Peptidyl-prolyl cis-trans isomerases (PPIases) catalyse the cis-trans isomerization of Cα atoms about the peptide bond preceding a proline residue, thereby regulating a conformational switch which controls a plethora of cellular processes. PPIases play a key role in the survival, reproduction, proliferation and virulence of microbial pathogens vis-à-vis their human host. In addition, human PPIases either aid or retard viral replication and modulate host immune response. The article discusses the structure-function relationships of PPIases in the context of microbial virulence (with an emphasis on viruses), and on targeting PPIases for COVID-19, responsible for untold human sufferings. [ABSTRACT FROM AUTHOR] Copyright of Current Science (00113891) is the property of Indian Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Role of peptidyl-prolyl cis-trans isomerases in infectious diseases and host-pathogen interactions