Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation . Stimulates SLC9A3 activity in the presence of elevated calcium ions .
Subcellular locations: Cell membrane, Cytoplasm
Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (, ).
Expressed in kidney and the gastrointestinal tract. Not detected in brain, heart, skeletal muscle or cells of hematopoietic origin.