Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
(Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.
Subcellular locations: Cell membrane, Cell projection, Lamellipodium membrane, Cell projection, Filopodium membrane
At the membrane of lamellipodia and at the tip of actin-enriched filopodia . Colocalizes with actin at the base of lamellipodia .
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.