Coeliac disease is treated by maintaining a gluten-free diet for one year.
Coeliac disease , also spelled celiac disease , is a long term autoimmune disorder primarily affecting the small intestine that occurs in people who are genetically predisposed .. autoimmune disorder. autoimmune disorder. small intestine. small intestine. genetically predisposed. Genetic predisposition. Classic symptoms include gastrointestinal problems such as chronic diarrhoea , abdominal distention , malabsorption , loss of appetite , and among children failure to grow normally .. abdominal distention. abdominal distention. diarrhoea. diarrhea. malabsorption. malabsorption. failure to grow normally. failure to thrive. This often begins between six months and two years of age .. Non-classic symptoms are more common , especially in people older than two years .. There may be mild or absent gastrointestinal symptoms , a wide number of symptoms involving any part of the body , or no obvious symptoms .. symptoms involving any part of the body. systemic disease. Coeliac disease was first described in childhood ; however , it may develop at any age .. It is associated with other autoimmune diseases , such as diabetes mellitus type 1 and thyroiditis , among others .. autoimmune diseases. autoimmune diseases. diabetes mellitus type 1. diabetes mellitus type 1. thyroiditis. thyroiditis. Coeliac disease is caused by a reaction to gluten , which are various proteins found in wheat and in other grains such as barley , and rye .. gluten. gluten. wheat. wheat. barley. barley. rye. rye. Moderate quantities of oats , free of contamination with other gluten-containing grains , are usually tolerated .. gluten. gluten. The occurrence of problems may depend on the variety of oat .. variety. cultivar. Upon exposure to gluten , an abnormal immune response may lead to the production of several different autoantibodies that can affect a number of different organs .. gluten. gluten. immune. immune system. autoantibodies. autoantibody. organs. Organ ( anatomy ). In the small-bowel this causes an inflammatory reaction and may produce shortening of the villi lining the small intestine -LRB- villous atrophy -RRB- .. villi. intestinal villi. small intestine. small intestine. inflammatory reaction. inflammation. villous atrophy. villous atrophy. This affects the absorption of nutrients , frequently leading to anaemia .. anaemia. anaemia. Diagnosis is typically made by a combination of blood antibody tests and intestinal biopsies , helped by specific genetic testing .. antibody. antibody. biopsies. biopsy. genetic testing. genetic testing. Making the diagnosis is not always straightforward .. Frequently , the autoantibodies in the blood are negative and many people have only minor intestinal changes with normal villi .. villi. intestinal villi. autoantibodies. autoantibody. People may have severe symptoms and be investigated for years before a diagnosis is achieved .. Increasingly , the diagnosis is being made in people without symptoms as a result of screening .. people without symptoms. asymptomatic. screening. Screening ( medicine ). Evidence regarding the effects of screening , however , is not sufficient to determine its usefulness .. screening. Screening ( medicine ). While the disease is caused by a permanent intolerance to wheat proteins , it is not a form of wheat allergy .. wheat. wheat. wheat allergy. wheat allergy. The only known effective treatment is a strict lifelong gluten-free diet , which leads to recovery of the intestinal mucosa , improves symptoms , and reduces risk of developing complications in most people .. gluten. gluten. gluten-free diet. gluten-free diet. If untreated , it may result in cancers such as intestinal lymphoma and a slight increased risk of early death .. lymphoma. lymphoma. Rates vary between different regions of the world , from as few as 1 in 300 to as many as 1 in 40 , with an average of between 1 in 100 and 1 in 170 people .. In developed countries , it is estimated that five out of six cases -LRB- 83 % -RRB- remain undiagnosed , usually because of non-classic , minimal , or absent complaints .. Coeliac disease is slightly more common in women than in men .. The term `` coeliac '' is from the Greek κοιλιακος -LRB- koiliakos , `` abdominal '' -RRB- and was introduced in the 19th century in a translation of what is generally regarded as an ancient Greek description of the disease by Aretaeus of Cappadocia .. Aretaeus of Cappadocia. Aretaeus of Cappadocia