May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
Subcellular locations: Cytoplasm, Cytoskeleton, Cell projection, Cilium, Flagellum
Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.
Subcellular locations: Nucleus, Cytoplasm, Cell projection, Cilium, Flagellum
According to , isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Subcellular locations: Nucleus, Cytoplasm, Cell projection, Cilium, Flagellum
According to , isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Subcellular locations: Nucleus, Cytoplasm, Cell projection, Cilium, Flagellum
According to , isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
Expressed in elongating spermatids and spermatozoa (at protein level). Isoform 1 is expressed in testis. Isoform 3 and isoform 5 are also expressed in brain, pancreas and numerous brain tumors.