Acts as a transcriptional regulator and plays a role in gene silencing (, ). Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of several tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) by inducing trimethylation of 'Lys-27' of histone H3 (H3K27me3)  in a Polycomb group (PcG) complexes-dependent manner. Associates at promoter regions of TSGs and mediates the recruitment of the corepressor complex containing the scaffolding protein TRIM28, methyltransferase DNMT1 and histone methyltransferase SETDB1 and/or the PcG complexes at those sites . Transcription factor involved in the metastatic cascade process by inducing cell migration and proliferation and gain resistance to anoikis of ovarian carcinoma (OC) cells via integrin-mediated signaling pathways . Associates with the ITGB1 promoter and positively regulates beta-1 integrin transcription expression . Promotes angiogenesis . Promotes tumor growth (, ).
Subcellular locations: Nucleus
Associates with chromatin .
Expressed in undifferentiated embryonic stem cells (ESCs) . Expressed strongly in colorectal cancers cells (CRCs) . Expressed strongly in ovarian carcinoma (OC) tumor cell lines compared to non-transformed ovarian epithelial cells (at protein level) . Expressed in lymphoid tissues, thyroid, adrenal gland, prostate, pancreas and skeletal muscles .