Receptor for angiotensin II, a vasoconstricting peptide ( , ). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways . Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation .
Subcellular locations: Cell membrane
In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.