1 ) A phytoceutical composition, comprising plants or extracts or active ingredients from a synergetic formulation, specifically designed for liver disease, derived from each of the following plants: Andrographis, Angelica, Astragalus, Bupleurum, Coptis, Eleutherococcus, Ganoderma, Glycyrrhizae, Grifola, Hydrastis, Morinda, Panax, Pfaffia, Picrorhiza, Rhodiola, Schizandra, Silybum, Smilax, and Sutherlandia, together with pharmaceutically acceptable excipients.