Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
Subcellular locations: Cell projection, Dendrite
Expressed exclusively in dendrites of the developing hippocampus.
Expressed in the vascular smooth muscle of coronary artery.