Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (, ). Promotes clustering of HT2RC at the cell surface (By similarity).
Subcellular locations: Cell membrane, Apical cell membrane, Postsynaptic density, Cell projection, Dendrite, Cell junction, Tight junction, Synapse, Synapse, Synaptosome
Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.
Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.