In vivo neutralization of tetrodotoxin by a monoclonal antibody.
This study examined the ability of monoclonal antibody against TTX to neutralize tetrodotoxin (TTX) in vivo. The mice were injected i.p. with 1.5 mouse units of TTX, followed 3 min later by administering graded doses of antibody immunoglobulin G (IgG). Animals injected with 100 micrograms IgG through the tail vein showed 100% survival. The 50% protective dose was c. 2 mg/kg. The present results indicate that monoclonal antibody can neutralize TTX in vivo.
ELECTRONIC COMPONENTS MATERIALS (China), Vol 19, No 3, P 5 6 (Jun 2000) In Chinese In conventional formula, SrTiO 3 is prepared by solid phase reaction and MnO 2 is used as acceptor. To lower the varistor voltage, SrTiO 3 prepared by oxalate decomposition and acceptor of Li 2CO 3 are adopted instead of the formers respectively. The experiment results show that varistor voltage is effectively lowered, and dielectric properties improved also. (6 refs.)