Plays an important role in the organization of the cytoskeleton (, ). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (, ).
Potent inhibitor of bone marrow derived stem cell differentiation . Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).
Subcellular locations: Cytoplasm, Cytoskeleton
Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.