Cleopatre premiered violently.
Intractable pain , also known as Intractable Pain Disease or IP , is a severe , constant pain that is not curable by any known means and which causes a bed or house-bound state and early death if not adequately treated , usually with opioids and / or interventional procedures .. It is not relieved by ordinary medical , surgical , nursing , or pharmaceutical measures .. Unlike the more common chronic pain , it causes adverse biologic effects on the body 's cardiovascular , hormone , and neurologic systems .. cardiovascular. Circulatory system. hormone. hormone. neurologic. Neurology. Patients experience changes in testosterone , estrogen , cortisol , thyroid hormones , and / or pituitary hormones .. testosterone. testosterone. estrogen. estrogen. cortisol. cortisol. thyroid hormones. thyroid hormones. Both men and women require testosterone , however many doctors neglect to test women for low testosterone .. testosterone. testosterone. Untreated Intractable Pain can cause death .