Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells . Also binds the DEAR/FBXW7-AS1 receptor .
Subcellular locations: Secreted
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.