Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer.
Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion.
Induces gene transcription inhibition.
Subcellular locations: Cell membrane, Endoplasmic reticulum, Golgi apparatus, Synapse, Cell projection, Dendritic spine, Cell projection, Filopodium, Cell projection, Growth cone, Postsynaptic cell membrane, Synapse, Synaptosome
Colocalizes with ADGRL1 across intercellular junctions.
Subcellular locations: Cell membrane
Colocalizes with ADGRL1 across intercellular junctions.
Subcellular locations: Nucleus, PML body
Highly expressed in heart, followed by brain, liver, kidney and fetal brain and weakly expressed in lung and testis. No expression was detected in skeletal muscle, pancreas, spleen, ovary and fetal liver.