May regulate cell growth likely by suppressing RB1 phosphorylation . May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages . Serve as a tumor suppressor in certain leukemia cells . Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation .
Subcellular locations: Cytoplasm, P-body
Colocalizes with ZC3H12A in GW bodies (GWBs) .
Subcellular locations: Cytoplasm
Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.
Subcellular locations: Cytoplasm, Nucleus
Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.