May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in fibrillar adhesion formation (, ). Essential for myofibroblast differentiation and myofibroblast-mediated extracellular matrix deposition . Enhances RHOA activation in the presence of DLC1 . Plays a role in cell polarization and migration . May be involved in cartilage development and in linking signal transduction pathways to the cytoskeleton .
Subcellular locations: Cell surface, Cell junction, Focal adhesion, Cytoplasm, Cytoskeleton
Localizes to both focal adhesions and fibrillar adhesions . Localized at the cell periphery preferentially to fibrillar adhesions rather than to focal adhesions. Translocates from the cell edge to the cell center in an ITGB1BP1-dependent manner .
In the lung, detected in the alveolar septa (at protein level) . Ubiquitous .