Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity).
Subcellular locations: Nucleus
In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
Expressed in all brain tissue observed.