Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (  ). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms . Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (  ).
Subcellular locations: Cell membrane