Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway . Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 . Necessary for hepatitis C virus replication in an otherwise non-permissive cell line .
Subcellular locations: Cytoplasm, Nucleus, Cell membrane
Localizes to the plasma membrane when complexed to MMP14.
Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.