Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells ( ). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (, ). Binds to serum IgG . Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells . May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (, ). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium .
Subcellular locations: Cell membrane
Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.