Could be a melanogenic enzyme.
Subcellular locations: Cell membrane, Melanosome membrane, Early endosome membrane
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Widely expressed, but very low expression, if any, in the brain (, ). Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) . Expressed in peripheral blood, but not bone marrow mononuclear cells . Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) . May be overexpressed in various cancers, including melanoma and glioblastoma multiforme ( ).