1. A medical imaging system for generating 3D anatomical imaging volume datasets from acquired 2D anatomical images, comprising: an image acquisition device for acquiring 2D anatomical images of a portion of patient anatomy in selectable angularly variable imaging planes in response to a synchronization signal derived from a patient blood flow related amplitude parameter signal; a synchronization processor for providing said synchronization signal derived from said patient blood flow related amplitude parameter signal by, in response to data indicating a type of clinical application, adaptively deriving at least one of, (a) a signal derived from a patient blood pressure signal and comprising at least one of, (i) an end of diastolic pressure (ED) phase signal and (ii) an end of systolic pressure (ES) phase signal and, (b) a patient blood flow acceleration signal, said synchronization processor provides said synchronization signal derived from amplitude of said patient blood pressure signal; and an image processor for processing 2D images acquired by said image acquisition device of said portion of patient anatomy in a plurality of different imaging planes having relative angular separation, to provide a 3D image reconstruction of said portion of patient anatomy.