what causes major depressive disorder
The cause of major depressive disorder is a combination of brain chemistry, family history, and psychosocial environment. It is not certain which of these factors dominates, but abnormal levels of the neurotransmitters norepinephrine, serotonin, and dopamine are closely linked with depression.
and keep reading. Major depressive disorder, also called major depression, is characterized by a combination of symptoms that interfere with a person's ability to work, sleep, study, eat, and enjoy once–pleasurable activities. Major depression is disabling and prevents a person from functioning normally.