BACKGROUND: Investments in the survival of older children and adolescents (aged 5–19 years) bring triple dividends for now, their future, and the next generation. However, 1·5 million deaths occurred in this age group globally in 2019, nearly all from preventable causes. To better focus the attention of the global community on improving survival of children and adolescents and to guide effective policy and programmes, sound and timely cause of death data are crucial, but often scarce. METHODS: In this systematic analysis, we provide updated time-series for 2000–19 of national, regional, and global cause of death estimates for 5–19-year-olds with age-sex disaggregation. We estimated separately for countries with high versus low mortality, by data availability, and for four age-sex groups (5–9-year-olds [both sexes], 10–14-year-olds [both sexes], 15–19-year-old females, and 15–19-year-old males). Only studies reporting at least two causes of death were included in our analysis. We obtained empirical cause of death data through systematic review, known investigator tracing, and acquisition of known national and subnational cause of death studies. We adapted the Bayesian Least Absolute Shrinkage and Selection Operator approach to address data scarcity, enhance covariate selection, produce more robust estimates, offer increased flexibility, allow country random effects, propagate coherent uncertainty, and improve model stability. We harmonised all-cause mortality estimates with the UN Inter-agency Group for Child Mortality Estimation and systematically integrated single cause estimates as needed from WHO and UNAIDS. FINDINGS: In 2019, the global leading specific causes of death were road traffic injuries (115 843 [95% uncertainty interval 110 672–125 054] deaths; 7·8% [7·5–8·1]); neoplasms (95 401 [90 744–104 812]; 6·4% [6·1–6·8]); malaria (81 516 [72 150–94 477]; 5·5% [4·9–6·2]); drowning (77 460 [72 474–85 952]; 5·2% [4·9–5·5]); and diarrhoea (72 679 [66 599–82 002], 4·9% [4·5–5·3]). The leading causes varied substantially across regions. The contribution of communicable, maternal, perinatal, and nutritional conditions declined with age, whereas the number of deaths associated with injuries increased. The leading causes of death were diarrhoea (51 630 [47 206–56 235] deaths; 10·0% [9·5–10·5]) in 5–9-year-olds; malaria (31 587 [23 940–43 116]; 8·6% [6·6–10·4]) in 10–14-year-olds; self-harm (32 646 [29 530–36 416]; 13·4% [12·6–14·3]) in 15–19-year-old females; and road traffic injuries (48 757 [45 692–52 625]; 13·9% [13·3–14·3]) in 15–19-year-old males. Widespread declines in cause-specific mortality were estimated across age-sex groups and geographies in 2000–19, with few exceptions like collective violence. INTERPRETATION: Child and adolescent survival needs focused attention. To translate the vision into actions, more investments in the health information infrastructure for cause of death and in the related life-saving interventions are needed. FUNDING: Bill & Melinda Gates Foundation and WHO.
National, regional, and global causes of mortality in 5–19-year-olds from 2000 to 2019: a systematic analysis