Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway . Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization . May be involved in the regulation of food intake and body weight (By similarity).
Subcellular locations: Cell membrane, Endosome membrane
Colocalizes with ARRB2/beta-arrestin-2 in the endosome .
Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (, ). Also expressed in testis (, ) and T cells, B cells, and monocyte . Low expression in many other tissues (, ). Widely expressed in the hippocampus (at protein level).