1. A method of acquiring image data of a subject with an imaging system, comprising: acquiring initial image data of at least a portion of the subject with a mobile imaging system including the gantry movably attached to a mobile cart; constructing an initial three-dimensional model of the portion of the subject prior to a procedure performed on the portion of the subject; acquiring discriminatory discrete location image data of the subject; executing instructions with a processor system to compare the acquired discriminatory discrete location image data to the constructed initial three-dimensional model of the portion of the subject; executing instructions with the processor system to identify specific regions of threshold change between the acquired discriminatory discrete location image data and the constructed initial three-dimensional model of the portion of the subject; and executing instructions with the processor system to determine one or more comparative paths along which a detector shall move to acquire comparative image data.