NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro . May have a role in steroid and/or xenobiotic metabolism .
Subcellular locations: Endoplasmic reticulum
May be attached to the ER membrane by its C-terminus segment.
Detected in heart, liver, adrenal glands, and at low levels in skeletal muscle, kidney, pancreas and brain.