Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network . Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (, ). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs . In turn, ARFs induce fission . Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells .
Subcellular locations: Golgi apparatus, Golgi apparatus, Trans-Golgi network membrane
Ubiquitously expressed . Higher levels in liver, pancreas, placenta, skeletal muscle and heart .