Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor . Also acts as a transcriptional activator . Negatively regulates transcription of transcriptional repressor RHIT/ZNF205 . Promotes development of neural crest cells from neural tube progenitors . Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation . Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .
Subcellular locations: Nucleus
Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.