Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) ( ). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis .
Subcellular locations: Cytoplasm, Cell projection, Axon, Secreted, Secreted, Extracellular exosome
In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus . Secreted by motor neuron, possibly through the exosome pathway (By similarity).
Subcellular locations: Mitochondrion, Cytoplasm
Subcellular locations: Cytoplasm, Cell projection, Axon
Widely expressed, including in brain and spinal cord.
Expressed in brain, spinal cord, muscle, heart and spleen.
Expressed in brain, spinal cord, muscle, heart, spleen and liver.