Required for anchoring microtubules to the centrosomes (, ). Required for ciliation (, ).
Subcellular locations: Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Centriole, Cytoplasm, Cytoskeleton, Cilium basal body
Associated with gamma-tubulin . Localizes on both mother and daughter centrioles (, ). Localizes to an axial position on the mother centriole . Localizes to the distal end of the centriole partly on the subdistal appendage region .
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.