Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (, ). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation . Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) .
Subcellular locations: Cytoplasm, Cytosol