1. A method of non-uniformity compensation (NUC) of the detection elements of a pixilated imager, comprising: registering a temporal sequence of input images from the imager having different fields of view (FOVs) to create a registered average image as an estimate of an input scene; backward mapping the estimated input scene to the different FOVs to create an estimate input image for each input image; comparing each said estimate input image to its associated original input image to estimate pixel-by-pixel response non-uniformity compensation (NUC) terms for the imager; and applying the NUC terms to the images to generate compensated images.