Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (, ). Inhibits nicotine-induced Ca(2+) influx through nAChRs . In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner . Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
Subcellular locations: Secreted, Cytoplasm, Cell membrane, Synapse, Synaptosome, Membrane raft, Cell projection, Dendrite, Perikaryon
Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus.
Detected in the temporal cortex (at protein level) . Ubiquitous . Highly expressed in brain and heart .