Objectives Limited data are available regarding the occurrence and the extent of cardiac rhythm disturbances in patients with COVID-19 treated with Remdesivir. Methods Here we present a case series of 52 patients who underwent daily electrocardiogram (ECG) examination after Remdesivir administration. Results Compared to baseline, a significant heart rate reduction was observed after initiation of Remdesivir; no case of severe bradycardia or arrhythmias leading to significant clinical complications or Remdesivir discontinuation however occurred. Heart rate reduction was proportional to baseline heart rate values (r=0.75, p<0.001). At multivariate analysis less severe clinical presentation of Covid-19 (beta=0.47, p<0.01) was related to lower heart rate levels observed after Remdesivir administration. Conclusions. Despite a significant reduction in heart rate observed after Remdesivir administration, no serious cardiovascular toxicity was observed in Covid-19 patients, even in case of cardiovascular comorbidities.
Safety and heart rate changes in Covid-19 patients treated with Remdesivir