Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (, ). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
Subcellular locations: Membrane, Lipid droplet
Expressed in kidney, liver, lung, prostate, heart and ovary.