Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
Subcellular locations: Cytoplasm
Localized to the region of the plasma membrane.
Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.