1. A computer readable medium embodying instructions executable by a processor to perform a method for automatically estimating a measure of a nodule, the method steps comprising: providing sliced image volume data comprising at least one marked position of the nodule; extracting a sub-volume from the sliced image volume data that includes the marked position; performing a figure-ground separation to determine a solid foreground of the sub-volume and a non-solid foreground of the sub-volume; determining a seed point corresponding to the nodule from each of the solid foreground and the non-solid foreground; selecting one of the seed point of the solid foreground or the seed point of the non-solid foreground; determining whether the selected seed point is solitary or non-solitary and performing region growing for non-solitary selected seed point; determining a segmentation of the selected seed point; estimating the measure of the nodule corresponding to the segmentation; and outputting the segmentation and an estimate of the measure of the nodule.