1. A method for detecting a feature of interest in a vascular image, the method comprising: receiving information from a first imaging modality and transforming information from the first imaging modality into a first coordinate space; receiving information from a second imaging modality and transforming information from the second imaging modality into a second coordinate space; aligning the first coordinate space and the second coordinate space, thereby combining information from the first modality and the second modality into a combined data set; and detecting a feature of interest in a vascular image based on the combined data set.