is candesartan a vasodilator
In SHR treated with candesartan (MAP=146 mm Hg) or hydralazine (16 mg/kg per day; MAP=145 mm Hg), AT 2 R-induced contraction was reduced by 50%. In SHR treated with perindopril (MAP=125 mm Hg), AT 2 R stimulation induced vasodilation.n this case, stimulation of AT 2 R induced vasodilation. A further decrease in MAP, with the use of a higher dose of hydralazine or candesartan plus hydralazine, was also associated with a vasodilator effect of AT 2 R stimulation.
Candesartan (rINN) /ËkaendÉ¨ËsÉrtÉn/ ËkÃ¦ndÉ¨ËsÉrtÉn is an ANGIOTENSIN ii receptor antagonist used mainly for the treatment of. hypertensionuring the first two years of the trial, half of participants were given candesartan, and the others received placebo; candesartan reduced the risk of developing hypertension by nearly two-thirds during this period. In the last two years of the study, all participants were switched to placebo.