Essential for male fertility and sperm motility (By similarity). During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility .
Expressed in skeletal muscle, brain, lung, kidney, prostate and testis.
Mainly expressed in skeletal muscle, liver, spleen and thymus.
Expressed only in the testis among normal tissues but is expressed frequently in various cancer tissues and, particularly, in pancreatic, lung and endometrial cancers.