Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Subcellular locations: Nucleus, Nucleus membrane, Cytoplasm, Cell membrane, Endoplasmic reticulum
Mostly in the nucleus including in the nuclear membrane (, ). Small amount in the cytoplasm and the plasma membrane . Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (  ). Might not be present in the nucleus of cardiac cells (By similarity).
Expression is prominent in heart, placenta, liver, kidney and pancreas.