Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (   ). Calcium-binding is required for the activation of calmodulin (   ). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (   ). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis . Is a regulator of voltage-dependent L-type calcium channels . Mediates calcium-dependent inactivation of CACNA1C . Positively regulates calcium-activated potassium channel activity of KCNN2 . Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding . Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 .
(Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity.
(Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity.
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Cytoskeleton, Spindle pole, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cell projection, Cilium, Flagellum
Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.