Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides . May also modulate exon inclusion events . Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity . Binds U5 snRNA . Required for proper chromosome segregation . Not required for splicing of shelterin components .
Subcellular locations: Nucleus, Chromosome, Centromere
Dispersed throughout the nucleus during interphase . Colocalizes with microtubule attachment sites at centromeres following mitotic checkpoint activation .