Serine hydrolase whose substrates have not been identified yet (, ). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation . May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 .
Expressed at higher levels in tumor tissues such as carcinoma.