Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Required for accumulation of METTL3 and METTL14 to nuclear speckle ( ). Acts as a mRNA splicing regulator . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes .
Subcellular locations: Nucleus speckle, Nucleus, Nucleoplasm, Cytoplasm
Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
Ubiquitously expressed.