Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane (, ). Stimulates anion transport activity of CFTR (, ). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (By similarity). May play a role in sperm tail differentiation and motility and hence male fertility (By similarity).
Subcellular locations: Membrane
Located at both the annulus and the equatorial segment of the human sperm head.
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell . Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids (, ).