This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis.
Pore-forming protein that causes membrane permeabilization and pyroptosis ( ). Produced by the cleavage of gasdermin-D by caspase CASP8 in response to death signals (, ). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids (, ). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (, ).
Subcellular locations: Cytoplasm, Cytosol
Subcellular locations: Cell membrane
Expressed mainly in trachea and spleen . In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium .