May play a role in apoptosis (, ). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed . Involved in dental enamel formation .
Subcellular locations: Cell membrane, Cytoplasm, Cytoplasm, Perinuclear region
Spleen, lymph node, brain, breast and peripheral blood leukocytes (at protein level) . Expressed highly in bone marrow and fetal liver. Very low levels in skeletal muscle, testis and colon. Not detected in kidney and pancreas.