1. A method for generating at least one image of a region of interest in a patient, the method comprising: obtaining at least two radiological images of the region of interest with a medical imaging system, wherein the at least two radiological images of the region of interest are identified with at least one marker arranged on and/or around the patient, wherein a first image was acquired with a first X-ray energy and a second image was acquired with a second X-ray energy; and determining with a processing system of the medical imaging system a final radiological image of the region of interest by linearly combining the at least two radiological images of the region of interest obtained by the medical imaging system to further obtain a final radiological image of the region of interest without the markers.