Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells ( , ). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
Subcellular locations: Cell membrane
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.