Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic . Acts by specifically binding and stimulating NPR2 to produce cGMP (, ). Binds the clearance receptor NPR3 .
Subcellular locations: Secreted
In the kidney, predominantly expressed in the distal tubular cells (at protein level).