Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses . Involved in the regulation of Wnt signaling . It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (By similarity). Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.
Subcellular locations: Nucleus, Cell junction, Adherens junction, Cell projection, Dendrite, Perikaryon
Expressed in brain; highest expression is observed in fetal brain .