Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
Subcellular locations: Membrane, Cell projection, Cilium, Flagellum, Cytoplasmic vesicle, Secretory vesicle, Acrosome
Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm.
Isoform 2 and isoform 3 are expressed in sperm. Isoform 1 is not detected in sperm (at protein level) . Testis-specific . Isoform 1, isoform 2 and isoform 3 are expressed in sperm .