1. An information processing system for selecting markers for modeling epistasis effects, the computer implemented method comprising: a memory; a processor communicatively coupled to the memory; and a feature selection module coupled to the memory and the processor, wherein the feature selection module is configured to perform a method comprising: receiving, by a processor, a set of genetic markers and a phenotype; determining, for each of the set of genetic markers, a relevance score with respect to the phenotype; setting a threshold based on the relevance score of a genetic marker in the set of genetic markers with a highest relevancy score; determining, for at least one genetic marker in the set of genetic markers, a relevance score for at least one interaction between the at least one genetic marker and at least one other genetic marker in the set of genetic markers; and adding the at least one interaction to a top-k feature set based on the relevance score of the at least one interaction satisfying the threshold, wherein each feature in the top-k feature set is one of a genetic maker and an interaction each comprising a top-k relevance score.