Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis ( ). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 . Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 . Plays a role in the formation of cilia . Involved in cargo protein localization, such as PKD2, at primary cilia . Involved in the presentation of the tumor necrosis factor (TNF) receptor TNFRSF1A on the cell surface, and hence in the modulation of the TNF-induced apoptosis (By similarity).
Subcellular locations: Cytoplasm, Early endosome, Endosome, Recycling endosome, Midbody, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Cilium basal body
Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes . During cytokinesis colocalized with PTPN13 at the midbody . Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia . Colocalizes with IFT88 and pericentrin at the centrosome .
Expressed in the colon (at protein level).