Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (, ). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition . Functions as a bridging factor between STAT6 and the basal transcription factor . Plays a role in PIM1 regulation of MYB activity . Functions as a transcriptional coactivator for STAT5 (By similarity).
(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).
(Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9.
Subcellular locations: Cytoplasm, Nucleus, Melanosome
In IL-4 stimulated cells colocalizes with STAT6 in the nucleus . Identified by mass spectrometry in melanosome fractions from stage I to stage IV .
Ubiquitously expressed.