Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms . Promotes the repair of DNA double-strand breaks through the homologous recombination pathway .
Subcellular locations: Nucleus, Chromosome, Cytoplasm
According to some authors, it is not localized to mitotic chromatin . Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3).