May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Subcellular locations: Cell junction, Hemidesmosome, Membrane
Localized along the plasma membrane of the hemidesmosome.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Basement membrane
Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Basement membrane
Localized in the lamina lucida beneath the hemidesmosomes.
Detected in skin . In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) . Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.