Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Subcellular locations: Nucleus speckle
Nuclear, in a punctate manner.
Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.