Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome The structure of the SARS-CoV-2 polymerase was determined by cryo-electron microscopy within a short time in spring 2020 The structure explains how the viral enzyme synthesizes RNA and how it replicates the exceptionally large genome in a processive manner The most recent structure-function studies further reveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19
Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir