Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin . Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity).
Subcellular locations: Cytoplasm, Cytosol, Recycling endosome membrane, Late endosome membrane, Golgi apparatus, Trans-Golgi network membrane, Cell membrane
Rapidly recruited to the plasma membrane and to Golgi structures in response to increased intracellular calcium concentration.
Predominantly expressed in brain . Also expressed in nonneural tissues such as breast and testes epithelium .