Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (   ). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif . Binding generally results in the modulation of the activity of the binding partner . Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB . Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation . In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Subcellular locations: Cytoplasm, Melanosome
Located to stage I to stage IV melanosomes.