The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment . The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors . Required for phosphorylation and localization of GJA1 . Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton .
Subcellular locations: Cytoplasm, Cytosol, Membrane
Present in kidney and various cell lines (at protein level). Widely expressed at low level.