Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 . Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity . Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (, ). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner .
Subcellular locations: Nucleus, Chromosome
Localizes to transcription start sites.
Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.