1. A method, comprising: identifying a plurality of different anatomical sub-regions of the cardiovascular system of a subject in image data of the subject based on a subject specific cardiovascular anatomical model, wherein the plurality of different regions corresponds to regions where calcifications occur; searching for and identifying calcifications in the sub-regions based on voxel grey value intensity values of the image data; and generating a signal indicative of one or more regions of voxels of the image data respectively corresponding to sub-regions including identified calcifications.