Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome (, ). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Subcellular locations: Nucleus, Nucleoplasm, Nucleus speckle
Localized in splicing speckles.
Widely expressed.