Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA . Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) .
Subcellular locations: Nucleus, Nucleolus, Nucleus, Nucleoplasm, Cytoplasm
Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export.