1. A computer-implemented system for inducing or more deeply integrating a change of state in a subject, comprising: at least one data input device configured to sample initial subject data, at a first time, the initial subject data including at least genetic or epigenetic expression data indicative of an initial state of the subject; a data storage device configured to store the initial subject data as part of a subject record associated with the subject; one or more processing devices configured to: determine at a rules engine, based on at least a subset of information stored in the subject record, one or more challenges to be presented to the subject that, at least partially, manipulate one or more bio-regulatory controllers; and a challenge presentation device configured to present the one or more challenges to the subject at a second time, wherein the one or more challenges include one or more of visual stimuli, tactile stimuli, olfactory stimuli, auditory stimuli, or electrical stimuli, wherein the at least one data input device is further configured to sample, at a third time, responsive subject data that is responsive to the one or more challenges, the responsive subject data including at least genetic or epigenetic expression data indicting a response by the subject to the one or more challenges, and wherein the data storage device is further configured to store a record of the one or more challenges and the responsive subject data as part of the subject record, wherein the one or more processors are further configured to: determine, from at least the initial subject data and the responsive subject data, whether the one or more bio-regulatory controllers have been manipulated by the one or more challenges so as to invoke at least one self-organizing mechanism in the subject that influences a transition from the initial state to a desired state, update the rules engine based on the determination, and determine, at the updated rules engine, one or more additional challenges that further manipulate the one or more bio-regulatory controllers to further invoke the at least one self-organizing mechanism to further influence the transition from the initial state to the desired state, wherein the challenge presentation device is further configured to present the one or more additional challenges to the subject at a fourth time.