Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (, ). Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex . Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation . Strong transcriptional coactivator .
Subcellular locations: Nucleus