Acts as a transcriptional repressor (, ). Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters . May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins .
Subcellular locations: Nucleus, Nucleus, Nuclear body
Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.