Cardiac hormone that plays a key role in mediating cardio-renal homeostasis ( , ). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (  , ). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (, ). Binds the clearance receptor NPR3 .
May affect cardio-renal homeostasis . Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 .
May have a role in cardio-renal homeostasis . Able to promote the production of cGMP .
Subcellular locations: Secreted
Detected in blood.
Subcellular locations: Secreted
Detected in blood.
Subcellular locations: Secreted
Detected in blood.
Subcellular locations: Secreted
Detected in blood.
Detected in the cardiac atria (at protein level) (, ). Detected in the kidney distal tubular cells (at protein level) .