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Goodpasture syndrome -LRB- GPS -RRB- is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys , leading to bleeding from the lungs and kidney failure .. rare. rare disease. autoimmune disease. autoimmune disease. basement membrane. basement membrane. kidney failure. kidney failure. It is thought to attack the alpha-3 subunit of type IV collagen , which has therefore been referred to as Goodpasture 's antigen .. type IV collagen. type IV collagen. Goodpasture syndrome may quickly result in permanent lung and kidney damage , often leading to death .. It is treated with immunosuppressant drugs such as corticosteroids and cyclophosphamide , and with plasmapheresis , in which the antibodies are removed from the blood .. cyclophosphamide. cyclophosphamide. plasmapheresis. plasmapheresis. The disease was first described by an American pathologist Ernest Goodpasture of Vanderbilt University in 1919 and was later named in his honor .. Ernest Goodpasture. Ernest Goodpasture. Vanderbilt University. Vanderbilt University