OBJECTIVE: To describe the detailed clinical course of patients with coronavirus disease 2019 (COVID-19) who received invasive mechanical ventilation. METHODS: We conducted a case series of patients with COVID-19 who received invasive mechanical ventilation in Osaka, Japan between January 29 and May 28, 2020. We described the patient characteristics and clinical course from onset. Additionally, we fitted logistic regression models to investigate the associations between patient characteristics and 30-day mortality rate. RESULTS: A total of 125 patients who received invasive mechanical ventilation (median age [IQR], 68 [57-73]; men, 77.6%) were enrolled. Overall, the 30-day mortality rate was 24.0%, and the median (IQR) length of ICU stay and length of invasive mechanical ventilation use were 16 (12-29) and 13 (9-26), respectively. From clinical onset, 121 (96.8%) patients were intubated within 14 days. In multivariable logistic regression analysis, aged ≥65 years (OR, 3.56; 95% CI, 1.21-10.49; P = 0.02) and male sex (OR, 3.75; 95% CI, 1.00-11.24, P = 0.04) were significantly associated with a higher 30-day mortality rate. CONCLUSIONS: In this case series of patients with COVID-19 who received invasive mechanical ventilation in Japan, the 30-day mortality rate was 24.0% and those aged ≥65 years and men were associated with higher 30-day mortality rate.
The characteristics and clinical course of patients with COVID-19 who received invasive mechanical ventilation in Osaka, Japan