An analysis of the ABO blood group clines in Europe
With estimates of the fitnesses of the genotypes and selection by incompatibility for the ABO locus which seem reasonable given the state of knowledge, a computer model has been developed to replicate the clines of the A and B genes in Europe. With a fitness change in the BB and BO genotypes of as little as 0.5%, the differences in the frequencies in East and West Europe can be maintained at equilibrium. Appreciable changes in the amount of migration does not affect the equilibrium frequencies in the two areas significantly, while with no selection through incompatibility the equilibrium frequencies were changed about 5%.
e18521Background: Acute Promyelocytic Leukemia (APL), a subtype of acute myeloid leukemia, has excellent outcomes, but continues to show high rates of early mortality. An epidemiologic study utiliz...