1. A method, comprising: obtaining a 4D data set in electronic format, wherein the 4D data set includes a plurality of 3D volumes of voxels of contrast enhanced perfusion imaging data for two or more time frames, and the 3D volumes include data representative of at least two different tissue components in a same region of interest in at least one of the time frames; generating a different time activity curve point for each of the different tissue components for each voxel being evaluated for each time frame being evaluated; and generating a signal indicative of a different parameter map for each of the different tissue components based at least on the time activity curves.