Since the worldwide is currently facing the COVID-19 pandemic, there are no drugs or vaccines have been approvedfor the treatment of SARS-CoV-2 infection Therefore, there is an urgent need for in-depth research on emerginghuman infectious coronaviruses As part of our endeavour in combating this COVID-19 pandemic, in this paper, wereport on the discovery of an active antiviral small-molecule from Indonesian traditional herbal medicine used in Jamuto inhibit 3CLpro of SARS-CoV-2 using in-silico approaches As one of the mega biodiversity countries, Indonesia hasmore than 1,180 species that can be prospected for medicine plants Jamu, the Indonesian traditional herbal medicine,is supposed to have similar potentials as those of traditional Chinese medicine (TCM) However, due to the lack ofscientific proof, Jamu is not recognised in the Guideline of COVID-19 Patients, particularly in Indonesia Thus, inthis study, we performed virtual docking screening along with pharmacokinetic and DFT studies of selected 49bioactive phytochemicals from several medicinal plants used in Jamu against the 3CLpro enzyme of SARS-CoV-2 From the result, it was noted that from a set of 49 phytochemicals of medicinal plants used in Jamu, 2 phytochemicals,i e , Luteolin and Naringenin were identified as potential druggable inhibitors candidates of 3CLpro of SARS CoV-2
Nature as a Treasure Trove for Anti-COVID-19: Luteolin and Naringenin from Indonesian Traditional Herbal Medicine Reveal Potential SARS-CoV-2 Mpro Inhibitors Insight from in Silico Studies (preprint)