1. A method for determining an extent of at least one of a pleural space and a pleural thickening, comprising: obtaining an image including at least one of the pleural space and the pleural thickening; segmenting at least one lung in the obtained image; obtaining an initial endpoint on one of a chest wall and a mediastinum boundary; determining a terminal endpoint on a boundary of the at least one segmented lung; and determining a distance between said initial endpoint and said terminal endpoint as the extent of the at least one of the pleural space and the pleural thickening.