E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus ( , ). Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection . In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity . Plays also a role in cataract formation together with TP53 . Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination . Regulates centrosome dynamics and mitotic progression by ubiquitinating STK3/MST2; leading to its redistribution to the perinuclear cytoskeleton and subsequent phosphorylation by PLK1 .
Subcellular locations: Cytoplasm, Nucleus, Nucleus speckle, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Adopts a filamentous distribution in the cell cytoplasm where it strongly colocalizes with stable microtubules.