1. A method of determining if reperfusion has occurred in a myocardial infarct patient after receiving thrombolytic therapy, comprising: (a) detecting a first variable comprising a first serum creatine kinase MB level in a myocardial infarct patient undergoing thrombolytic therapy at the an onset of said thrombolytic therapy; then (b) detecting a second variable comprising a second creatine kinase MB level in said patient a predetermined time after the onset of said thrombolytic therapy; and (c) detecting a third variable comprising a presence or absence of chest pain a predetermined time after the onset of said thrombolytic therapy; (d) detecting a fourth variable comprising a serum myoglobin level in said patient a predetermined time after the onset of said thrombolytic therapy; (e) generating a probability of the presence of a persistent occlusion from said first through fourth variables, the absence of a persistent occlusion indicating that reperfusion has occurred in said patient.