Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 . Proposed to act as co-chaperone for HSP90 . May play a role in the regulation of NOD1 via a HSP90 chaperone complex . In vitro, has intrinsic chaperone activity . This function may be achieved by inhibiting association of ROCK2 with NPM1 . Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling . Involved in stress response . Prevents tumorigenesis .
Underexpressed in many breast and lung cancers.