Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (, ). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores . Acts by interacting with STIM1, promoting STIM1 conformational switch . Involved in STIM1 relocalization to ER-PM junctions . Contributes to the maintenance and reorganization of store-dependent ER-PM junctions .
Subcellular locations: Endoplasmic reticulum membrane
Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells . May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable).
Widely expressed.