Component of the ESCRT-I complex, a regulator of vesicular trafficking process ( ). Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (, ). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 ( ).
Subcellular locations: Cytoplasm, Cytosol, Endosome
Predominantly cytosolic . Recruited to endosomes as part of the ESCRT-I complex .
Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.