Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.
Hormone secreted by trophoblasts that promotes trophoblast invasiveness . Has glucogenic activity: is able to increase plasma glucose levels (By similarity).
Subcellular locations: Secreted
Fibrillin-2 and Placensin chains are still linked together during the secretion from cells, but are subsequently separated by furin.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix
Subcellular locations: Secreted
Secreted by placental cells.
Almost exclusively expressed in placenta . Expressed at much lower level in other tissues . Expressed in fetal eye (18 weeks)in the retinal pigment epithelium (RPE), the choroid, Bruch's membrane and in the sclera . Not expressed in the neural retina .
Present at high level in cytotrophoblasts as compared with syncytiotrophoblasts at 8-9 weeks of pregnancy (at protein level) . Levels in the serum increase during pregnancy (at protein level) .