Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor . May play a role in cell growth and apoptosis .
Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (    ). Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa . Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin .
Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.
Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (, ). According to , lacks enzyme activity . Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin .
Lacks calcium-dependent NADPH oxidase activity.
Lacks calcium-dependent NADPH oxidase activity.
Subcellular locations: Endoplasmic reticulum, Cell membrane
Calcium-sensitive association and dissociation between the N- and C-terminal domains appears to facilitate its localization to the cell membrane.
Subcellular locations: Endoplasmic reticulum
Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells.
Expressed in spleen . Expressed in endothelial cells, pulmonary artery smooth muscle cells and epithelial colorectal adenocarcinoma cells (, ).
Expressed in microvascular endothelial cells (at protein level) . Expressed in testis . Expressed in endothelial cells and pulmonary artery smooth muscle cells (, ).
Expressed in pulmonary artery smooth muscle cells and epithelial colorectal adenocarcinoma cells.
Expressed in endothelial cells and pulmonary artery smooth muscle cells.
Expressed in microvascular endothelial cells (at protein level).