1. A computer-implemented method of identifying a personalized cardiovascular device based on patient-specific geometrical information, the method comprising: generating or obtaining a patient specific model of at least a portion of a patient's vasculature from image data of the patient's vasculature and one or more measured or estimated physiological or phenotypic parameters of the patient; determining one or more pathology characteristics of the patient from the patient specific model; defining one or more variables of a personalized cardiovascular device designed to treat the one or more pathology characteristics of the patient; defining an objective function defined by the one or more variables and one or more estimates of hemodynamic or mechanical characteristics derived from simulating the personalized cardiovascular device being deployed in the patient specific model; optimizing the objective function, by iteratively simulating at least one change in the one or more variables using fluid dynamic or structural mechanic analyses of one or more iterative updates of the personalized cardiovascular device being deployed in the patient specific model, to identify the one or more variables that optimize the one or more estimates of hemodynamic or mechanical characteristics in the patient specific model; and using the identified one or more variables to either (i) select a device from a set of available devices or (ii) manufacture a desired personalized cardiovascular device.