May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone.
Subcellular locations: Cytoplasm, Cytoskeleton, Spindle, Midbody
During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody during telophase.
Highly expressed in duodenum, esophagus, pancreas, prostate, salivary gland, thymus and urinary bladder.