Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (By similarity). Binds chromatin (By similarity). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity). May also repress MYOCD transcriptional activity (By similarity).
Subcellular locations: Nucleus, Nucleus envelope, Nucleus, PML body, Cytoplasm, Cytosol, Cell membrane, Sarcolemma
Predominantly expressed in the heart and skeletal muscle ( ). Also detected in liver .
Expressed in skeletal muscle.
Expressed in skeletal muscle.