1. A hyperspectral/multispectral medical imaging system, comprising: an illumination system that is configured to illuminate a subject; an optical acquisition system that is configured to acquire reflected light from a subject; a central processing unit (CPU); memory; and a plurality of program modules stored in the memory and configured to be executed by the CPU, the plurality of program modules including: a calibration module, and a data acquisition module, wherein the calibration module includes instructions for: (A) calibrating illumination power and uniformity of the illumination system by a procedure comprising: (i) acquiring a hyperspectral/multispectral image of a calibration pad comprising a surface having a predetermined reflectance, the hyperspectral/multispectral image comprising a plurality of sub-images of the calibration pad illuminated by the illumination system, each respective sub-image in the plurality of sub-images acquired at a corresponding spectral band; (ii) subtracting a dark radiation image from the hyperspectral/multispectral image, the dark radiation image acquired previously when the optical acquisition system was blocked from light; (iii) determining, for each respective sub-image of the hyperspectral/multispectral image, the measured value of light reflectance across the calibration pad at the corresponding spectral band of the respective sub-image; (iv) determining a maximum deviation, for each respective sub-image of the hyperspectral/multispectral image, between the measured value of light reflectance across the calibration pad at the corresponding spectral band of the respective sub-image and an ideal value of light reflectance across the calibration pad at the corresponding spectral band of the respective sub-image; (v) comparing the maximum deviation for each respective sub-image of the hyperspectral/multispectral image to a first threshold value; and (vi) determining a success of the calibrating (A) wherein the calibrating (A) is deemed to have failed when the maximum deviation for a sub-image of the first hyperspectral/multispectral image of exceeds the first threshold value, and the calibrating (A) is deemed to have passed when the maximum deviation for a sub-image of the hyperspectral/multispectral image does not exceed the first threshold value; (B) calibrating wavelength accuracy of the optical acquisition system; and (C) calibrating image focus of the optical acquisition system.