Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination . Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Subcellular locations: Cell membrane
Subcellular locations: Nucleus
Following proteolytical processing NICD is translocated to the nucleus.
Ubiquitously expressed in fetal and adult tissues.