Decreased energy demanding processes in the frontal lobes of schizophrenics due to neuroleptics? A 31P-magneto-resonance spectroscopic study
Abstract In the present investigation on 31 P-magneto-resonance spectroscopic parameters in the frontal lobe, we found phosphocreatine levels and the ratio phosphocreatine/adenosine triphosphate to be increased (12.62±1.98% resp. 0.31±0.06) in 50 neuroleptic-treated schizophrenics, whereas no differences were detected in 10 neuroleptic-free patients (11.66±2.57% resp. 0.29±0.08) compared to 36 controls (11.37±1.45 resp. 0.29±0.04). This result points to a major role of neuroleptics in the metabolism of high-energy phosphates.
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