Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Subcellular locations: Cytoplasm
Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.