1. A computerized method for generating an electronic bill having optimized insurance claim items based on an insurance carrier of a patient, the method comprising: receiving via a user interface insurance carrier data which identifies a patient's insurance carrier and patient data which identifies a patient; receiving via the user interface treatment data which identifies at least one drug including a chemotherapy drug administered to the patient and at least one type of administration used to administer the at least one drug to the patient on a date of service; displaying via the user interface a prompt offering to bill an additional expense item eligible for reimbursement based on a comparison between the treatment data and eligible coverage defined by the insurance carrier identified by the insurance carrier data; receiving via the user interface a signal which represents user acceptance of the offering to bill the additional expense item; processing the treatment data by a computing device to obtain nurse documentation, including at least one of: treatment sheet, flow sheet, drug inventory form, and reorder form; and automatically generating by the computing device the electronic bill having optimized reimbursable insurance claim items including the additional expense item in response to the signal, the claim items having predetermined codes based on the treatment data and the insurance carrier data to facilitate approval of the bill and to maximize reimbursement by the insurance carrier.