[The significance and expression of EGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype].
To determine the expression of epidermal growth factor (EGF) and its receptor in nasal inverted papillomas (NIP) and to clarify the function of EGF in the establishment of NIPs and the correlation with malignant phenotype. The expression of EGF and its receptor EGFR were examined by immunohistochemistry using LSAB method in sections of NIP from 24 patients and squamous carcinoma from 4 patients. Showed that all the epithelium in NIPs together with vascular and stroma adjacent to the epithelium, expressed different degree of EGF. The EGF, EGFR expression in epithelium was significantly stronger in severe atypical hyperplasia of NIP than that in mild atypical hyperplasia of NIP (P < 0.01). The results suggest that EGF, EGFR participate in the growth of NIPs, part of which shows the characteristics of containing plenty of blood vessels and being bloody in operation. The enhanted EGF, EGFR in the epithelium may be identified as one of the parameters of judging the propensity of NIPs malignant transformation.
PubMed Abstracts
PubMed Abstracts