1. A method, comprising: coupling a plurality of primary markers to a target; coupling at least one secondary marker to said target; capturing a plurality of primary marker data points including: illuminating said plurality of primary markers; and capturing a response of said plurality of primary markers to said illumination; wherein said plurality of primary markers includes a plurality of reflective markers, and said response includes a reflection of said illumination by said plurality of reflective markers; wherein each data point of the plurality of primary marker data points corresponds to one primary marker of said plurality of primary markers; wherein: said illumination is subject to periodic gating to generate on-states and off-states of said illumination; and said reflection of said illumination is captured during an on-state of said illumination; capturing at least one secondary marker signature, each marker signature corresponding to and uniquely identifying each secondary marker of said at least one secondary marker, wherein said capturing at least one secondary marker signature includes capturing a unique attribute of said at least one secondary marker during an off-state of said illumination; and identifying said plurality of primary markers using said at least one secondary marker signature by using a processor.