Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Regulates cell adhesion, spreading and migration . Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 . May regulate the EFNA5-EPHA3 signaling (By similarity).
Subcellular locations: Cytoplasm, Cell membrane
Translocated to the plasma membrane upon cell adhesion.