1. A computer implemented method for deformable registration comprising: determining a vector field from a two-dimensional matching of a simulated two-dimensional image of a volume of an object of interest and a two-dimensional image of the object of interest; providing a deformation profile comprising control points representing movement of the object of interest over time; and finding a volume deformation that maps to a state of the two-dimensional image, wherein the deformation is parameterized by the vector field and the control points of the deformation profile to update a control point configuration of the simulated two-dimensional image of the volume of the object of interest.