Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system ( , ). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 . By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) . Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity).
Subcellular locations: Endoplasmic reticulum membrane, Lysosome membrane, Cytoplasmic vesicle, Autophagosome membrane, Cell projection, Dendritic spine membrane, Cell projection, Axon, Endosome membrane, Cytoplasmic vesicle, Clathrin-coated vesicle membrane, Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane
Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.