1. A method for ex vivo evaluation of biological sample response to a stimuli comprising: obtaining a sample of a target biological sample and placing the sample in a chamber of a sample holder; performing biodynamic imaging (BDI) on the sample to extract BDI data of the entire sample; generating optical coherence imaging (OCI) data from the BDI data; generating motility contrast imaging (MCI) data from the OCI data; using the MCI data, selecting an area of the sample having the highest normalized standard deviation (NSD) value; subjecting the sample to a perturbation or external condition; and performing MCI analysis on the selected area to determine the biological sample response to the perturbation or external condition.