RAB5A effector molecule that is involved in vesicular trafficking of early endosomes . Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility .
Subcellular locations: Cytoplasm, Nucleus, Early endosome, Nucleus, Nuclear body
Diffuse presence in the cytoplasm and accumulation in the nucleus . In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes . In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity).
Produced abundantly in a wide variety of cell types.