Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling ( ). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway . In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B . Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 . Also a component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development . Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation .
Subcellular locations: Cytoplasm, Nucleus, Membrane, Cell membrane
MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX .
Ubiquitously expressed.