The reaction of the drug and physical dependence of the human body was first observed by Hollister and his collaborators in 1963 while they were studying the treatment of schizophrenic patients with diazepam.
ປະຕິກິລິຍາຂອງຢາເສບຕິດແລະການເພິ່ງພາອາໄສຂອງຮ່າງກາຍຂອງມະນຸດໄດ້ຖືກສັງເກດເຫັນຄັ້ງ ທໍາ ອິດໂດຍ Hollister ແລະຜູ້ຮ່ວມມືຂອງລາວໃນປີ 1963 ໃນຂະນະທີ່ພວກເຂົາ ກໍາ ລັງສຶກສາການປິ່ນປົວຄົນເຈັບທີ່ເປັນໂຣກ schizophrenic ດ້ວຍ diazepam.