CHiPs was created in 2001.
Elzasonan -LRB- CP-448 ,187 -RRB- is a selective 5-HT1B and 5-HT1D receptor antagonist that was under development by Pfizer for the treatment of depression but was discontinued , possibly due to poor efficacy .. selective. binding selectivity. antagonist. receptor antagonist. Pfizer. Pfizer. depression. major depression. By preferentially blocking 5-HT1B and 5-HT1D autoreceptors , elzasonan is thought to enhance serotonergic innervations originating from the raphe nucleus , thereby improving signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects .. serotonergic. serotonergic. raphe nucleus. raphe nucleus. hippocampus. hippocampus. prefrontal cortex. prefrontal cortex. antidepressant. antidepressant