1. A method for liver lesion detection, comprising: detecting a liver lesion in a spatial domain in each of a plurality of data sets based on a liver intensity subtracted (LIST) image and a maximum frequency-magnitude difference (MFMD) map created from the data set; detecting the liver lesion in a temporal domain across the plurality of data sets; and integrating a detection result from said detecting in the spatial domain with a detection result from said detecting in the temporal domain to generate an integrated detection result.