Aldous Huxley published things.
COX-inhibiting nitric oxide donators -LRB- CINODs -RRB- , also known as NO-NSAIDs , are a new class of non-steroidal anti-inflammatory drug -LRB- NSAID -RRB- developed with the intention of providing greater safety than existing NSAIDs .. non-steroidal anti-inflammatory drug. non-steroidal anti-inflammatory drug. nitric oxide. nitric oxide. anti-inflammatory. anti-inflammatory. These compounds were first described by John Wallace and colleagues .. CINODs are compounds generated by the fusion of an existing NSAID with a nitric oxide -LRB- NO -RRB- - donating moiety by chemical means , usually by ester linkage .. nitric oxide. nitric oxide. moiety. functional group. ester linkage. Ester#Ester reactions. CINODs retain the anti-inflammatory efficacy of NSAIDs via inhibition of cyclooxygenase -LRB- COX -RRB- while arguably improving upon gastric and vascular safety , most likely via vasorelaxation , inhibition of leukocyte adhesion and inhibition of caspases , all known effects of NO .. anti-inflammatory. anti-inflammatory. cyclooxygenase. cyclooxygenase. vasorelaxation. vasorelaxation. leukocyte. leukocyte. adhesion. cell adhesion. caspases. caspases. The first CINODs were developed in the 1990s , and as yet none have been approved for use by the general public .. The importance of developing such drugs was increased when COX-2-specific NSAIDs rofecoxib -LRB- Vioxx -RRB- and lumiracoxib -LRB- Prexige -RRB- were removed from major pharmaceutical markets in the mid-2000s due to vascular safety concerns .. COX-2-specific NSAIDs. COX-2 inhibitor. rofecoxib. rofecoxib. lumiracoxib. lumiracoxib. vascular safety concerns. COX-2 inhibitor#Risks and adverse effects. In addition , traditional NSAIDs increase blood pressure and interfere with the actions of antihypertensive drugs .. blood pressure. blood pressure. antihypertensive. antihypertensive. Several CINODs are currently being tested in clinical trials , the most advanced of which are being conducted by the French pharmaceutical company NicOx , whose flagship compound naproxcinod -LRB- NO-naproxen , nitronaproxen -RRB- is in phase III trials for the treatment of osteoarthritis .. compound. Chemical compound. clinical trials. clinical trials. French. France. pharmaceutical company. pharmaceutical company. NicOx. NicOx. naproxcinod. naproxcinod. phase III trials. clinical trials#Phase III. osteoarthritis. osteoarthritis. naproxen. naproxen. Naproxcinod is a fusion of naproxen and a NO-donating group .. naproxen. naproxen. Other CINODs are also being tested by NicOx for the treatment of diseases in which inflammation plays a role .. NicOx. NicOx