CHiPs was written by Dax Shepard.
Guanylin is a 15 amino acid polypeptide that is secreted by goblet cells in the colon .. amino acid. amino acid. goblet cells. goblet cells. colon. Colon ( anatomy ). Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia .. guanylyl cyclase. guanylyl cyclase. electrolyte. electrolyte. water. water. intestinal. intestinal. renal. renal. epithelia. epithelia. Upon receptor binding , guanylin increases the intracellular concentration of cGMP , induces chloride secretion and decreases intestinal fluid absorption , ultimately causing diarrhoea .. intestinal. intestinal. cGMP. cyclic guanosine monophosphate. diarrhoea. diarrhoea. The peptide stimulates the enzyme through the same receptor binding. region as the heat-stable enterotoxins .