1. A method for endoscopic evaluation, comprising: capturing an initial image of a surface under investigation using a first endoscope; delineating within the initial image a target region of interest containing first elements, surrounded by a peripheral region containing second elements, the target region of interest having a location defined with respect to the peripheral region; performing a first characterization of the first elements in the initial image, thereby generating an initial target region measure; recording information indicating that a medical procedure was executed after capturing the initial image; after capturing the initial image, capturing a subsequent image of the surface under investigation using a second endoscope; identifying the peripheral region in the subsequent image, by matching elements appearing in the subsequent image to the second elements in the initial image, irrespective of the first elements in the target region; computing the location of the target region of interest in the subsequent image in response to the peripheral region identified in the subsequent image; performing a second characterization of the target region in the computed location in the subsequent image, thereby generating a subsequent target region measure; comparing the initial and subsequent target region measures by computing a fraction of the initial and subsequent target region measures; setting a first predetermined threshold value if the information is recorded before acquiring the subsequent image; and confirming that the procedure has been performed when the fraction of the initial and subsequent target region measures is less than the first predetermined threshold value.