Sodium Output—Blood Pressure Relationships and Their Modification by Treatment
This study summarizes relationships among blood pressure, 24-hour sodium output, basal output and output under load, in patients on self-selected diets. Additional evidence was secured for the existence of a general correlation between blood pressure and sodium output. This correlation persisted when the blood pressure of hypertensive patients was chronically reduced by medical or surgical therapy.
The authors are grateful for financial support from the National Institutes of Health (grants GM23244 and GM53905), and to very helpful comments on the manuscript from Elliot Elson, Vlodya Gelfand, Paul Matsudaira, Julie Theriot, and Sally Zigmond. D. A. L. and A. F. H. would also like to thank Alan Wells, and Anna Huttenlocher and Rebecca Sandborg, respectively, for stimulating conversations on this subject, and Sean Palecek for Figure 2Figure 2. Finally, we extend our apologies to all our colleagues in the field whose work we were unable to cite formally because of imposed reference limitations.