Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase ( ). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (, ). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 . Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines .
Subcellular locations: Mitochondrion inner membrane
Widely expressed. Expressed at higher level in skeletal muscle, heart and liver.