Pharmaceutical contribution to the non specific challenge in bronchial provocation tests
Aerosols of methacholine chloride are used in inhalation tests to measure non-specific bronchial responsiveness. Inhalation challenge solutions are not commercially available neither by pharmaceutical industry nor in France by the PCH-APHP. To reply to doctor's request, dilute concentrations of methacholine must be prepared properly in order to protect the patient and to assure doctor of test reproductibility. Osmolarity, pH and degradation of different dilute concentration of methacholine chloride have been compared with two diluents. This study allowed us to validate our preparation of solutions.
The standards for testing quinoline insoluble(QI) content were developed by ISO,ASTM,our national and export standard departments.The differences and the gaps of the above standards were studied and analyzed in this article,and the research situation of the method of quinoline insoluble was discussed as well.Finaly,the opinions and suggestions of our national standard to integrate with the international standards were put forward.