Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Subcellular locations: Endomembrane system, Cell junction, Cell junction, Tight junction
Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.