1. In a system comprising a processor, an input device and an output device, a method of detecting regions of interest in a tomographic breast image, comprising: a. by means of an input device, acquiring tomographic breast image data; b. by means of a processor, deriving a plurality of synthetic sub-volumes from the tomographic breast image data; wherein each subvolume is defined by parallel planar top and bottom surfaces; wherein planar top and bottom surfaces of successive subvolumes are parallel to each other; and wherein a top planar surface of a sub-volume is offset from a top planar surface of a prior sub-volume, such that successive sub-volumes overlap; c. by means of a processor, for each sub-volume, deriving a two-dimensional image; d. by means of a processor, for each two-dimensional image, identifying regions of interest therein; e. by means of a processor, deriving at least one region of interest of potential clinical interest from a plurality of identified regions of interest; and f. by means of an output device, outputting information associated with at least one derived region of interest of potential clinical interest.