Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (, ). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida . Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa . Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa .
Subcellular locations: Secreted
This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy . Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) . Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) . Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) . Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling .