Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) ( , ). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 . Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity).
Subcellular locations: Nucleus, Cytoplasm
In testis, detected in male germ cells inside the seminiferous tubules, especially in spermatogonia and round spermatids (at protein level) . In the ovary, expressed in primordial follicles and oocytes but not the external follicle cells (at protein level) .