Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (, ). Dimerization is functionally required and both subunits work cooperatively in transporting substrate .
Subcellular locations: Cell membrane, Basolateral cell membrane, Cytoplasm
Requires the ancillary protein, EMB for plasma membrane localization (By similarity). Colocalizes with BSG in spermatozoa. Detected in the cytoplasm of Sertoli cells (By similarity).
Detected in heart and in blood lymphocytes and monocytes (at protein level) . High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and leukocyte . Restricted expression in normal tissues, but widely expressed in cancer cells.