DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination . Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair . Inhibits non-homologous end joining (NHEJ) . Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle .
Subcellular locations: Nucleus, Chromosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Spindle pole
Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks . Localizes to the centrosome in interphase and to the spindle pole in metaphase .
Expressed in heart, skeletal muscles, placenta and testis.