The effect of dipicolinic acid on maize tissue culture growth is not solely due to inhibition of lysine biosynthesis
Dipicolinic acid, a known inhibitor of an enzyme (dihydrodipicolinic acid reductase) in the maize (Zea mays L.) lysine biosynthetic pathway, inhibits the growth of maize suspension and callus cultures. Inhibited cultures contain somewhat lower free lysine levels, but the inhibition of suspension culture growth was not reversible with simultaneous addition of L-lysine to the culture medium. It is concluded that dipicolinic acid does not act solely as an analog blocking lysine production. Dipicolinic acid thus appears to be unsuitable as a selection for maize tissue culture mutants with lysine overproduction.
The present study deals with the synthesis and evaluation of antibacterial activity of various quinolino substituted benzimidazole derivatives coupled with different amines. The derivatives were synthesized in moderate to good yields. The structural characterizations were performed based on their analytical data and IR, 1H NMR & Mass spectral studies. All the compounds were subjected for antibacterial screening, among them 4a and 4e showed good activity against the organisms used. The antibacterial activity studies suggested that these derivatives may be developed further to prove useful in future drug development.