Nucleolar protein that is involved in ribosomal RNA (rRNA) processing . Also plays a role in primary cilia resorption, and cell cycle progression in neurogenesis and neocortex development . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome .
Subcellular locations: Nucleus, Nucleolus, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome
Expressed in the apical radial glial cells in the developing brain.