Indirect chemical conjugates hyaluronate obtained by forming or antitumor bio complex of its derivative, and their use in the pharmaceutical field
The present invention, hyaluronic acid and / or novel bioconjugates group which can be obtained by indirect synthesis means by molecular spacer between the agent having anti-tumor activity belonging to the derivatives with various groups, methods for their preparation , and it discloses the use in oncology. The novel derivatives have a variety of physicochemical properties for binding type and degree of substitution, by the characteristic, is their resistance and effectiveness improved, more accurate dosage adjustment, active target induction mechanisms It becomes available is. .BACKGROUND
In this study muon-spin rotation (μSR) serves as a tool for sensitive monitoring of the environment of muoniated radicals in isotropic liquids. A systematic investigation of the behaviour of the hyperfine coupling constants of cyclohexadienyl-type radicals is performed, and it is found that they are in linear dependence on solvent polarity, with certain deviations. These deviations are discussed in detail. It is found that with increasing length of the hydroxyalkyl substituent group the perturbation of the phenyl ring becomes smaller.