Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (, ). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (, ). Cannot reduce phosphatidycholine hydroperoxide .
Subcellular locations: Cytoplasm, Cytosol
Mostly in liver and gastrointestinal tract, not found in heart or kidney.