1. A mass spectrometry method comprising: performing mass-spectrometry measurements to evaluate a default mass spectrometer configuration parameter vector and a most-recent optimal mass spectrometer configuration parameter vector; selecting one of the default mass spectrometer configuration parameter vector and the most-recent optimal mass spectrometer configuration parameter vector as a starting parameter vector; constructing a starting simplex proximal in parameter-space to the starting parameter vector; and performing a simplex optimization using the starting simplex to generate an updated optimal mass spectrometer configuration parameter vector.