May participate in intramanchette transport and midpiece formation of the sperm tail. May play a potential role in somatic cell proliferation.
Subcellular locations: Cytoplasm, Cytoskeleton, Nucleus, Cytoplasm, Mitochondrion, Cell projection, Cilium, Flagellum
During spermatid elongation (step 10), localizes along the length of the manchette and later during the elongation process only at the distal ends of spermatid manchette (step 12). In late elongated spermatids (step 16), in the final steps of spermiogenesis, localization is restricted to the midpiece of the flagellum. Localizes at the contractile ring in dividing cells (By similarity). Predominantly perinuclear in bronchial epithelial cells but also detected in the nucleus in some primary epithelial cells and in a number of cell lines (By similarity).