Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response . Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) .
Subcellular locations: Cytoplasm, Nucleus, Nucleus, Nucleolus
Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.