Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer
The engineered Salmonella typhimurium ΔppGpp (S.t ΔppGpp) has been studied in terms of its ability to carry imaging probes (bacterial luciferase, Lux) for tumor imaging or carry therapeutic molecules (Cytolysin A) to kill cancer cells. To establish a novel cancer therapy, bacterial therapy was combined with radiotherapy using the attenuated strain S.t ΔppGpp/pBAD-ClyA. Radiotherapy (21Gy) contributed to S. typhimurium colonization in a colon tumor (CT26) model of BALB/c mice. The combination of bacterial therapy and radiotherapy treatments reduced tumor growth compared with only bacterial therapy.
A sensitivity simulation of neutron tomography was performed for the analysis of the spatial distribution of nuclear materials in the HANARO fuel rod. The internal distribution of the nuclear materials in the fuel rod is very important for the increase of the safety and economics of fuel burnup in the reactor. The neutron radiography facility installed at HANARO will be used for the spatial fuel analysis with a real-time image processing system. Monte Carlo simulation was performed to study the feasibility and sensitivity of the HANARO neutron beam for the spatial fuel assay and to find the optimum conditions for neutron detection. From the sensitivity simulation, the location of the nuclear materials in the rod was evident as expected.