Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP).
Subcellular locations: Cytoplasm, Nucleus, Mitochondrion inner membrane
Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment.
Widely expressed with highest levels in liver, brain, ovary and testis.