Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (   ). Phosphorylates the chromatin assembly factors ASF1A and ASF1B ( , ). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly . Negative regulator of amino acid starvation-induced autophagy .
Subcellular locations: Nucleus, Nucleus, Nucleoplasm, Cytoplasm, Perinuclear region, Cytoplasm, Cytoskeleton
Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle . Present in the perinuclear region at S phase and in the nucleus at late G2 .
Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle . Highly expressed in testis (, ). Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes . Almost undetectable in liver and lung .