RNA-binding protein involved in the histone pre-mRNA processing ( , ). Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) ( , ). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery ( , ). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression ( , ). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (By similarity). Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (By similarity).
Subcellular locations: Cytoplasm, Nucleus
Polyribosome-associated . Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase . Through the S phase, partially redistributes to the cytoplasm . Binding to histone mRNA is necessary for cytoplasmic localization . Shuttles between the nucleus and the cytoplasm . Imported in the nucleus by the Importin alpha/Importin beta receptor .
Widely expressed.