Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK ( ). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS . May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling .
Subcellular locations: Golgi apparatus membrane
Widely expressed.