5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) . Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation . Plays a role in lysosomal homeostasis . Involved in the regulation of endosomal protein sorting .
Subcellular locations: Endoplasmic reticulum membrane, Lysosome lumen, Early endosome membrane, Late endosome membrane, Golgi apparatus membrane, Endosome membrane
Localizes to ER-associated vesicles in differentiating myotubes . The soluble form in lysosome arises by proteolytic processing of the membrane-bound form . Colocalizes with APP in endosomes .
Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.