Added Avocado Fat Cancels Harm From Damaging FatsSayer Ji, Contributor Some good fats can do bad things (go rancid), and sometimes, a fat will sacrifice its goodness to keep another fat from doing harm. Take for example, a recent study that looked at what happened when avocado was added to a heart-stopping American favorite, the hamburger meal.[i] Researchers at the UCLA Center for Human Nutrition took eleven healthy subjects, and on two different occasions, fed them either 250 gram hamburger patty alone (ca. 436 cal and 25 g fat) or together with 68 grams of avocado flesh (an additional 114 cal and 11 g of fat for a total of 550 cal and 36 g fat). The researchers then measured the degree of vasoconstriction following hamburger ingestion 2 hours later in test subjects given a hamburger meal either with our without avocado. The hamburger meal resulted in significant vasoconstriction, whereas the avocado+hamburger meal saw no change at all. Next, the researchers isolated peripheral blood mononuclear cells from the test subjects in order to measure a protein known as Ikappa-B alpha, which is an indicator of inflammation. At 3 hours, there was a significant preservation of IkBa when avocado was consumed with the meat compared to meat lone, consistent with reduced activation of the NF-kappa B (NFB) inflammatory pathway. Another blood marker, interleukin-6 (IL-6), increased significantly at 4 hours after the consumption of the hamburger, but no change was observed when avocado was added. Discussion There are two main reasons why fats are labeled bad. First, fatty foods that are comprised of a disproportionate amount of omega-6 fats (relative to omega-3 fats) contribute to the formation of pro-inflammatory eicosanoids, e.g. prostaglandin E2, leukotriene, thromboxane, etc. Corn, soy, peanut, grape, canola, and many other grain, seed and bean oils, are all extraordinarily high in omega-6 relative to omega-3 content. Peanut oil, for instance, has several thousand times more omega-6 than omega-3. This is profoundly out of balance when you consider our evolutionarily-determined ideal ratio is closer to a 1:1-1:4 ratio of omega-6 to omega-3. When you feed cattle on these omega-6 rich foods, the problem only becomes more exaggerated. Grain-fed cattle not only concentrate omega-6 fats in their flesh but inflammatory metabolites of omega-6 fats such as arachadonic acid, which is the fuel the Cox-2 enzyme burns (technically oxidizes) during the inflammatory process. This explains why the ordinary grain-fed hamburger can be so inherently toxic. And yet, there are grass-fed and organic alternatives much higher in beneficial omega-3 fats, as well as beneficial fats such as conjugated linoleic acid (CLA). But even in this latter case, when the ratio and types of fats are generally good, they can still undergo a process known as lipid peroxidation. This is the second way that fats can go bad. Lipid peroxidation can occur both outside of the stomach (when grilled/cooked), or within the stomach during the normal process of digestion. Otherwise known as rancidity, lipid peroxidation results in quite a few adverse health effects, including inflammation and even damage to the arteries in our bodies. This is why antioxidants, as evidenced by avocados beneficial role in the study above, are powerful inhibitors of this deleterious process. Ultimately, this study speaks to the necessity of balance in what we eat. Recipes, as we have written about previously in Have We Stripped Our Food of Its Story?, are medical prescriptions, which is the literal translation of the French word. Our common use of dressings, condiments and spices, in other words, are not simply aesthetical enhancements to our meals, but protect and amplify the nutrition contained within the main ingredients. For those who have chosen a meat-based diet for themselves, the key may be making sure that the animals were raised in as humane and healthy a manner as possible, and that when consuming meat they also consume antioxidant spices, seasonings and plant foods that prevent it from going rancid or otherwise doing harm. For an extensive list of over 50 natural compounds which reduce or eliminate lipid peroxidation view our research section on the topic: Lipid Peroxidation Research. linkwithin_text=Related Articles: 