Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (, ). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 . Involved in the dephosphorylation of EEF1A1 .
Subcellular locations: Cell membrane, Cell membrane, Nucleus, Cell projection
Colocalizes with RPSA/LAMR1 in the cell membrane . Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections .