1. A method comprising: providing illumination radiation to a first plurality of small metrology targets and a plurality of large metrology targets disposed on a specimen, the illumination radiation provided by an illumination source of a metrology tool, the illumination radiation projected onto the first plurality of small metrology targets and the plurality of large metrology targets with an illumination spot size, wherein one or more of the first plurality of small metrology targets and one or more of the large metrology targets are located in close proximity to one another, and wherein each of the first plurality of small metrology targets occupies a smaller area than each of the plurality of large metrology targets; detecting an amount of radiation from the first plurality of small metrology targets and the plurality of large metrology targets specimen in response to the illumination radiation, the amount of radiation detected by a detector of the metrology tool; generating a measured response associated with the first plurality of small metrology targets and the plurality of large metrology targets based on the detected amounts of radiation, the measured response comprising a first set of measurement signals; training a signal reconstruction model that maps the measurement signals generated from the measurements of the first plurality of small metrology targets to the measurement signals generated from the measurements of the plurality of large metrology targets; providing illumination radiation to a second plurality of small metrology targets disposed on the specimen, the illumination radiation provided by the illumination source of the metrology tool, the illumination radiation projected onto the second plurality of small metrology targets with the illumination spot size, wherein each of the second plurality of small metrology targets occupies a smaller area than each of the plurality of large metrology targets; detecting an amount of radiation from the second plurality of small metrology targets in response to the illumination radiation, the amount of radiation detected by the detector of the metrology tool; generating a measured response associated with the second plurality of small metrology targets based on the detected amounts of radiation, the measured response comprising a second set of measurement signals; and determining reconstructed measurement signals for each small metrology target of the second plurality of small metrology targets based on the second set of measurement signals and the trained signal reconstruction model.