1. A compound of Formula I below: wherein: W, W 1 and W 2 are independently selected from the group consisting of hydrogen and a pharmaceutically acceptable prodrug; R is selected from the group consisting of hydrogen or (C 1 -C 3 )alkyl; R 1 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl and substituted alkynyl; Y is a bond, —CH 2 — or —O—; Y′ is selected from the group consisting of hydrogen, halo, hydroxyl, thioalkyl, amino and substituted amino; Z is selected from the group consisting of acyl, cyano, carboxyl, carboxyl ester, —C(O)NR 20 R 21 , halo, —B(OH) 2 , —C(═NR 2 )R 3 , nitro, alkenyl, substituted alkenyl, acetylenyl and substituted acetylenyl of the formula —C≡C—R 4 ; where R 2 is selected from the group consisting of hydrogen, —OH, —OR 5 amino, substituted amino, and (C 1 -C 2 )alkyl, where R 5 is selected from the group consisting of alkyl and substituted alkyl; R 3 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, amino and substituted amino; R 4 is selected from the group consisting of hydrogen, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, —Si(R 8 ) 3 , carboxyl, carboxyl esters, and —C(O)NR 6 R 7 where R 6 and R 7 are independently hydrogen, alkyl or R 6 and R 7 together with the nitrogen atom pendent thereto are joined to form a heterocyclic, substituted heterocyclic, heteroaryl or substituted heteroaryl group; each R 8 is independently (C 1 -C 4 )alkyl or phenyl; and R 20 and R 21 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic and substituted heterocyclic or R 20 and R 21 , together with the nitrogen atom pendent thereto form a heterocyclic or substituted heterocyclic group; or pharmaceutically acceptable salts thereof.