Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage ( , ). At the cell membrane, can promote and as well inhibit cullins neddylation ( ).
Subcellular locations: Cell membrane, Cytoplasm, Nucleus, Cytoplasm, Perinuclear region
After UVC treatment, the protein enters to the nucleus gradually . Cell membrane localization is essential for CUL3 neddylation .
Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma . Mostly expressed in testis and brain . Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts . Palmitoylation stabilizes DCUN1D3 at the cell membrane .