what causes migraine
Migraines may be caused by changes in the brainstem and its interactions with the trigeminal nerve, a major pain pathway. Imbalances in brain chemicals — including serotonin, which helps regulate pain in your nervous system — also may be involved. Researchers are still studying the role of serotonin in migraines.
Back to Top Causes. A migraine is caused by abnormal brain activity, which is triggered by stress, food, or something else. The exact chain of events is not known. However, it seems to involve various nerve pathways and chemicals in the brain. The changes affect blood flow in the brain and surrounding membranes.