1. A method of calibrating multi-block image sensors having a block readout format by employing look up tables (LUTs) that have their values determined during a calibration cycle comprising the steps of: providing a test pattern having a predetermined image; providing a multi-block image sensor with means for acquiring the predetermined image on the test pattern within the image sensor and reading the acquired image out of the image sensor; acquiring the image on the test pattern within the image sensor and reading the predetermined pattern out of the image sensor; generating a set of look up tables (LUTs) that have storage locations with values determined by comparing charges within cells along block borders of the image sensor to corresponding cells along adjacent blocks and determining a polynomial from cell values along adjacent blocks and determining the look up tables from the polynomial; and employing the LUTs to correct values representative of charges within cells along at least one border between blocks within the multi-block sensor.