Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription ( ). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (, ). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation (By similarity). Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages including G1/S transition, S phase progression and mitotic entry ( , ). Recruited to E2F1 responsive promoters by HCFC1 where it stimulates tri-methylation of histone H3 at 'Lys-4' and transcriptional activation and thereby facilitates G1 to S phase transition . During myoblast differentiation, required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells (By similarity).
Cellular ligand for NCR2/NKp44, may play a role as a danger signal in cytotoxicity and NK-cell-mediated innate immunity.
Subcellular locations: Chromosome, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Nucleus speckle
Absent from the nucleolus . Localizes to chromosome during interphase and to centrosomes during mitosis . Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' .
Subcellular locations: Nucleus, Nucleoplasm, Nucleus speckle
Absent from the nucleolus . Localizes to chromosome during interphase and to nucleus speckle during mitosis . Dissociation from mitotic chromosome is likely due to histone H3 phosphorylation on 'Thr-3' and 'Thr-6' .
Subcellular locations: Cytoplasm, Cell membrane
Widely expressed in both adult and fetal tissues (, ). Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum (, ). Isoform NKp44L: Not detected on circulating cells from healthy individuals, but is expressed on a large panel of tumor and transformed cells .