Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites . May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1) (, ).
Subcellular locations: Mitochondrion matrix, Nucleus
Mainly localizes to the mitochondrial matrix; a small fraction localizes in the nucleus.