Thought to form a receptor-activated non-selective calcium permeant cation channel (, ). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C . Seems not to be activated by intracellular calcium store depletion.
Subcellular locations: Cell membrane
Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.