1. A method, comprising: imaging a volume of interest (VOI) with an imaging system and acquiring positional data of a target within the VOI, wherein the positional data comprises a present position of the target relative to an imaging center of the imaging system, wherein the imaging center has a first location in a treatment room coordinate system; moving the VOI with a positioning system, to align the target in a radiation system, wherein the radiation system has a second location in the treatment room coordinate system different from the first location; and treating the target at the second location.