Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Subcellular locations: Cytoplasm, Endosome membrane
Upon insulin stimulation, translocates to the plasma membrane.
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.