Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis (, ). Inhibits osteoclast formation (, ). Inhibits bone resorption . Modulates the release of interferon-gamma . Binds high molecular weight sulfated glycosaminoglycans .
Subcellular locations: Cell membrane
Subcellular locations: Endoplasmic reticulum
Subcellular locations: Endoplasmic reticulum
Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells.