1. A computer-aided diagnostic method to predict a probability that a histological image contains a malignant region comprising: a. obtaining said histological image, wherein the histological image is a first of a series of further histological images ordered in increasing magnification; b. identifying a region or regions of said histological image classified as suspect; c. extracting one or more image features from at least one of said identified region or regions; d. reducing a dimensionality of said extracted feature image features; and e. classifying said identified region or regions as either benign, malignant, or suspect based on at least one of said extracted image features, wherein if said identified region or regions are classified as malignant, the histological image has a malignant region, otherwise; i. if the identified region or regions are classified as benign, then the histological image does not have a malignant region; or ii. if the identified region or regions are classified as suspect, a next histological image in the series is obtained and the steps of identifying, extracting, reducing and classifying are repeated.