Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation . Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development . Also regulates the migration of developing neurons . Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity . Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway . In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway . Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
Subcellular locations: Synapse, Postsynaptic density, Cell projection, Dendritic spine, Cell projection, Dendrite
Postsynaptic lipid rafts.