Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A . This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription . Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (, ). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity .
Subcellular locations: Nucleus, Nucleolus, Chromosome, Centromere, Kinetochore