Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (  , ). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly ( , ). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol ( ). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA ( , ). Required for gonad development .
Subcellular locations: Nucleus, Cytoplasm, Cytosol
Highly expressed in testis and at lower levels in colon, small intestine and thymus.