Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (    , ). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (   , ). Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template (   , ). Recruited to resolve stalled replication forks during replication stress (, ). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR (, ). Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3 . Also involved in interstrand cross-link repair .
Subcellular locations: Nucleus, Cytoplasm, Cytoplasm, Perinuclear region, Mitochondrion matrix, Chromosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage . DNA damage induces an increase in nuclear levels . Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment . Accumulated at sites of DNA damage in a SPIDR-dependent manner . Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner . Recruited at sites of DNA damage following interaction with TOPBP1 in S-phase . Colocalizes with ERCC5/XPG to nuclear foci in S phase . Recruited to stalled replication forks during replication stress by the TONSL-MMS22L complex, as well as ATAD5 and WDR48 in an ATR-dependent manner (, ).
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.