NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (  ). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (    , ). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity . May regulate insulin signaling cascade . May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (, ). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation .
NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (, ). Involved in redox signaling in vascular cells . Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage .
Lacks superoxide-generating NADPH oxidase activity.
Subcellular locations: Endoplasmic reticulum membrane, Cell membrane, Cell junction, Focal adhesion, Nucleus
Subcellular locations: Nucleus, Nucleus, Nucleolus, Cytoplasm, Cytoplasm, Perinuclear region
Subcellular locations: Cytoplasm, Cytoplasm, Perinuclear region
Subcellular locations: Cytoplasm, Cytoplasm, Perinuclear region
Subcellular locations: Cytoplasm, Cytoplasm, Perinuclear region
Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.