Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor . Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs . Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell (, ).
Subcellular locations: Nucleus, Chromosome, Secreted
In atherosclerotic lesions, it is found in the extracellular compartment and in foam cells cytoplasm.
Expressed in atherosclerotic lesions, not in normal intima. Expressed in foam cells.