Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (  ). Contributes significantly to heme formation during erythropoiesis .
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products . Catalytic activity is 75-85% of isoform 1 activity .
Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products . Catalytic activity is 65-75% of isoform 1 activity .
Subcellular locations: Mitochondrion inner membrane
Localizes to the matrix side of the mitochondrion inner membrane.
Subcellular locations: Mitochondrion inner membrane
Localizes to the matrix side of the mitochondrion inner membrane.
Erythroid-specific.
Erythroid-specific.
Erythroid-specific.
Erythroid-specific.