Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (, ). Regulates neuronal cell homeostasis by protecting neurons against apoptosis . Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction . Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (By similarity). May act at junctions between the membrane and the cytoskeleton.
Subcellular locations: Cell membrane, Cytoplasm, Cytoskeleton, Cytoplasm