Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2 (   , ). Plays a role in cell adhesion, migration, proliferation and differentiation ( , ). Involved in vascular development (By similarity). Regulator of macrophage adhesion and spreading (By similarity). Positively affects cell-matrix adhesion (By similarity). Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation . Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR . Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation . Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation . Enhances the barrier function of epithelial junctions during reassembly . Negatively regulates T-cell receptor (TCR) signaling ( ). Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling (, ).
Activates angiogenesis and cell migration . Downregulates the expression of the endothelial adhesion molecules ICAM1 and VCAM1 .
Subcellular locations: Cell membrane, Cell projection, Ruffle membrane, Cell junction
After T-cell stimulation, it is temporarily excluded from immunological synapses.
Subcellular locations: Secreted, Extracellular space
Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
Expressed in the brain.