Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code ( , ). Demethylates trimethylated and dimethylated H3 'Lys-27' ( , ). Plays a central role in regulation of posterior development, by regulating HOX gene expression . Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
Subcellular locations: Nucleus