Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC . May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade . May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 .
Subcellular locations: Cytoplasm, Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Cytoskeleton, Spindle pole
Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase.
Expressed in the testis.