Evaluation of oxidative events and copper accumulatıon in oral tissues of patients wıth Wilson’s disease: three case report
Wilson’s disease (WD), also known as hepatolenticular degeneration, was first described in 1912 by Kinnear Wilson. It is an autosomal recessive disorder caused by mutations in the ATP7B gene, a membrane-bound copper transporting ATPase. The disorder is caused by impairment of the copper transporting ATPase, ATP7B, in the liver, which disturbs copper transport, excretion into the bile, and incorporation into apoceruloplasmin. WD is an inherited copper metabolism disorder with pathological copper accumulation in many tissues, but especially in brain and liver. We conducted this study because copper accumulation in oral tissues in patients with WD have not been studied before. We think that copper accumulation and differences of oxidative events in oral tissues can cause tendency to periodontal diseases.
Abstract Cation concentration profiles in solid—solution scales on NiCo alloys have been calculated by making use of Wagner's theoretical analysis. As a result of the computation method used, it becomes unnecessary to incorporate experimental values in the calculation for either the parabolic rate constant, k p , or the boundary conditions of the cation profile. The agreement between the independently determined theoretical and experimental cation profiles provides strong support for Wagner's model. The calculated variation of k p with alloy composition is also in agreement with the experimental data.