Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (, ). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (, ). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 . May be involved in regulation of pre-mRNA splicing .
(Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.
(Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.
(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
Subcellular locations: Nucleus, Nucleus matrix, Nucleus speckle, Nucleus, PML body, Cytoplasm
Colocalizes with PRPF40A in the nuclear matrix . Nuclear at steady state but shuttles between the nucleus and cytoplasm . The shuttling property has been questioned . Colocalizes with EBNA-LP in PML bodies .
Ubiquitously expressed. Expressed in the brain cortex (at protein level).