Intracranial aneurysms: links among inflammation, hemodynamics and vascular remodeling.
Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key pathologic component of various vascular diseases, including abdominal aortic aneurysms, brain arteriovenous malformations and atherosclerosis. Based on findings from observational studies that analysed human intracranial aneurysms and experimental studies that utilized animal models, an emerging concept suggests that a key component of the pathophysiology of intracranial aneurysms is sustained abnormal vascular remodeling coupled with inflammation. This concept may provide a new treatment strategy to utilize agents to inhibit inflammation or cytokines produced by inflammatory cells such as matrix metalloproteinases. Such an approach would aim to stabilize these vascular lesions and prevent future expansion or rupture.
Objective To study the effects of hyperglycemia on structure of sural nerve.Methods Diabetic rats induced by streptozotocin were killed after twelve weeks.The morphometric quantitative analysis and ultrastructure of sural nerve were performed.Results Compared with normal controls the nerve transactional area and fiber size was markedly reduced.The “splitting” mylin phenominomen was more common in diabetic rats.A large amount of agranular vesicle can be found easily in axon.Conclusion Hyperglycemia can induce significant morphology abnormalities of sural nerve.