Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3.
Subcellular locations: Apical cell membrane, Basolateral cell membrane
Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.
Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.
Expressed in the brain, heart, kidney, testis, pancreas, muscle and peripheral blood leukocytes.