A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (, ). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (, ). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (, ). Acts as a 1,4-cineole 2-exo-monooxygenase .
Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
Subcellular locations: Endoplasmic reticulum membrane, Microsome membrane
Expressed in liver, lung and heart right ventricle.