1. A method for determining an analyte concentration in a sample, comprising: generating at least two output signals from a sample; measuring at least two analyte responsive output signals from the sample; determining at least two initial analyte concentrations from the at least two analyte responsive output signals; determining a first pseudo-reference concentration from the at least two analyte responsive output signals, where the first pseudo-reference concentration is a first substitute for true relative error, determining at least one first anchor parameter in response to the first pseudo-reference concentration, where the at least one first anchor parameter compensates for system error; incorporating the at least one first anchor parameter into at least two first compensation relationships; determining at least two first anchor compensated analyte concentrations in response to the at least two initial analyte concentrations, the at least two first anchor parameters, and the at least two first compensation relationships; determining a second pseudo-reference concentration by averaging the at least two first anchor compensated analyte concentrations, where the second pseudo-reference concentration is a second substitute for true relative error; and reporting the second pseudo-reference concentration as a final compensated analyte concentration of the sample.