Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells .
Subcellular locations: Secreted
Expressed in white adipose tissue (at protein level) . Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood . Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues . Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus .