E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . May operate on tyrosine-phosphorylated SRC substrates .
Subcellular locations: Cytoplasm
Localized over the postacrosomal perinuclear theca region and the entire length of sperm tail.
Exclusively expressed in testis and sperm, including spermatocytes, round and elongated spermatids, and Leydig cells.