Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo . Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (, ). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells .
Subcellular locations: Membrane, Cell projection, Axon
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.