Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 . Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (, ). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (, ).
Subcellular locations: Nucleus