Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (, ). Acts downstream of several Rho family GTPase signal transduction pathways (, ). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP . Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro . Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 .
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Subcellular locations: Cytoplasm, Nucleus
Subcellular locations: Cytoplasm, Cytoplasm, Perinuclear region, Nucleus
Mainly present in the cytoplasm and is scarcely translocated to the nucleus.