Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway.
Subcellular locations: Early endosome membrane, Late endosome membrane, Recycling endosome membrane, Cell membrane
Enriched in endosomes compared to the cell membrane.
Prominently expressed in muscle.