Transcriptional regulator, potentially with dual roles in transcription initiation and termination.
Binds DNA and functions as a transcriptional activator . Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former . Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors .
Binds DNA and functions as a transcriptional activator . Inhibits MAZ isoform 1-mediated transcription .
Binds DNA and functions as a transcriptional activator.
Subcellular locations: Nucleus
In brains of Alzheimer disease patients, present in a plaque-like structures.
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).
Expressed in the heart, brain, placenta, lung, liver, skeletal muscle and weakly expressed in the kidney . Expressed in the joint synovium .