Enantioselective synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed cyanoamidation.
The first enantioselective cyanoamidation of olefins provides quick access to a variety of 3,3-disubstituted oxindoles. The combination of Pd(dba)2, an optically active phosphoramidite, and N, N-dimethylpropylene urea (DMPU) in decalin were found to be the best conditions.
PubMed Abstracts
PubMed Abstracts