Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate . Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Subcellular locations: Endoplasmic reticulum membrane, Cytoplasmic vesicle, Secretory vesicle membrane, Cytoplasm, Perinuclear region
Endoplasmic reticulum and secretory granules (By similarity).
Widely expressed.