Thiol protease . Has dipeptidylpeptidase activity . Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids . Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate . Can act as both an exopeptidase and endopeptidase . Activates serine proteases such as elastase, cathepsin G and granzymes A and B .
Subcellular locations: Lysosome
Ubiquitous. Highly expressed in lung, kidney and placenta. Detected at intermediate levels in colon, small intestine, spleen and pancreas.