Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (By similarity).
Subcellular locations: Secreted, Cytoplasm, Apical cell membrane
Expressed in the brain, with expression in the epithelial cell layer of the choroid plexus (at protein level).