Rab effector playing a role in late endocytic transport to degradative compartments (  ). Involved in the regulation of lysosomal morphology and distribution (, ). Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments (, ). Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes .
Subcellular locations: Late endosome membrane, Lysosome membrane, Cytoplasmic vesicle, Phagosome membrane
Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes.
Ubiquitous. Strongly expressed in fetal heart, heart, stomach, spleen, adrenal gland, thyroid gland, salivary gland, fetal liver, liver and lung. Poorly expressed in brain.