Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (, ). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (, ).
As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (  ). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex ( , ). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 . In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation . In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex ( ). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex .
Subcellular locations: Chromosome, Centromere, Kinetochore, Nucleus, Nuclear pore complex, Lysosome membrane