1. A method for producing nucleic acid probes complementary to a target sequence comprising the steps of: (a) obtaining double strand polynucleotides that contain sequences complementary to the target sequence and to repetitive sequences; (b) fragmenting said double strand polynucleotides into fragments; (c) denaturing said fragments into single strands; (d) hybridizing said repetitive sequences to form a mixture of double strands and single strands; (e) cleaving said double strands; and (f) amplifying said single strands to form a probe set complementary to the target sequence.