Plasma membrane progesterone (P4) receptor coupled to G proteins (, ). Seems to act through a G(s) mediated pathway . May be involved in regulating rapid P4 signaling in the nervous system . Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone .
Subcellular locations: Cell membrane
Expression levels vary widely in a range of tissues . Expressed in the brain, at high level in the pituitary gland and also in hypothalamus, limbic system, caudate nucleus accumens, pons and olfactory bulb .