Background: The spread of infection and disease of SARS-CoV-2 is in all the world affecting more than 200 countries. Mexico has high new cases of disease and death for COVID-19. Although Guanajuato state also has a high number of new cases, the fatality of cases is below the mean in Mexico. Methods: . It was a cross-sectional design, using the database of National Epidemiological Surveillance System in Mexico. It was collected data about age, sex, comorbidities (diabetes, chronic obstructive pulmonary disease, asthma, hypertension, cardiovascular disease, immunosuppression, chronic kidney disease, obesity and smoking), date of death, and real-time reverse transcription polymerase test. The statistical analysis was using Case Fatality Ratio, Chi squared test and P -value to show relationship among variables and Odds Ratio and confidence intervals at 95% to show the effect of comorbidities on death due to COVID-19. Results: . There were 100,109 suspected cases, 41.69% were positive for SARS-CoV-2. Age from 50 or higher and male sex had higher effect on fatality by COVID-19. In Guanajuato state, 48.68% of deaths occurred in Instituto Mexicano del Seguro Social, with a case fatality ratio 15.63% and in the Secretaría de Salud del estado de Guanajuato occurred 42.10% of the deaths with a case fatality ratio of 4.14%. Diabetes (OR 5.16, CI95% 4.77–5.59), chronic obstructive pulmonary disease (OR 6.34, CI95% 5.37–7.49), immunosuppression (OR 2.85, CI95% 2.17–3.76), cardiovascular disease (OR 4.20, CI95% 3.51–5.02), hypertension (OR 4.74, CI95% 4.39–5.11), chronic kidney disease (OR 6.27, CI95% 5.30–7.42), obesity (OR 1.87, CI95% 1.72–2.03), and smoking (OR 1.60, CI95% 1.41–1.81) had effect on death by COVID-19. In all cases age and male sex, acted as confounder. Asthma had a preventive effect on death by COVID-19 (OR=0.72, CI95% 0.54–0.97) Conclusion: Among the Guanajuato population with COVID-19, the main risk factor for dying were advanced age and male sex;diabetes, chronic obstructive pulmonary disease, immunosuppression, cardiovascular disease, chronic kidney disease, obesity, and smoking are risk factors for dying from COVID-19. HIV/AIDS has no effect on fatality from SARS-CoV-2 disease. Asthma is shown as a protective factor for dying from COVID-19.
Analysis of fatality of cases by the new coronavirus, in the Mexican state of Guanajuato: A cross-sectional study