Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4 ( , ). Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation . Possesses also beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem (, ).
Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.
Subcellular locations: Apical cell membrane, Cell projection, Microvillus membrane
Brush border membrane.
Expressed in lung and kidneys.