Plays a role in actin cytoskeleton rearrangement.
The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.
Subcellular locations: Cell membrane, Cell projection
Detected on podocyte foot processes.
Subcellular locations: Secreted
Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.
Detected on kidney podocytes along the glomerular capillary wall (at protein level).