1. An Information Handling System (IHS), comprising: an Organic Light-Emitting Diode (OLED) screen; and a controller coupled to the OLED screen, wherein the controller is configured to: generate at least one current histogram matrix for a current frame; compare the at least one current histogram matrix against at least one previous histogram matrix generated for a previous frame, wherein the current frame and the previous frame each consists of a subset of pixels smaller than a total number of pixels present in the OLED screen, and wherein the subset of pixels excludes an area of the OLED screen that is subject to change over time in the absence of any user interaction with any input device coupled to the IHS; and enter a screen protection mode of operation in response to the comparison indicating that the at least one current histogram matrix is different from the at least one previous histogram matrix by an amount equal to or smaller than a threshold.