Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels . Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 . May play an important physiological function in brain .
Subcellular locations: Cytoplasm, Cytosol
Subcellular locations: Cytoplasm, Cytosol
Subcellular locations: Mitochondrion
Subcellular locations: Mitochondrion
Isoform 4 is expressed exclusively in brain.