May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest . May play a role in breast tumorigenesis .
Subcellular locations: Cell membrane
SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.
Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus . Also expressed in colon; down-regulated in colon cancer tissues .