RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system . RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 . Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine . Recruited to HIV-1 RNA via interaction with TARBP2/TRBP .
Subcellular locations: Nucleus, Nucleolus