1. A method of fracture risk assessment comprising: generating a volumetric model corresponding to a three-dimensional image of a bone structure for each bone structure in a set of bone structures wherein the volumetric model comprises a number of volumetric vertices; defining a vector of variables, wherein each variable in the vector of variables comprises a three-dimensional position of one of the number of volumetric vertices and at least one parameter associated with at least one volumetric vertex; generating a set of individual vectors, the generating comprising, for each individual vector, determining values for each variable in the vector of variables wherein each individual vector corresponds to one bone structure in the set of bone structures and the values for each variable in the vector of variables are based, at least in part, on the volumetric model corresponding to the one bone structure; performing variable reduction on the set of individual vectors providing a plurality of reduced variables; and determining a discriminator based at least in part on a result of the variable reduction wherein the discriminator comprises one or more of the plurality of reduced variables.