Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex .
(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.
Subcellular locations: Endoplasmic reticulum membrane
Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine.