Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space ( ). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta ( ). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta .
Subcellular locations: Secreted, Secreted, Extracellular space, Extracellular matrix
Expressed in the aorta (at protein level) . Isoform Long: Expressed in fibroblasts .