1. A method, comprising: determining, by a system comprising a processor, a reference set of image features from an electronic data file specifying a reference image in a reference coordinate space; receiving, by the system, training images representing respective different views of the reference image; ascertaining, by the system, rendering information describing a physical rendering of the reference image; deriving, by the system, calibration-enabling data from the reference set of image features and the ascertained rendering information, the deriving comprising: for each respective training image of the training images, generating a respective candidate set of image features from the respective training image, and comparing the image features of the respective candidate set to the image features in the reference set, for each respective image feature in the reference set, computing a metric representing a number of matches to corresponding image features in the candidate sets, and selecting, based on the computed metrics, a subset less than all of the image features in the reference set, wherein the calibration-enabling data is derived using the selected subset less than all of the image features in the reference set; and providing, by the system, the calibration-enabling data to calibrate an imaging system.