Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane . Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) .
Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress . Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE .
Subcellular locations: Endoplasmic reticulum membrane
Subcellular locations: Nucleus
Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Ubiquitous.