1. A biological specimen observation apparatus which observes temporal change in a biological specimen, comprising: an image acquisition unit to acquire an image by capturing an image of the biological specimen, while time lapse observation is performed; a biological change region extracting unit to extract a biological change region, which is a region of change in the biological specimen, from the acquired image; a micro observation point setting unit to register a micro observation point corresponding to the extracted biological change region; the image acquisition unit to capture an image of a micro region of change in the biological specimen identified at the micro observation point, while time lapse observation is performed; and a judgment unit to judge whether or not biological change has continued in the biological change region at the micro observation point, from the acquired micro image.