E3 ubiquitin-protein ligase . Positively regulates the NF-kappa-B signaling pathway (, ).
(Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation.
Subcellular locations: Cytoplasm, Cytoplasm, Cytosol, Nucleus