Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane . Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate . Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate . Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) ( ).
Subcellular locations: Cytoplasm, Cytosol, Lipid droplet, Cell membrane
Detected on the surface of cytosolic lipid droplets . Recruited to the cell membrane by phosphatidylinositol-phosphate binding .
Widely expressed.