Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity . In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics . Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells . Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation . Required for neural tube morphogenesis and neural crest cell migration (By similarity).
Subcellular locations: Nucleus matrix, Cytoplasm, Cytoskeleton, Cell projection, Ruffle membrane, Cell projection, Lamellipodium membrane, Cell projection, Lamellipodium, Cell projection, Growth cone, Cell projection, Axon
Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Widely distributed in various tissues.