1. A computer-implemented method of determining anterior commissure (AC) and posterior commissure (PC) points in a volumetric neuroradiological image, the method comprising: determining, by a computer, a mid-sagittal plane estimate to extract a mid-sagittal plane image from the volumetric neuroradiological image; determining, by the computer, AC and PC point estimates in the mid-sagittal plane image; determining, by the computer, a refined mid-sagittal plane estimate from the AC and PC point estimates to extract a refined mid-sagittal plane image; determining, by the computer, the AC point from the refined mid-sagittal plane image; and determining, by the computer, the PC point from the refined mid-sagittal plane image and the AC point.