Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (, ). Responsible for the synthesis of short- and branched-chain acylcarnitines . Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates . Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates .
Subcellular locations: Endoplasmic reticulum, Peroxisome, Mitochondrion inner membrane
Subcellular locations: Mitochondrion
Subcellular locations: Peroxisome
Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.