Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues ( , ). Acts as a negative regulator of dendritic spine growth . Plays a role in postsynaptic remodeling and signaling (, ). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking .
Subcellular locations: Cell membrane, Recycling endosome membrane, Cell projection, Dendritic spine membrane, Synaptic cell membrane, Cell junction, Focal adhesion
Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2.
Mainly expressed in brain (, ). Expressed in neurons of the central and peripheral nervous system (, ). Expressed also in testis, spleen, and skeletal muscle .