Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (, ). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (, ). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . Protects cells against apoptosis by protecting CDKN1A against degradation .
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cytosol, Cytoplasm, Perinuclear region, Nucleus, Nucleus, Nucleolus, Cell membrane, Cytoplasmic vesicle membrane, Cytoplasm, Cell cortex
Colocalizes with the actin cytoskeleton . Recruited to the membranes via its interaction with SPIRE1 (By similarity). Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Accumulates in the nucleus following DNA damage .
Expressed almost exclusively in the developing and mature central nervous system.