Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (, ). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (, ). Modulates transcription transactivation by NR3C1, AR and PGR .
Activates the U2 small nuclear RNA (snRNA) promoter.
Subcellular locations: Cytoplasm, Nucleus
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.