Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (  , ). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains ( , ). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 ( ). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development .
Subcellular locations: Membrane, Endosome membrane, Lysosome membrane, Cytoplasm, Cytosol
Following IL1 stimulation, translocation occurs from the membrane to cytosol . Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome .
Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.