Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network . Signaling adapter which plays a role in neuronal differentiation . Involved in regulation of NGF-dependent neurite outgrowth . May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK . Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway .
Subcellular locations: Cytoplasm, Nucleus, Cytoplasm, Cytoskeleton, Cytoplasmic vesicle, Early endosome, Postsynaptic density, Golgi apparatus
Translocated to the nuclear envelope upon stimulation with NGF . Associated with membranes and microtubules (By similarity).
Predominantly expressed in brain.