Guanine nucleotide exchange factor for ARF6 . Induces cytoskeletal remodeling (By similarity).
Subcellular locations: Cell membrane, Cell projection, Ruffle membrane, Cleavage furrow
Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane.
Isoform 2 is expressed in the brain.