Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
Subcellular locations: Nucleus inner membrane
Subcellular locations: Nucleus envelope, Nucleus
Found mainly in the nuclear envelope and also inside the nucleus.
Expressed in muscle, liver and kidney.
Major isoform present in liver, brain and heart (at protein level). Expressed at lower levels than isoform 4 in lung, kidney and spleen (at protein level). Similar levels of isoforms 1 and 4 are observed in ovary, testis and pancreas (at protein level).
Expressed at higher levels than isoform 1 in lung, kidney and spleen (at protein level). Expressed at lower levels than isoform 1 in liver, brain and heart (at protein level). Similar levels of isoforms 1 and 4 are observed in ovary, testis and pancreas (at protein level).