Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular locations: Cell membrane, Endoplasmic reticulum
In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi.
Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.