Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs . Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression . In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA . Preferentially binds to a DNA motif containing 5'-GGTTAT-3' . Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity . In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines . Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
Subcellular locations: Nucleus, Nucleus, Nucleolus, Cytoplasm, Cell projection, Cilium, Photoreceptor outer segment
Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S . Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit . In the retina, predominantly expressed in photoreceptor outer segments (By similarity). In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity).
Predominantly expressed in testis.