1. A method of estimating an electrophysiologic response contained in a measured electrophysiologic signal, said method comprising: obtaining a plurality of samples of said measured electrophysiologic signal; defining a plurality of bins, each of said bins corresponding to a range of values of a sorting parameter; for each sample, classifying said sample into one of said bins on the basis of a value of said sorting parameter, said value being associated with said sample; for each bin, maintaining a bin statistic indicative of samples classified into said bin; and estimating said electrophysiologic response on the basis of said bin statistics.