1. A method for quantitatively assessing a volumetric image from a subject comprising: obtaining a quantitative image volume of the subject that is represented as voxels; and using a computer to compare a parameter of each of the voxels being assessed from the image from the subject with a parameter of each of a corresponding voxel from a computer database of images from a control group of subjects, and comparing the parameter of each of the voxels from the image from the subject being assessed as an EZ-score computed for individual voxels wherein the EZ score for a voxel comprises a quotient of a voxel Z-score/a variance of the control group at a corresponding voxel estimated by a bootstrap resampling method, so as to thereby assess whether or not the image from the subject being assessed differs from the images from the control group.