Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body . Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components . Inhibits circadian clock function in cancer cells, when overexpressed .
Subcellular locations: Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin .
Subcellular locations: Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin .
Testis-specific . Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific . Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL .