Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3 . Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity).
Subcellular locations: Nucleus, Cell junction, Tight junction, Chromosome
The relevance of tight junction localization is however unclear.
Widely expressed, with highest level in brain, heart and kidney.