Deubiquitinating enzyme that functions as a negative regulator of the innate immune system ( , ). Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains . Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) . Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production . Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 . Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability .
Subcellular locations: Nucleus
Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.