1. A method to derive information, in a computer system, to create a set of data regarding one or more bone parameters from an image comprising: (a) obtaining image data of bone from a subject; (b) defining a first region of interest (ROI) from the image data; (c) defining a second region of interest (ROI) from the image data, wherein the first and second regions of interest (ROIs) overlap; (d) analyzing information in the first region of interest to determine at least a first value for a bone parameter, the bone parameter selected from the group consisting of bone microarchitecture, bone macroanatomy, biomechanical parameters and combinations thereof; (e) analyzing information in the second region of interest to determine at least a second value for the bone parameter; and (f) generating a set of data at least in part from the first and second values.