1. A method of correcting orientational misalignment between a charged particle beam axis of a charged particle beam microscope and a zone axis of a crystalline sample, comprising: irradiating, along the charged particle beam axis, the crystalline sample with a collimated beam of charged-particles; recording a sample diffraction pattern composed of multiple sample diffraction spots; correlating the intensity of diffraction spots in the sample diffraction pattern with the intensity of corresponding diffraction spots of multiple reference diffraction patterns, each of the reference diffraction patterns corresponding to a known misalignment between the charged particle beam axis and the zone axis of the crystalline sample; adjusting the relative orientation of the crystalline sample and the charged particle beam axis to correct the misalignment of the zone axis of the crystalline sample and the charged particle beam axis using the known misalignment of the reference diffraction pattern having the closest correlation with the sample diffraction pattern; and observing the crystalline sample using the charged particle beam microscope after adjusting the relative orientation of the crystalline sample and the charged particle beam axis, wherein the recording of only a single sample diffraction pattern is required for adjusting to correct the orientation of the crystalline sample.