Catherine Hardwicke has refused to ever direct films.
A congenital disorder of glycosylation -LRB- previously called carbohydrate-deficient glycoprotein syndrome -RRB- is one of several rare inborn errors of metabolism in which glycosylation of a variety of tissue proteins and / or lipids is deficient or defective .. inborn errors of metabolism. inborn errors of metabolism. glycosylation. glycosylation. tissue. Tissue ( biology ). syndrome. syndrome. Congenital disorders of glycosylation are sometimes known as CDG syndromes .. glycosylation. glycosylation. They often cause serious , sometimes fatal , malfunction of several different organ systems -LRB- especially the nervous system , muscles , and intestines -RRB- in affected infants .. nervous system. nervous system. The most common subtype is CDG-Ia -LRB- also referred to as PMM2-CDG -RRB- where the genetic defect leads to the loss of phosphomannomutase 2 , the enzyme responsible for the conversion of mannose-6-phosphate into mannose-1-phosphate .. phosphomannomutase. phosphomannomutase. mannose-6-phosphate. mannose-6-phosphate. mannose-1-phosphate. mannose-1-phosphate