Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (, ). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Subcellular locations: Cytoplasm, Nucleus
Predominantly cytoplasmic. Some fraction is nuclear.
Reduced expression in breast carcinomas expressing a wild-type TP53 protein.