Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
Subcellular locations: Cell membrane, Secreted, Secreted, Extracellular exosome, Endoplasmic reticulum membrane
Secreted by exosomes through a non-classical pathway.
Widely expressed with high expression in the ovary, pancreas and prostate . Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina . Expressed by activated peripheral blood mononuclear cells .