Advances in the study of Mycobacterium tuberculosis culture filtrate proteins
Culture filtrate proteins(CFPs) of Mycobacterium tuberculosis are secreted proteins in M.tuberculosis culture supernatants.In animal models of M.tuberculosis infection,they can promote protective immunity and stimulate immune cells to efficiently secrete cytokines such as IFN-γ.This paper reviews their composition,biological and immunological characteristics,and prospects for clinical diagnosis and vaccine development.
We report a patient with an overlap of relapsing polychondritis and Behcet disease whose cartilaginous inflammation and genital lesions were refractory to corticosteroids and immunosuppressants, but fully remitted with the tumor necrosis factor-alpha inhibitor, infliximab. We believe this case represents the first report of a response to a tumor necrosis factor inhibitor in a patient with mouth and genital ulcerations with inflamed cartilage syndrome.