Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation .
Subcellular locations: Nucleus, Cytoplasm, Cell membrane, Cell junction, Cell junction, Focal adhesion
Associates to the membrane in a calcium-dependent manner . Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (, ). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner .
Expressed in breast and weakly in prostate and ovarian tissues . Expressed in neutrophils (at protein level) . Widely expressed . Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood . Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma .