DNA helicase that plays an important role in DNA replication, transcription and repair (, ). Binds to the RNA polymerase II subunit POLR2A during transcription elongation and suppresses transcription-associated genomic instability . Associates also with POLR1A and enforces the stability of ribosomal DNA arrays . Plays an important role in mitotic chromosome separation after cross-over events and cell cycle progress . Mechanistically, removes RAD51 filaments protecting stalled replication forks at common fragile sites and stimulates MUS81-EME1 endonuclease leading to mitotic DNA synthesis . Required for efficient DNA repair, including repair of inter-strand cross-links . Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
Subcellular locations: Nucleus, Nucleoplasm, Nucleus
Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks. Re-localizes from the nucleolus into the nucleus after replicative stress and significantly associates with WRN during S-phase .
Subcellular locations: Cytoplasm
Subcellular locations: Cytoplasm
Ubiquitous.