Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) ( ). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment . In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation . Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells . Required for NLRP3 activation induced by viral dsRNA and bacterial RNA . In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity).
Subcellular locations: Nucleus, Nucleolus, Nucleus, Nucleoplasm, Cytoplasm, Nucleus, Inflammasome
Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions . Upon dsRNA-binding, localizes in the inflammasome .