Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (, ). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes ( ). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation .
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Secreted
Detected in urine (at protein level) . Expressed by osteoblasts ( ). Expressed by stem cells in dental pulp . Expressed by mesenchymal cells in dental papilla and dental pulp (, ). Expressed in teeth, specifically in decidious dentin . Expressed in ondotoblasts . Expressed in salivary glands . Secreted from oncogenic hypophosphatemic tumors .