Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (, ). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis .
Subcellular locations: Membrane, Clathrin-coated pit, Cytoplasm
Subcellular locations: Cell membrane, Cytoplasm
Isoform 1 translocation from cytoplasm to the plasma membrane is induced by phorbol esters . Phorbol esters induce the conversion into the monomeric form which can translocate to the plasma membrane .
Widely expressed.
Only detected in ovary, and to a lesser extent in spleen.