Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac) ( , ). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac . May also act as a transcriptional corepressor for KDM5C and EZH2 . Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination ( ). Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters (, ). Localizes to H3.1K36me2-H4K16ac marks at all-trans-retinoic acid (ATRA)-responsive genes and positively regulates their expression . Promotes neuronal differentiation by associating with regulatory regions within the MAPT gene, to enhance transcription of a protein-coding MAPT isoform and suppress the non-coding MAPT213 isoform ( ). Suppresses breast cancer, and prostate cancer cell invasion and metastasis ( ).
Subcellular locations: Nucleus, Chromosome, Cytoplasm
Sequestered in the cytoplasm through the interaction with DBN1 . Localizes to sites of DNA damage in a KAT5-dependent and DNA poly (ADP-ribose)-dependent manner (, ). On chromatin, localizes to demethylated regions, active promoters, and transcription start sites (, ).
Expressed in neurons (at protein level) . Absent in astrocytes (at protein level) . Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta (, ). Expressed in cutaneous T-cell lymphomas (CTCL) .