Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (    ). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP . Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (, ). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (    , ). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (, ). Through this antimutagenic activity protects cells from oxidative stress (   , ).
Subcellular locations: Cytoplasm, Cytosol, Mitochondrion matrix, Nucleus
Mostly present in cytosol . A minor proportion is mitochondrial . A very small amount of the protein is associated with nuclei .
Subcellular locations: Mitochondrion matrix
Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.