Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.
Subcellular locations: Mitochondrion outer membrane
Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.
Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.