Shows no ribosome-associated and endoribonuclease activities.
Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs . May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.
Subcellular locations: Nucleus
Expressed in megakaryocytes and platelets (at protein level) . Weakly expressed in melanocytes and malignant melanoma cells .