By inhibiting IDO1 and decreasing kynurenine in tumor cells, epacadostat increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs).
ໂດຍ inhibiting IDO1 ແລະຫຼຸດລົງ kynurenine ໃນຈຸລັງ tumor, INCB024360 ເພີ່ມແລະຟື້ນຟູການຂະຫຍາຍຕົວແລະການກະຕຸ້ນຂອງຈຸລັງພູມຕ້ານທານຕ່າງໆ, ລວມທັງຈຸລັງ dendritic (DCs), ຈຸລັງ NK ແລະ T-lymphocytes, ເຊັ່ນດຽວກັນກັບການຜະລິດ interferon (IFN) ແລະການຫຼຸດຜ່ອນ ໃນຈຸລັງ T ການຄວບຄຸມທີ່ກ່ຽວຂ້ອງກັບ tumor (Tregs).