Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate ( ). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (, ). Involved in intracellular deglycation in erythrocytes . Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines .
Widely expressed . Expressed in erythrocytes .