Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (, ). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex . Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development . Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (, ). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent ( ). May also regulate transcription through direct binding to DNA or transcription factors .
Subcellular locations: Cytoplasm, Nucleus
Localizes to sites of DNA damage . In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques .
Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).