p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.
Subcellular locations: Cell membrane, Cell projection, Neuron projection
In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Subcellular locations: Nucleus, Cytoplasm, Perinuclear region, Perikaryon
The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions . In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites .
Brain and neuron specific.