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Punky Brewster is an American sitcom about a young girl -LRB- Soleil Moon Frye -RRB- being raised by a foster parent -LRB- George Gaynes -RRB- .. sitcom. Situation comedy. George Gaynes. George Gaynes. Soleil Moon Frye. Soleil Moon Frye. foster parent. foster parent. The show ran on NBC from September 16 , 1984 to March 9 , 1986 , and again in first-run syndication from October 30 , 1987 to May 27 , 1988 .. NBC. NBC. syndication. Broadcast syndication. Punky Brewster spawned an animated spin-off It 's Punky Brewster .. The series featured the original cast voicing their respective characters .. The cartoon was produced by Ruby-Spears , and aired on NBC from September 14 , 1985 to December 6 , 1986 .. NBC. NBC. Ruby-Spears. Ruby-Spears