1. A system for performing tandem mass spectrometry (MS/MS) analysis of a sample, the system comprising: a mass spectrometer configured to perform a mass spectrometry (MS) scan of an ionized sample to provide a mass of an observed peak corresponding to a precursor ion; and a processor configured to perform operations comprising: determining whether the mass of the observed peak matches a mass of at least one of a plurality of expected peptides on a dynamic watch list, the expected peptides corresponding to a protein in the sample; and calculating a score of an accuracy of the determination when the mass of the observed peak is determined to match the mass of at least one of the plurality of expected peptides, wherein the peptide is excluded from the dynamic watch list and is excluded from a full tandem mass spectrometry (MS/MS) scan by the mass spectrometer when the accuracy score indicates that the determination is accurate.