Monuron metabolism in excised gossypium hirsutum leaves: Aryl hydroxylation and conjugation of 4-chlorophenylurea*
Abstract A new glycoside was isolated as a minor metabolite in excised cotton leaves treated with either [carbonyl-14C] or [ring-14C] 3-(4-chlorophenyl)-1-methylurea and 4-chlorophenylurea. The aglycone from β-glucosidase or hesperidinase hydrolysis was identified as 4-chloro-2-hydroxyphenylurea by TLC, radioisotope dilution and MS.
Background and Objective Chemotherapeutic drug treatment outcomes are genetically determined. Polymorphisms in genes encoding phase II drug metabolizing enzyme glutathione-S-transferase (GST) can possibly predict treatment outcomes, and can be of prognostic significance in breast cancer patients. The aim of this study was to determine the role of genetic variations in GST in predicting response to, and toxicity of, anthracycline-based chemotherapy in breast cancer patients. Method Two hundred and seven patients treated with anthracycline-based chemotherapy were genotyped for GSTM1 and GSTT1 deletion polymorphisms, and GSTP1 Ile 105 Val (rs1695), by polymerase chain reaction (PCR)/