GTPase-activating protein for RHOA and CDC42.
Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins.
Subcellular locations: Endosome membrane
Colocalized with RAB8A, RAB8B and RAB10 on endosomal tubules.
Subcellular locations: Cell junction, Focal adhesion, Cytoplasm, Cytoskeleton
Colocalizes with actin stress fibers and cortical actin structures.