By inhibiting IDO1 and decreasing kynurenine in tumor cells, Epacadostat powder increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs).
ໂດຍ inhibiting IDO1 ແລະຫຼຸດລົງ kynurenine ໃນຈຸລັງ tumor, Epacadostat ຜົງເພີ່ມແລະຟື້ນຟູການຂະຫຍາຍຕົວແລະການກະຕຸ້ນຂອງຈຸລັງພູມຕ້ານທານຕ່າງໆ, ລວມທັງຈຸລັງ dendritic (DCs), ຈຸລັງ NK ແລະ T-lymphocytes, ເຊັ່ນດຽວກັນກັບການຜະລິດ interferon (IFN), ແລະ ການຫຼຸດລົງໃນການຄວບຄຸມຂອງ tumor ທີ່ກ່ຽວຂ້ອງກັບຈຸລັງ T (Tregs).