As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores ( , ). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations .
Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle (, ). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations .
Subcellular locations: Nucleus envelope, Nucleus, Nuclear pore complex, Nucleus, Nucleoplasm, Chromosome
Predominantly located at the nuclear envelope, facing the nucleus interior ( ). Localization at the nuclear pore complex requires NUP153, TPR and ALYREF/ALY (, ). Also found associated with chromatin . In B-cells, targeted to the immunoglobulin variable region genes .
Subcellular locations: Cytoplasm, Nucleus
Translocates into the nucleus in the presence of MCM3 . Associates with chromatin possibly through interaction with MCM3 .
Widely expressed . Up-regulated in germinal center B-cells in tonsils (at protein level) .