Mitochondrial outer membrane protein involved in the regulation of mitochondrial organization . It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity.
Subcellular locations: Mitochondrion outer membrane
Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
Expressed in all tissues tested with highest expression in heart and skeletal muscle.