Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation
The last 5 years have been marked by profound innovation in the targeted treatment of chronic lymphocytic leukemia (CLL) and indolent lymphomas. Using CLL as a case study, we present a timeline and overview of the current treatment landscape for the radiologist, including an overview of clinical and radiological features of CLL, discussion of the targeted agents themselves, and the role of imaging in response and toxicity assessment. The goal is to familiarize the radiologist with multiple Food and Drug Administration (FDA)-approved targeted agents used in this setting and associated adverse events which are commonly observed in this patient population.
An overview status is given of the Lead Tungstate electromagnetic calorimeter which is being developped for the CMS detector at LHC. This includes the development status of PbW0 4 crystals, the mechanical design of the calorimeter, the read-out and a brief look into results from test measurements in particle beams.