Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival .
Subcellular locations: Cytoplasm, Nucleus, Nucleolus, Nucleus, Nucleoplasm, Cell membrane, Nucleus speckle
Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments . Colocalizes with TM4SF1 in the apical region of the cell . Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments . PIP2 plays an important role in the distribution of SDCBP2 .
Preferentially expressed in cells of the digestive tract . Low expression in skeletal muscle and kidney . Detected in differentiated keratinocytes of normal and malignant epithelium . In healthy skin, expression is localized in suprabasal epidermal layers .