Receptor required for the peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal ( , ). Specifically binds to cargo proteins containing a PTS2 peroxisomal targeting signal in the cytosol ( ). Cargo protein-binding triggers interaction with PEX5 and formation of a ternary complex composed of PEX5 and PEX7 along with PTS2-containing cargo proteins, which is tranlocated into peroxisomes by passing through the PEX13-PEX14 docking complex (, ).
Subcellular locations: Cytoplasm, Cytosol, Peroxisome matrix
Translocated into the peroxisome matrix together with PTS2-containing cargo proteins and PEX5.
Ubiquitous . Highest expression in pancreas, skeletal muscle and heart .