[Toxicologic and pharmacologic study of tributyltin oxide (TBTO)].
Toxicological study on bis-(tributyl-tin) oxyde shows a delayed toxicity of this compound in acute experiments. The same result is obtained in sub-chronic study. Most of the animals die after a great loss of weight. In pharmacological study, T. B. T. O. depresses central nervous system, but his action on ortho and parasympathetic system is slight and non specific. In rat, rabbit and dog, the effect is a fall in blood pressure that result from a depression of the vascular smooth muscle. The death of the animal is due to respiratory arrest by a central mechanism.
This paper presents application of sustainable tourism practices by leading tour operators in international ecotourism supply chains. Observations of actions implemented by the inbound and outbound operators creating the ecotourism experience are drawn from two case studies – one of trips to Peru and the other of trips to Nepal-Bhutan - both available on the Swedish market. The cases explore how sustainable tourism measures promoted by the outbound tour operator (OTO)are disseminated to, and endorsed by the inbound tour operators (ITOs) in destinations. The methodology used included participant observation as part of groups, complemented by field notes and data from extensive interviews with the operators’ ground staff, tour guides and management. Presentation of case studies supports a discussion on the role of ecotourism supply chains for the dissemination of a culture of corporate responsibility and for sustainable tourism practices in general. (Less)