Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors . Binding of FMLP to the receptor causes activation of neutrophils . This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system . The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4) . Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity). Acts as a receptor for humanin .
Subcellular locations: Cell membrane
Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized . Also internalized in the presence of humanin .
Detected in lung, bone marrow, neutrophils, spleen and testis.