Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton . Plays a role in axon guidance . During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone . Involved in invasive growth and cell migration . May participate in cytokinesis .
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Spindle, Cell projection, Growth cone, Cytoplasm, Cytoskeleton, Perikaryon
Associated with centrosomes and the mitotic spindle during metaphase . Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity).
Brain.