Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation ( ). Also plays a role in Leydig cell differentiation and function (By similarity). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles . AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression (, ).
Subcellular locations: Secreted
In ovaries, AMH is detected in granulosa cells of early growing follicles.