Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
Subcellular locations: Endosome, Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Recycling endosome membrane, Cleavage furrow, Midbody, Cytoplasmic vesicle
Recruited to the cleavage furrow and the midbody during cytokinesis.
Present at high level in testis (at protein level). Weakly expressed in other tissues.