1. A non-transitory computer readable storage medium having a computer program stored thereon and representing a set of instructions that, when executed by a computer, causes the computer to: access a first set of data of a first data type, the first set of data acquired from a patient with a first imaging modality; access a second set of data of a second data type, the second set of data acquired from the patient with a second imaging modality; perform a segmentation on the first set of data to identify a subset of the first set of data corresponding to a skeletal structure of the patient, the segmentation including: detect a jaw-bone of the patient in the subset of the first set of data; and remove data corresponding to a patient brain from the subset of the first set of data based on the detected jaw-bone; generate a segmented skeletal structure of the patient by filling a plurality of cavities in the subset of the first set of data, the plurality of cavities corresponding to bone marrow locations within the skeletal structure of the patient; automatically calculate a patient skeletal metric from the segmented skeletal structure, the patient skeletal metric representing a total bone volume of the patient; detect at least one lesion in the second set of data; classify the at least one lesion as one of a bone lesion and a non-bone lesion; automatically calculate a bone lesion metric based on the classification; and calculate a lesion burden as a ratio of the bone lesion metric and the patient skeletal metric.