1H-NMR study of the inclusion processes for α- and γ-cyclodextrin with fenbufen†
1H-NMR spectra of aqueous solutions of fenbufen and two cyclodextrins (α- or γ-cyclodextrin, respectively) mixtures confirm the formation of an inclusion complex if γ-cyclodextrin is used, whereas in the case of α-cyclodextrin no inclusion complex was obtained. The stoichiometry of the fenbufen/γ-cyclodextrin complex is of the [2:1] type. The geometry of this supramolecular architecture was established through MM+ molecular mechanics calculations. © 2005 Wiley Periodicals, Inc. Biopolymers 77: 361–367, 2005
The compounds reduced are given in the table in order of increasing empirical formulas. Compounds with the same empirical formula are arranged in order of increasing number of rings in the molecule, and compounds with the same number of rings in order of increasing number of substituents. In the case of complex reaction products, the structural formula is given only for that part of the molecule in which changes took place during Birch reduction. Tetrahydrofuran used as an auxiliary solvent is denoted in the table by THF.