May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates.
Subcellular locations: Nucleus, Cytoplasm, Cytosol
Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.