Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (, ). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cell cortex
Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.
Smooth muscle tissues and in some, but not all, nonmuscle cells.