1. A method for detecting, in single time-point, in-vivo imaging data related to artifacts in the imaging of objects, the method comprising: acquiring at least one in-vivo image with an imaging apparatus; forming a background image corresponding to an imaged air of the in-vivo image; obtaining the background image in a first step including establishing an object-air boundary and a second step formed of an atlas-based refinement of a background volume of interest; forming a histogram reflecting an intensity distribution of the background image; forming the background image of a set of voxels where artifacts are detected; providing an initial estimate of a range of artifact intensities from intensities above a definable intensity value; and executing a modified morphological opening operation, formed of an erosion of a set of voxels and a dilation, performed iteratively and constrained to voxels intensity above the intensity value, causing the opening operation to provide a natural definition of artifacts regions.