Partial Protection of Carbohydrate Derivatives. Part 27.1 Further Improvement in the Protecting Procedure for Oligonucleotide Synthesis in Terms of a Cellulose Acetate Derivative as a Polymer-Support
Abstract Utilization of a (3-carboxy)propionyl spacer for the cellulose acetate polymer-support, a comparative study of 2-cyanoethyl and diphenylcarbamoyl protecting groups for the O 6-position of the guanosine unit, protecting groups for 1-β-D-ribofur-anosylthymine (rT) and pseudouridine (Ψ) is described in connection with the syntheses of oligoribonucleotides, i.e., a tridecamer, ApAp-GpGpApApApApUpUpApUpG, and a dodecamer, UpCpCpGpGprTp-ΨpGpApUpU.
This paper presents an inferential property prediction scheme for a high pressure polyethylene autoclave reactor. The development of a dynamic model of the process is described. It was derived from a consideration of the reaction mechanism and uses reaction temperatures, pressure and gas composition to predict the degree of polymerisation of the polymer. The values of certain key parameters in the model were derived from steady state data from the ICI Alkathenc plant at Botany Site. The model was shown to predict the degree of polymerisation during grade transition with an appropriate accuracy although it benefited from an on-line adaption scheme.