Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule ( ). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic ( ). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood . Has a critical role in renal dicarboxylate transport (By similarity).
Subcellular locations: Apical cell membrane
Expressed in kidney and intestine . In kidney expressed in the proximal tubule (at protein level) .