Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (, ). Plays a role in the control of cell proliferation . Also plays a role in DNA break repair, participating in the DNA damage checkpoint response . Promotes transcription of PHB2 .
Subcellular locations: Nucleus
Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.