Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 alpha), which is embedded in the endoplasmic reticulum membrane ( ). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) ( ).
Transcription factor that initiates the unfolded protein response (UPR) during endoplasmic reticulum stress by activating transcription of genes involved in the UPR ( , ). Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') ( ). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor ( ). May play a role in foveal development and cone function in the retina .
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane
Translocates from the endoplasmic reticulum to the Golgi, where it is processed.
Subcellular locations: Nucleus
Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (, ). THBS4 promotes its nuclear shuttling (By similarity).
Ubiquitous.