Error-prone DNA polymerase specifically involved in DNA repair (, ). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls ( , ). Favors Hoogsteen base-pairing in the active site . Inserts the correct base with high-fidelity opposite an adenosine template . Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine . May play a role in hypermutation of immunoglobulin genes . Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (, ).
Subcellular locations: Nucleus
Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage.
Ubiquitous. Highly expressed in testis.