1. A method to derive information regarding one or more bone parameters from an image comprising: (a) obtaining image data of bone from a subject; (b) defining a region of interest from the image data; (c) defining within the region of interest at least first and second windows, wherein the first and second windows overlap; (d) analyzing information in the first window to determine at least a first value for a parameter, the parameter selected from the group consisting of bone microarchitecture, bone macroanatomy, biomechanical parameters and combinations thereof; (e) analyzing information in the second window to determine at least a second value for the parameter; and (f) generating a set of data at least in part from the first and second values.