Plays a critical role in endothelial cell capillary morphogenesis.
Subcellular locations: Secreted
Subcellular locations: Cell membrane, Cell junction, Tight junction
Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.
Subcellular locations: Secreted
Subcellular locations: Secreted
Subcellular locations: Cytoplasm
Detected in urine (at protein level) ( ). Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.