1. A method of obtaining nucleotide sequence information, the method comprising: a) fragmenting a nucleic acid sample to provide at least one double-stranded nucleic acid fragment comprising a double-stranded region comprising a sense strand and a complementary antisense strand; b) ligating a first hairpin adapter to a first end of said fragment and ligating a second hairpin adapter to a second end of said fragment, thereby providing a circular nucleic acid; c) performing a rolling circle replication process with said circular nucleic acid as a template, thereby producing a concatemer comprising repeating copies of said sense and antisense strands; and d) performing a real time, single-molecule sequencing process that generates a single sequencing read from said concatemer, said single sequencing read comprising at least one first sequence corresponding to said sense strand and at least one second sequence corresponding to said antisense strand.