Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells .
Subcellular locations: Cytoplasm, Cytoskeleton, Membrane, Cell projection, Dendrite, Postsynaptic density
Prominently expressed in the postsynaptic densities of dendritic spines, is also detected in dendritic shafts.