Component of the mitochondrial ribosome large subunit ( ). Also involved in apoptosis and cell cycle (, ). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins .
Subcellular locations: Mitochondrion
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).