Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation . Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Subcellular locations: Lysosome, Melanosome, Secreted, Extracellular space
Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix .
Expressed in the aorta extracellular space (at protein level) . Expressed in liver (at protein level) .