1. A method for detecting a ligand comprising: (a) contacting a sample having or suspected of having a ligand with an affinity substrate (inking), wherein the affinity substrate comprises a receptor capable of specifically binding to the ligand; (b) contacting the affinity substrate with a detection surface (stamping), wherein at least a portion of the ligand which is bound to the receptor is transferred to the detection surface; and (c) detecting presence of the ligand on the detection surface, wherein the detection surface further comprises a liquid crystal.