Functions as a transcription regulator in the hedgehog (Hh) pathway (, ). Functions as a transcriptional activator ( ). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (, ).
Involved in the smoothened (SHH) signaling pathway.
Involved in the smoothened (SHH) signaling pathway.
Involved in the smoothened (SHH) signaling pathway.
Involved in the smoothened (SHH) signaling pathway.
Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 .
(Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 .
(Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 .
(Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 .
Acts as a transcriptional repressor.
Subcellular locations: Nucleus, Cytoplasm, Cell projection, Cilium
STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus.
Subcellular locations: Nucleus
Subcellular locations: Nucleus
Expressed in breast cancers (at protein level) . Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines (at protein level) . Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines . Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines .