1. A computer implemented method comprising: obtaining, via an ultrasound transducer to interrogate a sample with an ultrasound pulse, two or more different ultrasound images, wherein a first of the ultrasound images comprises pixels having intensity values influenced by a first acquisition parameter, and wherein a second of the ultrasound images comprises pixels having intensity values influenced by a second acquisition parameter; receiving a selection of a portion of at least one of the two or more different ultrasound images, the portion circumscribing an area of an object under investigation; for each of a plurality of pixels within the selected portion, subtracting intensity values associated with the selected portion of the second ultrasound image from intensity values associated with the selected portion of the first ultrasound image to obtain differential intensity values, wherein the intensity values associated with the selected portion of the second ultrasound image are scaled by a scaling factor so as to vary as a function of space or time, and wherein a magnitude of the scaling factor to be applied is varied based on the portion of the second ultrasound image selected; and initiating display of an enhanced image using at least some of the differential intensity values.