Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (, ). Also involved in chromosome alignment . May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis . Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level .
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle, Chromosome, Centromere, Kinetochore, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Associated with the outer kinetochore.