Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Subcellular locations: Cell membrane, Cell projection, Ruffle membrane
In interphase associated with the plasma membrane, in particular with membrane ruffling regions . Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures . Recruited to membranes via phosphatidylinositol phosphate-binding (Probable).
Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood.