CAD Tools for the Design of High Performance MCMs
Advantages of using high speed and thermal analysis tools in a tightly integrated design environment are presented. The time to market, the quality of advanced technology designs, and the often assumed reliability of a product are all becoming the responsibility of the layout engineer. To ensure the success of the end‐product the designer must have available tightly integrated product design tools. They must reliably predict potential problems, such as transmission line delays, signal noise, device over‐heating etc., and therefore reduce multiple design iterations by producing designs that are correct first time.
Background ::: Spontaneously metastatic xenograft models of cancer are infrequent and the few that exist are resource intensive. In xenografts, caliper measurements can be used to determine primary tumor burden and response to therapy but in metastatic disease models determination of the presence of metastatic disease, metastatic burden, and response to therapy are difficult, often requiring serial necropsy. In this study we characterized the development of visceral metastases in a patient derived xenograft model (PDXM) using in vivo imaging.