Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) (By similarity). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity).
Subcellular locations: Mitochondrion, Cytoplasm, Cytosol
Released into the cytosol in a PARL-dependent manner when cells undergo apoptosis.