Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (, ). Involved in cellular response to oxidative stress .
Subcellular locations: Cytoplasm, Mitochondrion
Detected in erythrocytes (at protein level) (, ). Expressed in fetal brain .