Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation . In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 . Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development . May play a role in cell death control (By similarity).
Subcellular locations: Nucleus, Cytoplasm, Cytosol
Mainly nuclear.
In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart.