Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes ( ). May have a role in muscle signal transduction .
Subcellular locations: Cytoplasm, Cytosol
PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
Subcellular locations: Cytoplasm
PDE7A2 (50 kDa) is located to particulate cellular fractions.
Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart . It is expressed as well in two T-cell lines .
Found abundantly in skeletal muscle and at low levels in heart.