Required for pre-mRNA splicing as component of the activated spliceosome (  ). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).
Subcellular locations: Nucleus, Nucleus, Nucleolus
Ubiquitously expressed.