The effect of several different anaesthetics on the blood pressure and heart rate of the mouse and on the radiation response of the mouse sarcoma RIF-1.
Several anaesthetics were tested with mice to study: (a) their ability to immobilize the animal; (b) their effect on blood pressure and heart rate; and (c) their effect on the response to X-irradiation of the mouse sarcoma RIF-1. All anaesthetics which produced adequate immobilization also caused a fall in blood pressure and some radioprotection of tumour cells. Physical restraint of the tumour-bearing leg of an unanaesthetized mouse also caused radioprotection of the tumour cells.
Lower extremity atherosclerotic disease affects nearly 10 million people in the United States [1]. Recent advances in atherosclerosis include an understanding of the pathophysiologic role of inflammation in atherosclerosis and its progression [2], and the addition of magnetic resonance angiography (MRA) as a powerful diagnostic tool that has reduced the necessity for contrast angiography and its attendant risks. Medical and interventional radiologic techniques also help many patients to avoid more invasive surgical procedures. Subsequently, the vascular surgery patients who now enter the operating room for peripheral vascular surgery represent the subset whose lesions are refractory to medical management, not amenable to endovascular techniques, or who have significant comorbidities.