Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles . Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (, ). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 . Positively regulates the assembly and activity of the mTORC1 complex .
Subcellular locations: Nucleus
Expressed at low levels in normal mammary epithelial cells (at protein level) . Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus .