G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Subcellular locations: Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Cell projection, Dendrite
Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Detected in melanocytes.