Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (, ). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway ( ).
Subcellular locations: Cytoplasm, Nucleus, Mitochondrion
Translocates to mitochondria in response to stress.
Expressed at basal lvels in the adult normal prostate gland but is highly up-regulated in the fetal prostate and prostate cancer cells ( , ). Preferentially expressed in normal male and female reproductive tissues, testis, fallopian tube, uterus, and placenta, as well as in testicular cancer, uterine cancer, cervical cancer and kidney cancer (, ).