1. A method for controlling a device for determining a lesion location within a target site in a patient, the steps comprising: receiving a pair of images and associated pair of signal intensities, wherein the pair of images and pair of signal intensities are obtained simultaneously from multiple angles relative to the target site from a plurality of photon imaging devices; and determining a lesion location in the patient based upon the pair of images acquired by the plurality of photon imaging devices and the pair of signal intensities.