Synthesis and antifungal activities of new triazole compounds
Objective To design and synthesis novel triazole antifungal derivatives and study the antifungal activity.Methods All the target compounds were prepared from 1,3- difluorobenzene via click reaction;The antibacterial activities of the title compounds were determined with broth dilution method.Results Twelve compounds were synthesized and characterized by 1H NMR and MS.All the title compounds exhibited potent antifungal activities against nearly all fungi tested.Conclusion The electronic effects of the substituents affected the activity of compounds,specifically the electron- donating groups.
Abstract The crystal structure of [Ni(Hbim)3](nPr4N)•MeOH (1) (Hbim− =mono- deprotonated 2,2′-biimidazolate and nPr4N+ = tetra-n-propyl-ammonium cation) has been determined. The structure was consists of Ni(II) centers hexacoordinated by three 2,2′-biimidazolate (Hbim−) ligands in an octahedral arrangement. Complex 1 possesses an intermolecular hydrogen bonding structure of zigzag one-dimensional chains in which two of the three Hbim− ligands connect the metal complex units.