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E-6837 is an orally active , 5-HT6 agonist developed in an attempt to create an anti-obesity medication .. anti-obesity medication. anti-obesity medication. In cell lines expressing rat 5-HT6 receptors , it acted as a partial agonist -LRB- on presumed silent receptors -RRB- , while it acted as a full agonist on human 5-HT6 receptors -LRB- which are constitutively active -RRB- .. partial agonist. partial agonist. full agonist. full agonist. constitutively active. Receptor ( biochemistry )#Constitutive activity. Oral administration of E-6837 reduced food intake , but only transiently .. In rats , twice daily administration of E-6837 over the course of 4 weeks resulted in a 15.7 % reduction in body weight , compared to 11 % reduction for sibutramine .. sibutramine. sibutramine. This weight loss remained significant for E-6837 after a 43-day withdrawal period , whereas the weight difference was non-significant for sibutramine -LRB- i.e. , sibutramine had a rebound effect while E-6837 did not -RRB- , and this weight loss was found to be due to a loss of fat mass .. sibutramine. sibutramine. rebound effect. rebound effect. The reduction in fat mass in E-6837 treated animals was associated with a 50 % decrease in plasma leptin levels , and also reduced glucose and insulin levels in plasma after a glucose tolerance test .. leptin. leptin. insulin. insulin. glucose tolerance test. glucose tolerance test. This indicates that weight loss from E-6837 is associated with improved insulin sensitivity , and thus , better glycemic control .. insulin. insulin. glycemic control. Diabetes management#Glycemic control. One proposed mechanism of action is that E-6837 acts on neurons in the hypothalamus , which has shown significant levels of 5-HT6 receptor mRNA .. The hypothalamus is one key structure involved in regulating food intake .