1. A method for studying microstructural integrity or connectivity or both of a region of interest (ROI) in a patient comprising: acquiring, via an imaging system, diffusion magnetic resonance (MRI) data in said ROI by using Icosahedral Diffusion Tensor Encoding Scheme (IDTES); computing, via the imaging system, mean diffusivity (MD) and fractional anisotropy (FA) by using logarithm-moment algorithm (LMA); and displaying, on a display, the microstructural integrity or connectivity or both of ROI based on the computed MD and FA; wherein values of MD and FA are indicative of the microstructural integrity or connectivity of the ROI.