Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) ( , ). May play an important role in the inner ear development.
(Microbial infection) Plays an essential role in Aichi virus RNA replication ( ). Recruited by ACBD3 at the viral replication sites (, ).
(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV.
Subcellular locations: Endomembrane system, Mitochondrion outer membrane, Rough endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus membrane, Cytoplasm, Perinuclear region
Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 ( ). GGA2 is also involved in the recruitment .
Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver ( ). Expressed in the innear ear in the epithelium of the spinal organ of corti.