ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (  ). Binds DNA (, ). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (, ). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator . Involved in UV-damage excision DNA repair . The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation . Involved in DNA replication . Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle .
Subcellular locations: Cytoplasm, Nucleus, Cytoplasm, Cytoskeleton, Spindle, Chromosome
Localizes to the cytoplasm in quiescent cell . Associates with spindle microtubules during mitosis . Colocalizes with PCNA at replication forks during S-phase . Recruited to DNA damage sites in a ACTR8-dependent manner .
According to , widely expressed. According to , specifically expressed in brain, liver and pancreas.