Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
Subcellular locations: Nucleus, Cytoplasm, Endosome, Golgi apparatus