Membrane-bound component of the endocytic receptor formed by AMN and CUBN ( ). Required for normal CUBN glycosylation and trafficking to the cell surface (, ). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 ( ). Required for normal CUBN-mediated protein transport in the kidney (Probable).
Subcellular locations: Apical cell membrane, Cell membrane, Endosome membrane, Membrane, Coated pit
Subcellular locations: Secreted
Detected in proximal tubules in the kidney cortex (at protein level) (, ). Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes.