1. A method of acquiring image data of a subject with an imaging system, comprising: positioning a gantry to completely annularly encompass a region of interest; acquiring initial image data of the region of interest by moving at least one of a gantry or a detector from a first location to a final location relative to the region of interest while acquiring a selected image data set of the region of interest; constructing an initial three-dimensional model of at least a portion of the region of interest regarding which the selected image data was acquired; performing a procedure on the region of interest including altering an anatomical location at the region of interest; acquiring discriminatory discrete location image data of the region of interest at or near the altered anatomical location; comparing the acquired discriminatory discrete location image data to the constructed initial three-dimensional model of the portion of the region of interest; identifying specific regions having a threshold change between the acquired discriminatory discrete location image data and the initial constructed three-dimensional model of the portion of the region of interest; determining at least one location of at least one of the detector or the gantry to acquire comparative image data regarding the specific regions having the threshold change; and acquiring the comparative image data at the determined at least one location of at least one of the detector and the gantry.