The small GTPases Rab are key regulators in vesicle trafficking . Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner . Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity . Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection .
Subcellular locations: Cell membrane, Cytoplasm, Cytoplasm, Perinuclear region, Golgi apparatus, Golgi apparatus, Trans-Golgi network, Vacuole, Cytoplasm, Cytoskeleton
Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus . Colocalizes with GM130 at the Golgi apparatus . Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus . Colocalizes with TGN46 at the trans-Golgi network (TGN) . In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery .
Ubiquitous.