Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity).
Subcellular locations: Cytoplasm, Cytosol, Cell membrane, Cell junction, Adherens junction, Cell junction, Tight junction
Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Almost absent from liver, thymus and peripheral blood lymphocytes.