In order to form a basis for understanding the detailed mechanism of oxygen transport in biological systems, we wish to determine, by single crystal x-ray diffraction techniques, the structures of several artificial oxygen-carrying chelates of cobalt. It is presently feasible to determine the geometry and interatomic distances at the site of oxygen binding with a high degree of accuracy in these molecules; such is not the case for, say, hemoglobin. This research will involve the preparation of single crystals of oxygenated and un-oxygenated forms of bis (salicylaldehyde) ethylenediimine cobalt (II) and derivatives of this parent molecule. Complete x-ray data will be collected for such of these compounds as form suitable crystals and these data will be analyzed to determine the crystal and molecular structures of the compounds.
NIH ExPorter
NIH ExPorter