Von der Schizophrenie zum Salience-Syndrom - Thieme Connect
Der Begriff Schizophrenie ist seit seiner Einführung 1911 durch Stigmatisierung belegt, die durch ambitionierte Programme teilweise abgebaut werden konnte.
Thieme E-Journals - Nervenheilkunde / Abstract

nervenheilkunde

130445

- [DE](/products/ejournals/abstract/10.1055/s-0038-1628430?id=&lang=de)
- EN
- [Home](/products/all/home.html)
- Products

  - [Journals](/products/ejournals/journals)
  - [Books](/products/ebooks/books)
  - [Book Series](/products/ebooks/series)

- Service

  - [Library Service](/products/libraryservice)

- [Help](/products/all/help)
- [Contact](/products/all/contact)
- [Portal](https://www.thieme.de/en/thieme-connect/home-3939.htm)


Nervenheilkunde



Full-text search


- Full-text search
- Author Search
- Title Search
- DOI Search
- Metadata Search

- [Journal](javascript:;)  - [About this journal](https://www.thieme.de/de/nervenheilkunde/profil-120264.htm)
- [Authors](javascript:;)  - [Instructions for authors](https://www.thieme.de/de/nervenheilkunde/autoren-120265.htm)
- [Subscription](javascript:;)  - [Subscription information](https://www.thieme.de/shop/Neurologie/Nervenheilkunde-0722-1541/p/000000000022690101?text=Nervenheilkunde)
  - [Institutional Licensing](https://www.thieme.de/en/thieme-connect/licensing-information-18987.htm)
- [PharmaMarket](javascript:;)  - [PharmaMarket](https://fdi.thieme.de/)

- Not Logged In
Login


- Username or e-mail address:



Password:





[Forgot Access Data?](https://profile.thieme.de/HTML/sso/THIEME/thieme_forgotten_access_data.htm?hook_url=https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1628430&rdeLocaleAttr=en) [Register Now](/products/all/registration) [OpenAthens/Shibboleth Login](https://profile.thieme.de/HTML/sso/ejournals/shibboleth.htm?hook_url=https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1628430&rdeLocaleAttr=en)

- [Shopping Cart](/products/ejournals/buyDocument)

![](https://www.thieme-connect.de/media/10.1055-s-00034916/10.1055-s-014-60155/10.1055-s-00034916/cover_big.jpg)

Year (Archive)

2011


- [2024](/products/ejournals/issues/10.1055/s-00034916/2024)
- [2023](/products/ejournals/issues/10.1055/s-00034916/2023)
- [2022](/products/ejournals/issues/10.1055/s-00034916/2022)
- [2021](/products/ejournals/issues/10.1055/s-00034916/2021)
- [2020](/products/ejournals/issues/10.1055/s-00034916/2020)
- [2019](/products/ejournals/issues/10.1055/s-00034916/2019)
- [2018](/products/ejournals/issues/10.1055/s-00034916/2018)
- [2017](/products/ejournals/issues/10.1055/s-00034916/2017)
- [2016](/products/ejournals/issues/10.1055/s-00034916/2016)
- [2015](/products/ejournals/issues/10.1055/s-00034916/2015)
- [2014](/products/ejournals/issues/10.1055/s-00034916/2014)
- [2013](/products/ejournals/issues/10.1055/s-00034916/2013)
- [2012](/products/ejournals/issues/10.1055/s-00034916/2012)
- [2011](/products/ejournals/issues/10.1055/s-00034916/2011)
- [2010](/products/ejournals/issues/10.1055/s-00034916/2010)
- [2009](/products/ejournals/issues/10.1055/s-00034916/2009)
- [2008](/products/ejournals/issues/10.1055/s-00034916/2008)
- [2007](/products/ejournals/issues/10.1055/s-00034916/2007)
- [2006](/products/ejournals/issues/10.1055/s-00034916/2006)
- [2005](/products/ejournals/issues/10.1055/s-00034916/2005)
- [2004](/products/ejournals/issues/10.1055/s-00034916/2004)
- [2003](/products/ejournals/issues/10.1055/s-00034916/2003)

Issues

- [Table of Contents](/products/ejournals/issue/10.1055/s-008-37731)
- [Current Issue](/products/ejournals/journal/10.1055/s-00034916)
- [Free Sample Issue (01/02/2024)](/products/ejournals/sampleIssue/10.1055/s-00034916)

#### Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

[https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00034916.xml](https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00034916.xml)

[Download Bibliographical Data](/products/ejournals/ris/10.1055/s-0038-1628430/BIB "Download Bibliographical Data")

#### Share / Bookmark

FacebookXLinkedinWeibo

[Recommend Article](mailto:?subject=Recommendation: Nervenheilkunde&body=I would like to recommend this article in Nervenheilkunde: %0D%0A %0D%0AVon der Schizophrenie zum Salience-Syndrom %0D%0A %0D%0AAbstract: http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1628430 %0D%0AFull text HTML: http://www.thieme-connect.com/products/ejournals/html/10.1055/s-0038-1628430 %0D%0AFull text PDF: http://www.thieme-connect.com/products/ejournals/pdf/10.1055%2Fs-0038-1628430.pdf %0D%0A %0D%0AFree sample issue %0D%0Ahttp://www.thieme-connect.com/products/ejournals/sampleIssue/10.1055/s-00034916 "Recommend Article")[Subscribe to Alert Service](https://profile.thieme.de/HTML/sso/THIEME/login.htm?hook_url=https://www.thieme-connect.de/products/all/alerts&rdeLocaleAttr=en "Subscribe to Alert Service")

[Download PDF](/products/ejournals/pdf/10.1055/s-0038-1628430.pdf)

[PDF Download](/products/ejournals/pdf/10.1055/s-0038-1628430.pdf "PDF Download")

Nervenheilkunde 2011; 30(10): 819-821

DOI: 10.1055/s-0038-1628430

Übersichtsartikel

Schattauer GmbH

# Von der Schizophrenie zum Salience-Syndrom

Alter Wein in neuen Schläuchen?From schizophrenia to salience syndromeold wine in new bottles?
U. Palm

1

Klinik und Poliklinik für Psychiatrie, Psychotherapie und Psychosomatik, Ludwig-Maximilians-Universität, München

› Author Affiliations

Further Information

### Publication History

Eingegangen am:
06 March 2011

angenommen am:
06 April 2011

Publication Date:

22 January 2018 (online)

Also available at [![](/media/10.1055-s-00000000/btn-eRef-desktop.png)](https://eref.thieme.de/10.1055/s-0038-1628430)

- [Abstract](#abstract)
- [Full Text](/products/ejournals/html/10.1055/s-0038-1628430)
- [References](#references)

[Buy Article](/products/ejournals/buyDocument/10.1055/s-0038-1628430) [Permissions and Reprints](javascript:;)

[![](https://www.thieme-connect.de/media/10.1055-s-00034916/201110/lookinside/thumbnails/10-1055s-0038-1628430_de-1.jpg)](https://www.thieme-connect.de/media/10.1055-s-00034916/201110/lookinside/10-1055s-0038-1628430_de-1.jpg)

### Zusammenfassung

Der Begriff Schizophrenie ist seit seiner Einführung 1911 durch Stigmatisierung belegt, die durch ambitionierte Programme teilweise abgebaut werden konnte. Dennoch wurde in Japan deswegen die Schizophrenie in Integrationsstörung umbenannt. Gegenwärtig wird zur weiteren Entstigmatisierung diskutiert, die Schizophrenie in Salience-Syndrom umzubenennen, was eine Störung der Stimulusreaktionskontrolle beinhaltet. Begründet wird dies mit einer überschießenden Ausschüttung von Dopamin als Vermittlersubstanz zwischen Reiz und emotionaler Reaktion. Die Rückführung auf eine syndromale Ebene bildet jedoch nicht das Gesamtbild der Erkrankung ab, sondern lässt möglicherweise zusätzliche Symptome außer Acht, die für Verlauf und Prognose von essenzieller Bedeutung sind. Eine vereinfachte, rein syndromale Beschreibung mittels eines neu geschaffenen Kunstbegriffs geht am erwünschten Ziel einer Entstigmatisierung vorbei und erschwert nicht nur für Ärzte und Patienten die Einordnung und Akzeptanz der Erkrankung, sondern führt durch Zuhilfenahme des bekannten Schizophreniebegriffs als Erklärungsmodell zu einer neuerlichen Stigmatisierung.

### Summary

The term schizophrenia has been stigmatizing since its appearance in 1911. Several programs for destigmatizing brought favourable results in the past years. However, in Japan, schizophrenia was renamed to integration disorder. Today’s debate on salience syndrome replacing schizophrenia implies a disorder of stimulus-reaction-control. Increased dopamine is the supposed neurobiological correlate, being mediator between stimulus and affective reaction. The reduction of the disease entity schizophrenia to a syndromal level might lead to a neglect of accessory symptoms, which could be essential for course and outcome of the illness. A mere syndromal description with a new art term does not fulfil the aim of destigmatization but will blur doctor’s view and impair patient’s acceptance. The new term might even be stigmatized if the old schizophrenia term is used for explaining the new syndrome.

### Schlüsselwörter

Salience-Syndrom -
Schizophrenie -
Integrationsstörung -
Stigma -
Emil Kraepelin

### Keywords

Salience syndrome -
integration disorder -
schizophrenia -
stigmatization -
Emil Kraepelin

- ### Literatur

- **1**

Bleuler E.

Dementia praecox oder Gruppe der Schizophrenien. Leipzig: Deuticke; 1911

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Dementia praecox oder Gruppe der Schizophrenien)

- **2**

Kraepelin E.

Psychiatrie. Ein Lehrbuch für Studirende und Aerzte. Leipzig: Barth; 1899

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Psychiatrie)

- **3**

Chopra AK,


Doody GA.

Schizophrenia, an illness and a metaphor: analysis of the use of the term “schizophrenia” in the UK national newspapers. J R Soc Med 2007; 09: 423-26.

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Schizophrenia, an illness and a metaphor: analysis of the use of the term %E2%80%9Cschizophrenia%E2%80%9D in the UK national newspapers)

- **4**

Magliano L,


Read J,


Marassi R.

Metaphoric and non-metaphoric use of the term “schizophrenia” in Italian newspapers. Soc Psychiatry Psychiatr Epidemiol. Im Druck..

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Metaphoric and non-metaphoric use of the term %E2%80%9Cschizophrenia%E2%80%9D in Italian newspapers. Soc Psychiatry Psychiatr Epidemiol)

- **5**

Angermeyer MC.

Stigmatisierung psychisch kranker in der Gesellschaft. Psychiatr Praxis 2004; 31: 246-50.

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Stigmatisierung psychisch kranker in der Gesellschaft)

- **6**

Angermeyer MC,


Holzinger A,


Matschinger H.

Mental health literacy and attitude towards people wtih mental illness: a trend analysis based on population surveys in the eastern part of Germany. Eur Psychiatry 2009; 24: 225-32.

[Crossref](https://doi.org/10.1016/j.eurpsy.2008.06.010) [PubMed](https://pubmed.ncbi.nlm.nih.gov/19361961) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Mental health literacy and attitude towards people wtih mental illness: a trend analysis based on population surveys in the eastern part of Germany)

- **7**

Gaebel W.

et al. Evaluation of the German WPA “program against stigma and discrimination because of schizophrenia – Open Doors”: results from representative telephone surveys before and after three years of antistigma interventions. Schizophr Res 2008; 98: 184-93.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/17961985) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Evaluation of the German WPA %E2%80%9Cprogram against stigma and discrimination because of schizophrenia %E2%80%93 Open Doors%E2%80%9D: results from representative telephone surveys before and after three years of antistigma interventions)

- **8**

Sato M.

Renaming schizophrenia: a Japanese perspective. World Psychiatry 2006; 05: 53-55.

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Renaming schizophrenia: a Japanese perspective)

- **9**

Ono Y.

et al. Schizophrenia: Is it time to replace the term?. Psychiatry Clin Neurosci 1999; 53: 335-41.

[Crossref](https://doi.org/10.1046/j.1440-1819.1999.00555.x) [PubMed](https://pubmed.ncbi.nlm.nih.gov/10459734) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Schizophrenia: Is it time to replace the term?)

- **10**

Kim Y.

Renaming the term schizophrenia in Japan. Lancet 2002; 360: 879.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/12243954) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Renaming the term schizophrenia in Japan)

- **11**

Desapriya EB,


Nobutada I.

Debate over Japanese renaming of term for schizophrenia. Lancet 2003; 361: 181.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/12531615) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Debate over Japanese renaming of term for schizophrenia)

- **12**

van Os J.

“Salience syndrome” replaces “schizophrenia” in DSM-V and ICD-11: psychiatry’s evidence-based entry into the 21st century?. Acta Psychiatr Scand 2009; 120: 363-72.

[Crossref](https://doi.org/10.1111/j.1600-0447.2009.01456.x) [PubMed](https://pubmed.ncbi.nlm.nih.gov/19807717) [Google Scholar](https://scholar.google.com/scholar_lookup?title=%E2%80%9CSalience syndrome%E2%80%9D replaces %E2%80%9Cschizophrenia%E2%80%9D in DSM-V and ICD-11: psychiatry%E2%80%99s evidence-based entry into the 21st century?)

- **13**

van Os J.

A salience dysregulation syndrome. Br J Psychiatry 2009; 194: 101-3.

[Crossref](https://doi.org/10.1192/bjp.bp.108.054254) [PubMed](https://pubmed.ncbi.nlm.nih.gov/19182167) [Google Scholar](https://scholar.google.com/scholar_lookup?title=A salience dysregulation syndrome)

- **14**

Kapur S.

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003; 160: 13-23.

[Crossref](https://doi.org/10.1176/appi.ajp.160.1.13) [PubMed](https://pubmed.ncbi.nlm.nih.gov/12505794) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia)

- **15**

Takahashi H.

et al. Impact of changing the Japanese term for “schizophrenia” for reasons of sterotypical beliefs of schizophrenia in Japanese youth. Schizophrenia Res 2009; 112: 149-52.

[Crossref](https://doi.org/10.1016/j.schres.2009.03.037) [PubMed](https://pubmed.ncbi.nlm.nih.gov/19398303) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Impact of changing the Japanese term for %E2%80%9Cschizophrenia%E2%80%9D for reasons of sterotypical beliefs of schizophrenia in Japanese youth)

- **16**

Hoche A.

Die Bedeutung der Symptomenkomplexe in der Psychiatrie. Z Gesamte Neurol Psychiatr 1912; 12: 540-51.

[Crossref](https://doi.org/10.1007/BF02866386) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Die Bedeutung der Symptomenkomplexe in der Psychiatrie)

- **17**

Lieberman JA.

Renaming schizophrenia. BMJ 2007; 334: 108.

[Crossref](https://doi.org/10.1136/bmj.39057.662373.80) [PubMed](https://pubmed.ncbi.nlm.nih.gov/17235058) [Google Scholar](https://scholar.google.com/scholar_lookup?title=Renaming schizophrenia)

- **18**

Lawrie SM.

et al. The “continuum of psychosis”: scientifically unproven and clinically impractical. Br J Psychiatry 2010; 197: 423-5.

[Crossref](https://doi.org/10.1192/bjp.bp.109.072827) [PubMed](https://pubmed.ncbi.nlm.nih.gov/21119144) [Google Scholar](https://scholar.google.com/scholar_lookup?title=The %E2%80%9Ccontinuum of psychosis%E2%80%9D: scientifically unproven and clinically impractical)

- **19**

Craddock N,


Owen MJ.

The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry 2005; 186: 364-6.

[Crossref](https://doi.org/10.1192/bjp.186.5.364) [PubMed](https://pubmed.ncbi.nlm.nih.gov/15863738) [Google Scholar](https://scholar.google.com/scholar_lookup?title=The beginning of the end for the Kraepelinian dichotomy)

[Top of Page](#top)

©  Georg Thieme Verlag KG \|


[Imprint](https://thieme.com/impressum-gtv-en) \|
[Privacy policy statement](https://thieme.com/data-privacy-gtv-en) \|

[Smartphone Version](/products/)

Your Current IP Address: 96.9.90.11