May act as a GTPase-activating protein for Rab family protein(s) (, ). Involved in neuronal projections development, probably through a negative modulation of ARF6 function . Involved in the regulation of synaptic vesicle trafficking .
Subcellular locations: Cell membrane, Cytoplasm, Cytoplasmic vesicle membrane, Presynapse
Mainly cytoplasmatic with partial expression at the plasma membrane . Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity).
Highest expression in brain.