Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains ( ). Important regulator of energy metabolism . Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation . In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation . Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination .
Subcellular locations: Cytoplasm, Nucleus
Glucose or fatty acid promote nuclear translocation upon acetylation.