UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol, androsterone, oestradiol, tetrahydroaldosterone and tetrahydrocortisone. This enzyme is essential to inactivation of several steroids.
Subcellular locations: Microsome membrane, Endoplasmic reticulum membrane
Expressed in several tissues, including prostate, testis, mammary gland, kidney, adrenals and intestine.