cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes ( ). Has a higher efficiency with cGMP compared to cAMP . Plays a role in cell growth and migration .
Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L .
Subcellular locations: Cell membrane
Subcellular locations: Mitochondrion matrix, Mitochondrion inner membrane, Mitochondrion outer membrane
Subcellular locations: Cytoplasm
Subcellular locations: Mitochondrion
Widely expressed (, ). Expressed in brain, with high expression observed in the corpus striatum . Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas (, ).