1. A method for use in medical imaging, comprising the steps of: 1) immobilizing a patient with respect to an imaging reference frame; and 2) with said patient immobilized; a) acquiring first digital imaging information using a first imaging device having a first imaging modality; b) processing said first digital imaging information using a computer-based diagnostic tool to identify a feature for analysis, said step of processing comprises operating a trained system to identify the feature for analysis, wherein the trained system is trained to recognize suspicious features based on off-line training involving reference features having a known diagnosis; and c) based on said step of processing, acquiring targeted second imaging information associated with the feature for analysis using a second imaging device having a second imaging modality different from the first imaging modality, wherein the second imaging device is steered towards the feature for analysis using information provided by the step of processing.