Part of the nuclear pore complex . Has a critical role in nucleocytoplasmic transport . May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (, ).
(Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro).
Subcellular locations: Nucleus, Nuclear pore complex
Cytoplasmic side of the nuclear pore complex.
Expressed in thymus, spleen, bone marrow, kidney, brain and testis, but hardly in all other tissues or in whole embryos during development.