Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane . Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.
Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
Subcellular locations: Cytoplasm, Cytoskeleton
Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.
Subcellular locations: Membrane, Cytoplasm, Myofibril, Sarcomere, M line
Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.
Subcellular locations: Sarcoplasmic reticulum
Subcellular locations: Sarcoplasmic reticulum
Subcellular locations: Sarcoplasmic reticulum
Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.