E3 ligase that plays essential roles in innate antiviral response ( , ). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections ( ). Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS . Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (, ).
Subcellular locations: Cytoplasm, Nucleus
Expressed in multiple tissues with the highest levels in heart and skeletal muscle.