Myriam Gorospe, Ph.D.

Senior Investigator

Research Topics

RNA sequences modulate turnover and translation of mammalian mRNAs: RBPs and microRNAs associate dynamically with mRNAs and modulate their stability and translation rates. We use human diploid fibroblasts and immortal human cell lines to study specific mRNAs encoding proteins involved in cell division, cellular senescence, and the response to cellular damage (e.g., cdks, cyclins, cdk inhibitors, apoptosis-related proteins, oncoproteins, and tumor suppressors). We study the 5'-untranslated region (UTR), the coding region (CR) and the 3'UTR of mRNAs to identify sequences that affect mRNA half-life and translation, such as regions of association with RBPs and sequences of interaction with microRNAs.

Biography

Dr. Gorospe received her Ph.D. in Molecular and Developmental Biology from the State University of New York at Albany in 1993. She then joined the National Institute on Aging (NIA) for post-doctoral training and has been a Principal Investigator and head of the RNA Regulation Section since 1998. Her group studies post-transcriptional gene regulation in mammalian models of cellular stress, cell division, senescence, and aging. Her research program investigates the influence of RNA-binding proteins (RBPs) and microRNAs on the expression of gene products involved in these processes.