1. A method, comprising: obtaining a non-scaled irregularity map generated based on local weighted histograms of voxel distributions about voxels of interest from volumetric image data of a subject or object, wherein the local weighted histograms include a plurality of bins having a predetermined bin width, and wherein the local weights are determined based on a predetermined cluster length; and scaling the non-scaled irregularity map, generating a scaled irregularity map, wherein the non-scaled irregularity map is scaled based at least on the histogram bin width.