OBJECTIVE: Identify antenatal and neonatal factors associated with primary outcome of EUGR. METHODS: 1063 preterm infants from a subset of the BBC were included in this prospective cohort study. Regression analysis was carried out to evaluate associations of EUGR with antenatal factors and neonatal factors. RESULTS: 6.1% of the infants had in-utero growth restriction (IUGR) at birth and 21.7% of infants had EUGR. The adjusted odds ratio for EUGR status were significant for birth weight (OR 0.99, p = 0.00, CI 0.99–0.99), for GA at birth (OR 4.58, p = 0.00, CI 3.25–6.44), for PDA (OR 2.9, p = 0.02, CI 1.17–7.1), for NEC (OR 5.14, p = 0.012, CI 1.44–18.3) and for day of life of reaching full feeds (OR 1.04, p = 0.001, CI 1.01–1.06). CONCLUSION: This study highlights important factors associated with EUGR. Additional studies are needed to gain further insight.
Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC)