1. A method of generating design data associated with a custom arthroplasty guide, the method comprising: receiving patient data associated with a portion of a patient bone having a surface contour of an arthroplasty target area, the patient data captured using a medical imaging system; generating a model of the portion of the patient bone from golden bone data that has been modified using the patient data, the golden bone data being associated with an exemplary bone other than the patient bone; and generating arthroplasty guide design data from the model using a processor, the arthroplasty guide design data including a mating region having a surface contour that is generally a negative of the surface contour of the arthroplasty target area such that the surface contour of the mating region is configured to matingly receive the surface contour of the arthroplasty target area in a generally matching or interdigitating manner.