Involved in the regulation of stress granule and P-body formation.
Subcellular locations: Membrane, Cytoplasm, Nucleus speckle, Cytoplasmic granule
Predominantly cytoplasmic but is also detected in nuclear speckles . Component of cytoplasmic stress granules . Inhibition of methylation alters nuclear localization . Methylation does not seem to be required for localization to stress granules under stress conditions .
Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.