Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery . Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner .
Subcellular locations: Cytoplasm, Endomembrane system, Cell projection, Invadopodium, Perikaryon, Cell projection, Cell projection, Growth cone, Cell projection, Filopodium, Cell projection, Lamellipodium
Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery . Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles . Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity).
Overexpressed in gastric cancer cells and tissues (at protein level) .