Cell Proliferation Apoptosis and the Expression of Related Genes in the Developing Liver of Mouse
This study is to explore the dynamic trends of cell proliferation, apoptosis and expression of the significance of involved genes as P21 and Ki ras in developing livers of mouse. Lung tissues were taken from different developmental phases of kunming mouse. Immuno histochemistry and TUNEL techniques were adopted to observe the variation of cell proliferation and apoptosis and the expression of characteristics of P21 and Ki ras. Experiments show that cell proliferation is accompanied by apoptosis during the development of mouse livers. The dynamic changes of both ratios might be correlated to the different structures appearing in different developmental process.
A case of a malignant Brenner tumor of a postmenopausal woman presenting with vaginal bleedings is described. Clinical and laboratory findings demonstrated estrogenic secretory function and action. The presence of aromatase activity based on in vitro tumor microsomal metabolism of androgen to estrogen is described. Tumor cytosol contained progestin and androgen binding components in the absence of estrogen binding activity. Estrogen binding activity was undetectable both by biochemical as well as histochemical assays.