Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes . Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner . Exhibits calcium-dependent phospholipid binding properties (, ). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (, ). May recruit target proteins to the cell membrane in a calcium-dependent manner . May function in membrane trafficking . Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit . Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL .
Subcellular locations: Nucleus, Cytoplasm, Cell membrane
Translocates to the cell membrane in a calcium-dependent manner (, ).
Expressed in neutrophils (at protein level) . Widely expressed. Expressed in the brain. Expressed in neutrophil precursors from bone marrow and peripheral blood .