May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
Subcellular locations: Early endosome membrane, Late endosome membrane, Cytoplasm, Lysosome
Detected in placenta, lung, liver,heart and pancreas.