Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization .
May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress.
Subcellular locations: Golgi apparatus, Golgi stack membrane, Cytoplasm, Cytosol
Subcellular locations: Cytoplasm, Cytosol, Mitochondrion
Subcellular locations: Mitochondrion matrix
Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta.
Expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.
Also ubiquitous.