May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis .
Subcellular locations: Early endosome membrane, Endoplasmic reticulum
Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots . May translocate to the endoplasmic reticulum in the early phase of apoptosis .
Expressed in placenta, ovary and small intestine, as well as in heart and pancreas. Also expressed in peripheral blood mononuclear cells and dendritic cells.