1. A method for lesion detection, comprising: acquiring medical image data from a first modality; acquiring medical image data from a second modality; calculating a transformation matrix for transforming from an image space of the first modality to an image space of the second modality; defining a volume of interest from the medical image data of the first modality, wherein the volume of interest includes one or more lesions wherein defining a volume of interest includes: defining the volume of interest based on one or more threshold values; receiving user input including an adjustment to the one or more threshold values; and redefining the volume of interest based on the adjusted one or more threshold values; and automatically copying the volume of interest to the medical image data of the second modality using the calculated transformation matrix.