A highly performed nonenzymatic glucose sensor using surfactant template assisted platinum nanoparticles
In this work, we have successfully developed an enzyme free glucose sensor with highly performed electrodes, which was decorated with surfactant assisted platinum nanoparticles (PtNPs) on rectangular shaped thin Au film electrode. The PtNPs have been used for their outstanding catalytic activity for the redox reaction of H2O2. Diblock copolymer surfactant template was used to deposit platinum nanoparticles on the working and counter electrodes, simultaneously. Optimal potential was investigated and applied for the uniform distribution of PtNPs. The fabricated biosensor showed good electrocatalytic performance in terms of high sensitivity of 0.32 μA/mM, fast response of 5 s, and wide linear range from 0.0625 to 22 mM.
Background and Objective Chemotherapeutic drug treatment outcomes are genetically determined. Polymorphisms in genes encoding phase II drug metabolizing enzyme glutathione-S-transferase (GST) can possibly predict treatment outcomes, and can be of prognostic significance in breast cancer patients. The aim of this study was to determine the role of genetic variations in GST in predicting response to, and toxicity of, anthracycline-based chemotherapy in breast cancer patients. Method Two hundred and seven patients treated with anthracycline-based chemotherapy were genotyped for GSTM1 and GSTT1 deletion polymorphisms, and GSTP1 Ile 105 Val (rs1695), by polymerase chain reaction (PCR)/