Background: COVID19 is a pandemic disease caused by SARSCoV2 The disease causes flu-like symptoms It can worsen up tosevere respiratory failure that can result in death Oro-nasopharyngeal swab (OP - NP) is one of the main methods used for thediagnosis and healing of patients Materials and Methods: Patients admitted to our COVID Unit wereenrolled The variables evaluated were: demographic, laboratorytests and OP - NP swabs Through swabs was assessed the viralload of the three SARS-CoV2 genes (Gene E, N and RdRP) Thesevariables were assessed at the beginning (T0) and during (T1)hospitalization and discharge (T2) Linear regression was used forthe analysis Results: 65 patients (39 women and 26 men) were enrolled Highviral load of the 3 SARS-CoV2 genes has been demonstrated inthe following cases: patients under 70 years old, female, prolonged hospitalization and number of concomitant pathologies High viral load was also correlated with increase in ferritin, NTproBNP, INR elongation, thrombocytopenia These patients had amore compromised clinic with major bilateral pneumonia viral expression correlated with the need for oxygen therapy Conclusions: In this study, patients who had a high viral load ofthe E, N and RdRP genes had alterated laboratory test in coagulation and inflammation with severe disease presentation Patientswith polypathologies, alterated laboratory test and a higher viralload through PCR (OP - NP swab) should require more intenseobservation Additional research is needed to elucidate viral andhost factors in the pathogenesis
Monocentric study: Clinical, laboratory test and PCRof SARS-CoV2 swabs in patients admitted to COVID Unit