1. A system for a darkfield imaging system for automating screening of at least one cell comprising: a darkfield microscope comprising a motorized microscope stage for receiving the at least one cell; image acquiring apparatus configured to acquire one or more darkfield images, via transmitted or reflected darkfield illumination, of the at least one cell in color at one or more specified wavelengths or wavelength bands, the image acquiring apparatus for acquiring located at an end of the microscope, away from the stage, the image acquiring apparatus comprising one or more of an image spectrometer, an image spectrograph, and a CCD camera; an autofocus device; and a processor for controlling the system, the processor in communication with the microscope, the microscope stage, the image acquiring apparatus and the autofocus device.