Plays a pivotal role in hepatic lipid metabolism . In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 ( ).
Has retinol/retinal dehydrogenase activity in vitro.
Does not have retinol/retinal dehydrogenase activity in vitro.
Subcellular locations: Lipid droplet, Endoplasmic reticulum
Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.
Subcellular locations: Cytoplasm
Does not localize to lipid droplets.
Highly expressed in the liver . Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.