Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly.
Plays a role as an effector in the TP53-dependent apoptotic pathway.
Subcellular locations: Cell junction, Desmosome, Cell membrane
Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane .
Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.