1. A diagnostic imaging system, the system comprising: a computer workstation for controlling the imaging system, interfacing with an operator and generating images; a coordinate system in data communication with the computer workstation, the coordinate system adapted to describe relative position in the diagnostic imaging system; a subject support describable within the coordinate system; an X-ray sub-system, the x-ray sub-system positionable around the subject support; position sensors operatively connected to the x-ray sub-system and workstation, the position sensors providing signals to the workstation indicative of the position of components of the x-ray sub-system within the coordinate system; a nuclear camera sub-system, the nuclear camera sub-system positionable around the subject support; position sensors operatively connected to the nuclear camera sub-system and workstation, the position sensors providing signals to the workstation indicative of the position of components of the nuclear camera sub-system within the coordinate system; means for determining the position within the imaging coordinate system of a region of interest in an associated imaging subject from an image generated by the x-ray sub-system; and means for targeting the nuclear camera sub-system to precisely obtain an image at the region of interest.