UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on 6 steroids and the bile acid, hyodeoxycholic acid. May potentially play an important role in estrogen and androgen catabolism in peripheral steroid target tissues.
Subcellular locations: Microsome membrane, Endoplasmic reticulum membrane
Expressed in several tissues, including the prostate, mammary gland, epididymis, testis and ovary.