1. A detection system comprising: an image sensor configured to obtain image data relating to a region of interest including a pleural interface of a lung; and an image analyzer in communication with the image sensor to receive the image data therefrom, the image analyzer including processing circuitry configured to: identify the pleural interface in at least a first frame of the image data and a second frame of the image data; determine, based on computing optical flow between the first and second frames, a pleural sliding classification of the image data at the pleural interface; and determine whether a pneumothorax is present in the pleural interface based on the pleural sliding classification.