1. A digital x-ray imaging system, comprising: an x-ray source adapted to emit an x-ray beam onto an identified region of interest; a positioning system to translate or rotate the x-ray source from a first position to a second position, wherein the second position is different than the first position; a digital x-ray detector adapted to capture a first image of the region of interest when the x-ray source is in the first position, and capture a second image of the region of interest when the x-ray source is in the second position; a processing engine to extract features from each of the region of interest of the first and second captured images, wherein the extracted features evaluate pleural effusion causes of blood, pus, and water; and an analyzer analyzing the extracted features and generating an indicator of a disease responsive to the extracted features.