Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
Subcellular locations: Cell junction, Desmosome, Cytoplasm, Cytoskeleton, Spindle, Midbody, Cell membrane
Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
Expressed in salivary glands (at protein level) . Expressed in arrector pili muscle (at protein level) .