E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation . May play a role in the acrosome reaction and fertilization.
Subcellular locations: Cytoplasm, Cytoplasmic vesicle, Secretory vesicle, Acrosome, Cytoplasm, Cytoskeleton
Found in the acrosomal region of elongated spermatids and mature sperm.
Highly expressed in testis, prostate and brain . Weakly expressed in kidney, lung and heart . Expressed in fetal tissues .