Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes . Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth . Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form .
Subcellular locations: Endosome membrane, Cell membrane, Early endosome, Late endosome, Cell projection, Ruffle, Cytoplasmic vesicle, Cytoplasmic vesicle, Phagosome, Cytoplasmic vesicle, Phagosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis.