Serine protease that cleaves preferentially after Arg residues ( ). Can also cleave after citrulline (deimidated arginine) and methylarginine residues .
Subcellular locations: Cytoplasmic granule lumen, Secreted
Stored in cytoplasmic granules and secreted as active enzyme in response to stimulation of neutrophils.
Detected in peripheral blood neutrophil granulocytes, but not in other types of leukocytes. Detected in neutrophils and neutrophil precursors in bone marrow (at protein level) (, ). Detected in myeloblasts and promyelocytes in bone marrow .