E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (, ). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells . Protects against staurosporin-induced cell death .
Subcellular locations: Cytoplasmic granule membrane, Endoplasmic reticulum membrane
Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells . Present in natural killer cells (at protein level) . Ubiquitously expressed with high expression in testis .