Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (  , ). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Subcellular locations: Membrane, Cytoplasmic vesicle membrane, Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Detected in brain (at protein level) . Widely expressed .