Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion . Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).
Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Synapse, Cell projection, Axon, Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane, Presynapse
Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules .
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.