Actin-binding protein ( ). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 . Modulates the cell surface expression of IL2RA/CD25 and CD69 .
Subcellular locations: Cytoplasm, Cytoskeleton, Cell junction, Cell projection, Cell projection, Ruffle membrane
Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 . Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation .
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.