Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery .
May define a distinct membrane domain in the vicinity of the mitotic spindle . Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina .
Subcellular locations: Nucleus inner membrane, Cytoplasm, Cytoskeleton, Spindle pole
The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle.