Fluorinated analogues of lipidic dialkynylcarbinol pharmacophores: synthesis and cytotoxicity in HCT116 cancer cells
Lipidic alkynylcarbinols (LACs) have been identified as potential antitumor compounds, and a thorough understanding of their pharmacophoric environment is now required to elucidate their biological mode of action. In the dialkynylcarbinol (DAC) series, a specific study of the pharmacophore potential has been undertaken by focusing on the synthesis of three fluorinated derivatives followed by their biological evaluation. This work highlights the requirement of an electron-rich secondary carbinol center as a key structure for cytotoxicity in HCT116 cells.
The trianion of C60 reacts readily with the ::: commonly used electrochemical solvent dichloromethane to form ::: methanofullerenes of the type ::: C60>(CH2)n, signaling a ::: cautionary warning against the use of this solvent for electrochemical ::: studies of fullerenes and opening up a new synthetic avenue for these ::: adducts.