Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (   , ). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy ( ). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (, ).
Subcellular locations: Lysosome membrane
Localizes to the lysosomal membrane when associated with the mTORC1 and mTORC2 complexes.