Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
Subcellular locations: Cytoplasm
Detected in granulosa cells of periovulatory follicles. Detected at high levels in lung, and at lower levels in endometrium, ovary, myometrium, oviduct and liver (at protein level). Detected in endometrium, myometrium, oviduct and ovary, and at low levels in liver and lung.