High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors ( , ). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release ( , ). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (, ). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release . Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis .
Subcellular locations: Cell membrane
Internalizes in presence of its ligands, fMLP, TAFA4 and CTSG.
Neutrophils.