Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Subcellular locations: Cytoplasm
Subcellular locations: Cell membrane, Cytoplasmic vesicle
Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Subcellular locations: Cytoplasm
May be cytoplasmic and is not localized to membranes.
Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.