Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells . Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing . May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation .
Subcellular locations: Cytoplasm, Cell junction, Tight junction
Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner.
Expressed at higher levels in acute wounds than chronic wounds with increased expression in healing wounds, especially at the leading wound edge . Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in testis with lower levels in prostate and breast .