Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3.
Subcellular locations: Cytoplasm, Cell membrane
Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.
Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon.