1. A system for detecting or quantifying at least two different analytes, the system comprising a device and a cartridge, the cartridge comprising: a bottom layer, wherein, at least a portion of the bottom layer is non-porous; a sample distribution layer having an open channel extending longitudinally therewithin; and at least two test sites adjacent to or embedded within the open channel of the sample distribution layer, the two test sites having at least two test site read zones containing chemicals in a quantity sufficient to cause a reaction when exposed to a sample; the device comprising: a port configured to accept at least a portion of the cartridge; a light source; an array detector; memory; and a processing module configured to receive signals from the array detector and to perform an image analysis of the cartridge to identify the location of at least one of the test site read zones; wherein the device enables the detection or quantification of the at least two analytes using at least two different quantification techniques, wherein the at least two test sites are of different heights.