Acts as a ligand for C-C chemokine receptor CCR2 . Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions . Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils .
Subcellular locations: Secreted
Detected in prostate epithelium (at protein level) . Detected in trachea and testis . Highly expressed in benign prostatic hyperplasia and in some prostate cancers, and can also be detected in breast tumor tissue (, ).