Receptor for the cytotoxic ligand TRAIL . Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis . Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to , it cannot but according to , it can induce the NF-kappa-B pathway (, ).
Subcellular locations: Membrane
Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.