Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity ( ). Able to activate NK cells citotoxicity and cytokine production such as IFNG (, ). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry .
Subcellular locations: Cell membrane
Expressed on a discrete subset of peripheral blood NK cells.