Enhances the binding of the PAF1 complex to target gene promoters and plays a role in negative regulation of transcription . May function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA polymerase II-induced mRNA elongation . Inhibits FOXM1-mediated transcription of PHB2 .
Subcellular locations: Nucleus
Expressed in brain, liver, kidney and stomach with lower levels in breast, intestine, thyroid and pancreas.