Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (, ). Displays higher activity toward long chain acyl CoAs (C14-C20) (, ). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).
Subcellular locations: Mitochondrion
Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.