[The use of monolaurates for removing endotoxins from preparations of cell-free pertussis vaccine].
The possibility of using monolaurates for removing endotoxin from acellular pertussis vaccines developed at the Laboratory of Immunomodulators, Mechnikov Research Institute for Vaccines and Sera (Moscow), has been studied. Monolaurates PEG-400 and PEG-600 obtained, respectively, from Fluka Chemie AG and Ferak GmbH (Germany) have been used. The use of monolaurate PEG-600 ensures the decrease of the toxicity of acellular pertussis vaccines by 2.34-6.3 times.
A high resolution, laser desorption time of flight mass spectrometer (LITOF-MS) was used to study lead borate glasses and crystals. This technique provides valuable information about glass structure, including the superstructural network units. Several structural units were identified and we found evidence of a lead substructure beginning to form in the glass with increased lead content.