Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections . Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS . Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity).
Subcellular locations: Cytoplasm, Cell projection, Dendrite, Cytoplasm, Cell cortex, Cell junction, Cell projection, Growth cone
In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm . In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) . Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity).
Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) . Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) . Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) . Expressed in peripheral blood lymphocytes, including T-cells (at protein level) . Expressed in the brain (, Ref.2). Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref.2).