Molecular Determinants of Reperfusion-Induced Leukocyte Adhesion
The adhesion of circulating leukocytes to the endothelium has long been recognized as a principal feature of the acute inflammatory response (1). The activation of circulating leukocytes and their subsequent adhesion to the microvascular endothelium involves a multistep program including various inflammatory mediators and distinct surface adhesion molecules. Both are the prerequisite for leukocyte transmigration across the endothelium into the tissue. In host defense, leukocyte adhesion and emigration serve a beneficial role during the well-contained inflammatory response. Leukocytes may, however, also turn against the host, contributing to tissue damage by the breakdown of capillary perfusion, endothelial integrity and parenchymal cell function (2).
ABSTRACTObjectives: Minimal residual disease (MRD) is a strong prognostic factor in acute lymphoblastic leukemia (ALL), which progresses quickly and is fatal within months if untreated. This study ...