Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (, ). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (, ). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (, ). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes ( ). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 . With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation . Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling . Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 . The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 .
Subcellular locations: Nucleus, Chromosome
Found in actively RNAPolII-transcribed gene bodies.