Catalyzes the transfer of phosphatidylinositol (PI) between membranes (, ). Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC . Regulates RHOA activity, and plays a role in cytoskeleton remodeling . Necessary for normal completion of cytokinesis . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus . Required for protein export from the endoplasmic reticulum and the Golgi . Binds calcium ions .
Subcellular locations: Cytoplasm, Golgi apparatus, Golgi stack membrane, Endoplasmic reticulum membrane, Lipid droplet, Cleavage furrow, Midbody
Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets . Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis .
Ubiquitous.