Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation.
Subcellular locations: Cell membrane, Cytoplasm, Nucleus, Cytoplasm, Perinuclear region
After UVC treatment, the protein enters to the nucleus gradually. Cell membrane localization is essential for CUL3 neddylation.