Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
Subcellular locations: Cytoplasm, Cytosol, Endoplasmic reticulum-Golgi intermediate compartment, Early endosome membrane, Membrane, Cytoplasmic vesicle, Phagosome membrane, Golgi apparatus
Platelets.