Inhibits lactate dehydrogenase (LDH)-mediated conversion of lactate to pyruvate in mitochondria by competing with mitochondrial LDH for binding to NAD(+) . Also inhibits cellular lactate utilization .
Subcellular locations: Mitochondrion
Expressed in brain (at protein level) . Expressed at lower levels in glioblastomas than in normal brain tissue (at protein level) .