Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule . In particular, participates in the secretion of urate from the cell into the lumen . Urate is the end product of purine metabolism . May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide .
Subcellular locations: Endoplasmic reticulum membrane
Subcellular locations: Cell membrane
Expressed in the liver and kidney (, ). It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level) .