May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (, ). May also inhibit NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA (, ).
Subcellular locations: Cytoplasm, Nucleus
Recruited to specks formed by PYCARD within the cytoplasm.
Predominantly expressed in peripheral blood. Weakly expressed in testis.