1. A physiological parameter analysis system ( 10 ) that detects ECG electrode wire misplacement, comprising: a receiver for receiving original ECG information corresponding to a plurality of electrode leads in a first lead system; a combinationalyzer/decombinationalyzer ( 28 ) that is operatively connected to the receiver and that generates one or more combinations from the original ECG information, each combination representing a permutation of the received electrode leads; a processor that is operatively connected to the combinationalyzer/decombinationalyzer, the processor having; a transformation component ( 32 ) that transforms the original ECG information and each combination from a first lead system to a second lead system different from the first lead system; and an inverse transformation component ( 34 ) that reverse transforms the transformed original ECG information and each combination from the second lead system to the first lead system; a comparator ( 36 ), operatively connected to the combinationalyzer/decombinationalyzer and the inverse transformation component, which computes a difference between the original ECG information and the reverse transformed original ECG information, and which computes a difference between each combination and each reverse transformed combination; an analyzer ( 38 ), operatively connected to the comparator, that determines a misplaced electrode wire in the original ECG information based on the computed differences; and a notification component ( 56 ), operatively connected to the analyzer, that transmits a notification of the analyzer determination.