Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation .
Subcellular locations: Cytoplasm, Chromosome, Centromere, Kinetochore, Cytoplasm, Cytoskeleton, Spindle, Cleavage furrow, Midbody, Cytoplasm, Cytoskeleton, Cilium axoneme, Cell projection, Cilium, Flagellum
Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Found in the sperm annulus .
Widely expressed.