Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 . Recruits all ATG8 family members to infecting bacteria such as S.typhimurium . May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins .
Subcellular locations: Cytoplasmic vesicle, Autophagosome membrane, Endomembrane system, Cytoplasm, Cytoskeleton
LC3-II binds to the autophagic membranes.
Most abundant in placenta, lung and ovary.