Limited sampling model for the estimation of pharmacokinetic parameters in children.
Summary:A limited sampling model (LSM) is proposed for the first-time assessment of pharmacokinetic parameters (area under the concentration–time curve (AUC), Cmax, and T½) in children after a single oral dose of drug. Three drugs were evaluated in this study. The LSM was developed for each drug fro
This paper presents an extension of Petri net framework with imprecise temporal properties. We use possibility theory to represent imprecise time by time-stamping tokens and assigning durations to firing of the transitions. A method for approximation of an arbitrary temporal distribution with a set of possibilistic intervals is used to introduce the composition operation for two possibilistic temporal distributions. We developed a method to determining an effective enabling time of a transition with incoming tokens with possibilistic distributions. The utility of the proposed theory is illustrated using an example of an automated manufacturing system. The proposed approach is novel and has a broad utility beyond a timed Petri network and its applications.