Importance of Sparing Submandibular Gland Function to Improve Patient-reported Xerostomia
Results: Nine institutions recruited 48 pts from Sept 2008 to Oct 2009 averaging 6 pts per month. Registration errors made 1 pt ineligible. The median age was 60 years; 84% were male; 70% completed RT+C for . 12 months; and 21% received prior pilocapine. Among the initial 38 pts, 27 completed all sessions, 10 completed 20-23 sessions and one was not compliant because of transportation problems. The 6-month XeQOLS score was available for 13 pts. Eleven (85%) pts achieved a positive treatment response with a mean reduction of 34.7% (SD 30.4). Of the 47 pts treated, 4 had grade 1-2 gastrointestinal events and 1 had grade 1 pain event.
Introduction ::: The purpose of this study is to compare the tissue incorporation of a novel fenestrated and non-fenestrated crosslinked porcine dermal matrix (CPDM) (CollaMend™, Davol Inc., Warwick, RI) in a porcine model of ventral hernia repair.