Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (, ). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses ( , ). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons . Stimulates immunoglobulin production .
Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Subcellular locations: Cytoplasm, Cell membrane, Cytoplasm, Myofibril, Sarcomere, M line
Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
Subcellular locations: Nucleus
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.