The incidence of generalised convulsive seizures within 7 days of RTS,S/AS01 booster was 2�2 per 1000 doses in young infants and 2�5 per 1000 doses in children.INTERPRETATION: RTS,S/AS01 prevented a substantial number of cases of clinical malaria over a 3-4 year period in young infants and children when administered with or without a booster dose.