Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) ( ). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration . May play a role in neutrophil transendothelial migration, probably when associated with CD177 .
Subcellular locations: Cytoplasmic granule, Secreted, Cell membrane, Membrane raft
Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils ( , ). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (, ). Following secretion tethered to the cell membrane by CD177 (, ).
Expressed in polymorphonuclear leukocytes (at protein level) ( ). Expressed in neutrophils (at protein level) (  ). Expressed in differentiating neutrophils .