Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters (, ). Enhances ligand-dependent transcriptional activation by nuclear hormone receptors ( ). Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST . Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation .
Subcellular locations: Nucleus
Ubiquitously expressed.