1. A system to navigate an image-guided object traveling in an area of interest of an imaged subject in relation to an acquired image of the imaged subject, comprising: a four-dimensional (4D) imaging system to create a 4D model representative of a time-dependent three-dimensional spatial model correlated to a time interval and defined in spatial relation and orientation relative to a first image coordinate system; a second imaging system different than the 4D imaging system, the second imaging system operable to create a second three-dimensional model of the imaged subject defined in spatial relation and orientation relative to a second image coordinate system; a tracking system operable to track movement and orientation of the object through the imaged subject relative to a tracking coordinate system; and a controller electrically connected in communication with the 4D imaging system, the second imaging system, and the tracking system, the controller having a processor operable to execute a plurality of program instructions stored in a memory, the plurality of program instructions in combination with the processor operable to: register the first and second image coordinate systems and the tracking coordinate system relative to a world coordinate system, and combine the four-dimensional model created by the 4D imaging system with the second three-dimensional model created by the second imaging system.