1. A non-invasive imaging system, comprising: an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one anatomical substructure and more than one constituent tissue type; a signal processing system in communication with said imaging scanner to receive the imaging signal from said imaging scanner; and a data storage unit in communication with said signal processing system, wherein said data storage unit is configured to store a parcellation atlas comprising spatial information of said at least one anatomical substructure in the tissue region, wherein said signal processing system is adapted to: reconstruct an image of said tissue region based on said imaging signal; parcellate, based on the parcellation atlas, the at least one anatomical substructure in said image; segment the more than one constituent tissue type in said image; and automatically identify, in said image, a portion of the at least one anatomical substructure that corresponds to one of the more than one constituent tissue type.