1. A method comprising: with an ablation probe, delivering Radio Frequency (RF) energy for tissue ablation to a tissue region in a subject anatomy; with an optical image capture device associated with the ablation probe, capturing real-time images of the tissue region while delivering the RF energy to the tissue region; with a computer in communication with the ablation probe, measuring at least one blanching parameter of the tissue region based on the real-time images; and with the computer, during the delivering, causing the ablation probe to adjust a dosing parameter of the RF energy based on the measured blanching parameter, the dosing parameter being at least one of: a. ablation power for a current ablation b. initial ablation power for a next ablation c. ablation duration for the current ablation d. ablation duration for a next ablation e. catheter flow rate for the current ablation f. catheter flow rate for a next ablation.