The relationship between angiotensin-converting enzyme gene polymorphism and essential hypertension in Chongqing
Objective :To study the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with essential hypertension in Chongqing. Methods:We use polymerase chain reaction (PCR) method to amplify sixteenth intron of ACE gene to analyse 114 healthy controls and 75 patients with essential hypertension. Polymorphism was characterized by three genotypes: homozygous alleles DD, II, and heterozygous alleles ID. Results:The frequency of homozygous alleles DD and the frequency of deletion alleles were significantly higher in the essential hypertension group than in the healthy controls (P0.005). Conclusion:The results indicate that a deletion polymorphism of ACE gene is associated with essential hypertension in Chongqing.
People with long-QT syndrome (LQTS), a genetic disease associated with elevated risk for sudden death, often receive prophylactic beta-blocker therapy.