Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades . Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (, ). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' .
Subcellular locations: Cytoplasm, Cell junction, Focal adhesion, Cell projection, Podosome
Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.