Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation .
Subcellular locations: Cell membrane
Expressed in the proerythroblasts (at protein level) . Expressed strongly in the kidney . Expressed weakly in the pancreas, liver and lung . Expressed strongly in erythroid progenitor cells (EPCs) . Expressed weakly in T-cells and neutrophils .