Ribonuclease that cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (, ). Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus . Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA . Angiogenin induces vascularization of normal and malignant tissues . Angiogenic activity is regulated by interaction with RNH1 in vivo .
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle lumen, Secreted, Nucleus, Nucleus, Nucleolus
Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA .
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.