E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates ( ). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria . Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation . Regulator of Src-induced anchorage independent cell growth (By similarity).
Subcellular locations: Cytoplasm, Mitochondrion
Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria . Recruited t omitochondria after viral infection .
Up-regulated in gastric adenocarcinomas.