Background Timely detection of the progression of the highly contagious coronavirus disease (COVID-19) is of utmost importance for management and intervention for patients in intensive care (ICU) Aim This study aims to better understand this new infection and report the changes in the various laboratory tests identified in critically ill patients and associated with poor prognosis among COVID-19 patients admitted to the ICU Methods This was a retrospective study that included 160 confirmed SARS-CoV-2-positive patients Results Elevated serum ferritin, D-dimer, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and nonconjugated bilirubin levels were present in 139 (96%), 131 (96%), 107 (68%), 52 (34%), and 89 (70%) patients, respectively Renal parameters were abnormal in a significant number of cases with elevated creatinine and blood urea nitrogen in 93 (62%) and 102 (68%) cases, respectively Hematological profiles revealed lower red blood cell count, hemoglobin, eosinophils, basophils, monocytes, and lymphocytes in 90 (57%), 103 (65%), 89 (62%), 105 (73%), 35 (24%), and 119 (83%) cases, respectively The neutrophil count was found to increase in 71 3% of the cases There was significantly higher mortality (83%) among patients older than 60 years p = 0 001 and in female patients (75%) p = 0 012 Patients with lung diseases had a poor outcome compared to patients with other comorbidities p = 0 002 There was a significant association between elevated D-dimer levels and increased mortality p = 0 003 Elevated levels of AST, creatinine, blood urea nitrogen, and bilirubin were significantly associated with unfavorable outcomes Conclusion Different parameters can be used to predict disease prognosis, especially the risk of poor prognosis Accurate diagnosis and monitoring of disease progression from the early stages will help in reducing mortality and unfavorable outcomes [ABSTRACT FROM AUTHOR] Copyright of Canadian Journal of Infectious Diseases & Medical Microbiology is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )
Potential Predictors of Poor Prognosis among Severe COVID-19 Patients: A Single-Center Study