1. A method for generating a three-dimensional map of an object, wherein the three-dimensional map exhibits a first extended depth of field along a first axis and a second extended depth of field along a second axis, comprising the steps of: (a) collecting light from the object along both a first collection path comprising the first axis and a second collection path comprising the second axis, where the first axis and the second axis are not parallel; (b) deforming an optical wave front of light from the object to produce modified light, such that light in both the first collection path and the second collection path comprises modified light, and a point spread function (PSF) of an imaging system used to collect the modified light is substantially invariant across the first extended depth of field and the second extended depth of field; (c) focusing modified light from the first collection path to produce a first image of the object, the first image being formed by light simultaneously collected from a first plurality of different focal planes along the first axis, the first plurality of different focal planes comprising the first extended depth of field; (d) detecting the first image of the object using a first detector to generate first image data; (e) focusing modified light from the second collection path to produce a second image of the object, the second image being formed by light simultaneously collected from a second plurality of different focal planes along the second axis, the second plurality of different focal planes comprising the second extended depth of field; (f) detecting the second image of the object using a second detector to generate second image data; (g) processing the first and second image data to reduce artifacts introduced by deforming the optical wave front, to produce a first corrected extended depth of field image corresponding to the first collection path, and a second corrected extended depth of field image corresponding to the second collection path; and (h) using the first corrected extended depth of field image and the second corrected extended depth of field image to produce the three-dimensional model of the object.