E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway ( ). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).
Subcellular locations: Cell membrane, Endoplasmic reticulum membrane, Nucleus envelope
According to a report, may be secreted.
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.