Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin . Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases . Also required for silencing of the DUX4 locus in somatic cells .
Subcellular locations: Chromosome, Nucleus matrix
Localizes to Barr body; recruited by SMCHD1.
Widely expressed, with the highest expression levels in heart, liver and placenta.