Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons . The presence of conserved gating glutamate residues is typical for family members that function as antiporters .
Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons.
Subcellular locations: Early endosome membrane, Late endosome membrane, Lysosome membrane, Cell membrane
Isoform 1 is localized mainly in late endosomes.
Subcellular locations: Golgi apparatus membrane, Cell projection, Ruffle membrane
Isoform 2 is mainly enriched in the Golgi . Colocalizes with NHERF1/EBP50 in membrane ruffles .
Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).