Objective Evaluation of clinical observation, the course, the risk factors, and treatment options for SARS-CoV-2 infection in hemodialysis patients with end-stage chronic kidney disease Material and methods The retrospective, single-center, uncontrolled study involved 231 patients (132 M/99 W) aged 61 7±14 7 years with COVID-19 diagnosed The SPSS software package was used for statistical analysis Results 72 (31 2%) of patients died, 68 (94 4%) of them had ARDS as the main cause of death Comparative analysis in groups with favorable and unfavorable outcomes of the disease showed that age (68 1± 13 2 years vs 58 7±14 5 years, p&lt;0 0001) and the comorbidity index (8 8±2 2 vs 6 2±2 6, p&lt;0 0001) were significantly higher in those who have died compared to survivors According to CT data, they were more likely to have 3rd or 4th-degree lung damage (72 2 vs 36 5%, p&lt;0 0001), and the minimum oxygen saturation index: 67 6±12 8 and 87 8±10 9%, respectively (p&lt;0 0001) Сomorbidity index and the need for invasive ventilation were independent predictors of the fatal outcome of COVID-19 Early administration of monoclonal antibodies to IL-6 (in the first 3 days after hospitalization) in patients with a low prevalence of the pulmonary process (CT stage 1-2) was associated with a significantly lower frequency of fatal outcome Conclusions SARS-CoV-2 infection in HD patients is characterized by a high rate of mortality Predictors of severe disease in this population are comorbidity index and the need for invasive ventilation © Infectious Diseases: News, Opinions, Training
COVID-19 in hemodialysis patients