what are the capsid proteins in yellow fever
The flavivirus C protein belongs to the same class of alpha-helical capsid proteins as the hepadnaviruses and retroviruses (31, 38). Similar structural motifs have also been observed in the core proteins of arteriviruses and bacteriophage Ï6 (9).ffect of capsid mutations on virus production. To study the effect of mutations in C protein on the viability of YFV, C-terminal truncations, internal deletions, and point mutations in the C-terminal helix were engineered into the full-length infectious cDNA clone of YFV.
By use of a trans-packaging system that involved packaging a yellow fever virus (YFV) replicon into pseudo-infectious particles by supplying the YFV structural proteins using a Sindbis virus helper construct, the functional elements within the YFV capsid protein (YFC) were characterized.ffect of capsid mutations on virus production. To study the effect of mutations in C protein on the viability of YFV, C-terminal truncations, internal deletions, and point mutations in the C-terminal helix were engineered into the full-length infectious cDNA clone of YFV.