Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU (, ). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 . Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 . This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
(Microbial infection) Acts as a receptor for Semliki Forest virus.
Subcellular locations: Cell membrane, Membrane, Clathrin-coated pit
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.