Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides . Binds hemimethylated DNA as well (, ). Recruits histone deacetylases and DNA methyltransferases to chromatin (, ). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (, ). Acts as a transcriptional repressor and plays a role in gene silencing ( ). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression . May enhance the activation of some unmethylated cAMP-responsive promoters .
Subcellular locations: Nucleus, Chromosome
Nuclear, in discrete foci . Detected at replication foci in late S phase. Localizes to methylated chromatin . Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 .
Highly expressed in brain, heart, kidney, stomach, testis and placenta.