In a prospective, randomised double blind study of 47 phlebographies, diatrizoate and ioxaglate were compared with regard to possible postphlebographic thrombosis proved by 125I-Fibrinogen uptake test. A significantly lower rate of postphlebographic thrombosis was registered when the low-osmolar ioxaglate was used.
The objectives of this article are to review the diagnosis and management of acute nonrenal reactions to iodinated contrast media. We will begin by discussing the types of contrast media and their correlative rates of reaction. The mechanism of contrast reactions, predisposing risk factors, and preventative measures will then be discussed. The remainder of the article will review the assessment of potential reactions, initial management, and treatment algorithms for specific reactions.
3-R-1,4,2-dioxazol-5-ones are a class of compounds that are increasingly finding diverse uses, including as regioselective amidation reagents and as electrolyte additives that enable long cycling l...