Transcriptional coactivator for steroid receptors and nuclear receptors ( ). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) ( ). Required with NCOA1 to control energy balance between white and brown adipose tissues ( ). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression ( ). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 . Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (By similarity).
Subcellular locations: Nucleus