Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT . Involved in both early and late stages of the pre-rRNA processing pathways . Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus ( , ). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity ( ).
Subcellular locations: Nucleus, Nucleoplasm
Subcellular locations: Nucleus, Nucleolus, Nucleus, Nucleoplasm
Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus.
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.