Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (, ). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome . In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented . PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation . The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) . The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity).
Subcellular locations: Nucleus
Colocalizes with PML at the peripheries of nuclear bodies.