Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion . As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form . Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs . Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin . Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity).
Subcellular locations: Cytoplasm, Cell cortex, Nucleus, Golgi apparatus, Cell projection, Lamellipodium, Cytoplasm, Cell junction, Focal adhesion, Cytoplasm, Cytoskeleton, Cytoplasm, Cytoskeleton, Spindle pole, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Cilium basal body, Basolateral cell membrane
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle
Expressed in B-cells (at protein level) . Expressed in the respiratory epithelium of the main bronchi to the bronchioles in the lungs (at protein level) . High levels detected in kidney, lung, and placenta . Expressed in lymphocytes .