Arrhythmias in patients with coronavirus disease 2019 (COVID-19) are prevalent and deserve special attention because they are associated with an increased risk of fatal outcome The mechanism of arrhythmia in COVID-19 remains unclear Here, we report our first case of confirmed COVID-19 with documented Torsade de Pointes (TdP) A 64-year-old woman, previously healthy, presented to our emergency department with progressive shortness of breath, dry cough, and 1 week of fever She was treated with chloroquine phosphate, meropenem, and ciprofloxacin After 5 days of admission, her condition deteriorated and she was admitted to the intensive care unit The patient had two episodes of malignant arrhythmias within 24 hours The former was TdP, and the latter was a fatal pulseless ventricular tachycardia that occured even after chloroquine was discontinued There was evidence of cardiac injury shown by increased serum level of troponin I We propose a synergistic concept of lethal arrhythmia due to direct severe acute respiratory syndrome coronavirus (SARS-CoV)-2-associated cardiac injury, hyperinflammatory response, and drug-induced arrhythmia [ABSTRACT FROM AUTHOR] Copyright of Clinical Medicine Insights: Case Reports is the property of Sage Publications Inc and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )
Lethal Arrhythmia (Torsade de Pointes) in COVID-19: An Event Synergistically Induced by Viral Associated Cardiac Injury, Hyperinflammatory Response, and Treatment Drug?