Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (, ). Inactive towards proteins bearing poly-ADP-ribose (, ). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins .
Subcellular locations: Nucleus
Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.