Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (, ). Inactive towards proteins bearing poly-ADP-ribose (, ). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . Plays a role in estrogen signaling ( ). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen . May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (, ). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction . Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells . Enhances ESR1-mediated transcription activity .
Subcellular locations: Nucleus
Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.