Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) . Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation . Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites .
Subcellular locations: Nucleus, Nucleus, Nucleoplasm, Nucleus inner membrane, Nucleus matrix
Mainly soluble, the remaining is localized in the nuclear matrix . Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures .
Ubiquitously expressed.