Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis ( ). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 . Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes .
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane, Early endosome membrane, Late endosome membrane, Lysosome membrane, Cell membrane
Glutamatergic synaptic vesicles.
Widely expressed. High expression is detected in brain, lung and testis.