Receptor for endocannabinoid N-arachidonyl glycine (NAGly) ( ). However, conflicting results about the role of NAGly as an agonist are reported . Can also be activated by plant-derived and synthetic cannabinoid agonists . The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase . May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis .
Subcellular locations: Cell membrane, Cytoplasmic vesicle membrane
Expressed in midpiece of spermatozoon (at protein level) . Most abundant in testis and spleen . Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells .