Frankincense hunt threatens leopards
The habitat of one of the world's rarest and most elusive big cats is shrinking fast, with the latest pressure coming from frankincense collectors. Only around 200 critically endangered Arabian leopards remain in the wild, mainly in Oman. A small but thriving population there is now being squeezed out by humans, camera trap photos suggest. They have seen leopards moving away from areas where they used to be, says Hadi Al Hikmani, a wildlife biologist at the Office for Conservation of the Environment in Oman.
OBJECTIVE To study the effect of solvents on the permeation of leflunomide in excised mouse skin. METHODS Modified Franz-diffusion cell adopted as apparatus for in vitro skin permeation, excised mouse skin as permeation barrier and permeability as index, the concentration of leflunomide in the samples was measured by HPLC. RESULTS Ethanol has enhancement effect on the permeability of leflunomide, propylene glycol and lower concentration DMI have little effect on the permeability of leflunomide. CONCLUSIONS These solvents can be used in the skin local preparations of leflunomide.