May participate in the regulation of neuronal exocytosis.
Subcellular locations: Secreted, Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle, Synapse, Synaptosome, Cell projection, Axon
Found in the synaptosomal membrane fraction. Within peripheral myelinated axons, LGI3 is highly expressed at the juxtaparanodal membrane and colocalizes with the voltage-gated potassium channels Kv1.1 (KCNA1) and Kv1.2 (KCNA2), and with CNTNAP2, DLG4, ADAM22 and ADAM23 (By similarity).
Widely expressed, with highest levels in brain and lung.