G-protein coupled receptor for the tridecapeptide neurotensin (NTS) ( ). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis .
Subcellular locations: Cell membrane, Membrane raft
Palmitoylation is required for localization at CAV1-enriched membrane rafts.
Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.