1. A method for registering two-dimensional image data of a body of interest with three-dimensional image data of the body of interest, comprising: accessing data regarding the body of interest, wherein the data includes three-dimensional image data of the body of interest and a first orientation information of the body of interest relative to a first imaging device while acquiring the three-dimensional image data, wherein the three-dimensional image data is acquired prior to the two-dimensional image data; accessing the two-dimensional image data of the body of interest while a dynamic reference frame is attached to the body of interest; determining a second orientation information of the body of interest relative to a second imaging device that acquired the two-dimensional image data; creating a digitally reconstructed radiograph (DRR) from the accessed three-dimensional image data that illustrates a DRR image orientation of the body of interest that substantially corresponds to the two-dimensional image data based on the first orientation information and the second orientation information; acquiring a second two-dimensional image having a third patient orientation information; and identifying a center of the body of interest in both the two-dimensional image and the second two-dimensional image and registering the two-dimensional image and the second two-dimensional image using a first similarity/cost measure; wherein the digitally reconstructed radiograph includes a projection through the three-dimensional image data that substantially corresponds to the acquired two-dimensional image data.