Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors . May play a role in the regulation of spermatogenesis (By similarity).
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Acrosome
Localized in the acrosome in germ cells throughout spermiogenesis, it is also present in the manchette of elongating spermatids.