Plays a role in the normal development of the peripheral and central nervous system ( ). Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment .
Subcellular locations: Nucleus, Nuclear pore complex, Cytoplasm, Cytoskeleton, Spindle pole, Nucleus envelope
In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate . The localization to the spindle is microtubule-mediated .
Widely expressed (, ). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung .