EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) ( , ). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (, ). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (, ). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression ( ). Required for the formation of P-bodies ( , ). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay . Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (, ).
Subcellular locations: Cytoplasm, P-body, Cytoplasm, Nucleus, Nucleus, PML body, Nucleus speckle
Predominantly cytoplasmic . Mainly localizes to processing bodies (P-bodies) . Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner . Localization to nuclear foci and speckles requires active transcription .
Widely expressed.