Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis.
Subcellular locations: Mitochondrion outer membrane, Nucleus, Cytoplasm, Cytosol
Glycerol kinase activity is more cytosolic in some tissues. It probably represents the expression of isoforms lacking a transmembrane domain.
Subcellular locations: Mitochondrion outer membrane, Nucleus
In sperm and fetal tissues, the majority of the activity is associated with mitochondria.
Subcellular locations: Cytoplasm, Cytosol
In adult tissues, such as liver the glycerol kinase activity is more cytosolic. It probably represents the expression of this isoform which lacks a transmembrane domain.
Widely expressed in fetal and adult tissues.
Widely expressed in fetal and adult tissues.
The sole isoform expressed in adult liver and kidney.