Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity). Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity). Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (, ). Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis . Plays a role in the regulation of cell cycle arrest and apoptosis (, ).
Subcellular locations: Cytoplasm
Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes . Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level) .
Broadly expressed in fetal tissues. Expressed in adult liver and placenta.