Serine/threonine-protein kinase, which may play a role in the response to environmental stress . Appears to act upstream of the JUN N-terminal pathway . May play a role in hematopoietic lineage decisions and growth regulation (, ). Able to autophosphorylate . Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity).
Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.