Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand ( , ). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity).
Subcellular locations: Cytoplasm, Nucleus, Nucleoplasm, Nucleus, Nucleus, Nucleolus
Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung . Also found in high-grade lymphomas, squamous cell lung tumors and seminomas .