1. A method for calibrating a measurement system for non-invasive analyte measurement, the method comprising the steps of: obtaining in memory in communication with a processor, from a selected plurality of synthetic medium samples, each having a reference analyte concentration, a plurality of energy-value sets from the measurement system, each energy value in a particular energy-value set corresponding to a respective reference analyte concentration from the selected plurality of synthetic medium samples; generating by the processor a composite projector curve using the plurality of energy value sets and the plurality of reference analyte concentrations; and partitioning by the processor the composite projector curve into a set of non-overlapping individual projector curves according to a set of slopes of the composite projector curve, each individual projector curve being identified by a lower bound analyte concentration and an upper bound analyte concentration.