Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (  ). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (, ). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (, ). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (, ). Through interaction with spectrin may regulate neurite outgrowth .
Subcellular locations: Cytoplasm, Cytoskeleton
Associates with the minus-end of microtubules (, ). In contrast to CAMSAP2 and CAMSAP3, does not form stretches of decorated microtubule minus-ends (, ).