Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Subcellular locations: Cytoplasm, Cytoskeleton, Cell projection, Ruffle membrane, Cell projection, Phagocytic cup
Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
Detected in T-lymphocytes and peripheral blood mononuclear cells.