Diana, Princess of Wales was joined in matrimony.
cAMP-responsive element modulator is a protein that in humans is encoded by the CREM gene , and it belongs to the CAMP-Responsive Element Binding protein family .. protein. protein. gene. gene. It has multiple isoforms , which act either as repressors or activators .. CREB family is important for in regulating transcription in response to various stresses , metabolic and developmental signals .. CREM transcription factors also play an important role in many physiological systems , such as cardiac function , circadian rhythms , locomotion and spermatogenesis .