1. A nuclear camera calibration system, including: a nuclear camera that images a radiopharmaceutical point source; and a processor that: compares a measured point spread function (PSF) from a point source image to a simulated PSF to determine a difference value therebetween; generates a PSF correction curve by interpolating PSF data for the measured PSF to reduce the difference value using the simulated PSF; calibrates the measured PSF to generate a calibrated PSF; and stores the calibrated PSF to a memory.