Pharmacokinetics of skin penetration.
A model for estimating in vivo skin permeability coefficients is presented. Explicit expressions are derived for the permeability coefficient in terms of excretion rates and tissue absorption. The excretion rate has a linear asymptotic limit from which the permeability coefficient can be determined. The usefulness of the model is demonstrated with existing literature data.
PubMed Abstracts
PubMed Abstracts