Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Acrosome membrane, Cytoplasmic vesicle, Secretory vesicle, Acrosome inner membrane, Cytoplasmic vesicle, Secretory vesicle, Acrosome outer membrane
In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes.
Isoform 1 is highly expressed in testis. Isoform 2 is expressed at low levels in skin and blood.