1. A system admixture compensation method, comprising: providing reference profile density values for at least one overprint color combination having a plurality of colors produced by a reference device using a reference colorant set, the at least one overprint color combination having reference Initial Percent Dot Values (IPDVs); providing current profile density values for at least one color combination produced by a current device using a current colorant set, the at least one color combination having current IPDVs; quantifying reference Theoretical Percent Dot Values (TPDVs) as reference efficiency attributes using the reference colorant set; quantifying current TPDVs as current efficiency attributes using the current colorant set; and calculating factors that compensate for at least one difference between image data produced with the reference colorant set and image data to be printed with the current colorant set in response to the reference efficiency attributes and the current efficiency attributes, the factors to be used to adjust the image data to be printed.