1. A system, comprising: a model to represent a volumetric deformation of a brain corresponding to brain tissue that has been displaced or shifted by at least one of disease, surgery or anatomical changes; and a fusion engine to perform a coarse fusion to align a first image of the brain with respect to a second image of the brain after a region of the brain has been displaced and to employ the model to adjust one or more points on a displacement vector extending through a displaced region of the brain to compensate for spatial deformations that occur between the first and second image of the brain.