Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability . Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway . Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 . Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity .
Subcellular locations: Nucleus, Chromosome
Colocalizes with PARP1 to sites of DNA damage.