Localization of Antimony in Blood
SummaryLabeled fuadin prepared from neutron irradiated antimony trioxide has been used in a study of the localization of antimony in the red cell fraction of rat blood. The results are consistent with the hypothesis that the antimony is attached to the globin portion of hemoglobin.
Background: Fanconi Aneamia is a rare genomic instability inherited syndrome. Allo-BMT for life-threatening aplastic aneamia is associated to acute toxicity and secondary tumours. Gene therapy is an attractive alternative while obstacles need to be overcome: (i) the scarcity of BM-stem cells; (ii) their flimsiness (iii) gene transfer technical limitations.