Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol . 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols (By similarity). The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols (By similarity). Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts . In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs) (By similarity).
Subcellular locations: Mitochondrion, Mitochondrion matrix
Ubiquitously expressed . Highly expressed in small intestine, prostate and thyroid, while aorta and colon tissues exhibit weak expression levels .