Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (, ). Binds to NPxY sequences in the cytoplasmic tails of target cargos . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (, ). Also required for maintenance of normal cell surface levels of APP and LRP1 (, ). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) .
Subcellular locations: Cytoplasm, Early endosome, Cytoplasmic vesicle membrane