G-beta-like protein involved in cell signal transduction (  , ). Acts as a negative regulator in MAPK signaling pathway . Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (, ). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 . Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation . Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration . Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria . Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
Subcellular locations: Cytoplasm, Nucleus, Mitochondrion
Broadly expressed, with highest levels in heart and skeletal muscle.