1. A method of managing promotion of prescription drugs comprising: (a) automating design of a discount offer or free voucher and qualifying parameters for a drug co-pay coupon, or sample among other incentives; (b) implementing the promotional offer and qualification parameters for the drug sample incentive; (c) storing and managing the promotional offers and parameters in a central drug sample incentive database and system; (d) programming a software module to permit secure remote access to the central drug sample incentive database; (e) registering a healthcare provider to use the software module; (f) searching the drug sample incentive database using the software module; (g) determining eligible offers on prescription drugs by product, type or alternatives, as prescribing drugs for a patient from the central drug sample incentive database; (h) allocating specific incentives for the patient based on a check of formulary status data, or alternatives within class of drug among other specific prescription drug information in the central drug sample incentive database; (i) selecting the method of delivery for the patient to present the allocated incentive to the pharmacy of choice; (j) printing or transmitting the allocated incentives to the patient selected pharmacy; (k) enrolling the patient to receive refill reminders for available on-going discounts and other educational support on the allocated drugs; (l) capturing the information about the incentives selected by the healthcare providers and orders fulfilled by the pharmacies; (m) entering the information about the incentive selections and order fulfillments into the central drug sample incentive database; and (n) generating reports summarizing the selection, use, and overall effectiveness of the sample or offer incentives; thereby automating the management of distribution, selection and tracking of prescription drug sample vouchers, co-pay coupons, and free trials.