Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
Subcellular locations: Endoplasmic reticulum, Golgi apparatus, Lysosome, Secreted
Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin.
Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level).