1. A method, comprising: sensing, with a radiation sensitive detector array of an imaging system, radiation traversing an examination region and a portion of a subject or object therein and generation projection data indicative thereof; and reconstructing the generated projection data using an iterative statistical reconstruction algorithm that reduces or mitigates image artifact caused by differences in variances in projections of the projection data used to update a voxel of the image for one or more voxels of the image, wherein the iterative statistical reconstruction algorithm includes the following voxel update term: ∑ p ⁢ ∑ i ⁢ a pij ⁢ 1 κ pj 2 ⁢ ( m pi - l pi n ) ∑ p ⁢ ∑ i ⁢ a pij ⁢ 1 κ pj 2 ⁢ a pi wherein p represents a projection, i represents a measurement in the projection p, j represents a voxel index, a pij represent elements of a system matrix, m pi represents measured values of the measurement i of the projection p, n represents an iteration number, I pi represents the forward projection of the image, a pi represents a forward projection of a unity image, and κ pj 2 represents the constant variance based weighting factor.