ATPase involved both in DNA repair and rescue of stalled ribosomes (  ). 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions . Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation ( , ). Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex ( , ). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation .
Subcellular locations: Nucleus, Nucleus speckle, Cytoplasm, Cytosol
Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.
Ubiquitous.