Receptor on natural killer (NK) cells and T cells for MHC class I molecules (, ). Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions . Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity .
Subcellular locations: Cell membrane
Expressed in astrocytes.