1. A system for providing optimized cardiac chamber synchronization to a patient during delivery of a cardiac pacing therapy, comprising: means for obtaining an LVEDV value, an LVESV value, inter-atrial delay value, intra-atrial delay value and/or one or more ventricular filling characteristics for a subject; and means for utilizing at least one of the LVEDV value, the LVESV value, inter-atrial delay value, intra-atrial delay value, the one or more ventricular filling characteristics to set an operative A-V interval.