1. A method, comprising: (a) receiving, by a computer system, contrast-enhanced image data; (b) processing, by the computer system, the contrast-enhanced image data to generate at least one texture value of a region-of-interest (ROI), wherein the texture value comprises a function of r, wherein r is a radius of a sphere centered at the ROI's centroid and wherein the texture value comprises a ratio of r3 to number of voxels above a first pre-determined threshold in a sphere; and (c) classifying, by the computer system, the ROI as either a mass or a non-mass-like enhancement (NMLE) based on the texture value; and displaying by the computer system, the ROI and classification of the ROI.