Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin . Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription . Binds DNA and histones and promotes nucleosome assembly (in vitro) (, ). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 . Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA .
Subcellular locations: Nucleus, Nucleolus