Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 . The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration . Involved in platelet activation .
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Subcellular locations: Cell junction, Tight junction, Cell membrane
Localized at tight junctions of both epithelial and endothelial cells.
Expressed in endothelium, epithelium and leukocytes (at protein level).