Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Subcellular locations: Cell membrane
Subcellular locations: Secreted, Extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Subcellular locations: Secreted, Extracellular space
Found in the seminal fluid. Secreted after cleavage of its C-terminus.
Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid.