In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption .
May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
Subcellular locations: Cytoplasm, Cytoskeleton, Cell projection, Axon, Cell membrane, Sarcolemma, Postsynaptic cell membrane, Lysosome, Cell membrane, Sarcolemma, T-tubule
In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes.
Subcellular locations: Cytoplasm, Cytoskeleton, Golgi apparatus
Expressed in brain, neurons, muscles and other tissues.