Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (, ). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (, ). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread . May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission .
(Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Subcellular locations: Cell membrane, Membrane, Coated pit
Subcellular locations: Cell membrane, Membrane, Coated pit
Subcellular locations: Cytoplasm, Nucleus
After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.
Subcellular locations: Golgi outpost, Cytoplasm, Cytoskeleton, Microtubule organizing center
Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Most abundant in liver, brain and lung.