1. A method for navigating a device to a target location in a target area of a moving organ of a subject, the method comprises the steps of: acquiring at least one reference image under a first set of geometric conditions, the at least one reference image showing the target area and at least one first feature attached to the moving organ; defining the target location for the device on the reference image; determining a geometric relation between the at least one first feature and the target location by employing a relative location of said target area and said at least one first feature detected in said reference image; acquiring at least one positioning image; detecting a second feature in the at least one positioning image, indicating to a user a discrepancy between the target location and a current location of the device, using the second feature and the geometric relation, and wherein said at least one reference image comprises an X-ray run during which at least one first set of images is captured free of contrast material, showing said at least one first feature, and at least one second set of images is captured after injecting contrast material, showing said target area.