is heterochromatin used for recombination
Moreover, Ccq1 has been implicated in the inhibition of recombination at telomeres (19, 20). Similar to taz1 δ and ccq1 δ cells, poz1 δ cells are also defective in transcriptional silencing of a marker gene inserted near telomeres, indicative of a failure in proper heterochromatin formation (35).
Hydrogen-deuterium exchange mass spectrometry has been used to study proteins and their conformations for over 20 years. This type of protein structural analysis can be suitable for proteins that are challenging for other structural methods.e novo peptide sequencing for mass spectrometry is typically performed without prior knowledge of the amino acid sequence. It is the process of assigning amino acids from peptide fragment masses of a protein. De novo sequencing has proven successful for confirming and expanding upon results from database searches.