High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain . Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance .
Subcellular locations: Secreted
Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.