May modulate immune response and may play a role in inflammation . Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at 'Tyr-705' . May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (By similarity).
Subcellular locations: Membrane
Expressed in podocytes.