Patients offspring of nonconsanguineous parents were mostly identified withCOL1A1orCOL1A2heterozygous changes, although there were also a few cases withIFITM5andWNT1heterozygous mutations. Only one sporadic patient was a compound heterozygote for two recessive mutations. Patients offspring of consanguineous parents showed homozygous changes in a variety of genes includingCRTAP,FKBP10,LEPRE1,PLOD2,PPIB,SERPINF1,TMEM38B, andWNT1.