Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Subcellular locations: Secreted, Extracellular space, Extracellular matrix
Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).