Promotes the release of prenylated target proteins from cellular membranes . Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (, ). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E . Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
Subcellular locations: Cytoplasm, Cytosol, Cytoplasmic vesicle membrane, Cytoplasm, Cytoskeleton, Cilium basal body
Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.