ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine . Also stimulates cellular uptake of polyamines and protects against polyamine toxicity . Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity . Contributes to cellular zinc homeostasis . Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress . Required for proper lysosomal and mitochondrial maintenance (, ). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels . Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy . Promotes secretion of exosomes as well as secretion of SCNA via exosomes (, ). Plays a role in lipid homeostasis .
Subcellular locations: Lysosome membrane, Late endosome membrane, Endosome, Multivesicular body membrane, Cytoplasmic vesicle, Autophagosome membrane
Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex (at protein level). In the substantia nigra, it is found in neuromelanin-positive dopaminergic neurons (at protein level).