1. A guidance instrument for controlled delivery of a device to a target area of a bone, comprising: a guide frame having at least one rail arm and a plurality of device portals on the arm arranged in a grid pattern and configured for locating the target area, each portal defining an angular trajectory and being configured to provide controlled delivery of the device to the target area, the guide frame further including at least one visual marker that enables the guide frame to be aligned relative to an anatomical landmark on the bone to be treated by visualization of the marker; and a stabilizer element including an engagement portion configured to contact the bone or surrounding tissue.