Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity . As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation . Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). Has a crucial role in cardiac development and function .
Subcellular locations: Perikaryon, Cell projection, Axon, Cytoplasm, Cell junction, Desmosome, Cell junction, Adherens junction
Expressed in the skin (, ). Found in keratinocytes, dermal fibroblasts, and melanocytes . Basal-layer keratinocytes have lower KLHL24 expression than suprabasal keratinocytes . Expressed in the brain, spinal cord, liver, testis, heart and at higher levels in the skeletal muscle .