1. A method of providing a Karhunen-Love Transform Wavelet (KW) Filter to suppress random noise in an image series, comprising: applying a Karhunen-Loeve Transform (KLT) to the image series to compress signal information into a finite set of frames; discarding substantially noise-only frames; applying a Wavelet filter with an adaptive threshold to remaining frames; and applying an inverse KLT to obtain the de-noised image series.