Involved in pre-mRNA splicing as component of the spliceosome ( , ). PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides . Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 . Plays an important role in embryonic brain development; this function is independent of its isomerase activity .
Subcellular locations: Nucleus
Ubiquitous, with the most abundant expression in heart and skeletal muscle.