Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
Subcellular locations: Nucleus, Cytoplasm
Translocates to the nucleus on heterodimerization with E2F family members.
Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines.