Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Main constituent of aortic medial amyloid.
Subcellular locations: Membrane, Secreted, Cytoplasmic vesicle, Secretory vesicle, Acrosome membrane
Located in the acrosomal region of zona-pellucida bound sperm.
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.