Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity . Important for cell migration, and for normal structure and assembly of the Golgi complex . Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).
Subcellular locations: Cytoplasm, Golgi apparatus membrane, Cell membrane
Partially co-localizes with endogenous PXN at the leading edges of migrating cells.
Ubiquitous.