1. A magnetic resonance imaging system for generating information indicative of an MR response to an oxygen breathing challenge, the MRI system comprising at least one controller configured to: define a reference region within a region of interest of reconstructed MR image information including a plurality of voxels, the reference region comprising a plurality of reference voxels selected from the plurality of voxels, each of the plurality of voxels having associated ΔR 2 * and ΔR 1 values; select a cluster of voxels comprising voxels from at least the reference voxels from a multiparametric ΔR 2 * vs ΔR 1 mapping of the plurality of voxels; determine ΔR 2 * and ΔR 1 limit points based upon at least minimum ΔR 2 * and ΔR 1 values of voxels of the cluster of voxels; and determine outlier voxels based upon a comparison of ΔR 2 * and ΔR 1 of at least one of the plurality of voxels with respective values of the ΔR 2 * and ΔR 1 limit points.