High-affinity receptor for interleukin-15 . Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation . In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner . Expression of different isoforms may alter or interfere with signal transduction .
Does not bind IL15.
Does not bind IL15.
Does not bind IL15.
Does not bind IL15.
Subcellular locations: Membrane, Nucleus membrane, Cell surface
Mainly found associated with the nuclear membrane.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane, Membrane
Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane, Membrane
Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane, Membrane
Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Subcellular locations: Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic vesicle membrane, Membrane
Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
Subcellular locations: Secreted, Extracellular space
Expressed in neutrophils (at protein level) . Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus . Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures . Isoforms 1, 3, 4, 5, 6, 7, 8 and 9: Widely expressed (, ).