1. A computer-implemented method for segmenting a region in an image comprising: defining a plurality of initial points on the image; defining, with a processor, one or more control points placed relative to each pair of neighbouring ones of said plurality of initial points; generating, with the processor, an initial contour from the plurality of initial points by interpolating a Bezier curve between each pair of neighbouring ones of said plurality of initial points using the one or more control points placed relative to said each pair, wherein said interpolating comprises using a spline-based interpolation between said each pair wherein said control points are located outside of said initial contour; and adjusting, with the processor, the positions of said control points to modify each said Bezier curve to refine said initial contour according to information regarding an expected shape for said region.