Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (, ). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (, ). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (, ). Can also bind EPHB2 and EPHB3 . Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity). May play a role in constraining the orientation of longitudinally projecting axons (By similarity).
Subcellular locations: Cell membrane, Membrane raft
May recruit GRIP1 and GRIP2 to membrane raft domains.
Subcellular locations: Cell membrane
Subcellular locations: Nucleus
Colocalizes with ZHX2 in the nucleus.
Widely expressed (, ). Detected in both neuronal and non-neuronal tissues (, ). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord .