Q:

More than one '-e' in sed on OSX

I need to run sed -e 'command' -e 'command' file.txt but I get this error on mac: sed: -e: No such file or directory. Any idea how to fix this?

A:

Works fine with my sed:
$ echo ax | sed -e 's/a/b/' -e 's/x/y/'
by
$ uname -a
Darwin Equinox.local 12.3.0 Darwin Kernel Version 12.3.0: Sun Jan  6 22:37:10 PST 2013; root:xnu-2050.22.13~1/RELEASE_X86_64 x86_64
$ which sed
/usr/bin/sed

So the problem must be elsewhere. Judging by your command given in comments, I would try passing the '' argument to the -i option:
$ sed -i '' -e "s/\.$REGIONID\./\./" -e "/\.$NONREGIONID\./d" application.conf

With the caveat described in the man page:

If a zero-length extension is given, no backup will be saved. It is
  not recommended to give a zero-length extension when in-place editing
  files, as you risk corruption or partial content in situations where
  disk space is exhausted, etc.

