1. A method, comprising: using a first particle-optical device to image sample sections of a series of sample sections to generate a first series of images, coordinates of an imaged point of the sample being acquired and stored so that the coordinates of the imaged point of the sample are associated with the image of the point of the sample; generating a first 3D reconstruction based on information in the first series of images, the first 3D reconstruction being a reconstruction of at least a portion of the sample; selecting a volume of interest of the sample (VOI) based on information in the first series of images; transmitting the coordinates of the selected VOI to a second particle-optical device; and using the second particle-optical device to image a plurality of planes of a sample section that contains the selected VOI to generate second series of images; and generating a 3D image of the selected VOI based on information in the second series of images.