Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (, ). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (, ). Plays a key role in promoting cell growth . Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF . Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization .
Subcellular locations: Cytoplasm, Cell membrane
Translocated from the cytoplasm to endosomes in response to stress stimuli . Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association . Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS .
Expressed only in testis, kidney and colon.
Ubiquitously expressed.