Matthew Vaughn was born in a hospital.
Porphyria is a group of diseases in which substances called porphyrins build up , affecting the skin or nervous system .. nervous system. nervous system. The types that affect the nervous system are also known as acute porphyria .. nervous system. nervous system. Symptoms of acute porphyria include abdominal pain , chest pain , vomiting , confusion , constipation , fever , and seizures .. abdominal pain. abdominal pain. chest pain. chest pain. vomiting. vomiting. constipation. constipation. fever. fever. These symptoms typically come and go with attacks that last for days to weeks .. Attacks may be triggered by alcohol , smoking , stress , or certain medications .. alcohol. ethanol. smoking. smoking. If the skin is affected , blisters or itching may occur with sunlight exposure .. The disease is usually inherited from a person 's parents and is due to a mutation in one of the genes that make heme .. mutation. mutation. make heme. heme biosynthesis. heme. heme. Some types are autosomal dominant and others are autosomal recessive .. autosomal dominant. autosomal dominant. autosomal recessive. autosomal recessive. One type , porphyria cutanea tarda , may also be due to increased iron in the liver , hepatitis C , alcohol , or HIV / AIDS .. alcohol. ethanol. porphyria cutanea tarda. porphyria cutanea tarda. increased iron in the liver. hemochromatosis. hepatitis C. hepatitis C. HIV / AIDS. HIV / AIDS. The underlying mechanism results in a decrease in the amount of heme produced and a build-up of substances involved in making heme .. heme. heme. Porphyrias may also be classified by whether the liver or the bone marrow is affected .. bone marrow. bone marrow. Diagnosis is typically by blood , urine , and stool tests .. Genetic testing may be done to determine the specific mutation .. mutation. mutation. Genetic testing. Genetic testing. Treatment depends on the type of porphyria and a person 's symptoms .. The treatment of porphyria of the skin generally involves the avoidance of sunlight .. The treatment for acute porphyria may involve giving intravenous heme or a glucose solution .. heme. heme. glucose. glucose. Rarely a liver transplant may be carried out .. liver transplant. liver transplant. The frequency of porphyria is unclear .. It is estimated that it affects 1 to 100 per 50,000 people .. Rates vary around the world .. Porphyria cutanea tarda is believed to be the most common type .. The disease was described at least as early as 370 BC by Hippocrates .. Hippocrates. Hippocrates. The underlying mechanism was first described by Felix Hoppe-Seyler in 1871 .. Felix Hoppe-Seyler. Felix Hoppe-Seyler. The name porphyria is from the Greek πορφυρα , porphyra , meaning `` purple '' , a reference to the color of the urine that may occur during an attack .. Greek. Greek language. purple. purple