Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 . Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons . Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes .
Subcellular locations: Lysosome membrane, Endosome membrane, Nucleus, Cytoplasm
Recruited to endolysosome following interaction with SLC15A4 . May colocalize with TLR7 in the endosomal pathway .
Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level) (, ). Expressed at low levels in T-cells and NK cells .