1. A computerized image registration process, comprising: a. selecting a first digital image of a first tissue section from a set of digital images of adjacent tissue sections; b. selecting a second digital image of a second tissue section from the set; c. matching tissue structure between the first digital image and the second digital image, said matching tissue structure comprising: a coarse registration mode comprising: generating a first gray-level tissue foreground image from the first digital image and generating a second gray-level tissue foreground image from the second digital image; computing a first tissue binary edge map from the first gray-level tissue foreground image and computing a second tissue binary edge map from the second gray-level tissue foreground image; and d. automatically mapping an annotation drawn on the first digital image to the second digital image.