1. A method for performing patient specific analysis of disease relevant changes of a disease in an anatomical structure of interest, the method comprising: determining a percentage of the anatomical structure that is encompassed by a diseased tissue region using a patient specific healthy tissue model; and determining the amount or spatial distribution or a combination thereof of tissue volume variation due to the disease in the anatomical structure based on the percentage of the anatomical structure encompassed by the diseased tissue region and an estimated original amount of tissue.