Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (  ). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (  ). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense  (By similarity). Can mediate uncoupled fluxes of either protons or metal ions.
Subcellular locations: Early endosome membrane, Apical cell membrane
Predominantly localizes in early endosomes that underlie the apical membrane of polarized epithelia.
Subcellular locations: Late endosome membrane, Lysosome membrane, Apical cell membrane, Cell membrane, Extracellular vesicle membrane
Subcellular locations: Cell membrane
Subcellular locations: Mitochondrion outer membrane, Golgi apparatus, Trans-Golgi network membrane, Recycling endosome membrane
Ubiquitously expressed. Expressed in erythroid progenitors.