1. A method for removing marker artifacts from a tomosynthesis dataset in a tomosynthesis imaging system comprising: positioning at least one alignment marker anywhere within a field of view of the tomosynthesis imaging system; acquiring a first plurality of projection images by tomosynthesis x-ray imaging, the first plurality of projection images containing at least one imaged representation of the at least one alignment marker; minimizing the imaged representation of the at least one alignment marker on the first plurality of projection images to generate a second plurality of projection images; and reconstructing a plurality of tomographic images from the second plurality of projection images wherein if the at least one alignment marker is more than one, then a correlation between each alignment marker is not predetermined.