1. A defect detection system for computerized detection of defects in an inspected object based on processing of an inspection image of the inspected object, the system comprising: a memory; and a processor operatively coupled to the memory to: identify an analyzed pixel from a first cell of the inspection image of the inspected object; identify a plurality of reference pixels from a plurality of cells of the inspection image of the inspected object, the plurality of cells being other cells in the inspection image than the first cell of the inspection image; obtain an inspected noise-indicative value representative of the analyzed pixel of the first cell of the inspected image, and a plurality of reference noise-indicative values representative of the plurality of reference pixels from the plurality of cells other than the first cell of the inspection image; compute a representative noise-indicative value based on a plurality of noise-indicative values which comprises the inspected noise-indicative value and the plurality of reference noise-indicative values; calculate a defect-indicative value based on an inspected value representative of the analyzed pixel; and determine a presence of a defect in the analyzed pixel based on the representative noise-indicative value and the defect-indicative value.