G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN . Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity).
Subcellular locations: Cell membrane
Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus.
Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues.