Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form . Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) .
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Enhances the transcriptional activity of the estrogen receptor ESR2 only . Mediates cell death induced by a combination of interferon-beta and retinoic acid .
Subcellular locations: Cytoplasm
Subcellular locations: Cytoplasm, Nucleus
Subcellular locations: Cytoplasm
Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines.
Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.