RNA-binding protein involved in modulation of mRNA transcription by Polymerase II . Component of the tRNA-splicing ligase complex and is required for tRNA ligation . May be required for RNA transport .
(Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication .
Subcellular locations: Nucleus, Cytoplasm, Cytosol, Cytoplasm, Perinuclear region, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
May localize at the centrosome during mitosis . Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low .
Subcellular locations: Nucleus, Cytoplasm
(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (, ).
Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors.