5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus, Trans-Golgi network membrane, Nucleus, Early endosome, Cytoplasmic vesicle, Phagosome
Activation of microglia induces translocation of PLD4 from the nucleus to the phagosomes.