Methyltransferase which catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates containing the characteristic 3'-CCA terminus of mature tRNAs . Also catalyzes the formation of N(2)-methylguanosine at position 7 of tRNA(Trp) . Requires the methyltransferase adapter protein TRM112 for tRNA methyltransferase activity .
Subcellular locations: Cytoplasm