Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine ( ). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate ( ). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation .
Subcellular locations: Membrane
Mainly expressed in ileum and kidney, lower expression in cecum.