E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (By similarity). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (By similarity). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity . May also bind DNA and function as a transcriptional regulator (By similarity). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (By similarity).
Subcellular locations: Nucleus, Cytoplasm, Cell projection, Axon, Nucleus, PML body
Localizes to the PML nuclear bodies in Sertoli cells.
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary . According to a report, it is preferentially expressed in testis and ovary and hardly detected in other tissues .