Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Subcellular locations: Cytoplasm, Cytosol, Cytoplasm, Cytoskeleton, Membrane
Tightly but non-covalently associated with membranes.
Ubiquitous.