Kinetic studies on the aminolysis of O-(2,4-dinitrophenyl)-cyclopentanone oxime in benzene
The reaction of O-(2,4-dinitrophenyl) cyclopentanone oxime with four primary alkylamines and a secondary arylamine, pyrrolidine, in benzene has been investigated. In pyrrolidinolysis, a third order dependence on [amine] has been observed, which has been explained on the basis of a cyclic transition state. The aminolysis with primary alkyl amines shows a normal dependence of second order on [amine].
Objective To design and synthesis novel triazole antifungal derivatives and study the antifungal activity.Methods All the target compounds were prepared from 1,3- difluorobenzene via click reaction;The antibacterial activities of the title compounds were determined with broth dilution method.Results Twelve compounds were synthesized and characterized by 1H NMR and MS.All the title compounds exhibited potent antifungal activities against nearly all fungi tested.Conclusion The electronic effects of the substituents affected the activity of compounds,specifically the electron- donating groups.