1. A method of analysis of one or more decoy proteins to determine whether a decoy protein has a structure of a native globular protein, comprising: determining a normalized second-order hydrophobic moment profile for each decoy protein; using the normalized second-order hydrophobic moment profile to determine a scoring function for analysis of each decoy protein; using the scoring function to generate a score for each decoy protein, wherein the scoring function comprises S H =∫ 0 1 |{tilde over (H)} 2 |ds, wherein the score comprises an integral of an area under the normalized second-order hydrophobic moment profile of each protein, and wherein the score measures a prominence of a hydrophobic core and a prominence of a hydrophilic exterior of each decoy protein; outputting the score for each decoy protein to at least one of a user, a display, a memory and one or more additional computers on a network; and using the score of each decoy protein to determine whether the decoy protein has a structure of a native globular protein.