1. In a glucose sensing system comprising a glucose sensor configured for producing an output representative of glucose concentration in a host and processing circuitry configured to process the output, a method for processing data from the output, the method comprising: generating at least one data stream from the glucose sensor output; detecting a signal artifact comprising transient non-glucose dependent signal loss in the at least one data stream based at least in part on data stream content; and generating at least one estimated data stream or data stream portion to reduce or replace signal loss caused by the detected signal artifact.