1. A method of dynamically tracking one or more targets within an anatomical region in order to deliver therapeutic radiation to the targets during a motion of the anatomical region, the anatomical region including one or more reference structures, the method comprising: determining in real time the locations of the targets relative to the reference structures within the moving anatomical region; and generating a radiation dose distribution that prescribes a desired amount of the therapeutic radiation to be delivered in real time to the targets within the moving anatomical region, the dose distribution accounting for a deformation of the moving anatomical region during the motion.