Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (, ). Involved in megakaryocyte differentiation.
Subcellular locations: Nucleus
Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.