Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV) .
Subcellular locations: Mitochondrion, Mitochondrion membrane
Subcellular locations: Mitochondrion membrane
Subcellular locations: Mitochondrion membrane
Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.