1. A computer-implemented method for processing image data, comprising: accessing a first resolution level of compressed image data comprising a plurality of resolution levels of compressed image data, the first resolution level comprising a first region segmented algorithmically along contours of a specific tissue of interest compressed with lossless compression and a second region segmented algorithmically along the contours of the specific tissue of interest compressed with lossy compression; accessing a first resolution level of a multi-resolution mask corresponding to the first resolution level of the compressed image data, wherein a first region of the multi-resolution mask corresponds to the first region of the compressed image data, a second region of the multi-resolution mask corresponds to a second region of the compressed image data, and a third region of the mask corresponds to discarded image data; and processing the image data using the mask as a guide.