1. A method for correcting uneven brightness in an image comprising the steps of: (a) identifying a first structure on the image having a region with uneven brightness; (b) identifying a region of optimal brightness on the image (c) defining parameter information (d) approximating an observed brightness as a regression function of said optimal brightness and said defined parameter information, and (e) calculating the inverse of the regression function; and (f) correcting the region of uneven brightness by applying the inverse of the regression function to the region of uneven brightness.