Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (, ). Phosphorylates PFKFB2 . May play a role in the postsynaptic responses of hippocampal neurons .
Subcellular locations: Nucleus, Cytoplasm, Cell membrane
Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes.
Brain and testis.