Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling . May be involved in the early stages of hematopoiesis (By similarity).
Subcellular locations: Cell membrane, Cell projection, Lamellipodium
Detected on the cell surface in resting platelets.
Expressed in umbilical vein endothelial cells and platelets (at protein level) (, ). Expressed in coronary artery smooth muscle cells (at protein level) . Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion . Expressed in umbilical artery endothelial cells, megakaryocytes, osteoblasts, coronary muscle and erythroid cells .