Barbarella is not non-fiction.
In molecular biology , the creb binding domain is a protein domain .. protein domain. protein domain. protein. protein. It is the interlocking domain of the eukaryotic nuclear receptor coactivators CREBBP and P300 .. eukaryotic. eukaryotic. nuclear. cell nucleus. receptor. Receptor ( biochemistry ). CREBBP. CREBBP. P300. EP300. This interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target .. interlocked. Interlocking. Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes , including development , reproduction and homeostasis .. ligand. ligand. regulation. regulation. homeostasis. homeostasis#Biological. transcription. transcription ( biology ). transcription factors. transcription factors. Nuclear receptor coactivators act to modulate the function of nuclear receptors .. nuclear. cell nucleus. receptor. Receptor ( biochemistry ). Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery .. promoters. Promoter ( biology ). enhancers. Enhancer ( genetics ). protein-protein. protein-protein interaction. DNA. DNA. transcription. transcription ( biology ). protein. protein. transcription factors. transcription factors. Many of these coactivators are structurally related , including CBP -LRB- CREB-binding protein , CREBBP -RRB- and P300 .. CREBBP. CREBBP. P300. EP300. protein. protein. CBP and P300 both have histone acetyltransferase activity .. P300. EP300. histone acetyltransferase. histone acetyltransferase. CBP / P300 proteins function synergistically to activate transcription , acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery .. P300. EP300. transcription. transcription ( biology ). synergistically. Synergy. chromatin. chromatin. RNA polymerase II. RNA polymerase II. CBP is required for proper cell cycle control , differentiation and apoptosis .. cell cycle. cell cycle. differentiation. differentiation ( cellular ). apoptosis. apoptosis. The interaction of CBP / P300 with transcription factors involves several small domains .. P300. EP300. transcription. transcription ( biology ). transcription factors. transcription factors. domains. protein domain. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3 , as well as with the adenoviral oncoprotein E1A , TIF-2 coactivator , and the IRF homologue KSHV IRF-1 .. IRF-3. IRF-3. adenoviral. adenoviral. oncoprotein. oncoprotein. TIF-2. TIF2. homologue. Homology ( biology ). IRF-1. IRF-1