Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling . Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production . In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation . Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro .
Subcellular locations: Nucleus, Cytoplasm, Endosome, Cell membrane, Sarcolemma, T-tubule
Subcellular locations: Cytoplasm
Ubiquitous. Highest expression in the brain and muscle . Expressed in oligodendrocytes . Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter . Isoform BIN1 is widely expressed with highest expression in skeletal muscle.