Exhibits a potent RNase activity ( ). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (  ). Causes loss of bacterial membrane integrity . Probably contributes to urinary tract sterility . Bactericidal activity is independent of RNase activity .
Subcellular locations: Secreted
Detected in urine.
Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) . Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut . Expressed in liver, kidney, skeletal muscle and heart .