BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19 This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge
BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19