Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration ( ). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond . Cleaves NINJ1 to generate the Secreted ninjurin-1 form . Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments . Degrades fibronectin but not laminin or Pz-peptide.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix
Detected in neutrophils (at protein level) . Produced by normal alveolar macrophages and granulocytes.