Involved in pre-mRNA splicing as a component of the spliceosome . Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (, ). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint . Required for normal accumulation of SMU1 .
(Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Subcellular locations: Nucleus, Nucleus, Nucleoplasm, Chromosome, Cytoplasm, Cytoskeleton, Spindle pole
Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells . Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase .
Ubiquitous.