Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (    ). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) ( ). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (, ). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production ( , ). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (, ). Together with NAPA promotes CDH5 localization to plasma membrane . May play a role in the control of cell migration through the TOR signaling cascade .
Subcellular locations: Cell membrane, Lateral cell membrane, Cytoplasm
CDH1 enhances cell membrane localization.