Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure . Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency .
Subcellular locations: Secreted
Highly expressed in the cornea (at protein level) . Expression is restricted to the stromal layer . Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera .