1. A method for reconstructing list mode data, the method comprising: reconstructing all list mode data of a list mode data set to generate a first reconstructed image; after the first reconstructed image is generated, identifying a region of interest in image space based on a feature delineated in the first reconstructed image and selecting a sub-set of the list mode data set comprising list mode data contributing to image content of the region of interest in image space; and reconstructing only the sub-set of the list mode data set utilizing a higher resolution reconstruction parameter than the reconstructing used to generate the first reconstructed image to generate an enhanced reconstructed image with higher resolution than the first reconstructed image.