effects of gentamicin on transport proteins
Changes in kidney maturation in utero have been reported after gentamicin administration to pregnant rats. While the proteinuria commonly observed, could be related to modifications of the glomerular basement membrane, perturbed renal protein handling could be accounted for by changes in the proximal tubular cells. Therefore, we studied the effect of gentamicin on the renal handling and transport of proteins in proximal tubular ceils using the horseradish peroxidase, a fluid-phase marker, as a probe. Gentamicin
Early selective effects of gentamicin on renal brush-border membrane Na-Pi cotransport and Na-H exchange. Levi M(1), Cronin RE. Author information: (1)Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Gentamicin nephrotoxicity is associated with impairments in proximal tubular function. This study determined whether gentamicin administration to the rat, before a reduction in glomerular filtration rate (GFR), causes early and selective alterations in renal cortical brush-border membrane (BBM) enzyme and transport activity, lipid composition, and fluidity.