Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient ( , ). Plays an essential role in renal water homeostasis ( ).
Subcellular locations: Apical cell membrane, Basolateral cell membrane, Cell membrane, Cytoplasmic vesicle membrane, Golgi apparatus, Trans-Golgi network membrane
Shuttles from vesicles to the apical membrane . Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane . PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity).
Expressed in collecting tubules in kidney medulla (at protein level) . Detected in kidney .