Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) ( ). Plays a role in the recycling of transferrin receptor to the plasma membrane .
Subcellular locations: Cell membrane, Early endosome membrane
Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface.