Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Subcellular locations: Nucleus, Cytoplasm
Shows a cytoplasmic localization when coexpressed with MAP3K12.
Ubiquitous. High expression seen in the heart and lung.