1. A computer-aided diagnostic method to predict the probability that a histological image contains a malignant region comprising: a. obtaining a histological image, wherein the histological image is a first of a series of images ordered in increasing magnification; b. identifying a region or regions of said histological image classified as suspect; c. extracting one or more image features from at least one of said identified regions; d. reducing a dimensionality of said extracted feature data; and e. classifying said extracted region or regions as either benign, malignant, or suspect based on at least one said extracted image feature, whereby if said extracted region or regions are classified as malignant, the histological image has a malignant region, otherwise; i. if the extracted region or regions are classified as benign, then the histological image does not have a malignant region; or ii. if the extracted region or regions are classified as suspect, the next histological image in the series is obtained and the steps of identifying, extracting, reducing and classifying are repeated.