Study Probes Burkitt Lymphoma-Malaria Link
Burkitt lymphoma is unusually common in parts of Africa where malaria is widespread, but the reason for the association has been unclear. A new study suggests that parasitic infection triggers dramatic B-cell proliferation and increased expression of the enzyme activation-induced cytidine deaminase, which generates more potent antibodies-and causes mutations that lead to cancer.
Correction to: British Journal of Cancer (2004) 91, 725–731. doi:10.1038/sj.bjc.6602041 With reference to the above article published in the British Journal of Cancer, the authors wish to make the following statement: Although one of us participated in the work that resulted in the first publicationabout kallikrein 6/protease M, we were not physically involved in the first cloning of kallikrein 6 cDNA.