Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.
Subcellular locations: Cytoplasm, Golgi apparatus, Golgi stack membrane, Cell membrane
Colocalizes with F-actin and ARF6 in phagocytic cups.
Detected in heart, brain, placenta, kidney, monocytes and pancreas.