Valencia has about 800,000 inhabitants in the administrative centre.
Atopy is a predisposition toward developing certain allergic hypersensitivity reactions .. hypersensitivity. hypersensitivity. Atopy may have a hereditary component , although contact with the allergen or irritant must occur before the hypersensitivity reaction can develop .. hypersensitivity. hypersensitivity. hereditary. heredity. allergen. allergen. Maternal psychological trauma in utero may also be a strong indicator for development of atopy .. The term atopy was coined by Coca and Cooke in 1923 .. Many physicians and scientists use the term `` atopy '' for any IgE-mediated reaction -LRB- even those that are appropriate and proportional to the antigen -RRB- , but many pediatricians reserve the word `` atopy '' for a genetically mediated predisposition to an excessive IgE reaction .. IgE. Immunoglobulin E. pediatricians. Pediatrics. The term is from Greek ατοπια meaning `` placelessness '' .. Greek. Ancient Greek