1. A system for encoding a sequence of pictures at a given spatial resolution to an encoding format at a plurality of output spatial resolutions, comprising: a media transformation module (MTM) that transforms the sequence of pictures at the given spatial resolution to the plurality of output spatial resolutions and/or an additional spatial resolution that is lower than the plurality of output spatial resolutions; an estimation module that estimates, at the additional spatial resolution, a set of combinations of encoding parameters for each coding tree block (CTB) in each of the pictures at a lowest output spatial resolution among the plurality of output spatial resolutions; a set of coarse-to-fine mapping modules, one for each of the plurality of output spatial resolutions other than the lowest output spatial resolution, that map combinations of encoding parameters for each CTB in each of the pictures at an immediate coarser spatial resolution to corresponding blocks at their respective output spatial resolution; and a set of intelligent encoding modules, one for each of the plurality of output spatial resolutions, each of which receives the sequence of pictures and a picture type for each of the pictures at the respective output spatial resolution, determines a set of combinations of encoding parameters for each CTB in each of the pictures supported by the encoding format for the associated picture type based on outputs of at least one of the estimation module and the respective one of coarse-to-fine mapping modules, identifies best combinations of encoding parameters for each CTB in each of the pictures from the determined set of combinations of encoding parameters for the associated picture type, and, encodes the pictures in the encoding format based on the best of the identified combinations of encoding parameters for each CTB in each of the pictures to create a media bit stream at a desired output bitrate at the respective output spatial resolution.