Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (, ). Plays a role in cell growth and maintenance of cell morphology (, ). Plays a role in the proteolytic processing of ACE2 . Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization .
Subcellular locations: Cell membrane, Apical cell membrane
Detected in liver and kidney.