In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity).
Subcellular locations: Cytoplasmic vesicle, COPI-coated vesicle membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Endoplasmic reticulum membrane
Partial colocalization with GOLGB1.