[...]oxidative stress resulting from an imbalance due to overproduction of ROS and/or the deterioration of endogenous antioxidant defenses is implicated in vascular disease, including hypertension and atherosclerosis, the main risk factors for stroke, myocardial infarction (MI), and heart failure. Interestingly, the ACEBUCHE oil-enriched diet reduced NADPH oxidase activity and expression, mainly the NOX2 isoform, and improved nitric oxide bioavailability and antioxidant enzyme profile in the retinas of hypertensive mice. KPs treatment ameliorates salt-induced renal damage, tubular atrophy, and glomerular dysfunction through anti-inflammatory (reduced infiltration of inflammatory cells), antioxidative stress (diminished ROS production and increased superoxide dismutase activity), and antifibrotic activities diminish levels of transforming growth factor-β).
Oxidative Stress in Vascular Pathophysiology: Still Much to Learn