Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.
Subcellular locations: Cell junction, Adherens junction, Cell membrane
Colocalizes with the beta-catenin adherins.
Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.