1. A method for predicting an evolution of a clinical state of a subject, comprising: a) providing a statistical image-based predictive model for predicting said evolution of said state, said model incorporating one or more image-derived features derived from an image from at least one volume of interest (VOI) comprising information related to said clinical state; b) collecting image data from said at least one VOI in said subject; c) deriving said one or more image features from said collected image data from said subject; d) using said one or more derived image features from said at least one VOI of said subject and said predictive model to predict said evolution of said clinical state.