1. A method to generate a fly-through review for a digitally imaged tissue sample, said method comprising: determining a fly-through path based on a user-selected fly-through starting point and a segmentation of a tissue boundary in said sample image to generate one or more fly-through curves; applying, using a processor, an image manipulation to said sample image in accordance with said one or more fly-through curves to generate a sequence of frame images to be displayed in an automatic fly-through review; and displaying the automatic fly-through review to the user.