1. A method comprising accessing, on a processor, a plurality of pharmacy claims associated with an individual; generating, on a processor, a raw risk index indicative of at least one of said individual's medical costs, acute medical conditions, and variation in medical costs, by using the plurality of pharmacy claims; processing, on the processor, the plurality of pharmacy claims to identify a plurality of compliance medications prescribed to the individual; associating, on the processor, a regression coefficient with each compliance medication of the plurality of compliance medications; determining, on the processor, compliance of the individual with the plurality of compliance medications to generate a plurality of compliance medication scores a compliance medication score of the plurality of compliance medication scores being associated with a compliance medication prescribed to the individual; multiplying, on the processor, each of the plurality of compliance medication scores with an associated regression coefficient of the plurality of coefficients, the plurality of regression coefficients including the regression coefficient; and modifying, on the processor, the raw risk index based on multiplying each of the plurality of compliance medication scores with the associated regression coefficient to generate the risk index.