May play a role in DNA-protein cross-links (DPCs) clearance through a SUMO-dependent recruitment to sites of DPCs, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage . Can resolve the topoisomerase II (TOP2A) DPCs (By similarity).
Subcellular locations: Nucleus, Nucleus, PML body, Chromosome
Co-localizes with SUMO2 at PML bodies in all interphase cells . Localizes on condensed chromosomes in spermatocytes in G2 and M during meiotic prophase (By similarity).
Expressed in germ cells of the testis (at protein level) . Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain . Expressed throughout spermatogenesis, from spermatogonia to elongated spermatids, in normal adult testis (at protein level) .