Photochemical study of the interaction of phenothiazine derivatives with spin labelled lecithin multibilayers.
Abstract Nitroxide free radicals are destroyed by ultraviolet irradiation in the presence of phenothiazine derivatives. This property has been used in order to determine the type of interaction of these drugs with spin-labelled lecithin multibilayers. Kinetic measurements of the spin label signal decay under irradiation have shown that chlorpromazine and perphenazine are preferentially located in the polar part of the bilayer, whereas promethazine and oxidized derivatives of chlorpromazine are found principally in the hydrophobic part.
Introduction Poly(3-alkylthiophenes) (P3ATs), as a new kind of soluble, fusible and processable conductive polymers, have attracted a great interest and much attention of chemists and physicists[1,2]. It has been widely accepted that P3ATs can form similar layered structures with alkyl side chains being oriented in the lateral a-axis direction[3-6]. Moreover, when the number of the carbon atoms in the alkyl side chains is more than 10, some orderly arrangements of the side chains will occur between the layers[4].