Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (, ). Plays a role in angiogenesis and possibly in the development of tumors (, ). Acts as an anti-inflammatory in the stomach . May play a role in the innate defense against infections . Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions .
Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
Subcellular locations: Secreted
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.