1. A method of adaptive image acquisition, comprising: obtaining a guide image of patient tissue at a computing device; receiving an intraoperative image of a portion of the patient tissue at the computing device from an imaging instrument; storing the intraoperative image in a memory of the computing device; comparing the intraoperative image with the guide image to identify at least one region of the guide image matching the intraoperative image; determining whether the at least one region identified meets at least one accuracy criterion; when the at least one region meets the at least one accuracy criterion, rendering the guide image and an indication of the at least one region on a display; and when the at least one region does not meet the at least one accuracy criterion: receiving and storing a further intraoperative image; combining the further intraoperative image with the intraoperative image to generate a composite image; and repeating the comparing and determining.