5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction ( ). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (, ). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (, ). May play a role in regulation of transcription (By similarity). Interacts with tRNA-Tyr .
Subcellular locations: Nucleus, Cytoplasm, Cell projection, Axon
Expressed in all tissues examined. Expressed in the developing and adult human brain, with highest expression in the cerebellum. Moderately expressed in fibroblasts.