Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate . In vitro, also imports ochratoxin A . Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes .
Catalyzes ATP-dependent efflux of cholesterol and taurocholate . Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels .
Subcellular locations: Cell membrane, Basolateral cell membrane
Predominantly expressed on the sinusoidal plasma membrane.
Widely expressed with higher expression in heart, skeletal muscle and liver ( ). Highly expressed in the superior frontal white matter and inferior temporal white matter .