1. A method for vascular assessment comprising: receiving a plurality of 2D angiographic projection images of a portion of a vasculature of a subject, wherein one of the images has been acquired from a first viewing angle, and another of the images has been acquired from a second viewing angle; identifying vascular features within and corresponding among the plurality of 2D angiographic projection images; combining geometrical information for the corresponding vascular features to produce a stenotic model of the vasculature, said stenotic model having measurements of the vasculature at one or more locations along vessels of the vasculature; obtaining a flow characteristic of the stenotic model; and calculating an index indicative of vascular function, based, at least in part, on the flow characteristic in the stenotic model.