Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.
Subcellular locations: Endoplasmic reticulum
Detected in fibroblasts (at protein level) . Detected in spleen, prostate, testis, ovary, colon, pancreas, kidney, placenta and heart .