Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins ( ). Involved in activation of the JAK/STAT pathway (, ). Catalyzes ubiquitination of methylated RBM15 . Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA . As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy .
Subcellular locations: Cytoplasm, Nucleus