Alpha-methylparatyrosine and sleep in the rat
Abstractl-Alpha-methylparatyrosine administered orally in doses of 50, 75 and 100 mg/kg produced a significant increase in desynchronized sleep time (D-time) in the rat. However, 75 mg/kg of l-AMPT, administered intraperitoneally resulted in disturbed sleep and reduced D-time; this may explain some discrepancies in previous studies. Over a 24-h period, the time of maximum increase in D-time after oral l-AMPT coincided closely with the time of maximum decrease in brain norepinephrine levels; both occurred 7–10 h after drug administration.
Study Design.A meta-analysis.Objective.The aim of this study was to compare the diagnostic accuracies of F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) and magnetic resonance imaging (MRI) for the detection of spondylodiscitis through a meta-analysis.Summary of Background Data