1. A method for determining a profile weighted intensity feature for a cell useful for classifying cell phenotype, said profile weighted intensity feature determined from one or more images of the cell, the method comprising the steps of: (a) detecting a cell in an image; (b) computing a profile image for the cell, wherein pixel intensity of the profile image is a function of the closest distance from the pixel to a border of the cell; and (c) computing a profile weighted intensity feature for the cell using the profile image of the cell as a weight image, wherein the profile weighted intensity feature for the cell is a weighted mean intensity of pixels of the cell.