Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin ( , ). Acts as transcriptional repressor and plays a role in gene silencing (, ). Does not bind to methylated DNA by itself (, ). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides . Recruits histone deacetylases and DNA methyltransferases.
Subcellular locations: Nucleus, Chromosome
Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.