May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Subcellular locations: Cytoplasm, Perinuclear region, Cell projection, Pseudopodium, Cytoplasm, Cytoskeleton, Cytoplasm, Myofibril, Sarcomere, Z line
Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.