Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (, ). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (, ). Undergoes both rapid and slow structural rearrangements in response to changes in voltage . Contains a zinc-binding site that can regulate the slow conformational transition .
Subcellular locations: Cell membrane, Cell projection, Dendrite, Perikaryon
Present in the dendrites and soma of cerebellar granule neurons, but not in their axon.
Mainly expressed in the cerebellum . Also expressed in cerebral cortex, skeletal muscle and thyroid, but at much lower levels .