Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Subcellular locations: Nucleus, Cytoplasm, Cytoplasm, Cytoskeleton, Spindle
Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.