Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains ( ). Does not cleave 'Lys-48'-linked polyubiquitin chains . Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF . Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 . Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (, ). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (, ). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways .
Subcellular locations: Nucleus, Membrane, Cytoplasm, Early endosome
Ubiquitously expressed.