Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process . May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity).
Subcellular locations: Basolateral cell membrane, Cell membrane
In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane.
Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.