1. A method for creating a multidimensional morphological reconstruction of biological activity in a biological tissue sample comprising the steps of: micro dissecting a tissue sample to obtain first and second sample sets of tissue samples indexed to a 3-D grid; processing the first sample set to obtain a computer generated 3-D visualization of the tissue sample; analyzing each sample in the second sample set to measure values of biological data; and using the 3-D grid indices to spatially map, using a computer, biological data values of samples in the second sample set to corresponding indexed locations in the 3-D visualization.