Design and synthesis of a novel antitumor reagent XK469 derivatives
OBJECTIVE To design and synthesize a novel quinoxaline derivative as antitumor reagent.ME- THODS Using 2,7-dichloroquinoxaline and 2,4-pyridinediol as material,introducing a pyridine to the new quinox- aline derivatives.RESULTS The structures of the target molecules were characterized by elemental analysis,~1HNMR,MS,and IR.CONCLUSION A novel potential anfitumor reagent was synthesized and it can be a good representation of the knowing antitumor reagent XK469.
Background ::: Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic disease models determination of the presence of metastatic disease, metastatic burden, and response to therapy are difficult, often requiring serial necropsy. In this study we characterized the development of visceral metastases in a patient derived xenograft model (PDXM) using in vivo imaging.