Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity ( , ). Cleaves ASARM peptides between Ser and Glu or Asp residues . Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide . Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (, ). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation .
Subcellular locations: Cell membrane
Specifically expressed in ovary . Expressed at low levels in kidney .