Granular formulation and manufacturing method
Object of the present invention to provide a granular preparation hours even in average particle diameter, can be effectively controlled drug dissolution characteristics. The present invention provides a granule formulation, wherein that the first coating layer containing a water-insoluble polymer particles and inorganic particles and granular formulations of a drug having a first cladding layer of the coated drug particles and / or lipid components, the lipid component contains more C15 fatty acids.
The pharmacodynamics is affect by particle size of wild G.Lucidum.This paper uses laser equipment of particle size analysis of the particle size for wild G.Lucidum powders. The study is focused on dispersion medium kind, dispersion medium quantity, ultrasonic time and temperatures for the influence of wild G.Lucidum powder, the particle size analysis. The best condition:dispersion medium is Tween-80 ; dispersion medium quantity is 1.0%; ultrasonic time is ≥6min and temperature is 5℃～35℃ .