Receptor-proximal protein kinase regulating integrin-mediated signal transduction (, ). May act as a mediator of inside-out integrin signaling . Focal adhesion protein part of the complex ILK-PINCH . This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway . Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells . Regulates cell motility by forming a complex with PARVB . Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (, ).
Subcellular locations: Cell junction, Focal adhesion, Cell membrane, Cell projection, Lamellipodium, Cytoplasm, Myofibril, Sarcomere
Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.