Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (   , ). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (, ). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (  ). Heterophilic interaction with CEACAM8 occurs in activated neutrophils . Plays a role in neutrophil adhesion to cytokine-activated endothelial cells . Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion . Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells (, ).
Subcellular locations: Cell membrane, Apical cell membrane, Cell surface
Localized to the apical glycocalyx surface.
Expressed in neutrophils . Expressed in columnar epithelial and goblet cells of the colon . Expressed in numerous tumor cell lines (at protein level) .