Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs ( , ). Negatively regulates the activation of EIF2AK2/PKR .
Subcellular locations: Cytoplasm, Endoplasmic reticulum
Mainly at the endoplasmic reticulum.
Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level).