1. A method of identifying or quantifying an analyte in a sample using mass spectrometry, the method comprising: (a) providing a list of target analytes and target analyte product information, wherein the list comprises from 25 to 5,000,000 target analytes; (b) providing a sample containing an analyte; (c) generating a distribution of precursor analyte ions from the sample; (d) fragmenting precursor analyte ions having a preselected distribution of mass-to-charge ratios, thereby generating product ions; (e) measuring mass-to-charge ratios of at least a portion of the product ions in a mass analyzer, wherein the mass analyzer has a mass accuracy of at least 1000 ppm, thereby generating product ion mass spectrometry data; and (f) optimizing analyte identification or quantitation during data acquisition by comparing the product ion mass spectrometry data to the list of target analytes and target analyte product information; thereby identifying or quantifying an analyte in the sample using mass spectrometry.