Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion ( , ). Membrane clustering requires GTPase activity . It may involve a major rearrangement of the coiled coil domains (, ). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (, ). Overexpression induces the formation of mitochondrial networks (in vitro) . Has low GTPase activity (, ).
Subcellular locations: Mitochondrion outer membrane
Subcellular locations: Cytoplasm
Detected in kidney and heart (at protein level) . Ubiquitous (, ). Expressed at slightly higher level in kidney and heart . Isoform 2 may be overexpressed in some tumors, such as lung cancers .