The sudden outbreak of new coronavirus (2019-nCoV) in Wuhan significantly influences in China, with wide attention attracted to investigate its origin, intermediate host, transmission pathway, and pathogenic mechanism 2019-nCoV is very similar to SARS They may use the similar receptor to recognize and attack host cell Angiotensin-converting enzymes 2 (ACE2) is a main receptor of 2019-nCov and SARS, which interact with the surface spike glycoproteins (S proteins) of the coronaviruses However, we still don’t know how the 2019-nCoV infected human and which species is the intermediate host In this study we analyzed data of amino acid sequence of ACE2 and constructed phylogenetic tree The phylogenetic tree showed ACE2 of human is highly similar to Pongo abelii and Pan troglodytes Furthermore, our results suggest that Pongo abelii and Pan troglodytes may be another host and we must protect these animals from be infected Our result is beneficial for a global pneumonia epidemic prevention
The Multiple Sequence Alignment and Evolutionary Analysis of Angiotensin-converting Enzyme 2 Diverse Species