1. A method for real-time model based vehicle structural anomaly detection, comprising: receiving a real-time measurement corresponding to a location on a vehicle structure during an operation of the vehicle; comparing the real-time measurement to expected operation data for the location to provide a modeling error signal; calculating a statistical significance of the modeling error signal to provide an error significance; determining a persistence of the error significance; and indicating a structural anomaly, if the persistence exceeds a persistence threshold value.