Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Subcellular locations: Apical cell membrane, Cytoplasm, Synapse, Postsynaptic density, Cell projection, Growth cone, Cell projection, Dendritic spine
Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).
Isoform 3 is present in epithelial colonic cells (at protein level).