mTOR Pathway Mutations and Response to Rapalogs in RCC—Letter
We have read with interest the article by Kwiatkowski and colleagues ([1][1]) reporting mTOR pathway activating mutations as possible predictors of mTOR inhibitor response in renal cell carcinoma (RCC). Recent evidence indicate inferior global efficacy of rapalogs compared with new agents; however,
In this paper we study the problem of enabling uninterrupted delivery of messages between endpoints, subject to spatially correlated failures in addition to independent failures. We developed a failure model-independent algorithm for computing routing paths based on failure correlations using both a-priory failure statistics together with available real-time monitoring information. The algorithm provides the most cost-efficient message routes that are potentially comprised of multiple simultaneous paths. We also designed and implemented an Internet-based overlay routing service that allows applications to construct and maintain highly resilient end-to-end paths. We have deployed our system over a set of geographically distributed Planetlab nodes. Our experimental results illustrate the feasibility and performance of our approach.