Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
Subcellular locations: Cytoplasm, Myofibril, Cytoplasm, Myofibril, Sarcomere
Thick filaments of the myofibrils.
Both wild type and variant Gln-403 are detected in skeletal muscle (at protein level).