Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability.
Subcellular locations: Nucleus
Localizes at DNA replication sites.
Expressed in the brain, with higher levels in prenatal compared to adult brain.