Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Subcellular locations: Cell projection, Cilium, Cytoplasm, Cytoskeleton, Cilium basal body
Concentrates within the inner segment of cilia.
Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).