1. A method comprising: applying a magnetization transfer pre-pulse in combination with a diffusion weighted imaging pulse sequence that is a diffusion tensor imaging sequence to produce an image of a tissue under evaluation, the applying further comprising applying diffusion gradient along a plurality of orthogonal directions selected from a group consisting of two orthogonal directions and three orthogonal directions; generating analysis maps, being apparent diffusion coefficient maps representative of cell density and viscosity of tissue, and measurements from the produced image; and computing values representative of the macromolecular content of the tissue from the map and measurements, wherein the magnetization transfer pre-pulse suppresses signals from water that is bound to macromolecules.