Exhibits both phospholipase A1/2 and acyltransferase activities ( , ). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids ( ). For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) ( ). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor . Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity .
Subcellular locations: Cytoplasm, Membrane
Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.
Expressed in liver, kidney, small intestine testis and colon . Undetectable in testis, placenta, salivary gland and fetal brain .