Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (  ). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species ( , ). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery . May be involved in ATXN1 mutant-induced cell death . The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit . Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules . Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol . Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production .
Subcellular locations: Nucleus, Nucleus speckle, Cytoplasmic granule
Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2 . Colocalized with ATXN1 in nuclear inclusion bodies . Localizes to cytoplasmic stress granules .
Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes.