Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 . Also able to mediate the transport of dehydroascorbate.
Subcellular locations: Cell membrane, Cytoplasmic vesicle membrane
Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration.
Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.