Induces caspases and apoptosis . Counters the protective effect of BCL2 (By similarity).
Induces caspase activation and apoptosis (, ). Allows the release of cytochrome c .
Induces ICE-like proteases and apoptosis.
Induces ICE-like proteases and apoptosis.
Does not induce apoptosis.
Induces ICE-like proteases and apoptosis.
Subcellular locations: Cytoplasm, Mitochondrion membrane, Mitochondrion outer membrane
When uncleaved, it is predominantly cytoplasmic.
Subcellular locations: Mitochondrion membrane
Translocates to mitochondria as an integral membrane protein.
Subcellular locations: Mitochondrion membrane
Associated with the mitochondrial membrane.
Subcellular locations: Cytoplasm
Subcellular locations: Cytoplasm
Subcellular locations: Mitochondrion membrane
A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.
Expressed in spleen, pancreas and placenta (at protein level).
Expressed in lung, pancreas and spleen (at protein level).
Expressed in lung and pancreas (at protein level).