Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD .
Subcellular locations: Endoplasmic reticulum membrane, Nucleus envelope
Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).