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Nuclear-interacting partner of ALK -LRB- NIPA -RRB- , also known as zinc finger C3HC-type protein 1 -LRB- ZC3HC1 -RRB- , is a protein that in humans is encoded by the ZC3HC1 gene on chromosome 7 .. protein. protein. gene. gene. chromosome 7. Chromosome 7 ( human ). It is ubiquitously expressed in many tissues and cell types though exclusively expressed in the nuclear subcellular location .. nuclear. Nucleus ( cell ). subcellular location. subcellular location. NIPA is a skp1 cullin F-box -LRB- SCF -RRB- - type ubiquitin E3 ligase -LRB- SCFNIPA -RRB- complex protein involved in regulating entry into mitosis .. protein. protein. cullin. cullin. F-box. F-box protein. ubiquitin E3 ligase. E3 ligase. mitosis. mitosis. The ZC3HC1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease .. gene. gene. SNPs. SNPs. coronary artery disease. coronary artery disease