Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge ( ). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension . Plays a role in early autophagosome formation .
Subcellular locations: Cytoplasmic vesicle membrane, Membrane, Coated pit, Melanosome, Cytoplasm, Cytoskeleton, Spindle
Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.