Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular locations: Cell membrane, Endoplasmic reticulum
In CMV-infected fibroblasts, detected intracellularly.
Widely expressed . Expressed in trachea . Constitutively expressed in peripheral blood mononuclear cells, including B-cells and natural killer cells, as well as CD4+ and CD8+ T-cells and monocytes. Tends to be up-regulated in various lymphoid malignancies, including chronic lymphocytic leukemia .