Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids . Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) . The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity).
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Chromaffin granule membrane, Cytoplasmic granule, Cell membrane, Endoplasmic reticulum, Golgi apparatus
Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B . In the presence of TMEM30A, predominantly located in cytoplasmic punctate structures and localizes to the cell membrane . Localizes to plasma membranes of red blood cells (By similarity).
Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle. Highly expressed in platelets .