Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (       , ). Acts as a Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (, ). Involved in enamel formation . Activated following interaction with STIMATE, leading to promote STIM1 conformational switch .
Subcellular locations: Cell membrane, Endoplasmic reticulum membrane, Cytoplasm, Cytoskeleton, Sarcoplasmic reticulum
Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane ( , ). Associated with the microtubule network at the growing distal tip of microtubules . Colocalizes with ORAI1 at the cell membrane . Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium .
Ubiquitously expressed in various human primary cells and tumor cell lines.