Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B . Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 . Binds in a sequence-specific manner to the rhodopsin promoter .
Subcellular locations: Cytoplasm, Nucleus
Expressed in the brain and the retina . Expressed strongly in rod and cone cells (at protein level) .