Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors ( ). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (, ). May recruit NEDD4 to ADRB2 . Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes .
Subcellular locations: Cytoplasm, Cell membrane, Lysosome, Endosome, Early endosome
Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis ( ).
Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (, ). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow . Strong expression in differentiated adipocytes compared to preadipocytes . Detected in omental fat and subcutaneous fat tissue .