Introduction of photocrosslinkable chitosan to polyethylene film by radiation grafting and its blood compatibility
This paper describes research to improve the blood compatibility of polyethylene (PE) film. O-Butyrylchitosan (OBCS) was grafted to PE film by using a radiation grafting technique. The grafted sample films were verified by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA) and the water contact angle measurements. The blood compatibility of the OBCS-grafted PE films was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments that the results were described. The blood compatibility of OBCS-grafted PE film is better than that of blank PE film. These results suggest that the photocrosslinkable chitosan developed here has the potential of serving in blood-contacting applications in medical use.
Background ::: Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic disease models determination of the presence of metastatic disease, metastatic burden, and response to therapy are difficult, often requiring serial necropsy. In this study we characterized the development of visceral metastases in a patient derived xenograft model (PDXM) using in vivo imaging.