1. A method of enhancing expert system decision making through interaction with at least one source, wherein DNA profile peak calling expert system comprising a computer readable medium of a computer system, the computer system comprising an input device, memory, a processor and an output device, is presented with at least one DNA peak calling problem and wherein the expert system makes at least one first decision whether a peak corresponds to a DNA allele that attempts to resolve the at least one problem, wherein the first decision results from applying a rule base for the at least one problem, comprising: importing DNA electrophoresis data of specimen DNA obtained from a genetic analyzer for analysis via said processor; accepting input from at least one source comprising one of agreement with said first decision, modification of a modifiable analysis parameter and definition of a DNA profile as a mixture; in response to the input, re-applying the rule base for the at least one problem, the rule base comprising rules for application to objects comprising profile, peak and locus of said electrophoresis data stored in said memory having associated modifiable analysis parameters including one of noise and stutter peak parameters; and making a second decision that resolves the at least one problem, wherein the second decision results from re-applying the rule base, and wherein the second decision whether a peak corresponds to a DNA allele is different from the first decision and is displayable via said output device.