Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 . Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (By similarity).
Subcellular locations: Mitochondrion membrane, Endoplasmic reticulum membrane
Colocalizes with COX4I1.
Expressed in lung and in primary lung squamous cell carcinoma (LSCC).