Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum . Involved in the maintenance of the Golgi apparatus morphology . Has no detectable kinase activity in vitro .
Isoform 6 acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, Cis-Golgi network
Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.
Subcellular locations: Cytoplasm
Cytoplasmic throughout the cell cycle.
Subcellular locations: Cytoplasm
Cytoplasmic throughout the cell cycle.
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.
Subcellular locations: Nucleus
Ubiquitous.