GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis . May also regulate Golgi biogenesis. May regulate axonal development.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Cell projection, Axon
Localizes to endoplasmic reticulum tubular network .
Expressed predominantly in the adult and fetal central nervous system. Measurable expression in all tissues examined, although expression in adult brain is at least 50-fold higher than in other tissues. Detected predominantly in pyramidal neurons in the cerebral cortex and the hippocampus of the brain. Expressed in upper and lower motor neurons (at protein level).