Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission . The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome  Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).
Subcellular locations: Nucleus
Expressed in a wide variety of tissues.