Plays a role in immunological synaptic F-actin density and architecture organization . Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity . Required for the formation of membrane ruffles during macropinocytosis . Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes . Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) . Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells . Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D . Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells .
(Microbial infection) In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
Subcellular locations: Cell membrane