1. A method of X-ray diffraction-based analysis for determining the structure of a crystal sample, the method comprising the steps of: a) conducting a first experiment during which the sample is irradiated with an X-ray beam and a first set of diffraction images is collected by an X-ray detector, the diffraction images including reflections at corresponding intensities; b) conducting a second experiment during which the sample is irradiated by an X-ray beam and a second set of diffraction images is collected, the diffraction images of the second set including said reflections with higher relative intensities than those produced during the first experiment, at least some of the diffraction images of the second set including topped reflections resulting from detector saturation; and c) replacing intensities of the topped reflections from the second set of images with intensities obtained for the corresponding reflections from the first set of images.