Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates ( , ). In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine (, ). Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP ( , ). Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency (, ). Through these activities regulates the purine nucleoside/nucleotide pools within the cell ( , ).
Subcellular locations: Cytoplasm, Cytosol
Widely expressed.