The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes . Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane . Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity). In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity). Also plays a specific role in asymmetric protein transport to the plasma membrane . In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity). In epithelial cells, it regulates transport from the Golgi to the basolateral membrane . May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity). May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion . Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis . When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis . Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route .
(Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.
Subcellular locations: Cytoplasmic vesicle membrane, Golgi apparatus membrane, Golgi apparatus, Trans-Golgi network membrane, Endosome membrane, Recycling endosome membrane, Cytoplasmic vesicle, Phagosome membrane, Cytoplasm, Cytoskeleton, Cilium basal body, Endoplasmic reticulum membrane, Cytoplasm, Perinuclear region
Associates with SLC2A4/GLUT4 storage vesicles . Localizes to the base of the cilium when phosphorylated by LRRK2 on Thr-73 (, ). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth . Colocalizes with MICAL1, GRAF1/ARHGAP26 and GRAF2/ARHGAP10 on endosomal tubules .
Expressed in the hippocampus . Expressed in neutrophils (at protein level) . Expressed in the testis (at protein level) .