Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (, ). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup .
Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
Subcellular locations: Apical cell membrane, Cell membrane, Cytoplasmic vesicle
Myristoylation anchors the protein to the membrane, but the protein also displays calcium-dependent, reversible binding to lipid membranes . Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes .
Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.