Acts as a ligand for C-C chemokine receptor CCR2 ( ). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (, ). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils ( ). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis .
Subcellular locations: Secreted
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) . Expressed in monocytes .