Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors ( , ). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors .
Subcellular locations: Cell membrane
Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (, ). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle .