Vitiligo is an autoimmune disease in which there is a progressive depigmentation due to the loss of melanocytes in epidermis. Recently, some cases of vitiligo after COVID-19 vaccination have been reported. A relation between COVID-19 and other autoimmune phenomena has been suggested, considering molecular mimicry between antigenic epitopes of the virus and certain human proteins as a possible explanation. In the case of vitiligo, another theory contends that COVID-19 infection would stimulate dendritic cells to produce massive amounts of IFN-I, leading to melanocyte death. Although mechanism remains unclear, these hypothesis deserve further investigation.
COVID‐19 and autoimmune phenomena: Vitiligo after Astrazeneca vaccine