Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (, ). Required for localization of CUL7 to the centrosome .
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.