1. A method of producing an enhanced medical image of a subject, comprising: producing a reference set of medical images of a subject or a portion thereof using a medical imaging modality, wherein the reference set of medical images comprises a plurality of reference set images; producing a data set of medical images of the subject or a portion thereof using the medical imaging modality, wherein the data set of medical images comprises a plurality of data set images, each data set image comprising data received from an area of increased contrast; comparing each of a plurality of the data set images to each of a plurality of the reference set images to identify a data-reference image pair, wherein the identified data-reference image pair comprises the reference set image that has the smallest difference error as to the data set image versus the other compared reference set images; and subtracting the identified reference image of the data-reference image pair from the data image of the data-reference image pair to create the enhanced medical image, wherein each reference set image of the reference set is acquired from a portion of the subject undergoing dynamic motion during the acquisition, and each data set image of the data set is acquired from a portion of the subject undergoing dynamic motion during the acquisition, and wherein the area of increased contrast is not created in the subject when the reference images are produced.