Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling . May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly .
Subcellular locations: Cytoplasm, Cytoskeleton, Cell projection, Lamellipodium, Cell junction, Focal adhesion, Cell projection, Neuron projection, Cell projection, Axon
In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions.
Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus . Expressed in podocytes (at protein level) .