Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis (, ). Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates (, ). Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation . In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation (By similarity). In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway (By similarity). Plays also non-autophagy role by mediating the shuttle of IL-12 to late endosome for subsequent secretion (By similarity).
Subcellular locations: Cytoplasm, Cytoplasmic vesicle, Autophagosome, Lysosome, Cytoplasm, Myofibril, Sarcomere, M line
In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation .