CONVERSION OF A 4-QUINOLONE INTO A 1,6-DIAZAPHENALENE
Abstract 5,8-Dimethoxyquinolin-4-one has been transformed in five steps into a 7-oxo-1,6-diazaphenalene and in 4 steps into 6-aza-1-oxaphenalene.
Objective To optimize the extraction technology of Yanqing Granule by orthogonal test.Methods Using the contents of chlorogenic acid and total extraction as indexes,choosing solvent volume,extracting duration and extracting times as influential factors,the optimal extraction condition was studied by L9(34) orthogonal test.Results The optimal extraction condition of Yanqing Granule was: 200 mL water for 1/3 amount of drugs,refluxing extraction for 3 times and 0.5 h each time.Conclusion The optimal extraction technology obtained in this study is simple and reproducible,and it has a higher application value in the production of Yanqing Granule.