1. A system comprising: at least one detecting component detecting incident electromagnetic radiation at a number of pixels; a number of electromagnetic radiation sources; each electromagnetic radiation source emitting at substantially one wavelengths from a number of wavelengths; at least some of the number of wavelengths substantially coinciding with wavelengths in an absorption spectrum of predetermined materials; the number of electromagnetic radiation sources emitting substantially from one location; the at least one detecting component receiving reflected/scattered electromagnetic radiation from the area of interest; a patterning component disposed between the number of electromagnetic radiation sources and the area of interest; the patterning component receiving electromagnetic radiation from at least one electromagnetic radiation source from the number of electromagnetic radiation sources and providing at least a portion of the electromagnetic radiation received to the area of interest; each one of the number of the electromagnetic radiation sources sequentially illuminating the patterning component; a modulating component modulating, with respect to time, emission from said each one of the number of electromagnetic radiation sources; and an analysis component configured to: obtain a number of pixelated images by sequentially illuminating the area of interest; illumination through the patterning component producing areas in each pixelated image that are not directly illuminated; obtain, for each one or more pixelated images from the number of pixelated images, the one or more pixelated images illuminated at substantially one wavelength, one pixelated image, labeled a global pixelated image, produced substantially by the areas are not directly illuminated, constituting a number of global pixelated images; process the number of global pixelated images; the number of global pixelated images, after processing, constituting a vector of processed data at each pixel from a number of pixels; and compare, at each pixel, the vector of processed data to a predetermined vector corresponding to a predetermined material; presence of the predetermined material being determined by comparing.