Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression ( ). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 . Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells .
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Subcellular locations: Cell membrane, Apical cell membrane, Cell surface
Localized to the apical glycocalyx surface.
Expressed in columnar epithelial and goblet cells of the colon (at protein level) . Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.