[Protective action of a combined preparation and staphylococcal anatoxin in reproducing a local staphylococcal infection in white mice].
In experimental local staphylococcal infection in white mice, previously immunized with staphylococcal toxoid and the combined preparation (staphylococcal toxoid + protective somatic staphylococcal antigen), the advantage of the latter in protecting the animals against infection with Staphylococcus aureus belonging to different phage groups has been revealed. Immunization with the combined preparation, carried out in 2 injections, has been found to stimulate antimicrobial immunity, simultaneously with antitoxic one, which indicates the expediency of the further study of the combined preparation.
1. Erythrocytes have definite lipoidal constituents and lipoidal combinations peculiar to the species. 2. Certain lipoids and lipoidal combinations act as specific antigens. 3. The increase in serum lipase which occurs upon immunization of animals to foreign red cells is, at least in part, specific. 4. This specific lipase plays, no doubt, an important part in specific serum hemolyses.