Native heart ventricular tachycardia in a heterotropic heart transplant
A 24-year-old woman was admitted with a 24 h history of palpitations and breathlessness. She had no previous history of chest pain, dizziness or syncope. She had previously undergone a heterotropic heart transplant 14 years ago owing to cardiac failure related to idiopathic dilated cardiomyopathy. A physical examination demonstrated a pulse of 160 bpm with prominent A …
Background ::: Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic disease models determination of the presence of metastatic disease, metastatic burden, and response to therapy are difficult, often requiring serial necropsy. In this study we characterized the development of visceral metastases in a patient derived xenograft model (PDXM) using in vivo imaging.