Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (, ). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells .
Subcellular locations: Cytoplasm, Nucleus
In dendritic cells, translocates into the nucleus upon IL33 stimulation.
Expressed in eosinophils, dendritic cells and/or monocytes (at protein level) . Expressed predominantly in peripheral blood lymphocytes .