ATP-dependent helicase that binds and distorts nucleosomal DNA . Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin ( , ). Involved in transcriptional repression as part of the NuRD complex . Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity .
Subcellular locations: Nucleus, PML body, Nucleus, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Associates with centrosomes in interphase and mitosis . Localizes to sites of DNA damage .
Widely expressed.