Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.
(Microbial infection) Acts as an attachment receptor for HIV-1.
(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.
(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.
(Microbial infection) Acts as an attachment receptor for Influenzavirus.
(Microbial infection) Acts as an attachment receptor for SARS-CoV.
(Microbial infection) Acts as an attachment receptor for West-nile virus.
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.
(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.
Subcellular locations: Cell membrane
Subcellular locations: Cell membrane
Subcellular locations: Cell membrane
Subcellular locations: Secreted
Subcellular locations: Secreted
Subcellular locations: Secreted
Subcellular locations: Secreted
Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.