1. A method of automatic change quantification for medical decision support, comprising: automatically detecting a structure in a set of medical images; characterizing the detected structure including modeling of deformation characteristics of the detected structure; matching images based on the characterization of the detected structure, wherein a size measure of the detected structure is constrained according to the deformation characteristics; and quantifying a change in the detected structure; wherein estimating a uncertainty in the quantified change in the detected structure comprises estimating a confidence interval of a physiological, pathological or anatomical parameter measured from the detected structure.