In Call of Duty: Modern Warfare 2, it is first seen in the level "S.S.D.D.". The player uses the mounted Minigun during "Team Player", and sees it throughout other levels; However, it can't be used. Several HMMWVs also appear in multiplayer levels but are completely inoperable. Unlike the previous Modern Warfare title, they can explode like other vehicles after being shot enough or being hit by an explosive. In Afghan and Invasion, the player is able to jump into the hole in the roof of the vehicle that would normally serve as the gunner's position; The player can still crouch, but can't prone, making it an impractical place to take cover, unless to catch people off guard.

Mason and Woods are seen exiting out of two M1026s at the start of "Suffer With Me" in Panama, from one parked in a driveway by Mason, and one parked in the street by Woods, and used by American forces respectively the night before the invasion. Also, they appear in the first game cutscene and in the opening cutscene to the level "Cordis Die".

In "Team Player", the player will eventually enter a school. Once the player reaches the second floor of the school, if they look outside one of the windows they will see two HMMWVs. One is called "Dirty" and the other in front of the first is called "Diana" referencing the Michael Jackson song "Dirty Diana".

In "S.S.D.D.", if the player runs out quick enough they can get hit by a Humvee. If this happens, they might get clipped inside the Humvee.

The Humvee at the start of the "Wolverines!" will clip through the barricade (seen if HUD is disabled).

In November 2017, AM General filed a complaint, accusing Activision of taking advantage of the reputation of the HMMWV in their games, toys and books.[citation needed]