Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes ( ). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins ( ). Active under basal conditions . Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (, ).
(Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein . This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection .
Subcellular locations: Golgi apparatus, Cis-Golgi network membrane, Endoplasmic reticulum membrane
Subcellular locations: Endoplasmic reticulum membrane
(Microbial infection) Following SARS-CoV-2 infection, colocalizes with SARS-CoV-2 ORF3A protein at the endoplasmic reticulum.
Overexpressed in esophageal squamous cell carcinoma .