Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives ( ). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid ( ). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives ( ). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (, ). Catalyzes in the oxidative direction with higher efficiency (, ). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation ( ).
Subcellular locations: Cytoplasm
Preferentially expressed in stomach.