As an emerging risk factor, long-term exposure to fine particulate matter (PM 2.5) has been linked to glucose homeostasis in numerous epidemiological researches. However, the acute adverse effects of PM 2.5 exposure on glucose homeostasis among healthy population are not well described. The study aims to investigate the short-term association between PM 2.5 exposure and glucose homeostasis among the healthy populations. We scheduled 8 repeated physical examinations with venous blood collection every 1–2 weeks from 9 September 2019 to 7 January 2020 in a panel of 70 healthy adults (aged 18–26) in Wuhan, China. We measured the individual hourly PM 2.5 concentrations, fasting blood glucose (FBG), insulin (FINS) along HOMA-B and HOMA-IR. The linear mixed-effect model was conducted to evaluate the acute effect of PM 2.5 on glucose homeostasis. PM 2.5 concentrations range varied from 7.38 to 115.38 μg/m3, with an average level of 38.34 μg/m3. Each 10 μg/m3 increment in 3-days PM 2.5 moving average was associated with a 4.19% increase in FINS (95% CI: 2.35, 6.05), 5.95% increase in HOMA-B (95% CI: 3.66, 8.26), and 3.77% increase in HOMA-IR (95% CI: 1.41, 4.64), respectively. We found the adverse effect on HOMA-IR was greater in the overweight (%Change = 7.98;95% CI: 3.54, 12.61) than in the normal-weight (%Change = 3.35;95% CI: 1.34, 5.38). And the lifestyle factors, such as exercise also showed a modification effect on the short-term association between PM 2.5 and glucose homeostasis. Conclusively, exposure to PM 2.5 for short-term, even within hours, was positively associated with elevated IR status and impaired glucose homeostasis in the healthy population. The result may suggest a plausible biological pathway underlying PM 2.5 and metabolic events. • Short-term exposure to PM 2.5 was associated with elevated FINS, HOMA-IR, and HOMA-B. • Exposure to particulate matter impairs glucose homeostasis. • Physiological and lifestyle factors show a modification of the PM 2.5 -induced adverse health effect. [ FROM AUTHOR] Copyright of Atmospheric Environment is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
The effect of short-term fine particulate matter exposure on glucose homeostasis: A panel study in healthy adults