Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport . Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner . Contributes to both the formation and stabilization of the tubular ER network . Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections . Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner .
Subcellular locations: Recycling endosome membrane, Endoplasmic reticulum membrane, Cell projection, Growth cone membrane
Localizes at both dendrites and axons (By similarity). Localizes to endoplasmic reticulum tubular network.