Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors.
Subcellular locations: Endoplasmic reticulum membrane, Postsynaptic cell membrane, Cell projection, Dendrite, Cell projection, Dendritic spine, Postsynaptic density
Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells).
Expression is up-regulated in dorsolateral prefrontal cortex of patients with schizophrenia (postmortem brain study).