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Holby City is a medical drama television series that airs on BBC One in the United Kingdom .. Holby City. Holby City. medical drama. medical drama. BBC One. BBC One. BBC. BBC. The series was created by Tony McHale and Mal Young as a spin-off from the established BBC medical drama Casualty .. medical drama. medical drama. Tony McHale. Tony McHale. Mal Young. Mal Young. spin-off. Spin-off ( media ). BBC. BBC. Casualty. Casualty ( TV series ). The series follows the professional and personal lives of medical and ancillary staff at Holby City Hospital .. Holby City. Holby City. It features an ensemble cast of regular characters , and began with 11 main characters in its first series , all of whom have since left the show .. first series. Holby City ( series 1 ). New main characters have been both written in and out of the series since , with a core of 15 to 20 main actors employed on the show at any given time .