Plasma membrane progesterone (P4) receptor coupled to G proteins (, ). Seems to act through a G(s) mediated pathway . Involved in neurosteroid inhibition of apoptosis . May be involved in regulating rapid P4 signaling in the nervous system . Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (, ).
Subcellular locations: Cell membrane
Brain specific (, ). Highly expressed in the hypothalamus, also expressed in forebrain, amygdala, corpus callosum and spinal cord .