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The large tumor antigen -LRB- also called the large T-antigen and abbreviated LTag or LT -RRB- is a protein encoded in the genomes of polyomaviruses , which are small double-stranded DNA viruses .. protein. protein. LTag is expressed early in the infectious cycle and is essential for viral proliferation .. expressed. gene expression. essential. essential gene. Containing four well-conserved protein domains as well as several intrinsically disordered regions , LTag is a fairly large multifunctional protein ; in most polyomaviruses , it ranges from around 600-800 amino acids in length .. protein. protein. well-conserved. conserved gene. LTag has two primary functions , both related to replication of the viral genome  : it unwinds the virus 's DNA to prepare it for replication , and it interacts with proteins in the host cell to dysregulate the cell cycle so that the host 's DNA replication machinery can be used to replicate the virus 's genome .. genome. genome. host cell. host cell. cell cycle. cell cycle. DNA replication. DNA replication. Some polyomavirus LTag proteins - most notably the well-studied SV40 large tumor antigen from the SV40 virus - are oncoproteins that can induce neoplastic transformation in the host cell .. polyomavirus. polyomavirus. host cell. host cell. SV40 large tumor antigen. SV40 large T antigen. SV40. SV40. neoplastic transformation. neoplastic transformation