Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP+), the platinum-based drug oxaliplatin or weak bases that are positively charged at physiological pH, cimetidine, the platinum-based drugs cisplatin and oxaliplatin or the antidiabetic drug metformin. Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney.
Non-functional protein.
Subcellular locations: Cell membrane, Apical cell membrane
Detected in the renal urinary tubules.
Subcellular locations: Apical cell membrane
Localized at the brush border membranes of the proximal tubules.
High expression in kidney. Very small expression in adrenal gland and lung.
High expression in kidney. Very small expression in brain and testis.
Ubiquitously expressed in all tissues examined except the kidney.