Design and Synthesis of Certain Mesoionic Sydnonyl Styrylketones as Potential Nonsteroidal Antiinflammatory Agents.
Compounds containing both the structural features of mesoionic sydnones and styrylketone (III) (9 examples) are designed and synthesized as potential analgesic and antiinflammatory agents using a Claisen—Schmidt reaction.
We have used IR spectroscopy to study the reaction between L-cysteine and dimethyl sulfoxide in aqueous medium. We have found that reaction occurs with formation of an insoluble product, which we have identified. We show that oxidation of L-cysteine by dimethyl sulfoxide can occur at an appreciable rate under mild conditions, with formation of L-cystine, dimethyl sulfide, and water.