Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
Subcellular locations: Cytoplasm
Subcellular locations: Nucleus
Subcellular locations: Postsynaptic density, Cell projection, Dendritic spine, Nucleus, Nucleus, Cajal body
The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity).
Subcellular locations: Nucleus
The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
Subcellular locations: Nucleus
Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.