A decade after his heroic defeat of the monstrous Kraken, Perseus (Worthington, the demigod son of Zeuz (Neeson), is attempting to live peacefully as a village fisherman and the single parent to his one and only 10-year-old son, Helius.

But unbeknownst to Perseus, a struggle for his supremacy has been raging between the gods that will come to give a threat his idyllic life. Dangerously weakened by humanity's lack of devotion, the gods are losing hold of their immortality, as well as control over the imprisoned Titans and their ferocious leader, Kronos, father of the long-ruling brothers Zeus, Hades (Fiennes) and Poseidon (Danny Huston).

The triumvirate had overthrown their powerful father long ago, leaving him to rot in the gloomy abyss of Tartarus, a dungeon that lies deep within the cavernous Underworld. Now, Perseus cannot ignore his true calling as Hades, along with Zeus' godly son, Ares (Edgar Ramirez), switches loyalties and makes a deal with Kronos to capture Zeus. The Titan's strength grows as Zeus' remaining godly powers are siphoned...and hell is unleashed on earth.