Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (, ). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme . Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus .
Subcellular locations: Cytoplasm, Nucleus