Natural Cytotoxicity and Allograft Rejection
This book describes the role of natural cytotoxicity in health and disease. As virtually every aspect of natural cytotoxicity is covered by other contributors, we will limit ourselves strictly to the role of natural cytotoxicity and natural killer cells in the rejection of parenchymal organ allografts.
Background ::: Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic disease models determination of the presence of metastatic disease, metastatic burden, and response to therapy are difficult, often requiring serial necropsy. In this study we characterized the development of visceral metastases in a patient derived xenograft model (PDXM) using in vivo imaging.