Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils . Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (, ). In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway .
Subcellular locations: Membrane
Expressed on eosinophils and basophils.