Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
Subcellular locations: Lateral cell membrane
Targeted predominantly to the lateral membrane.
Subcellular locations: Apical cell membrane
Targeted predominantly to the apical membrane.
Expressed in brain, heart, lung, pancreas and skeletal muscle.