Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (  ). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons . The presence of conserved gating glutamate residues is typical for family members that function as antiporters .
Subcellular locations: Early endosome membrane, Late endosome membrane, Endoplasmic reticulum membrane, Lysosome membrane, Recycling endosome membrane
Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3.
Abundant in skeletal muscle and also detectable in brain and heart.