Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis . As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation .
Subcellular locations: Cell membrane, Cell projection, Dendrite
Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.
Brain specific. Detected in neuronal cells.