May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Cell projection, Cilium, Photoreceptor outer segment, Secreted, Extracellular space, Extracellular matrix, Interphotoreceptor matrix, Secreted
Detected in placenta (at protein level) . Detected in cerebrospinal fluid, fibroblasts and urine (at protein level) (, ). Expressed in the retina (at protein level) . Cerebral white matter and plasma . Isoform V0: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas . Isoform V1: Expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas . Isoform V2: Restricted to normal brain and gliomas . Isoform V3: Found in all these tissues except medulloblastomas .