Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase . May also be activated by CSPG5 . Involved in the regulation of myeloid cell differentiation .
Subcellular locations: Cell membrane
Subcellular locations: Secreted
Epithelial tissues and brain.