RNA helicase involved in mRNA processing and antiviral innate immunity (  , ). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA . In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns . Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome ( ). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) ( ). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses . The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu . Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).
Subcellular locations: Nucleus, Nucleus, Nucleolus
Ubiquitous.