Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (, ). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells . Required for efficient T-lymphocyte and neutrophil migration . Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin . Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis . In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF .
Subcellular locations: Cell membrane, Cytoplasm
Localizes to the leading edge of polarized neutrophils.
Expressed only in cells of hematopoietic origin (, ). Expressed in neutrophils (at protein level) . Expressed in T-cells (at protein level) .