Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit (, ). Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation . Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (, ).
Subcellular locations: Mitochondrion
Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.