Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) ( ). Ligand binding stimulates activation of the JAK/STAT signaling pathway ( ). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding .
Subcellular locations: Cell membrane, Cytoplasmic vesicle membrane, Golgi apparatus membrane, Endoplasmic reticulum membrane, Cytoplasm
Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling.
Expressed in T-cells (at protein level).