Relative bioavailability of acetazolamide tablets
Plasma acetazolamide concentrations were determined enzymatically after administration of three tablet dosage forms and a reference solution to 12 human subjects in a crossover study. Two of the tablet products represented different lots from the same manufacturer. There were no significant differences in area under the plasma level-time curves among the four treatments. However, significant differences were found among tablets in terms of peak plasma concentration and time to reach peak concentration. These apparent differences in rate of absorption were correlated with in vitro dissolution data obtained in pH 1.5 dissolution medium.
4 analogs of naturally occurring gallotannins have been synthesized upon acylation of sucrose by 2, 3, 6 and 8 galloyl groups. In a simple test using the DPPH radical, the antioxidant activity of such esters appears proportional to the number of the galloyl units. ::: ::: Sucrose derivatives bearing 2, 3, 6 and 8 galloyl groups have been synthesized and tested for antioxidant activity. ::: Download full-size image