1. A method for representing a tissue evaluated by a tissue-based assay as a data array in image analysis feature space, extracting at least one features of the geographical distribution of image objects, and using at least one summary statistic describing said geographical distribution features to guide medical research or practice, the method comprising: obtaining at least one digital image of at least one tissue section assayed with at least one tissue-based test; extracting at least one image analysis feature of at least one tissue object within the at least one digital image by applying at least one digital image analysis algorithm process implemented by a computer for the at least one digital image, wherein the at least one image analysis feature is selected from the group consisting of staining, localization, and morphometric features; storing the at least one image analysis feature for the at least one tissue object in a storage, wherein the storage is selected form the group consisting of storage device and storage repository; curating the at least one image analysis feature to generate at least one dataset that associates a quantity of a specific analyte or biomolecule at a specific location in the at least one tissue object in the at least one tissue section; extracting at least one geographical distribution feature from at least one tissue object in the at least one dataset using at least one spatial analysis framework; and deriving at least one summary statistic from the at least one geographical distribution feature.