Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Subcellular locations: Cell membrane, Membrane
Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
Strongly expressed in lung, breast, immune system and fetal tissues.