Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids . Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome . Involved in the regulation of lysosomal morphology and autophagy .
Acts also as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity).
Subcellular locations: Lysosome membrane
Colocalized with MTOR in lysosome after amino acid stimulation.
Expressed in kidney, heart, brain and placenta.