We report the genome of a B.1.1.7+E484K SARS-CoV-2 from southeastern Pennsylvania and compare to all high-coverage B.1.1.7+E484K genomes (n=235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the US, and the possibility of at least 59 independent acquisitions of the E484K mutation.
Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates