1. Method of removing the spatial response signature of a two dimensional x-ray detector comprising a photostimulable phosphor from a computed radiography (CR) image, the method comprising: retrieving the spatial response signature of a CR-detector used during the acquisition of said CR image, in-spatial-register demodulating said CR image by dividing pixel values of said CR image by corresponding values in the retrieved and spatially remapped signature, values of the spatially remapped signature being obtained by warping said spatial response signature according to a geometric transformation model, wherein a read out device used for reading said CR-image out of the detector and a read out device used during determination of the spatial response signature of the detector are different devices, re-sampling the retrieved signature to match the pixel size of the signature with that of the CR image.