Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis . Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
Subcellular locations: Mitochondrion
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to , high levels in kidney, whereas according to , levels are low. High expression is observed in the adrenal cortex .