Essential for the formation and stability of microtubules (MTs) (, ). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs . Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression .
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Cytoskeleton, Microtubule organizing center, Midbody
Localizes to microtubules (MTs) during interphase with a significantly reduced affinity for MTs during mitosis.