Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses . Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication . Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells . Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression . Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis ( ). However, it has also been shown to have a pro-apoptotic activity . Modulates innate immune response mediated by RIGI by preventing its activation .
Subcellular locations: Endoplasmic reticulum membrane, Mitochondrion inner membrane