Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton.
Subcellular locations: Apical cell membrane
Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons.
Expressed in infantile heart and muscle, and fibroblasts.