Efficacy and Standardisation of SF-RI 1: A Preparation from Bovine Lung Surfactant
Preparations from natural sources of pulmonary surfactant are subject to biological variability. Therefore Tanaka and colleagues [1] standardized their reconstituted lung surfactant by adjusting the lipid composition. The product, Surfactant TA, revealed a low variability of in vitro surface properties [2]. However, to date a convincing correlation between in vitro surface properties and physiological surfactant activity, determined as dynamic or static compliance of premature ventilated animal fetuses, has not been shown [3–5]. Nevertheless, in vitro surface properties have extensively been used for the development of artificial surfactants [6–10].
Abstract Some new possibilities of using specular neutron reflection in the study of roughness and interdiffusion in thin-film structures have been proposed and tested (the use of polychromators and supermirrors, direct measurement of the thickness of nonmagnetic interdiffusion layers). A statistical roughness growth law was found to be satisfactory in the interpretation of results, the growth rate being dependent on the materials used, film deposition techniques, etc. The use of ( λ 4 , λ 2 ) -sequences is proposed to increase the sensitivity of the method to the nonmagnetic interdiffusion layer thickness.