Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor.
Subcellular locations: Cytoplasm, Nucleus, Endosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Late endosome membrane
Colocalizes with F-actin. Some fraction may be nuclear.
Ubiquitously expressed except in skeletal muscle.