Nicotinanilides as inhibitors of neutrophil chemotaxis.
A series of 4-fluoronicotinanilides was synthesized and shown to be novel, potent, and selective inhibitors against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, autoimmune, and allergic disorders.
PubMed Abstracts
PubMed Abstracts