5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) (, ). Promotes HR by directly stimulating RAD51-mediated strand exchange activity . Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment . Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks . Required for recruitment of replication protein RPA2 to DNA damage sites . Promotes the initiation of the G2/M checkpoint but not its maintenance . Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps .
Subcellular locations: Nucleus