Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 ( , ). May function in skin immunity . Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).
Subcellular locations: Cell membrane, Presynaptic cell membrane, Cell projection, Axon
Expressed in CD14- and CD56-positive blood cells . Expressed in macrophages (, ). Expressed in keratinocytes . Expressed in a subset of dorsal root ganglia neurons (at protein level) . Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin ( ). Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts . Detected in all of the myelomonocytic lineage . Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients .