Histopathologic study of bone invasion by DMBA-induced carcinoma of the mouth in the hamster.
Carcinoma was induced in the floor of the mouth in the hamster, and the mechanism of bone invasion was studied microscopically. Conclusions are as follows: The periosteum is destroyed and, in general, the external surface of the cortical bone is resorbed through osteoclastic action. However, the periosteum at times resists the invasion of tumors. As the cortical bone is resorbed to some extent and tumor replaces the resorbed area, Volkmann and haversian canals begin to enlarge. Following enlargement of the canals, tumor invasion results in enlargement of the canals of the cortical bone far from the invaded area. In addition, tumors invade the periodontal space and resorb the inner surface of the alveolar bone. Tumors invade the bone marrow through the enlarged haversian canals or the periodontal space or by direct resorption of cortical bone, thus replacing the marrow spaces.
PubMed Abstracts
PubMed Abstracts