Involved in redox regulation of the cell (, ). Acts as an antioxidant (, ). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation . May affect bone resorption and help to maintain bone mass . Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway .
Subcellular locations: Cytoplasm, Secreted
Secreted from mature adipocytes but not from preadipocytes.
Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs).