Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor . Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression . Acts as a transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions .
Subcellular locations: Nucleus
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.