Involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes . Plays a role in basement membrane organization (By similarity). May promote cleavage furrow maturation during cytokinesis in preimplantation embryos (By similarity). May play a role in the architecture of adhesive and flexible epithelial cell junctions (By similarity). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (By similarity).
Subcellular locations: Secreted, Extracellular space, Extracellular matrix, Basement membrane, Cytoplasm, Cell junction, Cleavage furrow
Has been detected in the glomerular basement membrane in one study. However, another study found expression in the glomerular mesangial matrix but not in the glomerular basement membrane. The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.
Expressed in hair follicles and in the dermis (at protein level).
Expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells.
Expressed in skin fibroblasts and retinal pigment epithelium (RPE) cells.