1. A medical imaging system comprising code, which when executed, causes the system to: receive first image information corresponding with a first image acquired at a first time, wherein the first image information includes location information comprising coordinate information for one or more user-selected points of interest, the first image comprising a lesion; receive second image information corresponding with a second image acquired at a second time, wherein the second image information includes location information comprising coordinate information for the one or more user-selected points of interest, the second image comprising the lesion; render a first wire frame representing a first volume of the lesion based on the first image information; render a second wire frame representing a second volume of the lesion based on the second image information; and overlay the second wire frame and the first wire frame based at least in part on the coordinate information for the one or more user-selected points of interest in the first image and the second image.