1. A computer system including instructions recorded on a computer-readable medium and executable by at least one processor, the system comprising: a schedule manager configured to cause the at least one processor to determine a schedule of each of a plurality of manufacturing resources used to manufacture one or more items, relative to one or more time intervals, wherein the schedule manager includes an input handler configured to determine constraints related to the manufacturing resources and to the one or more items, a chromosome comparator configured to compare a plurality of schedule chromosomes, each schedule chromosome including a potential schedule of use of the manufacturing resources within the one or more time intervals in producing the one or more items, and configured to compare each of the plurality of schedule chromosomes relative to the constraints, to thereby output a selected subset of the plurality of schedule chromosomes; a chromosome combiner configured to combine schedule chromosomes of the selected subset of the plurality of schedule chromosomes to obtain a next generation of schedule chromosomes for output to the chromosome comparator and for subsequent comparison therewith of the next generation of schedule chromosomes with respect to the constraints, as part of an evolutionary loop of the plurality of schedule chromosomes between the chromosome comparator and the chromosome combiner; and a scheduler configured to monitor the evolutionary loop and to select a selected schedule chromosome therefrom for implementation of the schedule based thereon.