THE OXIDATION OF A COMPLEX URANIUM SALT IN ALKALINE SOLUTION
The reaction of hydrogen peroxide with U salts in the presence of an excess of alkaline carbonate produces a red-orange solution. Spectrophotometric studies indicate the formation of a peroxide complex as a result of the reaction between an H/sub 2/O/sub 2/ molecule and a U atom. The equilibrium constant, indicating the stability of the compound, was determined. (tr-auth)
Background ::: Unsaturated fatty acids (FA) are required for cancer cell growth. In normoxia cells can generate unsaturated FA from saturated stearic and palmitic acid by desaturation. However, since the desaturation step is oxygen-dependent hypoxic cancer cells display an increased dependence on the uptake of unsaturated FA. Up to now the mechanism of increased FA uptake in hypoxia is largely unknown. Here we aimed to study the role of human serum and glucocorticoid-inducible kinase (SGK1) in the regulation of FA uptake in cancer cells exposed to acute or chronic cycling hypoxia and explore its use as target for the radiosensitization of hypoxic cancer cells.