poems syndrome also known as crow fukase syndrome represents a rare multisystem syndrome characterized by polyneuropathy organomegaly endocrinopathy m protein and skin changes hypothyroidism is one of the common endocrine abnormalities which are central features of poems syndrome the clinical data associated with the measurement of thyroid function and its clinical significance in poems syndrome is still rare herein we report 24 cases with poems syndrome which were studied thyroid function and clinical manifestations and performed an associated analysis between hypothyroidism and edema effusions of the 24 patients with poems syndrome 17 70 8 had a recognized hypothyroidism including 11 clinical hypothyroidism and 6 subclinical hypothyroidism fourteen patients 58 3 had some form of extravascular volume overload in 14 patients with edema effusions 12 were diagnosed as having hypothyroidism hypothyroidism may be one of causes of edema effusions after thyroid hormone treatment and chemotherapy symptoms of hypothyroidism and edema effusions were improved greatly.