TFE3-positive renal cell carcinoma occurring in three children with dysfunctional kidneys on immunosuppression
Pediatric RCC is a rare pediatric neoplasm and is distinctly different compared to adult RCC, often demonstrating translocation morphology evidenced by unique histopathological features and TFE3 or TFEB nuclear expression. We report three cases of pediatric TFE3 positive RCC (TFE3-RCC) occurring in the setting of chronic kidney disease and long-term pharmacological immunosuppression, including two cases that developed in the native kidney following kidney transplantation. Together, these cases suggest that the kidney microenvironment in combination with immune dysregulation is likely contributing factors in the pathogenesis of some pediatric RCC, warranting further study. Long-term post-transplant surveillance may warrant screening for RCC.
Abstract The addition products of Ti(IV)-enolate derived from β-keto α-diazo carbonyl compound to ketones or α,β-unsaturated compounds were subjected to Rh 2 (OAc) 4 -catalyzed and photo-induced diazo decomposition. The Rh 2 (OAc) 4 -catalyzed reaction afforded intramolecular O–H insertion products, while the photo-induced reaction gave Wolff rearrangement/intramolecular nucleophilic addition products. The transformations represent new approaches to tetrahydrofuran and γ-butyrolactone derivatives.