N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (, ). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation . In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (, ). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (, ). May act as a tumor suppressor .
Subcellular locations: Cytoplasm, Cytosol
Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.