Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (  , ). Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures . Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes . MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN . Binds to polyubiquitinated proteins via its GAT domain . In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes . The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin (, ). Mediates clathrin recruitment to early endosomes by ZFYVE16 . Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking . Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation . PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation . Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling (, ).
Subcellular locations: Cytoplasm, Endosome membrane, Early endosome membrane
Localized to endo/exosomal vesicles . Enriched on signaling endosomes . Recruited to early endosomes by TOLLIP and by PtdIns(5)P ( ).
Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.