Alterations of inositol phosphate turnover in striatum of aged rats.
Age-related inositol phosphate turnover in the rat central nervous system was investigated. Higher phospholipase-C activity and drastically higher (almost 2.5-fold) inositol 1,4,5-trisphosphate concentration in the corpus striatum (caudate-putamen) of extremely old (approximately 40 months) female Wistar rats in comparison to the young adult (approximately 3.5 months) rats were observed. Dopamine seems to slightly inhibit total inositol phosphate formation and this effect was antagonized by (-)-sulpiride.
This article is the second of two parts. The first one was published in the issue no 2 of this same journal. The preseni study uses the dependency index and the youth ratio to describe the aging process both at regional and municipal levels. Our data show a yet moderate aging process in (he region. with an uneven distribution throughout the different municipalities.