Expression and significance of p53 protein inbladder transitional cell cancer
Objective:To study the relationship between the expression of p53 protein and biologic behavior and prognosis of bladder transitional cell cancer.Methods:Using immunohistochemistry labelled straptavidin biotin (LSAB) method,the p53 protein was examined in 50 cases of bladder transitional cell cancer.Results:No p53 protein was expressed in the 6 normal bladder tissue samples.The positive rate of p53 protein expression in the 50 cases of bladder transitional cell cancer was 64%.The expression of p53 protein correlated with tumor histological grade,clinical stage,recurrent rates and patient survival after operation.Conclusion:Examination of p53 protein expression is valuable in understanding the degree of malignancy,and evaluating prognosis of bladder transitional cell cancer.
Introduction Procedures and Techniques Approaches to the Interpretation of Transabdominal Fine-Needle Aspiration Biopsy The Liver The Pancreas Mass Lesions of the Kidney Primary Lesions of the Adrenal Gland Primary Retroperitoneal Mass Lesions Gynecologic Tumors Intraperitoneal Masses Malignant Lymphomas Immunomarkers for Transabdominal Aspiration Biopsy.