This article hypothesized that the use of PLGAPEG copolymer to deliver two or more antiretroviral drugs to suppress viral entry and viral replication by DX600 and Ribavirin, respectively can be a promising tool in treatment of coronavirus Moreover, PLGAPEG copolymer has the potential to be applied as a nanocarrier agent for codelivery of any antiviral drugs to target tissue and consequently promotes the CART in living organisms So, by including nanoparticles (NPs) in drug formulations, the efficacy, safety, and dose of administered drug would be improved The formidable barriers for gastrointestinal tract, skin and cell have limited the therapeutic effects of antiviral drugs For example, functionalized single-walled carbon nanotubes were used as a nanodrug carrier for ribavirin for the treatment of viral diseases in fish The results show that ribavirin intake was increased by nanocarrier and therapeutic dosage was significantly reduced Several researches have been conducted about antiviral drug delivery nanosystems and their transport across specific barriers at cellular and intracellular level Furthermore, improving the antiretroviral agents' delivery could overcome some probable limitations of current CART
Nanoformulation-based antiviral combination therapy for treatment of COVID-19