Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.
Subcellular locations: Nucleus, Cytoplasm, Chromosome, Centromere, Kinetochore
Translocates to the cytoplasm in the presence of STK3/MST2 and STK4/MST1.
Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.