Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Subcellular locations: Late endosome membrane, Lysosome membrane
Localizes to late endocytic compartment. Associates with lysosome membranes.