Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins ( , ). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation . Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (, ). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome .
Subcellular locations: Cytoplasm