Martin Johnsson's blog

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Morning coffee: pleiotropy

In the simplest terms pleiotropy means genetic side-effects: a pleiotropic gene is a gene that does several things and a pleiotropic variant is a variant that makes its carrier different from carriers of other variants in more than one trait. It’s just that the words ‘gene’ , ‘trait’ and ‘different’ are somewhat ambiguous. Paaby & Rockman (2013) have written a nice analytical review about the meaning of pleiotropy. In their terminology, molecular gene pleiotropy is when the product of a gene is involved in more than one biological process. Developmental pleiotropy, on the other hand, deals with genetic variants: a variant is developmentally pleiotropic if it affects more than one trait. This is the sense of the word I’d normally think of. Third, selectional pleiotropy is deals with variants that affect several aspects of fitness, possibly differently for different individuals.

Imagine that we have found a variant associated with two variables. Have we got a pleiotropic variant on our hands? If the variables are just different measures of the same thing, clearly we’re dealing with one trait. But imagine that the variables are actually driven by largely different factors. They might respond to different environmental stimuli and have mostly separate genetic architectures. If so, we have two different traits and a pleiotropic variant affecting both. My point is that it depends on the actual functional relationship between the traits. Without knowing something about how the organism works we can’t count traits. With that in mind, it seems very bold to say things about variants in general and traits in general. Paaby & Rockman’s conclusion seems to be that genetic mapping is not the way to go, because of low power to detect variants of small effect, and instead they bring up alternative statistical and quantitative genetics methods to demonstrate pleiotropy on a large scale. I agree that these results reinforce that pleiotropy must be important, in some sense of the word. But I think the opposite approach still has value: the way to figure out how important pleiotropy is for any given suite of traits is to study them mechanistically.