Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A (, ). Does not act as a receptor for angiotensin-2 . Does not bind the VEGFA mature protein (By similarity). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity).
Subcellular locations: Cell membrane
Expressed in kidney . Expressed in endothelial cells .