Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions . Mediates chloride-dependent transport of urate . Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) (, ). Can actively transport inorganic phosphate into cells via Na(+) cotransport .
Subcellular locations: Apical cell membrane
Apical in the intestinal brush border.
Abundantly expressed in pancreas, liver, colon and small intestine, less in kidney. Not detected in the adrenal glands, brain, placenta, heart, testis, skeletal muscle, and lungs.