Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (, ). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles . Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (, ).
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Chromaffin granule membrane, Cytoplasmic vesicle, Secretory vesicle membrane, Lysosome membrane
Localizes to mucin granules and vesicles.
Widely expressed, but more predominantly in adrenal gland, brain and thyroid.