1. An image processing apparatus for use in biology, histology and pathology comprising: an input port (IN) for receiving a stream of image frames from a first imaging procedure; an image matcher (M) switchable between two modes, the matcher configured to attempt matching the image frames from the first imaging procedure against a first image, wherein said first image was generated in a second imaging procedure, wherein the first image serves as a first reference template when the matcher operates in the first mode, wherein the matcher, once a first matching frame is found from among the frames in the stream of frames, or once a user issued switch signal is received, operates to switch over into the second mode to now use the first matching frame or a current frame as a second reference template instead of the first reference template to attempt matching image frames against said second reference template; an output port (OUT) configured to output a further matching frame once said further matching frame is found by the image matcher.