Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance . Receptor for FN1 . Receptor for apolipoprotein APOE . Receptor for ALCAM/CD166 . Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions . Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production . This inhibition of monocyte activation occurs at least in part via binding to FN1 . Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells ( ). Induces up-regulation of CD86 on dendritic cells . Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation .
Subcellular locations: Cell membrane
Ligand binding leads to internalization and translocation to an antigen-processing compartment.
Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung.