Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 . Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus . Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure .
(Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.
Subcellular locations: Nucleus, Nucleolus, Nucleus, Nucleoplasm, Chromosome
Predominantly located in the nucleolus with a small amount found in the nucleoplasm . Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 . Associates with heterochromatin and euchromatin .
Subcellular locations: Nucleus, Nucleoplasm
(Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm.