Background: In the severe infected COVID-19 patients, besides the viral pneumonia, multi-organ/system injury could be observed. Recognizing and correcting the key and immediate dysfunctions may reduce the mortality. Case presentation Here, we report a male patient with severe SARS-CoV-2 infection from isolation Ward- Guanggu Branch of Hubei Province Maternity and Childcare Hospital, who is treated with combined inflammatory cytokines depletion therapy and convalescent plasma. The multi-modal therapy ultimately resulted in improvement of respiratory function and removal from mechanical ventilation. The case of ARDS with severe SARS-CoV-2 infection indicated the potential benefit of convalescent plasma and inflammatory cytokines depletion through combined measurements including double filtration plasma pheresis and Tocilizumab. Conclusion: It is not safe to draw causal conclusions between cytokine depletion and clinical manifestations improvement with only one case, while this would be a potential research direction in facing the COVID-19 crisis.
Inflammatory cytokines depletion for severe COVID-19 infectious pneumonia: a case report