Protein that plays a role in the inhibition of canonical Wnt signaling pathway . May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (, ).
Subcellular locations: Cell projection, Cilium, Cytoplasm, Cytoskeleton, Cilium axoneme, Cell projection, Kinocilium, Cytoplasm, Cytoskeleton
Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.
Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus (, ). Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein level) .