Plays a role in DNA damage repair as component of the ASCC complex . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation . In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
Subcellular locations: Nucleus, Nucleus speckle
Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage.
Ubiquitous.