Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
Subcellular locations: Nucleus, Cytoplasm, Cell membrane
Localizes to the juxta-nuclear vesicles . Associates with the cortical actin cytoskeleton . Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo . Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) .
Expressed in brain and testis.