May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability . In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle pole, Nucleus, Cytoplasm
Also localizes to microtubules.
Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain.