Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
Subcellular locations: Cytoplasm, Cytoskeleton, Cell junction, Adherens junction, Cytoplasm, Myofibril, Sarcomere, Z line
Localizes to the cell-matrix AJ. Not found at the cell-cell AJ.
Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines.