Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry.
Subcellular locations: Cell membrane, Endoplasmic reticulum membrane
Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A or TMEM30B.
Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus.