Intracellular sigma-2 receptor that binds histatin 1/HN1 (Hst 1) at the endoplasmic reticulun (ER) membrane, which is critical for mitochondrial-targeting and -activating properties of Hst1 (, ). Thought to play important role in regulating cell survival, morphology and differentiation (, ). May play a role as a regulator of cellular cholesterol homeostasis . May function as sterol isomerase . May alter the activity of some cytochrome P450 proteins .
Subcellular locations: Nucleus membrane, Rough endoplasmic reticulum membrane
Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.
Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells .