Whole Genome Transplantation Becomes A Reality
Microbiologists at the J. Craig Venter Institute (JCVI) in Rockville, Md., transferred the genome from one bacterium to another, “resulting in new cells with both the genotype and phenotype of the input genetic material,” says Carole Lartigue, lead scientist on the project. “The recipient genome is completely replaced by that of the donor cell—a clean change of one bacterial species into another.” Moreover, unlike Oswald Avery's experiments involving transformed pneumococcal bacteria during the 1940s, she adds, “There isn't any recombination between incoming and outgoing chromosomes during genome transplantation.”
The following casestudy provides a workflow perspective on the Grid ENabled Integrated Earth system modelling (GENIE) framework, which was introduced in Vol. 2.