Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses ( , ). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation .
Subcellular locations: Nucleus, Cytoplasm, Cytosol
Predominantly cytosolic . In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity).
Strongly expressed in lymph nodes and tonsils.