1. A method of evaluating vascular tissue, comprising: inserting at least a portion of an intravascular device into a vascular structure; activating an ultrasound transducer of the intravascular device, wherein activating the ultrasound transducer results in an ultrasound signal being transmitted toward vascular tissue of the vascular structure; acquiring a scan line of backscattered ultrasound data from the vascular tissue; applying a one-dimensional homomorphic deconvolution operation to digital data corresponding to the scan line of backscattered ultrasound data to render an estimated scan-line system transfer function; and calculating ultrasound response data for the vascular tissue based upon the estimated scan-line system transfer function.