May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.
Subcellular locations: Cell membrane, Cytoplasmic vesicle membrane
Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions . Detected on cytoplasmic membranes in undifferentiated tumors .
Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).