E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 .
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton
Microtubule-associated.
Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.