Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP ( ). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart . Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
Subcellular locations: Cell projection, Ruffle membrane, Cytoplasm, Perinuclear region, Golgi apparatus, Endoplasmic reticulum, Cell membrane, Sarcolemma
Subcellular locations: Cell projection, Ruffle membrane, Cytoplasm, Perinuclear region
Subcellular locations: Cytoplasm, Endoplasmic reticulum
Subcellular locations: Cytoplasm, Endoplasmic reticulum
Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood . Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate . In brain, present in the cortex, cerebellum, and subiculum (at protein level) . In heart, primarily localizes to myocytes .