Sc(OTf)3 as Efficient Catalyst for Aryl C-Glycoside Synthesis
s: Sc(OTf) 3 was found to be an efficient catalyst for the C-glycosylation of phenols. Reactions of various functionalized phenols and glycosyl acetates, including an azido-bearing one, are achieved by using a catalytic amount of Sc(OTf) 3 (10 mol % for neutral sugars or 50 mol% for an azido sugar) under mild conditions.
We have used IR spectroscopy to study the reaction between L-cysteine and dimethyl sulfoxide in aqueous medium. We have found that reaction occurs with formation of an insoluble product, which we have identified. We show that oxidation of L-cysteine by dimethyl sulfoxide can occur at an appreciable rate under mild conditions, with formation of L-cystine, dimethyl sulfide, and water.