Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Subcellular locations: Membrane
In the kidney, localizes to primary cilia.
Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.