1. A system for determining proximity of a surgical device relative to an anatomical structure, comprising: at least one surgical device having a sensor assembly operably coupled to a processing unit and configured to transmit at least one electrical signal generated by the processing unit through the target anatomical structure to elicit a measurable response from the target anatomical structure, the processing unit configured to calculate a signature property value of the target anatomical structure based on the measurable response, wherein the processing unit is configured to determine proximity of the at least one surgical device relative to the target anatomical structure based on a comparison between the signature property value and at least one other signature property; and an indicator operably coupled to the processing unit and configured to alert a user of the identified target anatomical structure based on the determined proximity of the at least one surgical device relative to the target anatomical structure.