[Activity of cholesterol metabolism enzymes and lipid levels in the rat liver, aorta, adrenals and serum after exposure to triton WR 1339].
Injection of Triton WR 1339 into Wistar rats caused a marked increase in contents of free and ester-bound cholesterol, triglycerides, phospholipids and free fatty acids in tissues and a decrease in the activity of lecithin: cholesterol acyltransferase in blood. An increase in concentration of cholesterol esters in tissues was due to a decrease in activity of lysosomal cholesteryl esterase in vivo and in vitro and to an increase in non-sedimentable activities of acid phosphatase, beta-galactosidase and cholesteryl esterase. The decrease in proteolytic degradation of cholesterol esters was accompanied by an increase in the activity of tissue cytoplasmic cholesteryl esterase and by a decrease in activity of acyl-CoA: cholesterol O-acyltransferase in liver tissue.
PubMed Abstracts
PubMed Abstracts