Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Subcellular locations: Cytoplasm, Perinuclear region, Endomembrane system, Cytoplasmic vesicle, Clathrin-coated vesicle membrane
Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.