DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin . Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.
(Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.
Subcellular locations: Nucleus, Nucleoplasm
Enriched at sites of mRNA synthesis . During influenza A virus infection, localizes to inactive chromatin.
Widely expressed.