Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells . Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction . In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA . Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
Subcellular locations: Cytoplasm, Cytoskeleton, Nucleus
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.