Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles . Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade . May also play a role in the early development of embryos (By similarity).
Subcellular locations: Nucleus, Cytoplasm, Nucleus, Nucleoplasm
Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.
In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) . In hair follicles, mainly expressed in the outer root sheath (at protein level) . Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart . Expressed in the ovary, notably in oocytes .