Required for both DNA replication and mitosis (  ). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments . Potential oncogene (By similarity).
Subcellular locations: Nucleus, Chromosome, Centromere, Kinetochore
Transiently localizes to kinetochores during prometaphase and metaphase.