1. A method of determining a condition of a region of a tissue sample, said method comprising the steps of: (a) obtaining a first set of spectral data corresponding to a region of a tissue sample using light incident to said region at a first angle; (b) obtaining a second set of spectral data corresponding to said region using light incident to said region at a second angle; (c) selecting at least one of said first set of spectral data and said second set of spectral data that is representative of said region of said tissue sample; and (d) determining a condition of said region of said tissue sample based at least in part on a subset of said at least one set of spectral data selected in step (c).