1. A method for segmenting three-dimensional (3D) image volumes, the method comprising: obtaining a 3D volume data set corresponding to an imaged volume; rendering at least a portion of the 3D volume data set based on 3D rendering settings; creating a two-dimensional (2D) segmentation of the rendered 3D volume data set, wherein the 2D segmentation is a 2D region of interest selected within the rendered 3D volume data set; and segmenting the 3D volume data set using the 2D segmentation and the 3D rendering settings to define a 3D region of interest within the 3D volume data set.