Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins.
May act as alpha-secretase for amyloid precursor protein (APP).
Subcellular locations: Cell membrane
Subcellular locations: Secreted
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.