1. A system for generating a digital subtraction image of at least two input images, comprising: a registration subsystem for generating a plurality of different registrations of the input images, based on different values of a registration parameter, each different registration represents a different assumed depth and a different rotation origin of an object visible in each of the input images; a subtraction subsystem for generating a plurality of subtracted images by subtracting the input images in accordance with respective ones of the plurality of registrations; a combining subsystem for combining the plurality of subtracted images into a single combined subtracted image, and the single combined subtracted image is a single frame image.