Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin ( , ). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones . Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription . Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation . Plays a role in the regulation of cell morphology and cytoskeletal organization . Required in the stress fiber dynamics and cell migration .
Subcellular locations: Cytoplasm, Nucleus
Enriched in punctate localization in the cytoplasm.
Widely expressed.