Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (, ). Involved in protein transport . Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling . Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
Subcellular locations: Membrane, Cytoplasm, Early endosome membrane, Recycling endosome membrane
Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.