Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (, ). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (, ). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence . May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose . However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (, ).
Subcellular locations: Nucleus, Chromosome
Directly binds to the sequence motif 5'-CATCCCATAATA-3'.
Widely expressed.