Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras . Probably impairs the formation of GTP-Ras . Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 . Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin .
Subcellular locations: Cytoplasm, Cell projection, Ruffle membrane
Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity). Colocalizes with TESK1 in vesicular spots in the cytoplasm .