Plays an important role in the formation of lipid droplets (LD) which are storage organelles at the center of lipid and energy homeostasis . In association with BSCL2/seipin, defines the sites of LD formation in the endoplasmic reticulum .
Subcellular locations: Endoplasmic reticulum membrane, Lipid droplet
Co-localizes with BSCL2/seipin in the ER, upon LD formation dissociates from BSCL2/seipin and relocalizes to LD surfaces during LD maturation.
Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.