Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane .
Subcellular locations: Lysosome
Subcellular locations: Membrane
An amphipathic anchor region facilitates its association with the membrane.
Ubiquitous.