GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
Subcellular locations: Cytoplasm, Membrane, Mitochondrion membrane, Lipid droplet
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.