Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia ( , ). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity).
Subcellular locations: Apical cell membrane, Membrane, Cell membrane
Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity).
Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.