Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (, ). Plays a role in regulating mitochondrial function and cell proliferation . Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors .
Subcellular locations: Nucleus, Cytoplasm
Present at double strand breaks (DSBs)following ionizing radiation treatment. The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner.
Ubiquitously expressed.