What did da Vinci advise when your experience contradicted authority?
In the late renaissance various writers began to question the medieval and classical understanding of knowledge acquisition in a more fundamental way. In political and historical writing Niccolò Machiavelli and his friend Francesco Guicciardini initiated a new realistic style of writing. Machiavelli in particular was scornful of writers on politics who judged everything in comparison to mental ideals and demanded that people should study the "effectual truth" instead. Their contemporary, Leonardo da Vinci (1452–1519) said, "If you find from your own experience that something is a fact and it contradicts what some authority has written down, then you must abandon the authority and base your reasoning on your own findings."
In 1974, Feynman delivered the Caltech commencement address on the topic of cargo cult science, which has the semblance of science, but is only pseudoscience due to a lack of "a kind of scientific integrity, a principle of scientific thought that corresponds to a kind of utter honesty" on the part of the scientist. He instructed the graduating class that "The first principle is that you must not fool yourself—and you are the easiest person to fool. So you have to be very careful about that. After you've not fooled yourself, it's easy not to fool other scientists. You just have to be honest in a conventional way after that."