Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Subcellular locations: Secreted, Extracellular space
Subcellular locations: Parasitophorous vacuole
(Microbial infection) In P.falciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage . Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface .
Expressed in the retina pigment epithelium (at protein level) . Expressed in plasma (at protein level) . Expressed in serum (at protein level) .