1. An imaging system, comprising: one or more radiation sources configured to transmit x-ray radiation towards a subject for imaging a dynamic process in a region of interest of the subject; one or more detectors configured to acquire projection data corresponding to the region of interest; and a computing device operatively coupled to one or more of the radiation sources and to the detectors, wherein the computing device is configured to: provide control signals for performing one or more reference scans for acquiring reference data from a plurality of angular positions around the subject; provide control signals for performing one or more tomosynthesis scans using one or more tomosynthesis trajectories for acquiring tomosynthesis data following onset of the dynamic process; and reconstruct one or more images representative of the dynamic process using the reference data, the tomosynthesis data, or a combination thereof