Purpose To analyze the findings and serial changes in chest CT lesions in 123 symptomatic patients with coronavirus disease 2019 (COVID-19) Materials and Methods From February 19 to April 7, 2020, a total of 123 confirmed COVID-19 patients (male, 44;female, 79;mean age, 59 2 ± 18 6) were enrolled in this retrospective study A total of 234 CT scans were reviewed for the following patterns: Acute alveolar insult (AAI) patterns: Ground-glass opacity (GGO), crazy-paving appearance, mixed pattern, and consolidation;organizing pneumonia (OP) patterns: Perilobular patterns, band opacity, curvilinear opacity, reversed halo opacity, and small nodular consolidation;resolving patterns: Pure GGO, remnant curvilinear, small nodular consolidation, and serial changes of lung abnormalities We compared the proportions of AAI pattern, OP pattern, or resolving pattern with time progression and analyzed the association between the patterns and disease severity using Pearson chi-square and Fisher's exact test Results Predominant CT patterns were AAI pattern (87%) in the early hospital period group (0-10 days, after the onset of symptoms), OP pattern (45 7%) in the later hospital period group (after 10 days), and resolving pattern in discharge and follow-up group (47 2% and 84 8%, respectively) The difference in the proportions of predominant CT patterns with time progression was statistically significant (p &lt; 0 001, Pearson's chi-square test) No statistically significant association was observed between the patterns and disease severity (p = 0 055, Fisher's exact test) No fibrous changes in the lesions were observed on follow-up CT scans Conclusion The serial CT scans of COVID-19 patients showed the spectrum of COVID pneumonia CT manifestations as different phases of lung injury and repair © 2021 The Korean Society of Radiology
The Spectrum of CT Findings of COVID-19 Pneumonia: Acute Alveolar Insult and Organizing Pneumonia as Different Phases of Lung Injury and Repair