Transcription factor that activates insulin gene expression (, ). Acts synergistically with NEUROD1/BETA2 and PDX1 . Binds the insulin enhancer C1/RIPE3b element . Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (, ).
Subcellular locations: Nucleus
Expressed in the islets of Langerhans (at protein level).