Endometrial hyperplasia and the risk of endometrial carcinoma.
To determine the incidence of endometrial carcinoma in endometrial hyperplasia and try to identify those patients at greatest risk. We conducted a retrospective study of 116 patients who had simple, complex or mixed (simple with focal complex) endometrial hyperplasia with or without atypia, from January 1991 to December 1994. Twenty-nine patients had endometrial hyperplasia with atypia and 87 without atypia. Incidence of endometrial carcinoma was 27.6% in those with atypia; and 3.4% in those without atypia. All were stage I (A or B) adenocarcinomas. Polycystic Ovary Disease and subfertility were found significantly in the cases with cytological atypia; however, they were not significant in the cases with carcinoma. No significant historical differences that could predict carcinoma were found.