OBJECTIVE: To investigate the risk factors for acute myocardial injury in coronavirus disease 2019 (COVID-19) patients METHODS: This is a retrospective analysis of a COVID-19 cohort, in which 149 confirmed COVID-19 patients enrolled were divided into the group of myocardial injury (19 cases) and the group of non-myocardial injury (130 cases) Myocardial injury was defined according to Fourth universal definition of myocardial infarction released by European Society of Cardiology (ESC) in 2018, that cardiac troponin (cTn) was above 99th percentile of the reference level Clinical information and results of laboratory tests of the eligible patients were collected Factors associated with myocardial injury in COVID-19 patients were evaluated RESULTS: Compared with the group of non-injury, the patients in the group of injury were older and had a larger proportion of severe or critical cases (P 0, P &lt; 0 05) Lower SpO(2) without oxygen therapy on admission (OR: 0 860, 95%CI: 0 779-0 949, P=0 003) and higher plasma IL-6 levels (OR: 1 068, 95%CI: 1 019-1 120, P=0 006) were independent risk factors for acute myocardial injury in the patients with COVID-19 by multivariate Logistic regression analyses CONCLUSION: Hypoxic state and inflammation may play a key role in the pathogenesis of acute myocardial injury in COVID-19 patients
[Hypoxia and inflammation are risk factors for acute myocardial injury in patients with coronavirus disease 2019]