1. A workflow method for nodule detection review comprising: registering a reference image R with a floating image F, convolving said reference image R with a window function H w to generate R w , convolving said floating image F with the same window function H w to generate F w , generating a subtraction image by performing subtraction R w −F w (g(r)), wherein r represents a voxel (x, y, z) in reference image R, applying a pattern detector to said subtraction image to detect corresponding nodules in reference image R and floating image F, and displaying corresponding nodules.