The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes ( , ). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion ( , ). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion . Required to modulate the compacted morphology of the Golgi . Regulates the level of CASR present at the cell membrane . Plays a role in cell adhesion and cell migration, via its role in protein trafficking . Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria . Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (By similarity).
Subcellular locations: Golgi apparatus, Endoplasmic reticulum, Early endosome, Cytoplasm, Cytosol, Membrane, Melanosome
Alternates between membrane-associated and cytosolic forms.