Actin-binding protein that contains 2 major actin binding sites (, ). Organizes filamentous actin into parallel bundles ( ). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers . Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration ( ). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF .
Subcellular locations: Cytoplasm, Cytosol, Cytoplasm, Cell cortex, Cytoplasm, Cytoskeleton, Cytoplasm, Cytoskeleton, Stress fiber, Cell projection, Filopodium, Cell projection, Invadopodium, Cell projection, Microvillus, Cell junction
Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Ubiquitous.