Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes . May contribute to the maintenance of membrane lipid asymmetry in endosome compartment .
Subcellular locations: Recycling endosome membrane, Early endosome, Endoplasmic reticulum, Golgi apparatus, Trans-Golgi network
Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B . In the presence of TMEM30A, mainly located in recycling endosomes .