Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids . Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria . Negatively regulates lipid droplet size and motility . Required for efficient lysosomal protein degradation .
Subcellular locations: Mitochondrion outer membrane, Endoplasmic reticulum membrane, Endosome membrane, Lysosome membrane, Lipid droplet, Golgi apparatus, Cytoplasmic vesicle, Secretory vesicle, Neuronal dense core vesicle
Localizes at mitochondria-endosomes and mitochondria-endoplasmic reticulum contact sites ( ).
Expressed in red blood cells (at protein level) . Widely expressed, with high expression in brain, heart, skeletal muscle and kidney .