DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
Subcellular locations: Nucleus, Nucleoplasm, Nucleus speckle, Nucleus matrix
Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
Subcellular locations: Nucleus
Subcellular locations: Mitochondrion
Ubiquitous.