1. An image sensor comprising: a pixel array comprising a plurality of pixels arranged in rows and columns; a color filter array optically coupled to the pixel array, the color filter array comprising a plurality of tiled minimal repeating units, each minimal repeating unit including: a plurality of individual filters wherein the spectral photoresponses of the individual filters include at least three dual-band spectral photoresponses and one single-band spectral photoresponse; and circuitry and logic coupled to the pixel array, wherein the logic comprises instructions that, when executed by the circuitry, cause the image sensor to: capture a first image frame using an image sensor, the image sensor including a pixel array comprising a plurality of pixels arranged in rows and columns and a color filter array optically coupled to the pixel array; determine a region of interest within the first image frame; adjust the exposure time of the image sensor to eliminate a substantial fraction of the visible light captured by the image sensor; use a rolling shutter procedure with the pixel array to capture at least one subsequent frame using the adjusted exposure time; activate a source of invisible radiation while the rolling shutter enters the region of interest and deactivating the source of invisible radiation when the rolling shutter exits the region of interest; and output an image of the region of interest.