Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (, ). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators . Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (, ). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (, ). Also plays a role in thymic T-cell development (By similarity).
Subcellular locations: Cytoplasm, Endoplasmic reticulum membrane