Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Subcellular locations: Cell membrane
Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.