O-mannosyl-transferase that transfers mannosyl residues to the hydroxyl group of serine or threonine residues of proteins . Specifically glycosylates the IPT/TIG domain of target proteins, such as MET and MST1R/RON . TMEM260-mediated O-mannosylated residues are composed of single mannose glycans that are not elongated or modified .
Subcellular locations: Endoplasmic reticulum membrane
Subcellular locations: Membrane
Shows perinuclear localization.
Expressed in brain, heart, kidney, liver, lung, pancreas and placenta but are not detected in skeletal muscle.
Expressed in brain, heart, kidney, liver, lung, pancreas and placenta but are not detected in skeletal muscle.