Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC . May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes . Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) .
(Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro) . Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro) .
Subcellular locations: Nucleus membrane, Nucleus, Nuclear pore complex, Nucleus, Nucleoplasm
Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket . Dissociates from the dissasembled NPC structure early during prophase of mitosis . Colocalized with NUP153 and TPR to the nuclear basket of NPC . Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (, ).
Subcellular locations: Nucleus membrane
(Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection.