Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake . Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 .
Subcellular locations: Early endosome, Cell membrane, Cytoplasmic vesicle
Also found in extracellular vesicles different from exosomes.