Component of the large ribosomal subunit (, ). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (, ). Binds a specific region on the 26S rRNA (, ). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination .
Subcellular locations: Cytoplasm, Nucleus
Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn.