1. A method for detecting tampering of an object, said method comprising: providing a label on the object, wherein the object is a box, said label having at least one distinctively scannable region in form of a pattern and said label associated with at least one reference point external to said label, and wherein the providing the label on the object includes sealing an opening edge of the box, wherein said sealing includes providing a hard material disc having a diameter smaller than the label and applied below said label and thereby enabling detection of an intrusion by center line cut along the opening edge of the box without altering a spatial orientation of said scannable region on said label; determining a first spatial orientation of said label based on a computation between the pattern(s) and said reference point(s); determining a second spatial orientation of said label based on a computation between the pattern(s) mid said reference point(s); and generating an alert on noticing a change between the first and second spatial orientations.