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156. Chen Y., Yang C., Wu Y., Mo S., Wang S., Yang G., Mei Z. Glycosmisines A and B: Isolation of two new carbazole-indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities. Org. Biomol. Chem. 2005;13:6773–6781. doi: 10.1039/C5OB00695C. [ PubMed] [ <anchor>CrossRef</anchor>] [ Google Scholar]
Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities - Organic & Biomolecular Chemistry (RSC Publishing)
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## Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities †

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a
College of Chemistry and Materials Sciences, South Central University for Nationalities, 182 Minyuan Road, Wuhan 430074, P. R. China

b
College of Pharmacy, South Central University for Nationalities, 708 Minyuan Road, Wuhan 430074, P. R. China

### Abstract

Two unique carbazole–indole-type dimeric alkaloids, glycosmisines A ( 1) and B ( 2), have been isolated from the stems of Glycosmis pentaphylla and their structures are elucidated by 1D and 2D NMR analyses, and their cytotoxicity against the growth of three cancer cell lines (A549, HepG-2 and Huh-7 cells) in culture was investigated using an MTT assay. Compounds 1 and 2 exhibited significant levels of cytotoxicity against three human cancer cell lines, and these two compounds also induced apoptosis in the same cell lines, as evidenced by changes in the morphological features of cells treated with these compounds and their dose-dependent accumulation of a sub-G1 population.

Graphical abstract: Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities

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## Supplementary files

## Article information

Article typePaper

Submitted08 Apr 2015

Accepted12 May 2015

First published14 May 2015

### Download Citation

Org. Biomol. Chem., 2015, 13, 6773-6781

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### Glycosmisines A and B: isolation of two new carbazole–indole-type dimeric alkaloids from Glycosmis pentaphylla and an evaluation of their antiproliferative activities

Y. Chen, C. Tang, Y. Wu, S. Mo, S. Wang, G. Yang and Z. Mei,
Org. Biomol. Chem., 2015, 13, 6773

DOI: 10.1039/C5OB00695C

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Yu Chen

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