is fexofenadine an anticholinergic
Fexofenadine is the active metabolite of terfenadine. It is a selective histamine H 1 receptor antagonist that does not cross the blood brain barrier; therefore, it is not associated with sedation or adverse cognitive effects. Unlike older antihistamines, fexofenadine does not have anticholinergic activity.here have been no comparative trials with fexofenadine and the intranasal nonsedating antihistamines (azelastine and levocabastine) in patients with seasonal allergic rhinitis. As with other oral nonsedating antihistamines, fexofenadine has little effect on nasal congestion.
Drowsiness, reaction time, and physiological tremor were examined 1-, 2-, and 3-hr post-ingestion of antihistamines with known anticholinergic profiles. These were the first-generation promethazine, and second-generation loratadine, desloratadine, and fexofenadine.owever, the results of this study suggest that loratadine and desloratadine have the potential to affect movement control, and further research is warranted to understand the clinical relevance of these findings. Crown Copyright Â© 2013. Published by Elsevier Ireland Ltd.