GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells . Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm .
Subcellular locations: Cell membrane, Secreted
Released from the cell membrane by GPI cleavage.
Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.