Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (, ). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling . Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity).
Subcellular locations: Membrane
Abundant in adipose tissues.