Physogaleus are only known from their fossil teeth and isolated vertebra.

Physogaleus has teeth similar to the modern tiger shark, but smaller. It was actually thought to be a type of tiger shark (Galeocerdo). However, due to the many smaller differences in the shark teeth, it has been moved to its own genera.

Physogaleus teeth are smaller than the tiger sharks, they also do not have the heavy serrations, and are slender and twisted toward the crown. This indicates they probably had a diet of bony fish, similar to the living sand-tiger shark.[2]