The structure and chemistry of leucodrin
A novel oxidation procedure for cleaving glycol groups has been applied to leucodrin aryl methyl ether, to yield norleucodrinic acid aryl methyl ether. The study of derivatives of this product allows the derivation of the structure of leucodrin; the stability of the nor-derivative towards alkaline hydrogen peroxide is demonstrated. The cleavage of an intermediate α-keto-acid with periodic acid is substantiated.
Related Article: Qing-Zhu Zeng, Jian Ouyang, Shuo Zhang, Lei Zhang|2017|Eur.J.Pharm.Sci.|102|140|doi:10.1016/j.ejps.2017.02.035