1. A method for real-time model based vehicle structural anomaly detection, comprising: monitoring an entirety of a vehicle structure in real-time; receiving a real-time measurement corresponding to a location on the vehicle structure from among the entirety of the vehicle structure during an operation of the vehicle; comparing the real-time measurement to expected operation data for the location to provide a modeling error signal of the vehicle structure; calculating a statistical significance of the modeling error signal based on a Probability of False Alarm (Pfa) to provide an error significance of a vehicle structural anomaly in real-time; determining a persistence of the error significance based on a user selectable Probability of False Alarm (Pfa) threshold value, wherein the user selectable Pfa threshold depends on a quality of the modeling error signal and a tolerance for false positive indications in real-time; and indicating the vehicle structural anomaly in real-time, if the persistence exceeds a persistence threshold value of the vehicle structure anomaly.