1. A method, comprising: generating a first synthetically-generated image, comprising a segmented anatomical feature in a volume of interest (VOI), from three-dimensional (3D) imaging data, wherein the segmented anatomical feature substantially excludes a pathological anatomy; acquiring a first image of the VOI, wherein the first image comprises the segmented feature and the patholigical anatomy; and subtracting, by a processing device, the first synthetically-generated image from the first aquired image to substantially remove the segmented anatomical feature.