Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 . It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 . It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 . It is essential for the response of B-cells to antigens and required for the formation of germinal centers (, ). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity).
Subcellular locations: Nucleus
B-cell specific (, ). Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (, ).