Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether (, ). TRAPP II complex has also GEF activity toward RAB1A (By similarity). TRAPPC14 is dispensable for TRAPPII complex integrity but mediates RAB3IP preciliary vesicle trafficking to the mother centriole during ciliogenesis . Modulates YAP1 activity as transcriptional regulator .
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle, Vesicle, Midbody, Cytoplasm
During mitosis, precedes alpha-tubulin in gap formation of cell abscission at the midbody and is co-localized with PLK1 at the edges of microtubules extensions of daughter cells post cytokinesis abscission . Colocalizes with RAB3IP on preciliary vesicles .
Broadly expressed. High levels in brain, cerebellum, testis and whole blood.