Leucotrienes, SRS-A and the vascular manifestations of PCA
In order to study possible mediators of the vascular manifestations of passive cutaneous anaphylaxis (PCA), several arachidonic acid metabolites were injected into guinea-pig skin. SRS-A, LTB4, LTC and LTD increased vascular permeability, responses to LTs being enhanced by PGE2. Mepyramine inhibited responses to histamine, but not those to SRS-A and LTs: the latter were inhibited by the SRS-A antagonist FPL-55712. Both mepyramine and FPL-55712 exert limited inhibitory effects on vascular permeability during PCA. Leukotrienes may contribute towards vascular permeability during PCA.
Dear Sir, ::: ::: We read with interest the report by Geyshis et al.1 The authors have elegantly highlighted the occasionally competing therapeutic priorities of physicians of different specialties. Nonetheless, we consider it important to add that a therapeutic dilemma as the one described by the authors can sometimes be circumvented. ::: ::: Central serous chorioretinopathy (CSC) is most often associated with increased cortisol levels, so that the most important therapeutic step taken by ophthalmologists is the discontinuation of topical or systemic steroids the patient might be using. The pathophysiology of …