A Double-Blind Study of the Effect of Ribonucleic Acid in Senile Brain Disease
A double-blind study to test the effect of orally administered ribonucleic acid upon the course of senile and arteriosclerotic brain disease failed to confirm the positive findings of other investigators. The authors conclude that RNA administered in this form does not appear to bring about improvement or reversal of senile brain disease.
It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.