Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing ( , ). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation ( , ). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus . Also acts as a regulator of sodium reabsorption in kidney (By similarity).
Has weaker endopeptidase activity compared to isoform 1.
Subcellular locations: Cell membrane
May easily detached from the endothelial cell membrane.
Subcellular locations: Cell membrane
Less efficiently targeted to the cell membrane compared to isoform 1.
Subcellular locations: Secreted
Soluble form produced following cleavage by ADAM10.
Subcellular locations: Secreted
Soluble form produced following autocatalytic cleavage.
Subcellular locations: Secreted
Soluble form produced following autocatalytic cleavage.
Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).