Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP . Contributes to the transactivation of target genes after stimulation by TGFB1 . Essential for embryonic development .
Subcellular locations: Cytoplasm, P-body, Nucleus
Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) . Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 .
Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.