Part of a non-canonical MAPK signaling pathway . Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 . May be an activator of the JNK/SAPK pathway.
Subcellular locations: Cytoplasm, Cell membrane
Behaves essentially as an integral membrane protein.
Highly expressed in brain and kidney.