Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins ( , ). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (, ). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD . Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis .
Subcellular locations: Nucleus, Cytoplasm, Cytoskeleton, Spindle, Midbody
In mitosis, localizes to the spindle during metaphase and the spindle midbody during telophase . Co-localizes with KIF4A to the spindle midzone and midbody during telophase and cytokinesis .