1. A method of acquiring an X-ray image of an object comprising: positioning said object in field of view of an X-ray image acquisition device; selecting a set of a plurality of unique projection angles between said X-ray image acquisition device and an axis through said object, wherein said set spans at least 45 degrees around said object; selecting a targeted X-ray exposure at a detector region for each of said projection angles; determining a targeted total exposure duration time for each of said projection angles corresponding to said targeted X-ray exposure; implementing said plurality of targeted total exposure duration times in said X-ray image acquisition device over said set of projection angles to acquire an image data set; and reconstructing an X-ray image from said image data set.