Component of the signaling pathway of IL-1 and Toll-like receptors (, ). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex . Inhibits IRAK1 phosphorylation and kinase activity . Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates . The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates . In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes . Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) .
Subcellular locations: Cytoplasm, Endosome, Early endosome
Localized to endo/exosomal vesicles.