May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel . May activate the MAP kinase JNK . Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
Subcellular locations: Cell membrane, Cytoplasm, Cell projection, Axon, Cell projection, Dendrite
May localize to the cell body and growth cones of dendrite-like processes.
Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver.