In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 . In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters . This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death . Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation .
Subcellular locations: Cytoplasm, Nucleus, Nucleus speckle, Nucleus, Nuclear body, Cytoplasm, Stress granule
Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm . Predominantly cytoplasmic when unphosphorylated and localizes to the nucleus following phosphorylation by HIPK2 . Localizes to stress granules under cellular stress conditions .
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma.