1. A method for generating a volumetric image representing an imaged object associated with a patient, comprising: acquiring tomosynthesis projection data; and automatically generating, by a computer processor, the volumetric image based on the acquired tomosynthesis projection data, wherein distances between voxels in the volumetric image are spatially varied; wherein the distances between voxels is spatially varied along a z axis and spacing between voxels in an x/y plane, substantially parallel to a detector that acquired the projection data, is uniform.