1. A method, comprising: generating a patient-specific anatomical model of coronary arteries and a heart from medical image data of a patient; generating a multi-scale functional model of coronary circulation based on the patient-specific anatomical model; coupling, to the multi-scale functional model of coronary circulation, a cellular model of endothelial cell function that simulates changes in a mechanical property of a vascular wall due to a response of endothelial cells to hemodynamic forces, wherein a wall shear-stress value calculated by the multi-scale functional model of coronary circulation is used to couple the multi-scale functional model of coronary circulation to the cellular model of endothelial function through a mechanotransduction model; and simulating blood flow in at least one stenosis region of at least one coronary artery and changes in a mechanical property of a vascular wall in the at least one stenosis region of the at least one coronary artery due to a response of endothelial cells in the vascular wall to hemodynamic forces from the simulated blood flow using the multi-scale functional model of coronary circulation and the cellular model of endothelial cell function coupled to the multi-scale functional model of coronary circulation.