May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Subcellular locations: Nucleus speckle, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Colocalizes with NEK6 in the centrosome.
Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.