Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) . The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs . Involved in cell migration (By similarity).
Subcellular locations: Nucleus, Cytoplasm
Ubiquitously expressed with high levels in heart, brain, liver, skeletal muscle and testis.