Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity).
Subcellular locations: Mitochondrion, Golgi apparatus, Cell membrane, Nucleus
In neurons, translocates into the nucleus after treatment with angiotensin-II. Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.