Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size . Required for secretion of extracellular matrix proteins . Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors . Acts as a regulator of the unfolded protein response (UPR) (By similarity).
Subcellular locations: Endoplasmic reticulum membrane
Highest levels in heart, skeletal muscle, and kidney.