Catalyzes the reversible hydration of carbon dioxide (                         ). Can also hydrate cyanamide to urea (, ). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 . Essential for bone resorption and osteoclast differentiation . Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.
Subcellular locations: Cytoplasm, Cell membrane
Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.