1. A method for removing any inherent autofluorescence associated with a biological material, comprising the steps of: a) acquiring a first reference image of the biological material; b) acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; c) applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; d) coregistering the first and second reference images; e) and then removing any inherent autofluorescence exhibited in the images acquired in steps c).