The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module . Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex . Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity).
Subcellular locations: Cytoplasm, Cytoplasm, Perinuclear region, Lysosome membrane
Perinuclear distribution in response to stress signals such as UV radiation.
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Acrosome
Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte.
Expressed in testis and in acute myeloid leukemia (AML) patients.
Expressed in testis.