May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Subcellular locations: Cell membrane
Subcellular locations: Cytoplasm
C-terminally processed in the Golgi complex.
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).