1. A MRSI system, comprising: a structure identifier that is configured to identify a predetermined segmented structure in segmented MRI image data; a positioning rules bank which is configured to store rules for positioning a volume of interest with respect to the identified predetermined segmented structure of the segmented MRI image data for a MRSI data acquisition; and a volume of interest generator that is configured to position the volume of interest with respect to the identified predetermined segmented structure based on one or more of the rules for positioning the volume of interest with respect to the identified predetermined segmented structure and that is configured to perform the MRSI data acquisition of a signal from the volume of interest, wherein the MRSI system is configured to analyze the signal from the volume of interest to determine a biochemical composition of a predetermined region of the predetermined segmented structure, wherein the predetermined region of the predetermined segmented structure corresponds to the volume of interest.