Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex ( ). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (, ). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (, ). Ubiquitinates, in an oxygen-responsive manner, ADRB2 . Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR .
Subcellular locations: Cytoplasm, Cell membrane, Endoplasmic reticulum, Nucleus
Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated . Colocalizes with ADRB2 at the cell membrane .
Subcellular locations: Cytoplasm, Nucleus
Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
Expressed in the adult and fetal brain and kidney.