Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation.
Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response . Functions as an activator of STING1 by promoting its cGAMP-induced oligomerization and the recruitment of downstream signaling components .
Subcellular locations: Endosome membrane, Endoplasmic reticulum membrane, Golgi apparatus
Widely expressed with significant expression in heart, brain, placenta, lung, liver, kidney, testis, thymus and small intestine . Expressed at lower levels in adult pancreas and lung .