1. A method for reconstructing an x-ray image of an object under examination from measured projection data indicative of the object, comprising: converting the measured projection data into image data to generate a first instance of the image data; regularizing the first instance of the image data to generate regularized image data, wherein the regularizing comprises selecting a first quality metric in the image data for modification based upon a type of object of focus during the examination and selecting a second quality metric in the image data for modification based upon the type of object of focus during the examination, the second quality metric different than the first quality metric; isolating a region of the regularized image data that represents an aspect of the object that generates an inconsistency in the measured projection data; forward projecting the region to generate inconsistent projection data; forward projecting a portion of the regularized image data not corresponding to the region to generate a first instance of synthesized projection data, wherein the first instance of the first instance of the synthesized projection data excludes a forward projection of the region; correcting the measured projection data based at least in part upon the inconsistent projection data to generate corrected projection data; and updating the image data to generate a second instance of the image data using the corrected projection data and using the first instance of the synthesized projection data.