1. A method of evaluating for the presence of a target polynucleotide in a sample, using an addressable array of multiple polynucleotide probes linked to a substrate, the method comprising: (a) exposing the sample to the array and a set of polynucleotide target probes, such that target polynucleotide which may be present will bind to a predetermined feature of the array through multiple target probes of the set by forming at respective target regions on a target molecule, simultaneous hybrids with anti-target regions of the multiple target probes; and (b) observing a binding pattern on the array and evaluating the presence of the target polynucleotide based on the observed binding pattern.