Scaffolding protein that facilitates the localization of proteins to the cell membrane ( ). Required for the correct formation of tight junctions and epithelial apico-basal polarity (, ). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries .
Subcellular locations: Cell junction, Tight junction, Apical cell membrane, Cytoplasm, Perinuclear region
Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed . Localized in the paranodal region of myelinating Schwann cells (By similarity). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity).
Expressed in renal tubules (at protein level) . Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain.