Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (, ). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination . Might also be involved in the DNA damage response at telomeres .
Subcellular locations: Nucleus, Cytoplasm, Chromosome, Telomere, Nucleus, Cajal body, Nucleus, PML body
Predominantly detected in cytoplasm (, ). Localizes in a dynamic manner to actively processed telomeres . Localizes to the periphery of Cajal bodies . Associates with PML nuclear bodies in telomerase-negative cells .
Subcellular locations: Nucleus, Cytoplasm
Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart, bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, colon, lung, cardiac muscle and thyroid gland.