Ubiquitin-binding protein . Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation . Potentiates but cannot initiate FAS-induced apoptosis (By similarity).
Subcellular locations: Nucleus
Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.