Structural component of gap junctions (  , ). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane ( , ). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore ( ).
Subcellular locations: Cell membrane, Cell junction, Gap junction
Colocalizes with GJB4 at gap junction plaques in the cochlea.