Human hair keratin-associated proteins (KAPs).
Elucidation of the genes encoding structural proteins of the human hair follicle has advanced rapidly during the last decade, complementing nearly three previous decades of research on this subject in other species. Primary among these advances was both the characterization of human hair keratins, as well as the hair keratin associated proteins (KAPs). This review describes the currently known human KAP families, their genomic organization, and their characteristics of expression. Furthermore, this report delves into further aspects, such as polymorphic variations in human KAP genes, the role that KAP proteins might play in hereditary hair diseases, as well as their modulation in several different transgenic mouse models displaying hair abnormalities.
Abstract : As the Army downsizes over the next five years, it is imperative to establish and enduring system to meet the transition needs of our soldiers. The Army has initiated the Army Career and Alumni Program (ACAP) which is a comprehensive transition program for soldiers separating from the service both voluntarily and involuntarily. This study does a review of the background of the program to include the significance of the FY 1990 Veteran's Benefit Amendment package for soldiers involuntarily separated after 30 September 1990. The study examines the need for ACAP and lessons learned from transition programs from a historical perspective during World War I and II, Korea and Vietnam. The ACAP program design, functions, and organization are discussed in detail. The study provides observations and conclusions about the potential of the program. Recommendations are furnished that may assist the ACAP.