1. A method for adjusting the alignment of a grid with an image, wherein the grid includes a plurality of grid elements and the image includes a plurality of image features comprised of pixels, comprising the steps of: (1) determining an initial position of the grid; (2) determining one or more additional positions of the grid that are offset from the initial position and from each other; (3) determining a set of intensity scores for each of a plurality of test grid elements of the plurality of grid elements, wherein at least one member of the set is based, at least in part, on intensities of pixels of one or more image features within the test grid element in one of the initial or additional positions; (4) ranking the set of intensity scores with respect to each other to generate a set of rank scores for the test grid element; (5) combining the members of the sets of rank scores corresponding to the grid position to generate a combined rank score for the grid position for each of the initial and additional grid positions; and (6) adjusting the alignment of the grid based on a comparison among the combined rank scores of the initial and additional grid positions.