucleus
Retained in the cytoplasm via interaction with GNAZ and GNAI2 . Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus (, ).
Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.