1. A method for intraoperative guidance in a percutaneous mitral valve procedure comprising: generating a plurality of patient-specific models of the mitral valve, each from pre-operative image data obtained using a separate imaging modality; fusing the pre-operative image data from separate imaging modalities into a common coordinate system by registering the plurality of patient-specific models; and estimating a model of the mitral valve in real-time in intraoperative image data using a fused physiological prior resulting from the registering of the plurality of patient-specific models.