Coadministration of glecaprevir 400 mg increased pibrentasvir 120 and 40 mg steady-state C and AUC values to 2.9-6.3-fold, and coadministration of glecaprevir 700 mg increased pibrentasvir 160 mg steady-state C and AUC values to up to sevenfold of the values when pibrentasvir was administered alone.