Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).
Subcellular locations: Cell membrane, Cell junction, Secreted
Detected in cerebrospinal fluid (at protein level) . Expressed in many tissues, with low expression in thymus.