Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (   ). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration . The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription . Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells . The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again . May play a role in the perception of carbonation taste (By similarity). May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH (By similarity).
Subcellular locations: Cell projection, Cilium membrane, Cell membrane, Cytoplasmic vesicle
Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane.
Detected in taste bud cells in fungiform papillae (at protein level) . Ubiquitous . Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver (, ). Isoform 4 appears to be expressed only in transformed lymphoblasts.