Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription (, ). May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions (, ). Plays a role in thyroid hormone receptor and estrogen receptor transactivation (, ). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1 . Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B . May play a role in the development of neuromuscular junction . May play a role in late myogenic differentiation (By similarity). Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation ( ).
Subcellular locations: Nucleus, Cytoplasm, Cytosol, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Cytoplasmic under conditions of serum deprivation . Colocalizes with NEK6 in the centrosome .