1. A method of operating an imaging device with a two-dimensional field of image sensors as well as an evaluation unit which is capable of reading out and processing the pixel signals, representing output signals of image sensors combined by a binning operation, at a maximum rate of no more than G max , in which method at least one parameter is preset in order to define a sub-region of the field, any remaining parameters for defining the sub-region as well as the binning factor b and the imaging rate f are defined in such a manner that the maximum rate G max of the evaluation unit is not exceeded during the reading out of all pixel signals from the sub-region.