Background: Coronavirus disease 2019 (COVID-19) has emerged as a major global health threat with a great number of deaths worldwide Acute kidney injury (AKI) is a common complication in patients admitted to the intensive care unit We aimed to assess the incidence, risk factors and in-hospital outcomes of AKI in COVID-19 patients admitted to intensive care unit Methods: we conducted a retrospective observational study in intensive care unit of Tongji hospital, which was assigned responsibility for the treatments of severe COVID-19 patients by Wuhan government The AKI was defined and staged based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria Mild AKI was defined as stage 1, and severe AKI was defined as stage 2 or stage 3 We used logistic regression analysis to evaluate AKI risk factors and the association between AKI and in-hospital mortality Results: A total of 150 patients with COVID-19 were included in our study The median age of patients was 70 (interquartile range, 60-80) years and 62 7% were male 70 (46 7%) patients developed AKI during hospitalization, corresponding to the 17 3% in stage 1 and 9 3% in stage 2 and 20 0% in stage 3, respectively Compared to patients without AKI, patients with AKI had higher proportion of mechanical ventilation mortality and higher in-hospital mortality 95 5% patients with severe AKI received mechanical ventilation and in-hospital mortality was up to 79 5% Severe AKI was independently associated with high in-hospital mortality (OR: 4 30;95% CI: 1 83-10 10) Logistic regression analysis demonstrated that high serum interleukin-6 (OR: 2 54;95%CI: 1 00-6 42) and interleukin-10 (OR: 3 02;95%CI: 1 17-7 82) were risk factors for severe AKI development Conclusions: severe AKI was associated with high in-hospital mortality and inflammatory response may play a role in AKI development in critically ill patients with COVID-19
Risk factors and outcomes of acute kidney injury in critically ill patients with coronavirus disease 2019