Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.
Subcellular locations: Cytoplasm, Cytoskeleton
Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining.
Subcellular locations: Cytoplasm, Myofibril, Sarcomere, Z line
Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.
Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level).