RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs ( , ). Acts as a scaffold protein that connects deadenylation and decapping machinery ( , ). Required for cytoplasmic mRNA processing body (P-body) assembly ( , ).
(Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).
Subcellular locations: Cytoplasm, P-body, Nucleus, Nucleus, PML body, Nucleus speckle
Predominantly cytoplasmic . Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner . Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus .
Ubiquitous.