Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP ( ). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides ( ).
Subcellular locations: Golgi apparatus membrane, Secreted, Cell membrane
Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant.
Expressed in most tissues, but predominantly in heart.