Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
Subcellular locations: Cell membrane, Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Endosome membrane, Cytoplasmic vesicle membrane, Cell projection, Dendrite, Cell projection, Growth cone membrane, Early endosome membrane, Recycling endosome
Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles . Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides . Associates with cortical membranes . Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity). Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity).
Expressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells.