1. Within an image acquisition system comprising a non-linear, wide-angled lens and an imaging sensor, a method of enhancing a scene containing one or more off-center peripheral regions, the method comprising: acquiring an initial distorted image with a large field of view, including using a non-linear, wide-angled lens and an imaging sensor; determining and extracting an off-center region of interest (ROI) within said initial distorted image; applying a geometric correction to reconstruct the off-center ROI into an approximately rectangular frame of reference as a first reconstructed ROI; determining, on a pixel-by-pixel basis, a quality of reconstructed pixels within said first reconstructed ROI; wherein, within the first reconstructed ROI, a first plurality of pixels have quality measures above a threshold, and a second plurality of pixels have quality measures below the threshold; and acquiring one or more additional initially distorted images, and extracting and reconstructing matching additional ROIs to combine with the second plurality of pixels of said first reconstructed ROI using a super-resolution technique to provide one or more enhanced ROIs; wherein the method is performed using one or more computing devices.