1. A system, comprising: circuitry configured for obtaining a predictive transform based at least partially on (i) structural modeling of a brain, (ii) cyclical stress and strain information associated with at least one observation at a first side of the brain and at least one observation at a substantially opposite side of the brain, and (iii) at least one input related to one or more retractors located in the brain, the circuitry configured for obtaining a predictive transform including at least: circuitry configured for processing two or more fiducials included in a three-dimensional image of the brain and included in a current image to generate two or more transform coefficients of the predictive transform, wherein at least one transform coefficient of the two or more transform coefficients is at least partially derived from the at least one observation at a first side of the brain and at least another transform coefficient of the two or more transform coefficients is at least partially derived from the at least one observation at a substantially opposite side of the brain, and wherein at least one fiducial location in the current image differs from a corresponding fiducial location in the three-dimensional medical image; circuitry configured for applying the predictive transform to the three-dimensional image to form a present image; and circuitry configured for forming a time series of images corresponding to two or more instances of the present image, including at least one of extrapolating the time series of images forward to a future time, extrapolating the time series of images backward to a previous time, or interpolating the time series of images to an intermediate time.