Kinetic study of CO hydrogenation reaction over Fe–Co–Mn ternary catalyst
Abstract A new kinetic approach is presented to study the mechanism of the catalytic reaction of the hydrogenation of carbon monoxide on Fe–Co–Mn catalyst prepared by wet impregnation method over MgO support. The experimental data obtained by a fixed bed reactor are used for calculating the apparent activity energy of the LHHW kinetic models developed for the consumption of carbon monoxide, and formation of methane, alkenes and alkanes. Then, using the calculated activation energies and the available UBI–QEP relationships for the ternary catalyst and obtaining the relationships between the apparent activity energy of the LHHW kinetic model and the activity energy of surface elementary reactions involved in the kinetic equation extraction and by developing an appropriate software coupled with a genetic optimization algorithm, the surface binding energy of carbon, oxygen and hydrogen on the ternary catalyst are calculated.
A fluorometric enzyme assay was developed to evaluate the ability of a variety of compounds to bind to and/or inhibit pyroglutamyl aminopeptidase I. Among these compounds were a series of chloromethyl ketone analogues of thyrotropin releasing hormone (TRH) which had previously been shown to possess TRH-like activity in the central nervous system and have now been found to be good inhibitors of pyroglutamyl aminopeptidase. Thus, it is suggested that the observed TRH-like CNS activity could derive indirectly from inhibition of endogenous TRH degradation by pyroglutamyl aminopeptidase I.