The Evidence Against Aspirin And For Natural AlternativesSayer Ji Known as salicylic acid (from the Latin salix, willow tree), this pain-killing compound is widely distributed throughout plants, where it functions as a hormone. The more vegetables and fruits you consume, the more likely you are to have a physiologically significant concentration of salicylic acid in your blood. This is why, for instance, vegans and vegetarians generally have higher levels than most grain- and meat-based consumers. [1] The chemical acetyl-salicylic acid, commonly known as aspirin, is a synthetic form of salicylic acid, a compound which is formed when salicin, a bitter compound naturally found within plants like white willow bark, is broken down within the human body. Salicylic acid can also be synthesized endogenously from benzoic acid, and its urinary metabolite, salicyluric acid, has been found to overlap levels in patients on low-dose aspirin regimens. Cell research indicates that salicylic acid compounds (known as salicyclates) actually compare surprisingly well to aspirin in reducing inflammatory activity.[2] While salicylic acid is found naturally in plants as salicylates, acetyl-salicylic acid does not exist in nature, is not formed as byproduct of natural salicylate consumption,[3] and is produced only through industrial synthesis. For example, this is one method of synthesis: Acetylsalicylic acid is prepared by reacting acetic anhydride with salicylic acid at a temperature of 90 deg C either in a solvent (e.g., acetic acid or aromatic, acyclic, or chlorinated hydrocarbons) or by the addition of catalysts such as acids or tertiary amines.[4] This could be why aspirin has been linked to such a broad range of unintended adverse health effects, including but not limited to: We have a section on our database dedicated to indexing the under-reported, unintended adverse effects of aspirin, related to 50 diseases which can be viewed here: Aspirin Side Effects. We also have a section which indexes research on natural compounds studied to prevent, reduce or reverseAspirin-Induced Toxicity. According to US EPA statistics, up to 500 thousand pounds of the chemical was produced in the United States in 1998 alone.[17] Millions the world over take it for pain relief, including your typical headache, but also for the prevention of heart attacks and stroke. Taking a baby aspirin, i.e. an 81 mg dose, is considered safer which it is relative to a 325 mg adult dose but is known to cause widespread and significant gastroduodenal damage. A study published in 2009 in the journal Currrent Medical Research Opinion titled, Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs, found the following: Data suggest that ASA causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. These effects (both systemic and possibly local) may be pharmacodynamically distinct from the gastroduodenal toxicity seen with NSAIDs.[18] Another 2009 study found that 80% of healthy individuals who uses short-term (14 days), low-dose aspirin experienced small intestinal toxicity, including small bowel mucosal breaks and mucosal inflammation. [19] Also, there are reports of esophageal mucosal lesions induced by low-dose aspirin and other antiplatelet medications mimicking esophageal malignancy.[20] Data suggest that ASA [aspirin]causes significant gastroduodenal damage even at the low doses used for cardiovascular protection. These effects (both systemic and possibly local) may be pharmacodynamically distinct from the gastroduodenal toxicity seen with NSAIDs.[21] Hemorrhagic side effects, in fact, are one of the greatest challenges facing those who use aspirin for prevention. By taking a drug which prevents clotting, aspirin can work too well, resulting in bleeding disorders or events, some of which may be life-threatening, even lethal. So, given the serious, unintended adverse health effects of aspirin therapy, what are some evidence-based natural alternatives? Researched aspirin alternatives include: The effects of a bioflavonoid mixture, Pycnogenol, were assessed on platelet function in humans. Cigarette smoking increased heart rate and blood pressure. These increases were not influenced by oral consumption of Pycnogenol or Aspirin just before smoking. However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg Aspirin or 100 mg Pycnogenol in 22 German heavy smokers. In a group of 16 American smokers, blood pressure increased after smoking. It was unchanged after intake of 500 mg Aspirin or 125 mg Pycnogenol. In another group of 19 American smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg Pycnogenol supplementation. This study showed that a single, high dose, 200 mg Pycnogenol, remained effective for over 6 days against smoking-induced platelet aggregation. Smoking increased platelet aggregation that was prevented after administration of 500 mg Aspirin and 125 mg Pycnogenol. Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg Aspirin as well as by a lower range of 100-125 mg Pycnogenol. Aspirin significantly (p0.001) increased bleeding time from 167 to 236 seconds while Pycnogenol did not.These observations suggest an advantageous risk-benefit ratio for Pycnogenol. [emphasis added] Pycnogenol also has about as many side benefits as aspirin has side effects. You can view them on our pycnogenol research page. There are actually a broad range of natural compounds, including foods and spices, with demonstrable platelet-inhibiting activity. You will find a list of them on our natural platelet inhibitorpharmacological actions page. Another highly relevant section on our website is the Thrombosis Research page. Ultimately, however, cardiovascular disease and heart attacks, for instance, are not caused by a lack of aspirin. To explore further the research related to preventing and treating heart disease naturally, visit our Health Guide: Heart Health. RESOURCES [1] C J Blacklock, J R Lawrence, D Wiles, E A Malcolm, I H Gibson, C J Kelly, J R Paterson. Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin. J Clin Pathol. 2001 Jul ;54(7):553-5. PMID: 11429429 [2] Pharmacokinetics of aspirin and salicylate in relation to inhibition of arachidonate cyclooxygenase and antiinflammatory activity. Proc Natl Acad Sci U S A. 1987 Mar ;84(5):1417-20. PMID: 3103135 [3] P L Janssen, M B Katan, W A van Staveren, P C Hollman, D P Venema. Acetylsalicylate and salicylates in foods. Cancer Lett. 1997 Mar 19 ;114(1-2):163-4. PMID: 9103279 [4] [Ullmanns Encyclopedia of Industrial Chemistry. 6th ed.Vol 1: Federal Republic of Germany: Wiley-VCH Verlag GmbH Co. 2003 to Present, p. V31 725 (2003)] [5] K R Bridges, G J Schmidt, M Jensen, A Cerami, H F Bunn. The acetylation of hemoglobin by aspirin. In vitro and in vivo. J Clin Invest. 1975 Jul;56(1):201-7. PMID: 237937 [6] Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs. Curr Med Res Opin. 2009 Nov;25(11):2785-93. PMID: 19788350 [7] Analgesic use and the risk of hearing loss in men. Am J Med. 2010 Mar;123(3):231-7. PMID:20193831 [8] Hearing loss in a woman on aspirin: the silent pharmacokinetic parameter. Ther Drug Monit. 2009 Feb;31(1):1-2. PMID: 19155962 [9] Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity. Hear Res. 2010 Jun 14;265(1-2):63-9. Epub 2010 Mar 6. PMID: 20214971 [10] Long-term administration of salicylate enhances prestin expression in rat cochlea. Int J Audiol. 2009 Jan;48(1):18-23. PMID: 19173110 [11] Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats. Neuroscience. 2010 Feb 17;165(4):1323-32. Epub 2009 Dec 1. PMID: 19958810 [12] Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling. Neuroscience. 2010 Jun 16;168(1):288-99. Epub 2010 Mar 15. PMID: 20298761 [13] Predictors of mortality in trauma patients with intracranial hemorrhage on preinjury aspirin or clopidogrel. J Trauma. 2008 Oct;65(4):785-8. PMID: 18849791 [14] The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis. J R Soc Med. 2010 Oct;103(10):403-11. PMID: 20929891 [15] Aspirin in the aetiology of Crohns disease and ulcerative colitis: a European prospective cohort study. Aliment Pharmacol Ther. 2011 Sep ;34(6):649-55. Epub 2011 Jul 26. PMID: 21790683 [16] Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption. World J Gastroenterol. 2011 Oct 28 ;17(40):4509-16. PMID:22110282 [17] Toxnet.nlm.nih.gov, Hazardous Substances Data Base: Aspirin [18] Neville D Yeomans, Christopher J Hawkey, Wayne Brailsford, Jrgen Naesdal. Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs. Curr Med Res Opin. 2009 Nov;25(11):2785-93. PMID: 19788350 [19] Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers. Digestion. 2009;79(1):44-51. Epub 2009 Feb 26. PMID: 19246922 [20] Esophageal mucosal lesion with low-dose aspirin and prasugrel mimics malignancy: a case report. World J Gastroenterol. 2011 Sep 21 ;17(35):4048-51. PMID: 22046096 [21] Gastroduodenal toxicity of low-dose acetylsalicylic acid: a comparison with non-steroidal anti-inflammatory drugs. Curr Med Res Opin. 2009 Nov;25(11):2785-93. PMID: 19788350 [22] M Puuml;tter, K H Grotemeyer, G Wuuml;rthwein, M Araghi-Niknam, R R Watson, S Hosseini, P Rohdewald. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res. 1999 Aug 15;95(4):155-61. PMID: 10498385 [23] M L Arruzazabala, S Valds, R Ms, D Carbajal, L Fernndez. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res. 1997 Oct;36(4):293-7. PMID: 9425618 This article first appeared at GreenMedInfo. Please visit to access their vast database of articles and the latest information in natural health. linkwithin_text=Related Articles: 