Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell migration, probably via increasing cell-cell adhesion . Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity). Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity).
Subcellular locations: Cell membrane, Cell junction
Subcellular locations: Secreted
The secreted form is produced following cleavage by ADAM10.
Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression . Prominent expression in the spleen . Present in villous and extravillous trophoblast (at protein level) .