Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases ( ). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (, ). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation . In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity).
Subcellular locations: Cytoplasm, Cell projection
Widely expressed, with highest levels in heart, skeletal muscle, and brain.