1. A system for computing the efficacy of a surgical treatment in a region of a lung, the system comprising a processor, the processor programmed and being operable to: a) receive first image data of the lung in a first state; b) receive second image data of the lung in a second state; c) perform a rigid registration to initially align the first image data and the second image data with one another using a fixed reference feature; d) compute a change in the region in the lung between the first state and the second state based on generating a motion vector field comprising a magnitude of each point in the first image data and second image data of the lung indicating movement and location between the first state and second state and direction of local motion of lung tissue between the first state and second state and computed independent of the fixed reference feature defined in the performing a rigid registration step; e) determine efficacy of the surgical treatment based on said change in the region in the lung; and indicate the change in the region in the lung between the first state and the second state.