Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins (, ). Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins . Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation .
Subcellular locations: Cytoplasm, Endoplasmic reticulum, Nucleus
Expressed in brain.