Positively regulates primary cilium biogenesis . Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriole, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Cilium basal body, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cell projection, Cilium, Flagellum
Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia. Colocalizes with ENTR1 and pericentrin at the centrosome.
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.