Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (, ). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
Subcellular locations: Cell membrane
Localized to the cell membrane and intracellular organelles.
Ubiquitous . Highly expressed in skeletal muscle, liver and placenta . Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung .