1. A method of three dimensional (3D) image data processing and collecting processed data in a designated database to represent 3D route, comprising the following steps: (a) selecting image data from a source file, wherein a 3D image presents a structure spanned within multiple space regions in a standard area; (b) dividing the 3D image with voxels, and defining each space region with different characters; (c) transforming spatial distribution information of the 3D image into a sequence of characters, which is simplified as space code; and (d) collecting the image data and the results of the previous step into a non-transitory computer-readable recording medium, wherein transforming spatial distribution information of the 3D image into a sequence of character comprises the following steps: (a1) evaluating spatial distribution information of the 3D image in each space region by the results of equation: A times [log y m], wherein A indicates the character of each space region, y is a positive real number, m stands for the voxel numbers of the 3D image and [log y m]is an integer; (a2) transforming the results of (a1) into characters, wherein the quantification of spatial distribution information in each space region is represented by a plural number of “A”s, which represents the [log y m]times of repetition of “A”; (a3) combining repeated characters of each space region to form a sequence of characters, which is called a space code; and (a4) selecting a hub position in the 3D image and rearranging the space code of (a3) according to the topology of routes starting from the hub position.