we present a case of a woman with unique multisystem disorder poems syndrome and endocrine abnormalities coexisting with it the poems acronym comprises the dominant features polyneuropathy organomegaly endocrinopathy monoclonal protein m protein skin changes association between plasma cell dyscrasia and polyneuropathy was described in 1956 year by crow the main features were coined in the acronym poems by bardwick in 1980 year the polysymptomatic clinical picture progressive course and no concurrent manifestations of main features impede the diagnosis in this case the first symptoms were the sensomotor polyneuropathy peripheral oedema osteosclerotic bone lesions skin changes organomegaly they preceded diagnosis by 3 years the first endocrinopathy was hypothyroidism definite diagnosis was delayed because we couldn t detect the presence of m protein immunoelectrophoresis didn t detect it but analysis by immunofixation detected m protein in serum and urine within 3 years of the first symptoms she developed hypogonadism hypergonadotropic at first the monotherapy with corticosteroids was used then melfalan with prednisone due to the progression of the disease a thalidomide was used in therapy it is anti vegf agent one of the side effects of the treatment of thalidomide is the progression of polyneuropathy which was observed in this patient after finishing this therapy she received chemotherapy this case report imposes the necessity of constants observation of patients with poems syndrome because there is a possibility of their developing other disorders in the event of coexistence polyneuropathy and plasma cell dyscrasia this disease should be taken into consideration.