1. A method for motion correction of a plurality of uncorrected subtracted medical image frames, comprising the steps of: acquiring a sequence of image frames of vessels including frames acquired before and after introduction of contrast agent to patient vessels; generating, without display of said uncorrected subtracted frames, a plurality of shifted 2D (two dimensional) mask frames by translational shift of a mask frame acquired in the absence of contrast agent and by generating a plurality of motion correction translation vectors individually corresponding to one of a corresponding plurality of 2D fill frames, the generated shifted 2D mask frames each corresponding to one of a plurality of 2D fill frames displaying contrast agent; and, generating, without display of said uncorrected subtracted frames, a plurality of motion-corrected subtracted frames by subtracting from each of said plurality of 2D fill frames, a corresponding shifted mask frame generated by applying a corresponding motion correction translation vector to the whole mask frame; and displaying said plurality of motion-corrected subtracted frames.