1. A method for registering 2D images with 3D volume data, comprising the following steps: a) providing 3D volume data of an object, comprising a frame of reference; b) defining a first and a second transformation direction in relation to the 3D volume data, which are together forming a transformation plane in relation to the 3D volume data; c) providing a 2D image of the object with an image plane; and projecting the transformation plane on the image plane; d) aligning the frame of reference with the 2D image; wherein at least one alignment interaction value is projected on the transformation plane to determine at least one transformed interaction value; and e) translating the frame of reference with the at least one transformed interaction value.