1. A method, comprising: imaging a volume of interest (VOI) with an imaging system and acquiring positional data of a target within the VOI, wherein the positional data comprises a present position of the target relative to an imaging center of the imaging system, wherein the imaging center has a first location in a treatment room coordinate system; moving the VOI with a positioning system, to align the target in a radiation system that is separated from the imaging system, wherein the radiation system has a second location in the treatment room coordinate system different from the first location; treating the target at the second location with the radiation system; detecting movement of the (VOI) in the radiation system; returning the (VOI) from the radiation system back to the imaging system if the detected movement exceeds a movement threshold; and re-imaging the (VOI) with the imaging system to acquire updated positional data of the target within the (VOI).