1. A method of processing graphical image data representing optically scanned medication-related units comprising: receiving image data generated responsive to disposal of the units on a tray disposed a distance from an image acquisition component, the image data including data indicative of visually observable features of the units disposed on the tray; comparing, via processing circuitry, at least two features among the visually observable features from the image data to reference data indicative of corresponding features of reference units, the reference data being selected for comparison based on an identification of the reference data as corresponding to a prescription being processed, the reference data including data indicative of features of the reference units extracted from images captured using hardware corresponding to hardware used to generate the image data such that the images are captured using substantially the same camera disposed the same distance from reference units in the reference data as the units on the tray; and generating a likelihood rating for each of the at least two features based on the comparing, wherein generating the likelihood rating comprises generating a score indicative of a degree of matching between features of the image data and corresponding features of the reference data, the score being comparable to at least two thresholds to determine at least three classifications of likelihood ratings for the corresponding features based on comparing the score to the at least two thresholds, and wherein the at least three classifications comprising at least one classification for which an automated response is provided and at least one classification for which operator intervention is solicited, and wherein generating the likelihood rating comprises generating the likelihood rating in association with a counting operation in which the units are counted, and wherein both the counting operation and generating the likelihood rating are accomplished prior to the units being removed from the tray.