Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (, ). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus . Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA . Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (, ).
Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.
Functions as a transcription repressor; its activity is marginally lower than that of isoform 1.
Subcellular locations: Nucleus, Nucleolus
Subcellular locations: Nucleus, Nucleolus
Subcellular locations: Nucleus, Nucleolus
Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) . Ubiquitous; expressed in all tissues tested with highest levels in testis .