Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis . Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis .
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytosol, Nucleus
The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.
Widely expressed in adult and fetal tissues.