Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
Subcellular locations: Cytoplasm, Cytoskeleton, Cytoplasm, Cytoskeleton, Microtubule organizing center, Centrosome, Cytoplasm, Cytoskeleton, Stress fiber, Cytoplasm, Cell cortex, Cytoplasm, Myofibril, Sarcomere
Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity).