1. An image analysis system, comprising: one or more processing components configured to receive measured views that generally encompass an organ or region of interest from which radiation is emitted by decay of a radiopharmaceutical, wherein some, but not all, of the measured views include radiation contributions from a secondary organ or tissue that is not of interest, and to execute one or more executable routines stored in a memory; the memory storing the one or more executable routines, wherein the stored routines, when executed, reconstruct the measured views to generate an initial image using an initial camera system matrix that models the physical and geometric relationship of a detector used to acquire the measured views, generate a corresponding estimated view for each measured view using the initial image, compare each measured view with the corresponding estimated view to derive an indication, if any, of the radiation contributions from the secondary organ or tissue present in each measured view, and use the indications to update the camera system matrix to form an updated camera system matrix that is used to reconstruct a final image in which the radiation contributions from the secondary organ or tissue are reduced or eliminated; and interface circuitry configured to allow user interaction with the image analysis system.