1. A system for processing image data including a memory and a processor communicatively coupled to the processor, comprising: an imaging module capable of gathering four-dimensional image data from a subject; a time series module including a first extraction module capable of extracting time series data of each voxel of the subject, wherein the time series module is capable of deriving at least one feature from the time series data; a graph module including a second extraction module capable of extracting spatial and degree data of each voxel of the subject, wherein the graph module is capable of deriving at least one feature from the spatial and degree data; a combination module capable of combining the at least one feature from the time series data, and the at least one feature from the spatial and degree data to generate combined data; and a classifier capable of receiving the combined data from the combination module, and outputting a classification based on the combined data.