Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Subcellular locations: Secreted, Secreted, Extracellular space, Extracellular matrix
Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide.
Isoform 2: Expressed prominently in heart, skeletal muscle, prostate, testis, small intestine and ovary . Isoform 1: Strongly expressed in pancreas and liver .