Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling.
Potently inhibits endothelial cell proliferation and angiogenesis . May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 .
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Secreted, Extracellular space, Extracellular matrix, Basement membrane
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Basement membrane, Secreted
Subcellular locations: Secreted, Secreted, Extracellular space, Extracellular matrix, Basement membrane
Detected in placenta (at protein level) . Present in multiple organs with highest levels in liver, lung and kidney.