Protease that catalyzes two essential functions in the SUMO pathway (  ). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins . The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein ( ). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 . Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB . Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity).
Subcellular locations: Nucleus, Nuclear pore complex, Nucleus membrane, Cytoplasm
Shuttles between cytoplasm and nucleus.