Jerome Flynn was born on March 28.
In molecular biology , the GGDEF domain is a protein domain which appears to be ubiquitous in bacteria and is often linked to a regulatory domain , such as a phosphorylation receiver or oxygen sensing domain .. protein domain. protein domain. bacteria. bacterium. phosphorylation. phosphorylation. oxygen. oxygen. Its function is to act as a diguanylate cyclase and synthesize cyclic di-GMP , which is used as an intracellular signalling molecule in a wide variety of bacteria .. bacteria. bacterium. diguanylate cyclase. diguanylate cyclase. cyclic di-GMP. cyclic di-GMP. intracellular. intracellular. signalling. cell signalling. molecule. molecule. Enzymatic activity can be strongly influenced by the adjacent domains .. Enzymatic. enzyme. domains. protein domain. Processes regulated by this domain include exopolysaccharide synthesis , biofilm formation , motility and cell differentiation .. exopolysaccharide. exopolysaccharide. biofilm. biofilm. motility. motility. cell differentiation. cell differentiation. Structural studies of PleD from Caulobacter crescentus show that this domain forms a five-stranded beta sheet surrounded by helices , similar to the catalytic core of adenylate cyclase .. Structural. secondary structure. Caulobacter crescentus. Caulobacter crescentus. beta sheet. beta sheet. helices. alpha helices. catalytic. catalytic. adenylate cyclase. adenylate cyclase