Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (, ). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer . Binds to the SYDE1 promoter . Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development .
Subcellular locations: Nucleus
Highly expressed in the placenta . Expressed in trophoblast cells of the villi .