Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner . Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (, ). May play a role in tumor development .
Subcellular locations: Nucleus, Cytoplasm, Cytoskeleton, Stress fiber, Cell junction, Focal adhesion, Cell projection, Ruffle membrane, Synapse
Colocalizes with F-actin and COMMD1 in the nucleus . Colocalizes with MAP1A along actin stress fibers and membrane ruffles .
Widely expressed . Expressed in neurons . Expressed in malignant glial tumors . Expression is reduced or absent in a number of cancer cell lines .