1. A computer-implemented method of modeling at least a portion of a patient's vasculature, using a computer system, the method comprising: receiving one or more three-dimensional images of a portion of a patient's coronary vasculature; receiving one or more two-dimensional images that are generated independently from the one or more three-dimensional images, wherein the one or more two-dimensional images include images of the portion of the patient's coronary vasculature; determining, from the one or more three-dimensional images, one or more three-dimensional image based anatomical parameters of the portion of the patient's coronary vasculature; determining, from the independently-generated one or more two-dimensional images, one or more two-dimensional image based anatomical parameters of the portion of the patient's coronary vasculature; updating the one or more three-dimensional image based anatomical parameters based at least on the one or more two-dimensional image based anatomical parameters; and generating a model of at least the portion of the patient's coronary vasculature based on the updated three-dimensional image based anatomical parameters.