1. A method for correcting the signal in an image having a plurality of regions of interest, the method comprising the steps of: (a) providing an image having a plurality of regions of interest, these regions of interest having areas between them; (b) extracting geometric information for the plurality of regions of interest; (c) selecting at least one parameter to describe a region of correction the at least one parameter defining a shape of the region of correction; (d) determining the region of correction between at least two regions of interest based on the extracted geometric information for the plurality of regions of interest and the at least one parameter selected to describe the region of correction; (e) calculating a correction signal from the region of correction; and (f) using the correction signal to correct a signal measurement from the at least two regions of interest and reduce cross-talk between the at least two regions of interest.