Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators.
Abstract The optimization of a series of nonsteroidal glucocorticoid modulators is reported. Potent selective GR ligands that have improved metabolic stability were discovered typified by the subnanomolar acid 12 (GR binding IC 50 = 0.6 nM).
A computational study on the supersonic flow around the lateral jet controlled missile has been performed. For this purpose a three dimensional Navier-Stokes computer code(AADL3D) has been developed and case studies have been performed by comparing the normal force coefficient and the moment coefficient of a missile body for several parameters such as angles of attack, circumferential jet positions, and spouting jet angles. Missile surface is divided into four regions with respect to the center of gravity, and the normal force and moment distribution at each region are compared. The results show different behavior of the normal force and moment variation according to each parameter. Furthermore, it is shown that the pitching moment can be minimized through proper combination of each parameter.