Exploiting the inherent invasive property to treat glioblastoma multiforme
Glioblastoma multiforme(GBM)is the most malignant brain tumor with high infiltration.The routine surgical resection followed by radiation and chemotherapy only provides patients with a survival period ranging 12–15months.Here,I propose that the high invasiveness property of the GBM cells be exploited to treat this deadly disease.That is,instead of inhibiting the dissemination of GBM cells,we should take advantage of the high mobility of the disseminated GBM cells and directionally induce these cells to return to the center of surgical resection cavity of the primary neoplasm and subsequently kill them.This idea may provide a new promise to defeat this deadly disease.
A healthy tissue tolerance study1,2 with Beagle dogs was carried out at the Finnish BNCT facility FiR 1 during February-March 1998. Three dose groups of dogs without boron carrier, each comprising five Beagles, and one dose group with BPA-F infusion were irradiated. Individual dose plans1 were done for each dog. The absorbed doses, which were actually delivered to healthy tissues, were monitored in vivo by placing the dosimeters on the shaved skin of the dogs or in the accessible cavities. In this study, absorbed gamma doses were monitored with thermoluminescent (TL) dosimeters, and neutron fluences were determined with activation foils. The obtained results were compared to the calculated values.