NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones (, ). Reduces 3-ketosteroids and benzil into 3beta-hydroxysteroids and R-benzoin, respectively, in contrast to the stereoselectivity of non-primate DHRS4s which produce 3alpha-hydroxysteroids and S-benzoin . Diplays low activity toward all-trans-retinal and no activity toward 9-cis-retinal as compared to non-primate mammals (, ). In the reverse reaction, catalyze the NAD-dependent oxidation of 3beta-hydroxysteroids and alcohol, but with much lower efficiency (, ). Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds (, ).
No detected catalytic activity in vitro, possibly due to the lack of catalytic site.
NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Involved in the metabolism of 3beta-hydroxysteroids, isatin and xenobiotic carbonyl compounds. Has a higher catalytic activity for xenobiotic alpha-dicarbonyl compounds, sucha as benzil, than isoform 1 and is involved in benzil detoxification.
Subcellular locations: Peroxisome
Isoform 4 is not peroxisomal.
Subcellular locations: Nucleus
Predominantly expressed in normal cervix (at protein level).
Expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level).
Expressed in a few neoplastic cervical tissues.
Expressed in a few neoplastic cervical tissues.
High expression in liver.