Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer . Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA . Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A . Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity . In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Subcellular locations: Cytoplasm, Nucleus
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.