Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis .
Subcellular locations: Secreted, Endoplasmic reticulum-Golgi intermediate compartment, Endoplasmic reticulum, Golgi apparatus
The C-terminal RTEL motif may provide retention in the endoplasmic reticulum.
Expressed in eosinophils (at protein level) . Expressed in bone marrow cells . Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties .