Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (, ). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface . Synergizes with DISP1 to increase SHH secretion . Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis .
Subcellular locations: Secreted, Cell surface
Secreted and tethered at the cell surface .
Expressed in a broad spectrum of adult tissues .