1. A tomosynthesis system for creating a reconstructed image of an object from a plurality of two-dimensional x-ray projection images, the system comprising: an x-ray detector; an x-ray source capable of emitting x-rays directed at the x-ray detector, wherein the tomosynthesis system utilizes asymmetric image acquisition geometry, where θ 1 ≠θ 0 , during image acquisition, wherein θ 1 is a sweep angle on one side of a center line of the x-ray detector, and θ 0 is a sweep angle on an opposite side of the center line of the x-ray detector; wherein the total sweep angle (φ asym ) is: φ asym =θ 1 +θ 0 ; and wherein θ asym is about 40° to about 60°.