Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing . Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription . Thereby acts as a negative regulator of cell proliferation . When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).
Subcellular locations: Nucleus
Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.