Browse our IL7 Proteins (IL7)

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Interleukin 7 Proteins (IL7)

On www.antibodies-online.com are 111 Interleukin 7 (IL7) Proteins from 25 different suppliers available. Additionally we are shipping IL7 Antibodies (268) and IL7 Kits (104) and many more products for this protein. A total of 490 IL7 products are currently listed.

These data indicate the involvement of IL-7 into a direct upregulation of growth and functional activity of human T cells in the absence of antigenic stimulus and the relative scarcity of costimulatory effects.

these findings add further evidence that IL-7 is a key regulatory factor that may tune the balance between functionally different T-cell subsets following haematopoietic stem cell transplantation

The constitutively signaling C7R system developed here delivers potent IL7 stimulation to CAR T cells, increasing their persistence and antitumor activity against multiple preclinical tumor models, supporting its clinical development

we demonstrated that Imatinib mesylate (IM)impaired T cell survival through the inhibition of IL-7 and STAT5 (show STAT5A Proteins)-p but not TCR signaling which remained unaffected during IM therapy. Thus, off-target inhibitory effects of IM on IL-7 and STAT5 (show STAT5A Proteins)-p explain how T cell lymphopenia occurs in patients treated with IM.

In this study, authors compared the concentrations of IL-15 (show IL15 Proteins) and IL-7 in the plasma of MDS (show PAFAH1B1 Proteins) patients (n = 20) compared with that in the plasma of healthy controls (n = 20).

Mouse (Murine) Interleukin 7 (IL7) interaction partners

A key role of the IL7 and Interferon (show IFNA Proteins) type I receptor axis in the regulation of intratumoral t-cell functions and in the development of primary breast tumor growth and metastasis.

BMP4 (show BMP4 Proteins) and IL7 appear to be involved in the interaction between intestinal epithelial cells and intestinal epithelial cells and in the mechanism underlying intestinal mucosal barrier dysfunction.

the in vivo biological role of m(6)A modification in T-cell-mediated pathogenesis and reveals a novel mechanism of T cell homeostasis and Il-7 signal-dependent induction of mRNA degradation

Our new compelling findings have established the critical roles of both IL-7 and IL-15 (show IL15 Proteins) in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 and IL-15 (show IL15 Proteins) further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.

this study shows that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells

lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7; the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (show LTB Proteins) (LT)betaR signaling

IL7 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.