Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11 . In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10 . In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities . In vitro, suppresses AP-1 transcription factor complex DNA-binding activities (By similarity).
Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG.
Subcellular locations: Cytoplasm, Nucleus
Localization depends on differentiation status of myoblasts (By similarity). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (By similarity).
Ubiquitously expressed, including in the fetal brain and liver . Expressed in brain, lung, spleen and skeletal muscle (, ). Lower levels detected in heart and kidney (, ). Not detected in the pancreas . In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage . Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes . Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells .