Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (, ). Plays an essential role in maintaining nucleolar integrity in planarian stem cells . Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 . Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 . May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.
(Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection.
(Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon.
(Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation.
Subcellular locations: Nucleus, Nucleolus
Detected in heart, brain, liver, pancreas, placenta and lung.