Trimethoprim and a case of lower urinary tract infection
This article discusses the use of trimethoprim in the treatment of uncomplicated lower urinary tract infections (LUTI) in adult women. It takes the form of a case study and will explore the pharmacological dynamics of the drug, as well as comparing it to others also used in the treatment of LUTI. Trimethoprim is considered the gold standard for treatment and the three-day course has become the usual recommended treatment for non-complex LUTIs and for empirical treatment of cystitis with a 90% eradication rate (Salvatore et al, 2001; Scottish Intercolleguiate Guidance Network, 2006). This article describes the presenting symptoms, possible differentials, treatment, and rationale for the treatment chosen.
SummaryA study was carried out of plasma electrolyte estimations made before and after long-term use of a combination of amiloride and hydrochlorothiazide in 23 patients. The mean duration of use was 20.3 months. No significant differences were found in plasma potassium, sodium, bicarbonate or urea from baseline levels.