The Embryonic Mouse Hindbrain and Postnatal Retina as In Vivo Models to Study Angiogenesis
Angiogenesis, the growth of new blood vessels from preexisting ones, is a fundamental process for organ development, exercise-induced muscle growth, and wound healing, but is also associated with different diseases such as cancer and neovascular eye disease. Accordingly, elucidating the molecular and cellular mechanisms of angiogenesis has the potential to identify new therapeutic targets to stimulate new vessel formation in ischemic tissues or inhibit pathological vessel growth in disease. This chapter describes the mouse embryo hindbrain and postnatal retina as models to study physiological angiogenesis and provides detailed protocols for tissue dissection, sample staining, and analysis.
EUROPEAN SCIENCEVIENNA-- Founded in 1985, the Institute of Molecular Pathology (IMP) has put Vienna on the biomedical research map, exemplifying the promise of Austria's scientific rehabilitation. IMP's 13 research groups--which boast 120 scientific staff members from 25 nations--have done groundbreaking work in such areas as chromatid separation in yeast and cell adhesion in cancer. And more expansion is in the works.