1. A method comprising: performing non-rigid registration of a radiological brain image of a subject acquired after administration of a radiotracer to the subject that binds to a target substance indicative of a clinical pathology with a positive template indicative of having the clinical pathology wherein the non-rigid registration with the positive template employs a cost function quantifying the closeness of the non-rigid registration and generates a positive result metric comprising the value of the cost function output by the non-rigid registration of the radiological brain image with the positive template; performing non-rigid registration of the radiological brain image with a negative template indicative of not having the clinical pathology wherein the non-rigid registration with the negative template employs the cost function quantifying the closeness of the non-rigid registration and generates a negative result metric comprising the value of the cost function output by the non-rigid registration of the radiological brain image with the negative template; generating a test result for the subject respective to the clinical pathology based on the positive result metric generated by the non-rigid registration of the radiological brain image with the positive template and the negative result metric generated by the non-rigid registration of the radiological brain image with the negative template, wherein the generated test result indicates the presence or absence of the clinical pathology of the brain; and displaying the test result on a display device; wherein the non-rigid registration operations and the generating operation are performed by a digital processing device.