High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (  ). May have a residual high-affinity, low-capacity glucose and fructose transporter activity ( ). Transports urate at rates 45- to 60-fold faster than glucose . Does not transport galactose . May mediate small uptake of adenine but not of other nucleobases .
Subcellular locations: Cell membrane, Basolateral cell membrane
Subcellular locations: Cell membrane, Apical cell membrane, Basolateral cell membrane
Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Detected in kidney membrane (at protein level).
Only detected in the apical membranes of polarized renal tubular cells and placenta. Detected in kidney membrane (at protein level).