1. An imaging system comprising: a light-detection subsystem that illuminates a sample or a portion of the sample to activate light emitters within the sample, excites light emission from the light emitters, and records, over a period of time, intermediate output images of light emitters within the sample or the portion of the sample; and an image-generation subsystem that processes the intermediate output images to identify and record initially determined positions of the light emitters within the sample or the portion of the sample and that iteratively computes computed output images from light-emitter-position models in order to disambiguate overlapping light-emitter images in the intermediate output images to produce a composite image that includes indications of the positions of the light emitters within the sample or the portion of the sample.