1. A physiological parameter analysis system ( 10 ) that detects ECG electrode wire misplacement, comprising: a transformation component ( 32 ) that transforms original ECG information and combinations thereof from a first ECG lead system to a second ECG lead system; an inverse transformation component ( 34 ) that derives ECG information in the first ECG lead system from the transformed ECG information and the combinations thereof; and an analysis component ( 38 ) that determines a correct ECG lead configuration in the first ECG lead system from among the original ECG information and the combinations thereof based on the derived ECG information.