1. A method to specify a region of interest in a graphical presentation, the method comprising: determining an initial template region to represent the region of interest, a location of the initial template region based on a first point selected in the graphical presentation by a user; determining a first modification to perform on the initial template region in response to a second point selected in the graphical presentation by the user, the first modification at least one of selected by the user or corresponding to a default modification; detecting the second selected point in the graphical presentation, the second selected point at least one of outside or inside the initial template region, but not substantially on a boundary defining the initial template region; and reshaping the initial template region toward the second selected point, the reshaping corresponding to the first modification, the reshaping being performed in response to detecting the second selected point without also requiring the user to select any point substantially on the boundary defining the initial template region to initiate the reshaping.