Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular locations: Postsynaptic cell membrane, Cell membrane
Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.