Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates ( , ). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor ( ). Also displays broad nucleoside diphosphate kinase activity ( ). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (, ). Plays a protective role in the cellular response to oxidative stress ( ).
Subcellular locations: Mitochondrion matrix
Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.