ATP-dependent helicase that binds and distorts nucleosomal DNA (, ). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin ( , ). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination . Involved in neurogenesis (By similarity).
Subcellular locations: Nucleus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Associates with centrosomes in interphase (By similarity). Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687 (, ).
Widely expressed.