Real world data on the use and sequence of targeted and immuno-oncology drugs in metastatic melanoma (MM) patients (pts).
e21541Background: Immunotherapy (iTx) and BRAF targeted therapy (tTx) have radically changed the outcomes of MM pts. However, data on real life use are scant and optimal sequence is unknown. Our ai...
Reflected confocal microscopy has been widely used in clinical application in dermatology. In recent years, ::: multiphoton microscopy has also emerged as an important minimally invasive bioimaging technique for the skin. In this ::: study, we combine reflected confocal microscopy and multiphoton microscopy for skin imaging. In the epidermis, ::: reflected confocal signals are expected to help in delineating cell borders while multiphoton signals provide cytoplasmic ::: morphologies. In the dermis, second harmonic generation signals provide the morphology of collagen fibers. When ::: three-dimensional images are projected, the detailed distribution of cellular component and extracellular matrix in skin ::: can be obtained. Properly developed, this technique is of great potential for in vivo clinical application.