1. A method of producing an enhanced medical image of a subject, comprising: producing a reference set of medical images of the subject or a portion thereof using a medical imaging modality, wherein the reference set of medical images comprises a plurality of reference set images; creating an area of increased image contrast in the subject; producing a data set of medical images of the subject or a portion thereof using the medical imaging modality, wherein the data set of medical images comprises a plurality of data set images, each data set image comprising data received from the area of increased contrast; comparing at least one data set image to a plurality of reference set images to identify a data-reference image pair, wherein the data-reference image pair comprises the reference set image that has the smallest difference error as to the data set image versus the other compared reference set images; and subtracting the reference image of the data-reference image pair from the data image of the data-reference image pair to create the enhanced medical image.