1. A method of indicating regions of interest in a breast by comparing a cranio-caudal (CC) image and a medio-lateral oblique (MLO) image, comprising: obtaining a first image of an object in a breast in a first region along a first axis; subsequently obtaining a second image of the object in the breast in a corresponding first region along a second axis; selecting one or more pixels indicative of a breast density from one of the first image and the second image; determining the breast density from a whiteness of the one or more pixels; identifying geometric changes in the breast based on the breast density; defining a boundary enclosing the first region such that a size of the first region is inversely related to the breast density; and performing an automated comparison operative to look for the object in the first region by comparing the first region of the first image and the corresponding first region in the second image.