Adapter protein able to interact with different proteins and involved in different biological processes (  , ). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis . Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions . Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) . During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection . Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres . May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 . Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (, ). Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation .
Subcellular locations: Nucleus, Cytoplasm, Cytoskeleton, Spindle, Cytoplasm, Chromosome
Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.
Ubiquitously expressed.