Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response . Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1 . Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis . Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation . Essential for testicular stem-cell differentiation and sustained spermatogenesis (By similarity).
Subcellular locations: Nucleus, Nucleus, Nucleoplasm
Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.