Beneficial effects of an open artery on left ventricular remodeling after myocardial infarction.
During the last 2 decades researchers have developed a clearer understanding of the pathophysiology of acute myocardial infarction (AMI). The use of thrombolysis and coronary angioplasty early in the course of AMI salvages myocardium and preserves left ventricular function, which results in improved survival rates. Late reperfusion after AMI, however, may provide beneficial effects on long-term prognosis, especially owing to attenuation of left ventricular remodeling. This article reviews the evidence of the benefits of an open infarct-related artery on left ventricular remodeling after AMI.
In this article, we study a piecewise smooth dynamical system inspired by a previous reduced system modeling compartimentalized brain metabolism. The piecewise system allows the introduction of an autoregulation induced by a feedback of the extracellular or capillary Lactate concentrations on the Capillary Blood Flow. New dynamical phenomena are uncovered and we discuss existence and nature of two equilibrium points, attractive segment, boundary equilibrium and periodic orbits depending of the Capillary Blood Flow.