In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Cell membrane, Cell projection, Lamellipodium
Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.
Kidney. Reduced expression in patients with focal segmental glomerulosclerosis.