Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.
Subcellular locations: Cell membrane, Endomembrane system, Cytoplasm, Perinuclear region
Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation.
Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus . Expressed in adipose tissue .