Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (  ). Positively regulates MAPK signal transduction pathway . Dephosphorylates GAB1, ARHGAP35 and EGFR . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity . Dephosphorylates CDC73 . Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L .
Subcellular locations: Cytoplasm, Nucleus
Widely expressed, with highest levels in heart, brain, and skeletal muscle.