Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Subcellular locations: Nucleus
Excluded from nucleoli.
Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.