Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Subcellular locations: Cell membrane, Endomembrane system, Cytoplasm, Perinuclear region
Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized . The dileucine internalization motif is critical for intracellular sequestration . Insulin stimulation induces translocation to the cell membrane (By similarity).
Skeletal and cardiac muscles; brown and white fat.