1. A process for fitting and manufacturing an orthosis for a subject, the process comprising the steps of: (a) capturing and storing 3-dimensional coordinates for a plurality of landmarks corresponding to points characteristic of elements selected from the group consisting of: anatomical characteristics of the subject, means for attachment of the orthosis to the subject, and a reference plane; (b) calculating coordinates of one or more virtual landmarks corresponding to one or more anatomical joint centers or joint projection locations; (c) clinically aligning the landmarks in a reference position of one of the anatomical joint centers; (d) creating a customized computer model of the orthosis using the clinically aligned landmarks; and (e) fabricating the orthosis using a computer aided manufacturing process based upon an output from the customized digital model.