Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family ( , ). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) .
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Secreted
Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.