Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (     , ). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT . Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion.
Subcellular locations: Cell membrane, Basolateral cell membrane
Isoform beta is more mobile in the plasma membrane . Colocalizes with STIM1 at the cell membrane .
Expressed in naive CD4 and CD8 T cells (at protein level) . Expressed at similar levels in naive and effector T helper cells .