Transcription factor . Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5 (, ). Plays a role in natural killer (NK) cell maintenance and immunity . May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity).
Subcellular locations: Nucleus
Widely expressed in many different tissue types including thymus and placenta, with high expression in brain . Expressed in both inhibitory and excitatory neurons in cortex .