1. A method of operating an image capture device, the method comprising: displaying a real-time image on a display of the image capture device, the real-time image being based on digital image data acquired by a digital image sensor; receiving a selection of one or more selected regions within the real-time image; setting, in response to the selection, a plurality of regions of interest (ROIs), each ROI being a region defined within the real-time image for applying a respective set of image acquisition parameters, the plurality of ROIs including one or more user-defined ROIs defined in accordance with the one or more selected regions; when an input to cancel a given one of the plurality of ROIs is detected, cancelling the given one of the plurality of ROIs while maintaining a remainder of the plurality of ROIs; using a signal generated by at least one motion, position or orientation sensor of the image capture device to determine when position or orientation of the image capture device has changed more than a predetermined threshold amount, wherein a determination that the position or orientation of the image capture device has changed more than a predetermined threshold amount is an indicator that the plurality of ROIs are no longer valid; when the signal generated by the least one motion, position or orientation sensor indicates that the position or orientation of the image capture device has changed more than the predetermined threshold amount, cancelling all of the plurality of ROIs and setting one or more default ROIs; and acquiring digital image data by the digital image sensor in accordance with the remainder of the plurality of ROIs or the one or more default ROIs.