Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cell membrane, Membrane
Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.