Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds (, ). In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs . Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal . May play a physiological role in retinoid metabolism .
No oxidoreductase activity observed with the tested substrates.
Subcellular locations: Mitochondrion
Subcellular locations: Cytoplasm, Cytosol
Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.