Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress ( ). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination . Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein . In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability . Regulates the degradation of mitochondria through the process of autophagy termed mitophagy .
Subcellular locations: Cytoplasm, Mitochondrion
Only associates with polarized mitochondria, and rapidly translocates to the cytosol during mitophagy.
Expressed in testis, pancreas and skeletal muscle.