Involved in the cross-linking of microtubules and microfilaments (, ). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers . Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Regulates ciliary orientation and performance in cells located in the airway .
Subcellular locations: Cytoplasm, Cytoskeleton, Cell membrane, Cytoplasm, Cytoskeleton, Stress fiber, Cytoplasm, Cytoskeleton, Cilium basal body
Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends .
Expressed in bronchial and nasal epithelial cells (at protein level) . Expressed in brain, kidney, lung, testis, fallopian tubes, and skeletal muscle (, ). Expressed at low levels in stomach and colon .