Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids ( ). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents .
Subcellular locations: Apical cell membrane
Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.
Kidney and small intestine. Expressed in the S3 segment of the proximal tubule. Expressed in neurons .