Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
Subcellular locations: Cell membrane, Cytoplasmic vesicle, Cytoplasm, Cytoskeleton
Enriched in selected actin structures (, ).
Subcellular locations: Nucleus
Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).