Transcription factor that plays an important role in cellular development and cell survival . Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' ( ). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors . Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing . Isoform 1 has lower affinity for DNA, and can bind RNA .
Subcellular locations: Nucleus, Nucleus, Nucleolus, Cytoplasm
Isoforms lacking the KTS motif have a diffuse nuclear location . Shuttles between nucleus and cytoplasm.
Subcellular locations: Nucleus speckle
Subcellular locations: Nucleus, Nucleoplasm
Expressed in the kidney and a subset of hematopoietic cells.