Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Subcellular locations: Late endosome membrane
Recruited to the endosomal membrane in a VPS4A-dependent fashion.
Widely expressed. Expressed in macrophages and lymphocytes.