1. A method for performing deep brain stimulation (DBS) therapy, the method comprising: acquiring at least one first image of a brain of a patient with at least one imaging sub-system; determining a location of a target area for therapy in the at least one first image; forming a burr hole through a skull of the patient based on the location the target area; positioning one or more reference members on or within the brain through the burr hole; acquiring at least one second image of the brain having the one or more reference members; registering a position of the one or more reference members with one or both of the at least one first image and the at least one second image using a registration module; tracking movement of at least one probe within the brain based on the registering operation with a tracking module; and displaying movement of a representation of the at least one probe on the one or both of the at least one first image and the at least one second image based on the tracking operation with a display module.