1. A system to navigate an image-guided object traveling in an area of interest of an imaged subject in relation to an acquired image of the imaged subject as created by an imaging system, a spatial relation of the at least one image defined with respect to an image coordinate system, comprising: a navigation system operable to track movement of the object in the imaged subject, the object tracked in spatial relation to a navigation coordinate system; and a controller electrically connected in communication with the imaging system and the navigation system, the controller having a processor operable to execute a plurality of program instructions stored in a memory, the plurality of program instructions comprising: registering a spatial relation of the imaging coordinate system relative to the navigation coordinate system, detecting an image of the object in the at least one image of the imaged subject, calculating a spatial relation between the location of the image of the object and a tracked location of the object, and modifying the spatial relation of the image coordinate system relative to the navigation coordinate system so as to reduce the difference between the location of the image of the object and the tracked location of the object by the navigation system relative to the image.