Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP ( , ). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively ( ).
Subcellular locations: Cytoplasm, Cytosol
Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex.