1. A virtual slide generation device for generating a virtual slide by patching/combining a plurality of observation images obtained by shooting and picking up an observation object observed by a microscope, comprising: an image patching/combination information calculation unit for calculating image patching/combination information about an area overlapping between observation images for the patching/combination on the basis of a plurality of observation images shot and picked up by a first observation method; and an image patching/combination unit for patching and combining a plurality of image areas shot and picked up by a second observation method on the basis of the image patching/combination information calculated by the image patching/combination information calculation unit.