Demonstration of Aleutian Mink Disease Virus in Cell Culture
THE successful application of affinity chromatography to the isolation of Aleutian disease (AD) virus has provided an opportunity for characterization of the agent1. Although AD was described in 1958, the agent had remained incompletely defined and the various strains used by researchers uncharacterized2. Before the work reported here characterization of AD virus was difficult because the only available assay consisted of producing the disease in mink.
Author contributions ::: ::: GH helped design the study, establish the animal model, collect and analyze samples, and write the manuscript. YY and DH helped establish the animal model, performed Western blotting, immunohistochemistry analyses. YY and DH also helped analyse data and revise the manuscript. QYW and JK contributed to study planning, analyse and interpret data, review and revise the manuscript. All authors have approved the final version of this article to be published and agreed to be accountable for all aspects of the work in ensuring the questions related to the accuracy or integrity of any part of the work. ::: ::: ::: ::: Disclosure ::: ::: The authors report no conflicts of interest in this work.