Essential component of the nuclear pore complex . The N-terminal is probably involved in nucleocytoplasmic transport . The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (, ). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation . It might be involved in protein recruitment to the centrosome after nuclear breakdown .
Subcellular locations: Nucleus, Nuclear pore complex, Cytoplasm, Cytoskeleton, Spindle pole, Nucleus envelope, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Central region of the nuclear pore, within the transporter . During mitotic cell division, it associates with the poles of the mitotic spindle .