1. A method, comprising: generating with a processor a respective first weight for each pixel of multiple acquired images of a scene based on a distribution of brightness values that includes the brightness values of all pixels within the acquired image that includes the pixel; generating with a processor a respective second weight for each pixel of the multiple acquired images based upon an interpolated weight value of a subset of pixels within the acquired image and based on the respective brightness values of other pixels within a specified distance from the pixel; generating with a processor a resulting weight for each pixel of the multiple acquired images from the respective first and second weights of the pixel; weighting with a processor each pixel with its resulting weight to generate a respective weighted pixel; and generating with a processor a single resulting image by combining corresponding weighted pixels from each image.