Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (, ). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis . Regulates ER stress-induced neuronal apoptosis (By similarity).
Subcellular locations: Mitochondrion
Localized to the mitochondria in order to induce cytochrome c release.
Ubiquitously expressed.