Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis ( , ). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) ( ). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (, ). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
Subcellular locations: Cytoplasm, Nucleus
Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.
Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level) (, ). Low expression in spleen, thymus and prostate .