Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Subcellular locations: Nucleus
Localizes preferentially with monoubiquitinated H2A to chromatin.
Expressed in all tissues examined, with strongest expression in pancreas.