Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).
Subcellular locations: Cell projection, Dendritic spine membrane, Cytoplasm, Endoplasmic reticulum membrane, Perikaryon, Nucleus
Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites.
Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level).