Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Subcellular locations: Cell membrane
Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.