Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling . Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels . Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function . Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels . Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Perinuclear region, Cell membrane, Golgi apparatus, Postsynaptic density
L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.
Subcellular locations: Cytoplasm, Cytoskeleton
L-CaBP1 is associated most likely with the cytoskeletal structures.
Subcellular locations: Cytoplasm, Cell cortex, Cell membrane
S-CaBP1 is localized at or near the plasma membrane.
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.