Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.
Subcellular locations: Cell membrane, Cytoplasm, Cytoskeleton, Cilium basal body, Cell projection, Cilium, Cell projection, Cilium membrane, Nucleus
The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner.
Found in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.