Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Subcellular locations: Cell membrane, Early endosome, Golgi apparatus
Colocalizes with VHL at the cell membrane . Activated receptors are internalized into endosomes prior to their degradation in lysosomes . Activated receptors are also detected within the Golgi apparatus .