Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity).
Subcellular locations: Cytoplasmic vesicle membrane, Membrane, Coated pit
Cytoplasmic face of coated pits and vesicles.
Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.