Transcriptional repressor (, ). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (, ). Enhances MBD2-mediated repression (, ). Efficient repression requires the presence of GATAD2B .
Subcellular locations: Nucleus speckle, Nucleus, Chromosome
Speckled nuclear localization requires both CR1 and CR2 regions . Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 .
Ubiquitous, both in fetal and adult tissues.