Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex . Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair .
Subcellular locations: Nucleus, Nucleus, Nucleoplasm
Recruited to sites of DNA damage . Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability .