Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (, ). Regulates ATR-mediated checkpoint signaling in response to DNA damage . Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles . Promotes maturation of pre-60S ribosome together with AFG2A, AFG2B and AIRIM .
Subcellular locations: Nucleus
Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.