1. A method of acquiring image data with an imaging system, comprising: positioning a movable single x-ray source tube in a housing, wherein the housing is connected to a mobile cart operable to move the housing from a first operating room to a second operating room; powering the single x-ray source tube with a first power source having a first power characteristic to emit x-rays at a first selected position relative to the patient; powering the single x-ray source tube with a second power source having a second power characteristic different from the first power characteristic to emit x-rays relative to the first selected position relative to the patient; gating the powering of the single x-ray source tube with the first power source and the second power source to acquire a plurality of two-dimensional projection image data of the first selected position at both the first power characteristic and the second power characteristic during a first image data acquisition phase at a first time period, wherein gating includes powering the single x-ray source tube to emit x-rays and not powering the single x-ray source tube to not emit x-rays; indexing the plurality of two-dimensional projection image data to determine a time when each two-dimensional projection image data was acquired; and operating a processor to execute instructions to reconstruct a first three-dimensional model of a first portion of the patient and a second three-dimensional model of a second portion of the patient based on the acquired plurality of two-dimensional projection image data acquired during the first image data acquisition phase at the first time; wherein at least one of the first or the second three-dimensional model includes dynamic contrast reconstruction based upon a x-ray attenuation difference in a first tissue and a second tissue based on the two-dimensional image data that is acquired at the first selected position by powering the single x-ray source tube at both the first power characteristic and the second power characteristic; wherein the first image data acquisition phase at a first time period is configured to generate sufficient image data for operating the processor to execute instructions to reconstruct the first three-dimensional model of the first portion of the patient and the second three-dimensional model of the second portion of the patient; wherein operating the processor to execute instructions further includes altering a theoretical formed model of the patient, wherein the theoretical model is associated with theoretical two-dimensional image data projections that are used to construct the theoretical model based on a priori knowledge of at least one of a configuration of (i) the first portion of the patient and a second portion of the patient, wherein the first portion includes an arterial portion and the second portion includes a venous portion; wherein the first power characteristic is selected to be at least one of a first voltage of about 40 kV to about 180 kV and a first amperage of about 10 mA to about 500 mA; wherein the second power characteristic is selected to be at least one of a second voltage that is about 40 kV to about 60 kV different than the first voltage and a second amperage that is about 20 mA to about 150 mA different than the first amperage.