Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID . Displays anti-inflammatory activity . Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection . Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens . Exhibits both ATPase and GTPase activities .
Subcellular locations: Cytoplasm, Cell membrane
Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection.
Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) . Widely expressed with highest levels in heart, brain and skeletal muscle . Also expressed in liver, colon, dermis and epidermis . Little expression detected in myeloid cells or peripheral blood mononuclear cells .