Required for centrosome assembly and function ( ). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (, ). Required to anchor microtubules to the centrosome (, ). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites ( ). Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites .
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasmic granule, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriolar satellite, Cytoplasm, Cytoskeleton, Cilium basal body
Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling.
Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.