Synthesis of Some Quinolino Substituted Benzimidazole Derivatives as Possible Antibacterial Agents
The present study deals with the synthesis and evaluation of antibacterial activity of various quinolino substituted benzimidazole derivatives coupled with different amines. The derivatives were synthesized in moderate to good yields. The structural characterizations were performed based on their analytical data and IR, 1H NMR & Mass spectral studies. All the compounds were subjected for antibacterial screening, among them 4a and 4e showed good activity against the organisms used. The antibacterial activity studies suggested that these derivatives may be developed further to prove useful in future drug development.
Objective To study the chemical constituents from the fresh herb of Stellaria media.Methods The chemical constituents of the plant were isolated and purified by column chromatography and their structures were elucidated by spectroscopic analysis. Results Five chemical constituents were isolated and elucidated as apigenin (1), 6,8-di-C-glucopyranosyl apigenin (2), quercitin 3-Ο-α-L-rhamnoside (3), querctin (4), daucosterol (5), respectively. Conclusion Compounds 3, 4, and 5 were isolated from this plant for the first time.