1. An anatomical data registration device, comprising: a dental device configurable to be subject specific such that upon configuration, the dental device is positionable in a substantially fixed spatial relationship relative to a portion of the subject; and one or more radiopaque markers positioned in the dental device, wherein at least one of the radiopaque markers is configured to facilitate alignment of two or more images of the portion of the subject; wherein at least a portion of the dental device is positionable within a subject's mouth, and wherein one or more of the radiopaque markers are positioned in the portion of the dental device that is positioned in the subject's mouth during use.