E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response . Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response . May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
Subcellular locations: Cytoplasm, Nucleus
Expressed in skeletal muscle, brain, heart and pancreas.