identifying genomic variants is a fundamental first step toward the understanding of the role of inherited and acquired variation in disease the accelerating growth in the corpus of sequencing data that underpins such analysis is making the data download bottleneck more evident placing substantial burdens on the research community to keep pace as a result the search for alternative approaches to the traditional download and analyze paradigm on local computing resources has led to a rapidly growing demand for cloud computing solutions for genomics analysis here we introduce the genome variant investigation platform genomevip an open source framework for performing genomics variant discovery and annotation using cloud or local high performance computing infrastructure genomevip orchestrates the analysis of whole genome and exome sequence data using a set of robust and popular task specific tools including varscan gatk pindel breakdancer strelka and genome strip through a web interface genomevip has been used for genomic analysis in large data projects such as the tcga pancanatlas and in other projects such as the icgc pilots cptac icgc tcga dream challenges and the 1000 genomes sv project here we demonstrate genomevip s ability to provide high confidence annotated somatic germline and de novo variants of potential biological significance using publicly available data sets.