Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (, ). Implicated in induction of cell migration and cell branching ( ). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity).
Subcellular locations: Cell junction, Focal adhesion, Cytoplasm, Cell projection, Axon
Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity).
Expressed in B-cells (at protein level) . Widely expressed with an abundant expression in the testis . Low level of expression seen in the liver, thymus, and peripheral blood leukocytes .