1. A method of imaging a tissue sample comprising: illuminating a first region of tissue within a tissue sample with light; detecting light from the first region of tissue in response to the illuminating light to form an image of the first region of tissue, the imaged first region including tissue below a first sectioning depth; sectioning a portion of the imaged tissue at the first sectioning depth to expose a second region of tissue and form a first section of tissue; illuminating the second region of tissue within the tissue sample; detecting light from the second region of tissue to form an image of the second region of tissue, the imaged second region of tissue including tissue below a second sectioning depth; sectioning a portion of the second region of tissue at the second sectioning depth to form a second section of tissue; processing the first section of tissue and the second section of tissue; imaging the processed first section of tissue and the processed second section of tissue to form processed OCT tissue images using an optical coherence tomography (OCT) imaging mode; and analyzing the processed OCT tissue images in combination with at least the image of the first region of tissue to register the OCT tissue images of the first section of tissue and the second section of tissue.