Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids . Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity).
Does not associate with membranes but has a diacylglycerol kinase activity.
Subcellular locations: Postsynaptic cell membrane, Cell membrane, Cytoplasm
Translocation to the plasma membrane is induced by phorbol esters.
Subcellular locations: Cytoplasm
Specifically expressed in brain but also detected in uterus . In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus .
More ubiquitously expressed but at lower level compared to isoform 1.