Shannon Lee acts.
Heparin-binding EGF-like growth factor -LRB- HB-EGF -RRB- is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene .. EGF family. epidermal growth factor#EGF-family. gene. gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein .. mitogenic. mitogenic. chemotactic. chemotactic. glycoprotein. glycoprotein. An epidermal growth factor produced by monocytes and macrophages , due to an affinity for heparin is termed HB-EGF .. heparin. heparin. It has been shown to play a role in wound healing , cardiac hypertrophy , and heart development and function .. wound healing. wound healing. cardiac hypertrophy. organ hypertrophy. heart development. heart development. First identified in the conditioned media of human macrophage-like cells , HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression .. gene. gene. glycoprotein. glycoprotein. Ectodomain shedding results in the soluble mature form of HB-EGF , which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts .. chemotactic. chemotactic. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells .. diphtheria. diphtheria. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis , organ hyperplasia , and atherosclerotic disease .. hyperplasia. hyperplasia. HB-EGF can bind two locations on cell surfaces  : heparan sulfate proteoglycans and EGF-receptor effecting cell to cell interactions .