Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (, ). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (, ). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation .
Subcellular locations: Endoplasmic reticulum, Golgi apparatus, Golgi stack, Cell surface
Subcellular locations: Secreted
Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.