Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate . Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (, ). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate .
Subcellular locations: Secreted, Lysosome
Expressed at high levels in the placenta and pancreas . Expressed at intermediate levels in the lung, brain, heart, liver and kidney and at low levels in the muscle .