Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (  ). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (  , ). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef (, ). Protects blood cells against infection with HIV-1 (in vitro) . Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) . Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) .
Subcellular locations: Secreted, Cytoplasmic vesicle, Secretory vesicle
Stored as mature peptide in neutrophil granules.
Expressed in neutrophils (at protein level) ( ). Expressed in bone marrow .