1. A method of predicting a fracture path in bone using a computer system comprising: (a) obtaining image data of the bone in the computer system; (b) defining two or more positions in the image; (c) placing a region of interest (ROI) at each of the two or more positions; (d) analyzing electronically each of the ROIs to determine at least one value for two or more parameters selected from the group consisting of bone density, bone micro-architecture, bone macro-anatomy, biomechanical parameters and combinations thereof; (e) for each analyzed parameter, assigning electronically the at least one value from each ROI to its respective position, thereby creating a parameter map for each analyzed parameter; (f) generating electronically a composite parameter map from the parameter maps of step (e); and (g) analyzing the composite parameter map.