1. A method for integrated image registration of cardiac magnetic resonance perfusion data, the method comprising: providing a contoured region of interest on a first image having a plurality of pixels; receiving a second image corresponding to a time other than that of said first image; calculating pixel intensities for the second image; estimating edge parameters for at least one of said first and second images; calculating a template-match between said first and second images; selecting a pair of pixel locations from at least one of said first and second images in accordance with said template-match; registering the estimated edge parameters in correspondence with said calculated template-match for a pair of pixel values at said selected locations in said first image and a pair of pixel values at said selected locations in said second image; and detecting a changed pixel location in accordance with said registration.