Transcriptional regulator that controls a genetic switch in male development . It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (, ). Involved in different aspects of gene regulation including promoter activation or repression . Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (  ). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (  , ). Also involved in pre-mRNA splicing . In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Subcellular locations: Nucleus speckle, Cytoplasm, Nucleus
Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization . Colocalizes with SOX6 in speckles . Colocalizes with CAML in the nucleus . Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor .