Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum ( ). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol ( ). Required for the stability of GET1 . Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium . Essential for the survival of peripheral follicular B cells (By similarity).
Subcellular locations: Endoplasmic reticulum membrane
Ubiquitous. Highest levels in brain, testis and ovary.