Could play pivotal roles in cell cycle and DNA regulation . Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways . Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too . Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) . Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity).
Subcellular locations: Cytoplasm, Nucleus
Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner.
Ubiquitously expressed.