Effect of ultra violet irradiation on low voltage cable insulation
To connect the low voltage (1.1 kV rating) underground XLPE and PVC insulated power cables with the overhead distribution network, short lengths of the core insulation are used with their ends often exposed to the atmosphere. Such exposed insulation is reported to develop cracks and become brittle within a few months of installation. Experimental investigation with accelerated UV irradiation in the laboratory revealed significant aging effect on the mechanical properties of XLPE core insulation material. The aging process was found to be faster when the insulation material was under mechanical stress.
A series of novel coumarin-chalcone hybrids have been synthesized in good yields and evaluated for their in vitro & in vivo anticancer activity. Cytotoxicity study was done against MCF-7 and Zr-75-1 human cancer cell lines. All compounds exhibited significant antiproliferative properties on both cell lines. The most active ER modulators found in in vitro screening are subjected for in vivo screened using methyl nitrosourea (MNU) induced mammary carcinoma in female spraque dawley rats. The Glide XP docking was performed for designed scaffold to optimize its structural requirement for ER-α inhibition.