The Development of Environmentally Friendly Micro-Emulsion Cutting Fluid
A type of new environmentally friendly water base micro-emulsion cutting fluid was developed with nontoxic or low-toxic additives by studying the combinations of base oil,corrosive inhibitors,surfactants,oiliness agent,extreme pressure anti-wear agent,and other agents.Its anti-wear and friction-reducing properties,anti-rust ability and biodegradability were evaluated.The results showed that the cutting fluid possesses excellent rust-inhibiting property,corrosion resistance,lubricity and other comprehensive properties.The biodegradability test showed that the cutting fluid has excellent biodegradability as well as low eco-toxicity,and it is a perfect environmentally friendly cutting fluid.
OBJECTIVE To study the effect of solvents on the permeation of leflunomide in excised mouse skin. METHODS Modified Franz-diffusion cell adopted as apparatus for in vitro skin permeation, excised mouse skin as permeation barrier and permeability as index, the concentration of leflunomide in the samples was measured by HPLC. RESULTS Ethanol has enhancement effect on the permeability of leflunomide, propylene glycol and lower concentration DMI have little effect on the permeability of leflunomide. CONCLUSIONS These solvents can be used in the skin local preparations of leflunomide.