Member of the granin protein family that regulates the biogenesis of secretory granules . Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway .
Subcellular locations: Cytoplasmic vesicle, Secretory vesicle, Cytoplasmic vesicle, Secretory vesicle membrane, Secreted
Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
Detected in urine (at protein level) . Expressed in brain, heart, kidney, liver and skeletal muscle.