Study on Injuries to Hippocampus, Amygdala, Cerebral Cortex and Their Effects on Conditioned Taste Aversion in Total Body 60 Co-γ-irradiated Rats.
The objective was to study the effects of one time exposure to small clinically relevant dose of 60 cobaltgamma ( 60 Co-γ) radiation on histological changes in brain and consequent effects on conditioned taste aversion (CTA) in experimental rats. Rats were total body 60 Co-γ-irradiated in GammaCell; CTA to saccharin was assessed in terms of saccharin preference ratio (SPR) using a standardized two bottle regime; brain histology was performed as per standard procedures. Total body exposure to 60
Samples of Fermi, Semple, modified Semple, Duck embryo and tissue culture rabies vaccine were inoculated by different routes and in different doses into rabbits, mice and hamsters. The vaccines induced neither detectable interferon nor immediate protection against lethal challenge with CVS rabies virus.Under similar conditions, high but transient levels of interferon were induced in control animals of the same species with the polynucleotide complex Poly I.C. Hamsters but not mice were protected by Poly I.C.-induced interferon.No autointerference by vaccine with challenge virus was established. Vaccine-induced protection in mice was directly related to immune response.