1. A method for differentiating tissues in Magnetic Resonance Imaging comprising: applying a Magnetization Transfer (MT) pre-pulse in combination with a Diffusion Weighted Imaging (DWI) pulse sequence to produce an image of a tissue under evaluation; generating analysis maps and/or measurements from the produced image; and computing values representative of the macromolecular content of the tissues from the map and/or measurements, wherein the Magnetization Transfer (MT) pre-pulse suppresses signals from water bound to macromolecules.