Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
Subcellular locations: Cytoplasm, Nucleus, Chromosome, Centromere, Cytoplasm, Cytoskeleton, Spindle pole
In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.