Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.
Stimulates natural killer cells to secrete IFNG.
Subcellular locations: Cell membrane, Endoplasmic reticulum
Mainly found intracellularly.
Subcellular locations: Secreted
Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.