The 49ers can run the ball (6th) in the NFL; the Browns can’t stop the run (20th).

The 49ers can’t pass the ball (31st in the NFL); the Browns have the top pass defense in the league.

The Browns can’t run the ball (29th in the NFL); the 49ers are tough to run on (2nd in the NFL).

The Browns can’t really pass the ball either (22nd in the NFL); but the 49ers can’t stop the pass (22nd).

The Browns possibly (likely?) will be without Peyton Hillis again this week, as his hamstring continues to bark. Injuries continue to plague Hillis, who has seen his numbers drop across the board through the first six games this year as compared to last year (28 fewer carries, 180 less yards, almost a full yard difference in yards per carry).

The team clearly misses him as they are only averaging 91.2 yards per game on the ground. If Hillis can’t go, we’re not sure how much success Montario Hardesty and Chris Ogbonnaya can have, although Ogbonnaya looked good catching the ball last week.

Meanwhile, San Francisco is averaging 193.3 yards per game in October, and running back Frank Gore has rushed for more than 125 yards in each of his last three games.

If the Browns can slow down the San Francisco rushing attack, and at least move the ball well enough on offense to keep the clock moving (like last week against Seattle) they may be able to find a way to keep themselves in the game.

But with the offense currently struggling, and with Hillis possibly missing the game, Ben Watson maybe limited because of a head injury and Mohamed Massaquoi definitely out, it’s not going to be an easy day.