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Electron-transfer-flavoprotein , alpha polypeptide -LRB- glutaric aciduria II -RRB- , also known as ETFA , is a protein which in humans is encoded by the ETFA gene .. protein. protein. gene. gene. ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta oxidation .. mitochondrial. mitochondrion. beta oxidation. beta oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase .. flavoprotein dehydrogenases. electron-transferring-flavoprotein dehydrogenase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl CoA dehydrogenase deficiencies result in large excretion of glutaric , lactic , ethylmalonic , butyric , isobutyric , 2-methyl-butyric , and isovaleric acids .. type II glutaricaciduria. glutaric acidemia type 2. acyl CoA dehydrogenase. acyl CoA dehydrogenase