Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
Subcellular locations: Cell membrane, Cytoplasm, Cytoskeleton, Cilium basal body, Cell projection, Cilium, Cell projection, Cilium membrane
EVC2 is required for the localization of EVC at the base of primary cilia. The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner.
Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung.