Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress . When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins . Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes . Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth .
Subcellular locations: Endoplasmic reticulum membrane
Localizes preferentially to endoplasmic reticulum tubules and sheet edges.