Anticonvulsant and neuroprotective effects of Rosa damascena hydro-alcoholic extract on rat hippocampus
Previously, analgesic, hypnotic, and anticonvulsant effects have been suggested for Rosa damascena (R. damascena). In the present study, possible anti-seizure and neuro-protective effects of hydro-alcoholic extract of R. damascena has been investigated after inducing seizures in rats by pentylenetetrazole (PTZ).
Abstract The dirhodium tetraprolinate, Rh 2 ( S -DOSP) 4 is an efficient catalyst in an enantioselective C–H activation protocol. Rh 2 ( S -DOSP) 4 catalyzed decomposition of aryldiazoacetates or vinyldiazoacetates results in the formation of transient rhodium carbenoid intermediates. These intermediates are capable of selectively inserting into the C–H bond of acetals. The resulting products are protected β-keto esters, and so the C–H activation protocol can be considered as strategically equivalent to the Claisen condensation.