After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Subcellular locations: Postsynaptic cell membrane, Cell membrane
TMEM35A/NACHO promotes its trafficking to the cell membrane . RIC3 promotes its trafficking to the cell membrane (By similarity).