S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA ( ). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (, ). Required for corpus callosum and cerebral cortex development (By similarity).
Subcellular locations: Nucleus, Nucleolus
Ubiquitous (, ). Detected in placenta, heart and skeletal muscle (, ).