THE EFFECT OF CORTICOTROPIN AND CORTICOSTERONE ON THE PRODUCTION OF HEMOLYTIC ANTIBODIES IN THE MOUSE
It has been demonstrated by quantitative immunochemical methods that corticotropin, when administered at sufficiently high levels, will suppress the formation of circulating hemolytic antibodies in the mouse; this apparent block on the antibody producing mechanism can be overcome by increasing the dose of antigen. Furthermore, it has been shown that corticosterone, which appears in greater amounts in the blood of mice after treatment with corticotropin, will also suppress the normal rise of circulating immune hemolysins in the mouse.
This study was performed to examine the acute phase response in calves during dairy calf pneumonia. We measured acute phase proteins (App) and identified some potential markers useful for evaluation of calves’ health status. Sixty Holstein calves were selected in this study. After clinical examination, clinical findings were recorded from physical examination of individual. Two blood samples were taken from the calves. One of the sample had EDTA anti coagulant. Blood samples were used for CBC and serum biochemical analysis. The results of this study showed a significant increase in Hp and fibrinogen. Our results indicated the application of Haptoglobin and fibrinogen measurements as indicators of health in calf herds, thereby facilitating treatment decisions.