Applications of a monomeric orthopalladate complex containing mixed phosphorus–nitrogen donors in the Heck reaction
Abstract The [Pd{C 6 H 2 (CH 2 CH 2 NH 2 )-(OMe) 2 ,3,4}Br(PPh 3 )] monomeric orthopalladate complex of homoveratrylamine and triphenylphosphine was synthesized and its application in Heck coupling reactions was investigated. This complex had been demonstrated to be more active than the corresponding dimeric catalyst for Heck reactions of aryl iodides, bromides and even chlorides and also arenesulfonyl chlorides. The cross-coupled products were produced in excellent yields using catalytic amounts of [Pd{C 6 H 2 (CH 2 CH 2 NH 2 )-(OMe) 2 ,3,4}Br(PPh 3 )] as a thermally stable and oxygen insensitive complex in NMP at 130 °C.
Abstract : We are interested in studying the muscarinic acetylcholine receptor. Our work will involve molecular modeling of muscarinic agonists and antagonists to determine their bioactive conformations. From the modeled ligands we hope to derive a pharmacophoric pattern common to the ligands. This pharmacophoric pattern will enable a topography of the muscarinic receptor to be derived which will facilitate the design of novel agonists and antagonists. The work will concentrate on the design of new antagonists which could be synthesized and tested by army collaborators. These antagonists we hope will prove to be new antidotes for organophosphate poisons. Keywords: Molecular structure; Molecule molecule interactions; Synthesis (Chemistry); Computer programs.