Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).
Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome ( , ). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (, ). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression .
Subcellular locations: Golgi apparatus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Golgi apparatus
Associated with the microtubule network at the growing distal tip of microtubules . Targeting to the Golgi apparatus requires AKAP9 .
Highly expressed in adult and fetal heart, in skeletal muscle and, to a lower extent, in brain and placenta.