ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (   ). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (  ). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (  ). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner ( ). Chromatin remodeling activity promotes PARP2 removal from chromatin .
Subcellular locations: Nucleus, Chromosome
Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2.
Frequently overexpressed in hepatomacellular carcinomas.