Necessary for cellular interactions with laminin and the extracellular matrix.
(Microbial infection) Receptor for the protective antigen (PA) of B.anthracis ( ). Binding of PA leads to heptamerization of the receptor-PA complex ( ). Upon binding of the PA of B.anthracis, the complex moves to glycosphingolipid-rich lipid rafts, where it is internalized via a clathrin-dependent pathway (, ). In the endosomal membrane, at pH under 7, the complex then rearranges and forms a pore allowing the other components of anthrax toxin to escape to the cytoplasm (, ).
Subcellular locations: Cell membrane
Expressed at the cell surface.
Subcellular locations: Endoplasmic reticulum membrane
Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
Subcellular locations: Secreted
Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.