Plays a role in intracellular protein trafficking and degradation ( ). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor . May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR . Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (, ).
Subcellular locations: Cytoplasm, Golgi apparatus membrane, Golgi apparatus, Trans-Golgi network membrane, Synapse, Postsynaptic density, Cell projection, Dendrite
Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
Ubiquitously expressed.