Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system ( , ). DYNC2I1 plays a major role in retrograde ciliary protein trafficking in cilia and flagella ( ). Requires also to maintain a functional transition zone .
Subcellular locations: Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Located at the base of the primary cilium in serum-starved fibroblasts.
Expressed in chondrocytes (at protein level).