Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (, ). Mediates export of the GPCR receptor ADRA2B to the cell surface . Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (, ).
Subcellular locations: Golgi apparatus, Trans-Golgi network membrane, Endosome membrane, Early endosome membrane
Ubiquitously expressed.