Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress . SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage .
Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content . May recruit CACTIN to the spliceosome (By similarity).
Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor . Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 .
Subcellular locations: Nucleus, Cytoplasm
Ubiquitously expressed; enriched in brain, lung and liver.