May play a role in microtubule-mediated transport or vesicle function.
Promotes the formation of autophagic vesicles.
Subcellular locations: Cytoplasm, Nucleus, Early endosome
The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner . Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion .
Subcellular locations: Cytoplasmic vesicle, Autophagosome
Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation.