1. A method for patient-specific guidance of an ablation procedure, comprising: registering a patient-specific anatomical heart model extracted from pre-operative cardiac image data to a coordinate system of an intra-operative image acquired during the ablation procedure; estimating a patient-specific computational model of cardiac electrophysiology based on the registered patient-specific anatomical heart model and intra-operative patient-specific measurements acquired during the ablation procedure; and generating one or more ablation site guidance maps based on the patient-specific computational model of cardiac electrophysiology.