Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (, ). Has anti-apoptotic activity . Plays a role in the HSF1 nucleocytoplasmic transport .
Subcellular locations: Nucleus, Cytoplasm
Colocalizes with HSF1 to the nucleus upon heat stress .