Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Subcellular locations: Cytoplasm, Nucleus
Predominantly found in the nucleus, with a small fraction found in the cell periphery.
Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.