1. A system configured to assess treatments for disease of a human heart, comprising: a CPU; and a system memory coupled to the CPU, wherein the system memory stores one or more computer programs executable by the CPU; wherein one or more computer programs are executable to: perform a first modification of at least one feature of one or more first images of heart tissue; perform at least one second modification of at least one of the features, wherein the second modification is performed independent of the first modification; compare at least one effect of the first modification to at least one effect of the second modification, or compare at least one effect of the second modification to at least one effect of the first modification; determine at least a first and second volume of a portion of the heart tissue and blood flow through a portion of the heart; and assess a mitral regurgitation with a provided velocity of a fluid through at least a portion of the aorta.