Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (   ). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events ( ). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (, ).
Subcellular locations: Cell membrane, Cytoplasmic vesicle
Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.