Behavioral and arterial pressure effects of pimetine in conscious dogs.
Abstract Pimetine, 1-dimethylaminoethyl-4-benzylpiperidine, was investigated for activity in two experimental models using conscious dogs which have demonstrated high predictive ability in discerning psychotropic agents and categorizing them into tranquilizer or antidepressant classes. Pimetine treatment produced a dose-related reversal of the Ditran Rating Scale score at dose levels devoid of apparent direct behavioral effects. This drug also produced a moderate pressor effect associated with a potentiated acetylcholine arterial pressure response and inhibited responses to serotonin, bilateral carotid occlusion, tyramine and histamine. A clinical study of the antidepressant effects of pimetine is indicated by the results.
In the wake of Fransella's (1972) seminal application of Kellyian ideas to the understanding of stammering, the impact of personal construct psychology (PCP) upon speech and language therapists working in this area has been significant. This article reviews the literature and considers the developments in the management of stammering wrought through the application of PCP. A number of key issues relating to the meshing of traditional speech therapy methods and PCP are discussed and these are illustrated further by a specific personal clinical experience.