Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (, ). May act as a negative regulator of Ras-mediated mitogenic activity . Plays a role in ciliogenesis .
Subcellular locations: Nucleus, Cytoplasm, Cytoplasmic vesicle, Endosome, Cytoplasm, Cytoskeleton, Cilium basal body, Early endosome