Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains ( ). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (, ). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress .
Subcellular locations: Cytoplasm, Nucleus
Mostly present in the nuclear fraction. Localizes to DNA lesions.