1. A method for detecting in-vivo content in images captured by an in vivo imaging capsule, the method comprising: receiving an in vivo image captured by the imaging capsule; calculating a pixel content score, per pixel, for at least a subset of the image pixels, wherein the pixel content score corresponds to a probability of the pixel to depict in vivo content; and calculating an image content score based on the pixel content scores, wherein the image content score indicates a probability that the image depicts more content than a threshold content amount and is calculated by selecting a pixel content score from the calculated pixel content scores corresponding to a content amount threshold percentile.