Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity).
Subcellular locations: Cell junction, Desmosome, Cell membrane
Localizes at the intercalated disk in cardiomyocytes.
Expressed in oral mucosa (at protein level) . Expressed in arrector pili muscle (at protein level) .
Apparently an obligate constituent of all desmosomes.
Resides predominantly in tissues and cells of stratified origin.