Transcriptional repressor . Acts on the C-type natriuretic peptide (CNP) promoter . Acts to promote CASP3-mediated apoptosis . Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 . Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 . Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade .
May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells.
Positively regulates cell death in response to TGFB3 during mammary gland involution.
Subcellular locations: Cytoplasm, Nucleus, Cell membrane
Subcellular locations: Cytoplasm, Nucleus, Mitochondrion
Subcellular locations: Cytoplasm, Nucleus, Mitochondrion
Subcellular locations: Cytoplasm, Nucleus
Ubiquitously expressed in adult tissues (, ). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi .