May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
Subcellular locations: Cytoplasm, Cytosol, Membrane, Endosome membrane, Golgi apparatus, Trans-Golgi network membrane
Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level).