BRCA2 Phosphorylated by PLK1 Moves to the Midbody to Regulate Cytokinesis Mediated by Nonmuscle Myosin IIC
This study suggests that BRCA2 may prevent cancer in part by enforcing checkpoint controls on cytokinesis, the last step in mitosis, where it may be possible to prevent aneuploidy and multinucleation leading to cancer.
Summary The influence on the blood cholesterol level and on cholesterol biosynthesis ([ 14 C] acetate incorporation) in the liver, small intestine and blood was investigated in rats after daily oral treatment with nicotinic acid, methyltestosterone and an anabolic steroid, PS-179, for one week. Plasma cholesterol levels were significantly decreased with PS-179, but not with nicotinic acid or methyltestosterone. None of the drugs altered the cholesterol levels in the liver and intestine. All drugs produced a significant decrease in the incorporation time of labelled cholesterol into liver and a significant increase in the intestine. Total cholesterol biosynthesis in liver and intestine were not altered with any of these drugs.