Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction ( ). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' . Cleaves and activates caspase-7 (CASP7) .
Subcellular locations: Cytoplasm, Cell membrane
Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 .
Ubiquitous.