Functions as a Na(+)-independent bidirectional multispecific transporter ( , ). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (, ). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates ( , ). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (, ). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood . Involved in renal secretion and possible reabsorption of creatinine (, ). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (, ). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified .
Non functional transporter.
Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha).
Subcellular locations: Basolateral cell membrane, Apical cell membrane, Cell membrane
Localized to the basolateral side of the proximal tubules (, ). Apical side of the renal tubule .
Subcellular locations: Cytoplasm, Cytosol
Mainly expressed in liver and kidney ( , ). In kidney, expressed in proximal tubular cells . Also expressed in pancreas, small intestine, spinal cord, lung, brain and heart . Expressed in fetal liver .