Infiltration of 3D printed tricalciumphosphate scaffolds with biodegradable polymers and biomolecules for local drug delivery
D printing is well suited and the most impor- tant technique to produce scaffolds with a reproducible complex internal structure directly from powder materials based on tricalciumphosphates (TCP) for the reconstruc- tion of bone defects. In this study, we could show success- ful infiltration of fabricated TCP scaffolds with biode- gradable polymers and a model biomolecule in order to provide the structure with a sustained drug release func- tion.
Abstract Phosphoinositide 3-kinase alpha (PI3Kα) has proved to be an attractive target for the development of therapeutics for the treatment of cancer. Herein we report a successful application of the structure-based virtual screening to identify the novel inhibitors of PI3Kα. These inhibitors have desirable physicochemical properties as a drug candidate and reveal a moderate potency with IC 50 values ranging from 20 to 40 μM. Therefore, they deserve a consideration for further development by structure–activity relationship (SAR) studies to optimize the inhibitory activities. Structural features relevant to the stabilization of the newly identified inhibitors in the ATP-binding site of PI3Kα are addressed in detail.