Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis ( , ). Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC) .
Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Subcellular locations: Mitochondrion, Mitochondrion intermembrane space, Nucleus
Localizes predominantly to the mitochondria and to a lesser extent to the nucleus. Found in both the mitochondria and the nucleus throughout the cell cycle, with the exception of the G2/M phase when it is restricted to mitochdondria.
Subcellular locations: Cytoplasm
Subcellular locations: Cytoplasm
Subcellular locations: Cytoplasm
Expressed in the brain (at protein level) (, ). Ubiquitous . Highly expressed in the testis . Expressed in the umbilical vein endothelial cells (HUVEC) .