Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (  ). Active against both single-stranded and double-stranded RNAs (, ). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) . Cleaves mRNAs and tRNAs containing inosine (, ). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (, ). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures .
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine . Active against both single-stranded and double-stranded RNAs . Cleaves tRNAs containing inosine .
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine . Active against both single-stranded and double-stranded RNAs . Cleaves tRNAs containing inosine .
Subcellular locations: Cytoplasm, Nucleus, Nucleolus, Cytoplasm, Stress granule
Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with PABPC1.
Subcellular locations: Cytoplasm, Nucleus, Nucleolus, Cytoplasm, Stress granule
Relocalizes to cytoplasmic stress granules upon cellular stress.
Subcellular locations: Cytoplasm, Nucleus, Nucleolus, Cytoplasm, Stress granule
Relocalizes to cytoplasmic stress granules upon cellular stress.