Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 ( ). Required for cortical dynein-dynactin complex recruitment during metaphase . Plays a role in metaphase spindle orientation . Also plays an important role in asymmetric cell divisions . Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity).
Subcellular locations: Cytoplasm, Cytoplasm, Cell cortex, Cytoplasm, Cytoskeleton, Spindle pole, Lateral cell membrane
Localizes in the cytoplasm during interphase and at cell cortex during metaphase ( ). Colocalizes with NUMA1 to mitotic spindle poles (, ). Localized at the central and lateral cell cortex regions in a RanGTP-dependent manner . In horizontally retinal progenitor dividing cells, localized to the lateral cortical region. In vertically retinal progenitor dividing cells, localized at the polar cortical region (By similarity).
Ubiquitously expressed.