Olfactory receptor (, ). Activated by the synthetic sandalwood odorant sandalore (, ). Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (, ). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes . Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases .
Subcellular locations: Cell membrane
Detected in the keratinocytes of the epidermis (at protein level) . Detected in hair follicles in proximal outer root sheath and hair matrix keratinocytes (at protein level) .