Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriole
Localizes to procentriole and daughter centriole in growing and quiescent cells . May loose association with centrosomes during mitosis .
Widely expressed at high levels (including brain).