Binds bacterial lipopolysaccharide (LPS) (, ). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (, ). Enhances TLR4-dependent activation of NF-kappa-B . Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS .
Subcellular locations: Secreted, Extracellular space, Secreted
Retained in the extracellular space at the cell surface by interaction with TLR4 .