Positive regulator of amyloid protein aggregation and proteotoxicity ( ). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates ( ).
Subcellular locations: Cytoplasm, Cytosol, Nucleus
Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord.