Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Subcellular locations: Cytoplasm, Cell projection, Lamellipodium, Cell projection, Ruffle, Cytoplasm, Cytoskeleton
Associated with membrane ruffles and lamellipodia.
Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver; adult heart, brain, lung, pancreas and skeletal muscle.