Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function . Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning . Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis . Plays a role in axon formation .
Subcellular locations: Cytoplasm, Secreted, Cytoplasm, Cytoskeleton
Mainly localizes in the cytoplasm . Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion . Associates with microtubules .