Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (  ). Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (   , ). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (   ). Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (   ). Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis (   ). Involved in chromosome condensation and proper cytokinesis (   ). Nucleosomes are preferred as substrate compared to free histones (   ). Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes . Plays a negative role in TGF-beta response regulation and a positive role in cell migration .
Subcellular locations: Nucleus, Chromosome
Specifically localizes to mitotic chromosomes . Colocalized with SIRT2 at mitotic foci . Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner . Associates with silent chromatin on euchromatic arms . Not associated with constitutive heterochromatin .