1. A method of examining a breast of a patient includes the steps of: immobilizing the breast, and while the breast is immobilized: i. acquiring a three dimensional image of the breast using a first imaging modality; ii. selecting a region of interest in the three dimensional volume, the step of identifying including indentifying coordinates of the region of interest (ROI) in the three dimensional volume; and iii. acquiring images of the breast using a second imaging modality, the second imaging modality being guided by the first imaging modality to enable location of the ROI in second imaging modality images; and releasing the breast from immobilization.