E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Subcellular locations: Cytoplasm, Endosome
Colocalizes with endosomal compartments.
Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.