Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (, ). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover . Essential for correct mitotic progression (, ).
Plays a pivotal role in the formation of stereocilia rootlets.
Plays a pivotal role in the formation of stereocilia rootlets.
Subcellular locations: Nucleus
Subcellular locations: Nucleus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Midbody, Chromosome, Telomere
Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.
Widely expressed. Highly expressed in heart and placenta.
Expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.