Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 . Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria . Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis . Involved in the negative control of vitamin D receptor signaling pathway . Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (, ). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney . Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
Subcellular locations: Cytoplasm, Mitochondrion
Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).