Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) . Inhibited by the CDK-specific inhibitor CDKN1A/p21 . May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (, ).
Subcellular locations: Nucleus speckle, Nucleus, Nucleoplasm
Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC).