Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.
Subcellular locations: Secreted
Subcellular locations: Secreted
Subcellular locations: Endoplasmic reticulum
Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Subcellular locations: Endoplasmic reticulum
Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Subcellular locations: Endomembrane system
Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Subcellular locations: Endomembrane system
Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Subcellular locations: Secreted
Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.