1. A method of providing decision support in diagnosis of a disease in a subject, the method comprising: extracting a volume of interest from an image of the subject; segmenting the image to delineate at least one lesion within the volume of interest from a background of the image; extracting image-based features in a plurality of dimensions; converting clinical information into a compatible format and combining the clinical information with the image-based features to form a feature pool; and selecting an optimal feature subset or an optimal group of feature subsets from the feature pool to be used by a classifier or committee of classifiers that outputs a decision, wherein the classifier or committee of classifiers provides a prediction of diagnosis of the lesion.