1. A system for producing a time-resolved three-dimensional image of a subject, the system comprising: a computer processor configured to: receive image projection data for the subject acquired using a medical imaging system during a single contrast injection, the medical imaging system including a single source/single detector system; generate a time-series of two-dimensional images from at least a portion of the acquired image projection data; reconstruct a three-dimensional image substantially without temporal resolution from at least a portion of the acquired image projection data; select, for each two-dimensional image in the time-series, a current image and a paired image; multiply, for each two-dimensional image in the time-series, the current image into the three-dimensional image substantially without temporal resolution to determine a first product value; multiply, for each two-dimensional image in the time-series, the paired image into the three-dimensional image substantially without temporal resolution to determine a second product value; take the square root of the multiplication of the first and second product values to produce a frame of a time-resolved three-dimensional image having a signal-to-noise ratio substantially higher than a signal-noise-ratio of the acquired image projection data, wherein one or more voxels in the frame is nullified based on the current image or the paired image; and combine frames of the time-resolved three-dimensional image to form the time-resolved three-dimensional image.