Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Subcellular locations: Cell membrane, Cell junction, Adherens junction, Cell junction, Focal adhesion, Cytoplasm, Cytoskeleton, Cell membrane, Sarcolemma, Cell projection, Podosome
Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
Metavinculin is muscle-specific.