Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity ( ). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (, ). Probably only regulates a subset of ATR targets (, ).
Subcellular locations: Nucleus
Localizes at sites of DNA damage following replication stress ( ). Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex (, ).
Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.