Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) . Involved in pigmentation, possibly by participating in ion transport in melanosomes (, ). Predominant sodium-calcium exchanger in melanocytes (, ).
Subcellular locations: Golgi apparatus, Trans-Golgi network membrane, Melanosome
Enriched in late-stage melanosomes.