Potent orally active inhibitors of angiotensin-converting enzyme (ACE).
1-[3-Mercaptoalkanoyl] pyroglutamic acids and 1-[3-mercaptoalkanoyl]-4-hetero (oxa, thia and aza) pyroglutamic acids were prepared and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined. (2S)-1-[(2S)-3-Mercapto-2-methylpropanoyl] pyroglutamic acid 2 was found to be the most potent orally active inhibitor of ACE of rabbit lung among the derivatives synthesized in the present study and appeared to have great potential for use as an oral antihypertensive agent.
Abstract A laser–diode-pumped passively Q-switched new type crystal Nd 3+ :NaY(WO 4 ) 2 (known as Nd:NYW) laser with GaAs semiconductor saturable absorber has been realized. The dependence of pulse repetition rate, pulse energy, pulse width, and peak power on pump power for different output coupler reflectivities are measured. The coupled rate equations are used to simulate the Q-switched process of laser, and the numerical solutions agree with the experimental results.