Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health ( , ). In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt-responsive genes (By similarity).
Subcellular locations: Mitochondrion membrane, Nucleus, Endoplasmic reticulum
Partial co-localization with endoplasmic reticulum . Linked to mitochondrial ribosomes .
Ubiquitously expressed in fetal and adult tissues and cancer cell lines.