1. A method for providing tomosynthesis 3-D volume image data, executed at least in part on a computer, comprising: a) acquiring a plurality of radiographic projection images of a subject over a range of angles; b) generating reconstructed volume image data from the acquired projection images; c) defining a plurality of regions of interest within the reconstructed volume image data, wherein each region of interest has a plurality of image voxels; d) conditioning image voxel data values within at least one of the regions of interest to enhance contrast within the at least one region of interest; e) adjusting the conditioned image voxel data values within the at least one of the regions of interest according to interpolation with two or more neighboring regions of interest; and f) displaying an image slice having at least a plurality of the adjusted image voxel data values.