Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals . Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A . Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).
Subcellular locations: Nucleus, Cytoplasm
Translocation to the nucleus is induced by metals.