1. A workflow method for nodule detection review comprising: registering a reference image R with a floating image F, convolving said reference image R with a window function Hw to generate Rw, convolving said floating image F with the same window function Hw to generate Fw, generating a subtraction image by performing subtraction Rw−Fw (g(r)), wherein r represents a voxel (x, y, z) in the reference image R, applying a pattern detector to said subtraction image to detect corresponding nodules in reference image R and floating image F, and displaying corresponding nodules.