Involved in the biogenesis of cilia . Required for the recruitment of PLK1 to centrosomes and S phase progression .
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriole, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Cilium basal body, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasmic granule, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriolar satellite
Localizes to the centrosome throughout cell cycle progression . Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP .
Widely expressed. Detected in brain, heart, kidney, liver, lung, skeletal muscle, placenta and intestine.