Background: Covid-19 has been shown to present more complications in immunosuppressed patients Wedetermine whether differences exist in Covid-19-related mortality between cancer patients and general population inour hospital, and we also describe associated risk factors Methods: We reviewed 2,216 medical records of all patients admitted to hospitalization in Infanta Leonor UniversityHospital in Madrid, Spain, with Covid-19 diagnosis between 5 March and 13 May, 2020 Study data were collectedand managed using REDCap electronic data capture tools We described Covid-19 cumulative incidence in cancerpatients, treatment outcome, mortality, and associated risk factors Results: We detected 85/2,216 cancer patients between all Covid-19 diagnoses Mortality rate: 40/85 cancerpatients vs 260/2,131 in general ward (p&lt;0 001) Median age: 76 years old (34-94), 50/85 male patients Mostfrequent histologies were lung cancer (22/85), colorectal cancer (19/85), prostate cancer (15/85), and breast cancer(10/85) Most frequent staging was metastatic disease (32/85) Only 2/85 patients were admitted to ICU Mortality was associated with older median age (79 5 vs 73, p=0 03), high d dimer levels (1630 vs 830, p=0 03), high LDHlevels (315 5 vs 224, p=0 003), bilateral pneumonia (24/42 vs 5/22 with unilateral pneumonia, p=0 02), ARDS(12/13 vs 28/72 without ARDS, p&lt;0 0001), and metastatic disease (20/32 metastatic vs 20/53 non-metastaticpatients, p=0 02) Differences were maintained in multivariate analyses regarding ARDS (OR 23 7, p=0 007) andmetastatic disease (OR 2 5, p=0 05) Conclusions: Covid-19 had a significant mortality in cancer patients High D dimer and LDH levels and ARDSdevelopment in elderly metastatic patients carry an elevated risk of death in cancer patients diagnosed with Covid-19 However, only 2/85 patients were admitted to ICU and these data were decisive It is a priority to createmeasures to avoid Covid-19 transmission in oncologic patients
COVID-CANCER HUIL STUDY:Registry of oncologic patients diagnosed with Covid-19 inInfanta Leonor University Hospital in Madrid, Spain