Temporally and Regionally Disparate Differences in Plasmin Activity by Tranexamic Acid
Background ::: A major complication associated with cardiac surgery is excessive and prolonged bleeding in the perioperative period. Improving coagulation by inhibiting fibrinolysis, primarily through inhibition of plasmin activity (PLact) with antifibrinolytics such as tranexamic acid (TXA) has been a pharmacological mainstay in cardiac surgical patients. Despite its almost ubiquitous use, the temporal and regional modulation of PLact profiles by TXA remain unexplored. Accordingly, the present study developed a fluorogenic-microdialysis system to measure in-vivo dynamic changes in PLact following TXA administration in a large animal model.
OBJECTIVE:To establish the quality control standard of Xuebao Capsules. METHODS:Applying the technique of TLC to identify the main ingredients Fructus Psoraleae , Radix Polygoni multiflori prepared, Pericarpium Citri reticulatae, Radix Ginseng, Radix Astragali by using chemical reference substance or reference crude drug.RESULTS: Fructus Psoraleae, Radix Polygoni multiflori prepared, Pericarpium Citri reticulatae , Radix Ginseng , Radix Astragali could be detected by TLC.CONCLUSION:The methods were practical, special and reproducible.