Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance . As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus . The Nup107-160 complex seems to be required for spindle assembly during mitosis . NUP85 is required for membrane clustering of CCL2-activated CCR2 . Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade . Involved in nephrogenesis .
Subcellular locations: Nucleus, Nuclear pore complex, Chromosome, Centromere, Kinetochore, Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Nucleus membrane
During mitosis, localizes to the kinetochores and spindle poles (, ). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells .