May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation.
Subcellular locations: Cytoplasm, Mitochondrion
A V5 epitope-tagged construct has been shown to localize to the nucleus . 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells .
May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas. Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary.