Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane
Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.