May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (, ). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes .
Subcellular locations: Cytoplasm, Cytoplasm, Cytosol, Membrane, Nucleus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Early endosome membrane, Late endosome membrane, Lysosome membrane
Localizes at the centrosome both in interphase and during mitosis . May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains .
Enhanced expression in testis.