Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation ( ). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 ( ). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex .
Subcellular locations: Nucleus, Cytoplasm
Predominantly nuclear.
Widely expressed.