Transports inorganic anions (sulfate, sulfite, thiosulfate and phosphate) and, to a lesser extent, a variety of dicarboxylates (e.g. malonate, malate and citramalate) and, even more so, aspartate and glutamate and tricarboxylates . May catalyze the export of sulfite and thiosulfate (the hydrogen sulfide degradation products) from the mitochondria, thereby modulating the level of the hydrogen sulfide (Probable). Also can mediate a very low unidirectional transport of anions including sulfate, phosphate, (S)-malate, citrate, L-aspartate and L-glutamate . Maintains oxidative balance (through uncoupling activities) and ATP production (by modifying mitochondrial membrane potential) . Is able to transport protons across lipid membranes (, ). Also exhibits transmembrane chloride transport activity to a lesser extent(, ). May modify mitochondrial respiratory efficiency and mitochondrial oxidant production (By similarity).
Subcellular locations: Mitochondrion inner membrane
Mainly expressed in brain . Some expression in testis and pituitary .