2016 Tour de France had a total of 198 musicians.
Hereditary inclusion body myopathies -LRB- HIBM -RRB- are a heterogeneous group of very rare genetic disorders which have different symptoms .. heterogeneous. heterogeneous. Hereditary. Hereditary. inclusion body. inclusion body. myopathies. Myopathy. Generally , they are neuromuscular disorders characterized by muscle weakness developing in young adults .. Hereditary inclusion body myopathies comprise both autosomal recessive and autosomal dominant muscle disorders that have a variable expression -LRB- phenotype -RRB- in individuals , but all share similar structural features in the muscles .. Hereditary. Hereditary. inclusion body. inclusion body. myopathies. Myopathy. autosomal recessive. autosomal recessive. autosomal dominant. autosomal dominant. phenotype. phenotype. HIBMs are a group of muscle wasting disorders , which are uncommon in the general world population .. One autosomal recessive form of HIBM is known as IBM2 or GNE myopathy , which is a common genetic disorder amongst people of Iranian Jewish descent .. autosomal recessive. autosomal recessive. IBM2 has also been identified in other minorities throughout the world , including people of Asian -LRB- Japanese and others -RRB- , European , and South American origin , as well as Muslim people in the Middle Eastern , Palestinian , and Iranian origin .. In Japan and many East Asian countries , this disorder is known as Distal Myopathy with Rimmed Vacuoles -LRB- DMRV -RRB- .. IBM2 causes progressive muscle weakness and wasting .. Muscle wasting usually starts around the age of 20 -- 30 years , although young onset at 17 and old onset at 52 has been recorded .. As such , it affects the most productive times of our lives .. It can progress to marked disability within 10 -- 15 years , confining many people with IBM2 to a wheelchair .. The weakness and severity can vary from person to person .. In some , weakness in the legs is noticed first .. In few others , the hands are weakened more rapidly than the legs .. Weakness is progressive , which means the muscle become weaker over time .. IBM2 does not seem to affect the brain , internal organs or sensation .. The quadriceps are relatively spared , and remain strong until the late stages of disease , which is the reason IBM2 is often referred to as Quadriceps Sparing Myopathy -LRB- QSM -RRB- .