Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity).
Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.
Required for bundling actin filaments around the nucleus.
Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cytoskeleton, Stress fiber, Cell projection, Axon
Associates with intermediate filaments, actin and microtubule cytoskeletons. Localizes to actin stress fibers and to actin-rich ruffling at the cortex of cells (By similarity). Associated at the growing distal tip of microtubules.
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Myofibril, Sarcomere, Z line, Cytoplasm, Myofibril, Sarcomere, H zone
Localizes to microtubules and actin microfilaments throughout the cytoplasm and at focal contact attachments at the plasma membrane.
Subcellular locations: Cytoplasm, Cytoskeleton
Colocalizes both cortical and cytoplasmic actin filaments.
Subcellular locations: Cytoplasm, Cytoskeleton, Cell junction, Hemidesmosome
Localizes to actin and intermediate filaments cytoskeletons (By similarity). Colocalizes with the epidermal KRT5-KRT14 intermediate filaments network of keratins. Colocalizes with ITGB4 at the leading edge of migrating keratinocytes.
Subcellular locations: Nucleus, Nucleus envelope, Membrane, Endoplasmic reticulum membrane, Cytoplasm, Cytoskeleton, Cytoplasm, Cytoskeleton, Stress fiber
Localizes to actin and intermediate filaments cytoskeletons. Localizes to central actin stress fibers around the nucleus and is excluded form focal contact sites in myoblast cells. Translocates to the nucleus (By similarity). Associates with actin cytoskeleton in sensory neurons.
Subcellular locations: Cytoplasm, Cytoskeleton, Cell projection, Axon, Membrane
Associates with axonal microtubules and intermediate filaments, but not with actin cytoskeleton, in sensory neurons.
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cell cortex, Cell membrane
Isoform 1 is expressed in myoblasts (at protein level). Isoform 3 is expressed in the skin. Isoform 6 is expressed in the brain. Highly expressed in skeletal muscle and cultured keratinocytes.