Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.
Subcellular locations: Secreted, Cytoplasmic granule
Granules of large granular lymphocytes.
Highly and constitutively expressed in activated natural killer (NK) cells.