1. A method comprising: receiving pre-operative two dimensional (2D) image data of a reference bone structure and a bone fragment, the reference bone structure including a first set of fiducial markers provided thereon, and the bone fragment including a second set of fiducial markers provided thereon; performing a 2D-3D registration between the pre-operative 2D image data and a 3D model of the reference bone structure and the bone fragment; after manual repositioning of the bone fragment, receiving second 2D image data; performing 2D-2D registration of the first set of fiducial markers and the second set of fiducial markers between the pre-operative 2D image data and the second 2D image data; and determining 3D movement of the bone fragment based at least in part on the 2D-2D registration.