Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation . The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 . Plays a role in the reorganization of the actin cytoskeleton . Promotes growth of cell projections in oligodendrocyte precursors .
Subcellular locations: Cytoplasm, Cytoskeleton, Cell projection, Ruffle, Cell projection, Cell projection, Lamellipodium, Cytoplasm, Cytosol
A proportion colocalizes with the actin cytoskeleton . When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity).
Ubiquitous. Detected throughout the brain.