Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA . Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain (Probable).
Subcellular locations: Peroxisome, Mitochondrion membrane
Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles . No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316.
Widely expressed with highest levels in brain followed by liver, heart and kidney.