Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
Subcellular locations: Nucleus, Cytoplasm
Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling . Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses .