1. A method for optimizing system output in production systems, comprising: separating, by a processor, one or more initial input variables into a plurality of output variables, the output variables including environmental variables and system response variables; building, using the processor, a nonparametric estimation that determines a relationship between one or more initial control variables and the system response variables; estimating a global input-output mapping function, using the determined relationship, and a range of the environmental variables; generating one or more optimal control variables from the initial control variables by maximizing the input-output mapping function and the range of the environmental variables; and incorporating one or more of the optimal control variables into a production system to increase production output of the production system.