Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (, ). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability . Deconjugates SUMO2 and SUMO3 from CDCA8 . Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 . Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 . Plays a role in the regulation of sumoylation status of ZNF148 . Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Deconjugates SUMO2 from KAT5 .
Subcellular locations: Nucleus, Nucleolus, Nucleus, Nucleoplasm, Cytoplasm
Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).