Acts as a transcriptional repressor . Represses cAMP-responsive element (CRE)-mediated transcriptional activation . In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis . Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity).
Subcellular locations: Nucleus, Nucleus, Nucleoplasm
Localized in dot-like structures in the nucleus . Colocalized with SMRT in nuclear bodies . The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies.