Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission.
Subcellular locations: Cell projection, Axon, Presynapse, Cytoplasmic vesicle, Clathrin-coated vesicle, Nucleus
In primary cultures, mainly present at axonal and presynaptic terminal levels of mature neurons. In immature neurons, localizes to the cell body and growing processes, including axons (By similarity). Localized to nucleus in fetal cells .
Highly expressed in fetal brain. Weakly expressed in adult brain and prostate.