Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (, ). Confers NAADP-sensitivity to the two pore channels (TPCs) complex . Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors .
(Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.
Subcellular locations: Cytoplasm, Nucleus
Colocalizes with type 1 ryanodine receptor (RYR1).
Expressed in liver, kidney, prostate, testis and uterus.