1. A computer-implemented method comprising: receiving biomedical imaging data and patient demographic data corresponding to a current scan of a patient; using a data processor to create an off-line aligned database based on a common feature present in the biomedical imaging data; using the data processor to create off-line lumen-intima and media-adventitia coefficients for use as dependency linear or non-linear coefficients for on-line lumen-intima and media-adventitia borders; using the data processor to retrieve a reference image from the off-line aligned database, the reference image being associated with a different patient having demographic characteristics similar to the patient demographic data; using the data processor to process the biomedical imaging data corresponding to the current scan and to automatically identify a centerline of a blood vessel of the patient in the current scan; using the data processor to align the current scan with the reference image in an aligned image based on the centerline of the blood vessel of the patient; using the data processor to compute the initial lumen-intima and media-adventitia borders in the current scan using the multi-resolution approach; and using the data processor to regress the initial lumen-intima and media-adventitia borders of the current scan using the off-line linear and non-linear coefficients.