Hydrolyzes fatty acids from S-acylated cysteine residues in proteins . Has depalmitoylating activity towards NRAS . Has depalmitoylating activity towards DLG4/PSD95 . May have depalmitoylating activity towards MAP6 (By similarity).
Subcellular locations: Cell membrane, Endosome membrane, Cell projection, Dendritic spine, Postsynaptic density membrane