May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Subcellular locations: Cytoplasm, Cell membrane, Cytoplasmic vesicle, Phagosome
Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).
Subcellular locations: Cytoplasm, Cell cortex, Cell projection, Bleb
Colocalized with F-actin in bleb protrusions.
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.