Role for Gβγ G-proteins in protease regulation during remodeling of the murine femoral artery.
Background ::: Intimal hyperplasia remains the principal lesion in the development of restenosis after vessel wall injury. G-protein coupled receptors are involved in smooth muscle cell proliferation but the role of Gβγ in arterial intimal hyperplasia has not been well defined. The aim of this study is to characterize the expression of Gβγ G-proteins in the developing intimal hyperplasia in a murine model and the impact of disruption of Gβγ signaling on intimal hyperplasia development.
Ultrastructural changes in the parietal cells of the fundal glands were studied by analysis of the phases of secretion after injection of histamine in patients with gastric and duodenal ulcer and with different levels of acidity of the gastric juice. In patients with normal and increased acidity of the gastric juice structural changes reflecting increased functional activity of the cells were discovered in the parietal cells after injection of histamine, although the phasic character of the secretory process still remained. In patients with reduced acidity the phases of the secretory process were illdefined and no ultrastructural changes indicating increased functional activity of the parietal cells could be detected.