Novel method for preparing entecavir and intermediate used therein
PURPOSE: A novel method for preparing entecavir and a novel intermediate used for the same are provided to easily produce a large amount of novel intermediates. CONSTITUTION: A method for preparing entecavir of chemical formula 1: a step of hydrolyzing alpha-exomethylene compound of chemical formula 2 to synthesize a compound of chemical formula 3; a step of reacting the compound of chemical formula 3 with a purine compound of chemical formula 4 by Mitsunobu reaction to obtain a nucleoside compound of chemical formula 5; a step of reacting the compound of chemical formula 5 with tetrabutyl ammonium fluoride to obtain a compound of chemical formula 6; and a step of hydrolyzing the compound of chemical formula 6.
Despite the fact that since 1985 the government of Quebec increased by 5.75 % on average the amount of money spent on healthcare per year, little improvement was noted. It is obvious that an optimal use of resources is essential to reduce waiting times and provide safer and faster services to patients. The use of new technology can contribute to improve the healthcare system efficiency. Our study aims to assess the impact of a medication distribution technology on 1) the performance of a health and social services center’s pharmacy, 2) the performance of one care unit in a nursing home and on 3) the medication-use process safety. To measure performance we were inspired by the Lean approach. The results show that medication distribution technology is considered as an effective way to significantly detect medication errors, to allow nurses to focus more on patients and pharmacy to react more rapidly to changes in patient medications.