1. A non-transitory computer-readable storage device storing computer executable instructions that when executed by a computer, control the computer to perform a method for predicting a response to immunosuppressive (IS) therapy in a region of tissue, the method comprising: accessing a radiological image of a region of tissue demonstrating Crohn's Disease (CD) pathology; delineating a region of interest (ROI) in the image; generating a corrected ROI by bias field correcting the ROI; extracting a set of features from the corrected ROI; providing the corrected ROI and the set of features to an automated CD classifier; receiving, from the automated CD classifier, a reduced set of features based, at least in part, on the corrected ROI and on the set of features; and controlling a computer aided diagnosis (CADx) system to generate a radiomic enterographic treatment (RET) score of the region of tissue based, at least in part, on the reduced set of features, where the RET score represents a probability that the region of tissue responds to IS therapy.