Translocates drugs and phospholipids across the membrane ( , ). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins . Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells ( ).
Subcellular locations: Cell membrane, Apical cell membrane, Cytoplasm
ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes .
Expressed in small intestine . Expressed in liver, kidney and brain.