Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit .
Subcellular locations: Nucleus, Nucleoplasm, Cytoplasm, Nucleus, Nucleolus
Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.