1. An apparatus for generating multispectral images of tissue, comprising: an illumination source configured to illuminate the tissue with radiation; a detector configured to collect radiation from the tissue; an illumination filter in operative relation with the illumination source, the illumination filter configured to select a first wavelength and a first polarization of radiation to be directed from the source to the tissue; a detection filter in operative relation with the detector, the detection filter configured to select a second wavelength and a second polarization of radiation to be directed from the tissue to the detector; and an analysis unit in operative relation with the detector, the analysis unit configured to generate a plurality of multispectral images of the tissue according to different combinations of first and second wavelengths and first and second polarizations.