1. A method of measuring a characteristic of nuclear organization of DNA of a cancer test cell sample, optionally a cancer test obtained from a subject, comprising: a. characterizing nuclear organization of DNA of the test cell sample comprising: i. obtaining DNA image data of the cancer test cell sample nuclei using microscopy; ii. processing the image data using granulometry to obtain one or more data points corresponding to DNA occupied space and/or DNA low space; b. quantifying a feature of the DNA occupied space and/or a feature of the DNA low space, the quantifying providing the characteristic of nuclear organization of DNA.