GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains.
Subcellular locations: Cell membrane, Cytoplasm, Cytosol
Localization to membranes is increased by binding of poly-ubiquitin chains . Enriched in tangle aggregates in cells of Alzheimer's disease brain .
Expressed in brain (at protein level).