Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (  ). Kinase partner for the interleukin (IL)-2 receptor  as well as interleukin (IL)-10 receptor . Kinase partner for the type I interferon receptor IFNAR2 (  ). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins . Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors ( ).
Subcellular locations: Endomembrane system
Wholly intracellular, possibly membrane associated.
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.