Plays an important role in pancreatic tumor progression and metastasis (, ). Promotes pancreatic cancer cells migration and invasion through the TLR4/MyD88/NF-kaapaB signaling pathway, without the involvement of the TLR4/TRIF pathway .
Subcellular locations: Secreted, Cytoplasm, Cell membrane, Apicolateral cell membrane
Co-localizes with TLR4 at the cell membrane of pancreatic cancer cells.
Highly expressed in pancreatic cancer tissues (at protein levels). Also expressed in the placenta and colon and ovarian cancer tumors.