Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (  , ). The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase ( ). E2F1 binds preferentially RB1 in a cell-cycle dependent manner ( ). It can mediate both cell proliferation and TP53/p53-dependent apoptosis . Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters . Directly activates transcription of PEG10 ( ). Positively regulates transcription of RRP1B .
Subcellular locations: Nucleus