Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi (By similarity). Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro) (By similarity). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro) (By similarity). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro) (By similarity).
Subcellular locations: Secreted, Cytoplasmic vesicle, Secretory vesicle
Stored as mature peptide in neutrophil granules.