1. A method for registration of images of tissue slices for pathology diagnostic investigation, the method comprising: receiving a first image of a first tissue slice and a second image of a second tissue slice, both tissue slices being prepared from the same tissue block; determining an unreliable area in the first image showing folded tissue ( 15 ); registering the first image and the second image by registering an area of the first image and the second image outside of the unreliable area.