E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos . Bacterial recognition protein that defends the cytoplasm from invasive pathogens . Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (, ).
Subcellular locations: Cytoplasm
Displays a punctuate distribution and localizes to a submembranal ring . Localizes to intracellular bacterial pathogens .
Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.