1. A system for validating calibration of at least one camera in a vision system that images a volume space within a field of view thereof operatively connected to a processor comprising: a calibration process performed during vision system set up that generates and stores camera calibration parameters and result statistics based upon calibration images of a first calibration object, the calibration images being captured by the at least one camera during the vision system set up, the first calibration object having a known pattern and dimensions acquired at at least one position within the volume space, the calibration process computing, during the vision system set up, a set of calibration discrepancies between positions of extracted calibration features from the calibration images within the field of view and predicted positions expected of the known pattern of the first calibration object; a validation process that, during runtime system operation and subsequent to the calibration process, based on the camera calibration parameters and the result statistics, (a) acquires at least one validation image of the first calibration object or a second calibration object having a known pattern and dimensions, (b) extracts validation features of the at least one validation image of the first calibration object or the second calibration object, (c) predicts positions expected of validation features of the first calibration object or the second calibration object using the camera calibration parameters from the calibration images acquired during the calibration process, and (d) computes a set of validation discrepancies between positions of the extracted validation features and the predicted positions of the validation features; and wherein the validation process is constructed and arranged to determine whether at least one of the set of calibration discrepancies or at least one of the set of validation discrepancies exceeds an acceptance threshold associated therewith.