1. A method of using a patient-matched surgical instrument to implant an orthopedic implant in a patient, comprising: placing a patient-specific surface of the patient-matched surgical instrument against a corresponding surface portion of or near a joint of the patient such that the patient-specific surface is substantially entirely engaged against the corresponding surface portion of the patient; cutting or drilling a portion of the tissue in or near the joint of the patient using a guide of or attached to the patient matched surgical instrument; and implanting an implant in or near the joint based at least in part on the location of the cut or drill portion; wherein the patient-specific surface is derived from first image data of at least a portion of the joint; and wherein the guide has a predetermined alignment relative to the patient-specific surface derived at least in part from second image data of at least a portion of a second joint.