Prothrombin and Factor VII Genotypes and Phenotypes in healthy Individuals — Results from the Lugen Study
Elevated plasma levels of prothrombin (PT) and coagulation factor VII (FVII) are discussed to be associated with an increased risk of venous thromboembolism or coronary heart disease [1,3,6,8], Activities of PT and FVII are influenced by genetic and environmental factors: In addition to polymorphisms of the PT gene (G20210A) and the FVII gene (R353Q, HVR4), smoking habits, use of oral contraceptives or postmenopausal hormone replacement therapy May also influence PT and FVII activities [1’4,7,12].
Author contributions ::: ::: GH helped design the study, establish the animal model, collect and analyze samples, and write the manuscript. YY and DH helped establish the animal model, performed Western blotting, immunohistochemistry analyses. YY and DH also helped analyse data and revise the manuscript. QYW and JK contributed to study planning, analyse and interpret data, review and revise the manuscript. All authors have approved the final version of this article to be published and agreed to be accountable for all aspects of the work in ensuring the questions related to the accuracy or integrity of any part of the work. ::: ::: ::: ::: Disclosure ::: ::: The authors report no conflicts of interest in this work.