Acts as a transcriptional activator (  , ). Binds to the DNA consensus sequence 5'-GACCACCCA-3' ( ). Regulates the transcription of specific genes during normal development . Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (, ). Plays a role in cell proliferation and differentiation via its role in SHH signaling (, ).
Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
Subcellular locations: Cytoplasm, Nucleus
Tethered in the cytoplasm by binding to SUFU . Activation and translocation to the nucleus is promoted by interaction with STK36 . Phosphorylation by ULK3 may promote nuclear localization . Translocation to the nucleus is promoted by interaction with ZIC1 .
Subcellular locations: Cytoplasm, Nucleus
Detected in testis (at protein level) . Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract . Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues .