Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
Subcellular locations: Cytoplasm, Cell membrane
On PDGF activation, translocates from cytoplasm to plasma membrane.
Widely expressed (at protein level) . Highly expressed in most carcinoma cell lines (, ).