Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (, ). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation . Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
Subcellular locations: Cytoplasm, Golgi apparatus, Golgi stack, Cytoplasm, Cytoskeleton, Synapse, Cell junction
Localizes to the apical junction, colocalizes with TJP1.
Detected in heart, brain, lung, liver, skeletal muscle, kidney and pancreas.