As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization . Also plays a role in apoptosis ( ). It is for instance required for endoplasmic reticulum stress-induced apoptosis . As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
Subcellular locations: Endoplasmic reticulum membrane, Mitochondrion membrane
Localization to the mitochondrion is regulated by RNF186.
Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.