Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (, ). Plays a role in lipoprotein assembly and dietary cholesterol absorption . Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates . May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa .
Has lower enzymatic activity compared to isoform 1.
Has lower enzymatic activity compared to isoform 1.
Subcellular locations: Endoplasmic reticulum membrane
Expression seems confined in hepatocytes and enterocytes.