Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis . Promotes cleavage of GSDMB, thereby inhibiting pyroptosis . Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae .
Subcellular locations: Cytoplasmic vesicle, Phagosome
Localized in phagolysosomes following ingestion of E.coli by neutrophils.
Bone marrow cells. Neutrophil .