Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids ( , ). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (, ). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides . Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (, ). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) ( ). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers .
Subcellular locations: Cell membrane