1. A system for stereoscopically imaging at least a portion of one or more samples, comprising: a stage configured to support a sample; an illumination source configured to illuminate at least a portion of the sample, wherein the illumination source is configured to backlight at least a portion of the sample whereby illumination is transmitted through at least a portion of the sample; collection optics defining a collection path, the collection optics configured to receive illumination transmitted through the sample, the collection optics including a substrate, the substrate including two or more apertures positioned in the same plane and arranged to direct a first portion of the illumination along a first imaging path to a first detector and a second portion of the illumination along a second imaging path parallel to the first path to a second detector; a wave front coder disposed along the collection path, the wave front coder configured to induce one or more imaging effects on the received illumination, transmitted through at least a portion of the sample, prior to entry of the received illumination along at least one of the first imaging path or the second imaging path at least by phase shifting the illumination directed along the collection path, wherein the wave front coder, collection optics, illumination source and stage are arranged in a columnar structure; and at least one computing system communicatively coupled to the first detector and the second detector, the at least one computing system configured to acquire a first image from the first detector and a second image from the second detector, and further configured to filter the first image and the second image to remove at least a portion of the one or more imaging effects induced by the wave front coder.