Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Subcellular locations: Cytoplasm, Perinuclear region
Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.
Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.