Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ . Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network ( ). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity . Required for ciliation .
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Spindle, Nucleus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriole, Cytoplasm, Cytoskeleton, Cilium basal body
Associated with mitotic spindles . Nuclear, in discrete foci. Associated with intermediate filaments . Also present in the pericentrosomal area . Localizes on both mother and daughter centrioles. Localizes to an axial position on the mother centriole . Localizes to the distal end of the centriole on the subdistal appendage region .
Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.