Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity .
Subcellular locations: Cytoplasm, Cytoplasm, Cytosol, Membrane, Nucleus, Cell membrane
Interaction with GNB5 mediates translocation to the nucleus.