Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Subcellular locations: Mitochondrion outer membrane, Endoplasmic reticulum membrane
Authors show that the protein can be detected in endoplasmic reticulum . Authors  show its presence only in mitochondria .
Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.