바이러스 단백질체학 및 대사체학 질량분석법 - Thermo Fisher Scientific
연구자들이 바이러스의 기능뿐만 아니라 COVID-19와 같은 질병을 유발하는 바이러스가 숙주 세포와 어떻게 상호작용하는지 이해하려면 바이러스 구조를 구성하는 모든 성분 ...
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- Viral Proteomics & Metabolomics Mass Spectrometry

# Viral Proteomics & Metabolomics Mass Spectrometry

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[‹Proteomics Mass Spectrometry](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry.html)

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## The latest mass spectrometry tools and workflows for studying viruses

Scientists focusing on virus research are looking to study the virus itself, how it interacts with host cells, host immunity, and the virus cellular machinery. Mass spectrometry (MS) techniques such as proteomics, glycomics and metabolomics help advance the understanding of viruses. These techniques help determine how the virus interacts with host cells, how the immune system responds and how the viral system functions during its lifecycle. Studying viruses requires integrating several complementary mass spectrometry techniques.

[Contact us](/us/en/home/global/forms/industrial/proteomics-protein-mass-spectrometry-contact-us.html)

* * *

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and the cumulative COVID-19 human health impact have provided a global case study for the need to maintain a responsive and effective ability to rapidly understand emerging viruses. Our proteomics, glycomics and metabolomics MS workflows provide virus researchers multiple approaches for studying intact viral particles, their surfaces and binding characteristics, their protein compositions, and their impacts on the biochemical pathways of host cells upon infection. Virus research using mass spectrometry can help provide detailed insights into virus structure and function, which can contribute to understanding a novel virus and it’s resulting disease, such as COVID-19, and drive actions to mitigate its impact on human health.

On this page


- [Viral structure mass spectrometry](#virus-structure)
- [Pathogen biology and virus-host cell interaction mass spectrometry](#pathogen-biology)
- [Host immune response mass spectrometry](#host-immune)
- [Translational research mass spectrometry](#translational-research)
- [Virus detection mass spectrometry](#virus-detection)

* * *

## The Role of Mass Spectrometry in Virus Research eBook

The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on human health has provided a global case study for the need to rapidly understand emerging viruses. Download this eBook to learn more about:

- The current state of virus research
- Different MS techniques being used to advance virus research

[Download eBook](/us/en/home/global/forms/industrial/role-mass-spectrometry-virus-research-ebook.html)

* * *

## Virus structure

To understand viral functions and how a virus that causes a disease like COVID-19 interacts with host cells, it is essential that researchers determine all the components that make up the virus structure.

Click image to enlarge

* * *

### Virus structure mass spectrometry workflows

[Glycoproteomics (protein glycosylation and glycomics)](#glycoproteomics)

[Glycoproteomics (protein glycosylation and glycomics)](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/proteomics-mass-spectrometry-workflows/protein-glycosylation.html)

The surface of the virus envelope is covered with proteins, specifically glycoproteins, which are involved in the process of binding to the host cells for viral entry. Glycan diversity on these proteins are used by the virus to evade immune system response. Surface glycans have conformational flexibility that provides conformational dynamics to the virus, which can help shield drug binding sites. In order to get more detail on the type of glycosylation and the sites where it occurs (site occupancy) on viral surface glycoproteins, a glycoproteomics strategy can be used. Glycoproteomics can provide information on the sites of glycosylation and glycan compositions. Glycopeptide workflows involve sample preparation and enrichment, mass spectrometry analysis, data analysis and interpretation. Below is a short list of recommended products, but we invite you to explore more product information and resources on glycopeptide analysis on our [protein glycosylation workflow](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/proteomics-mass-spectrometry-workflows/protein-glycosylation.html) page.

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* * *

[Glycomics](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/proteomics-mass-spectrometry-workflows/protein-glycosylation.html)

Glycomics can expand on glycoproteomics to provide further details on the glycans. Glycomics can provide structural information on the glycans like branching and linkage and can help resolve structural isomers. Glycomics workflows involve deglycoslyation, isolation, mass spectrometry analysis and glycan identification using powerful software.

#### Recommended products

[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[SimGlycan Software](/order/catalog/product/IQLAAEGABSFAMMMAZU)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![SimGlycan Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-lc-ms-simglycan-software-icon-270x195.jpg)](/order/catalog/product/IQLAAEGABSFAMMMAZU)

[Native MS](#nativems1)

[Native MS](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/protein-structure-analysis-mass-spectrometry/native-mass-spectrometry.html)

Native MS provides an unaveraged picture of the solution conditions, meaning that different proteoforms (such as differential glycosylations) can be detected simultaneously. Native MS is also a useful tool for examining virus capsids, quantifying cargo encapsulation and monitoring capsid assembly. Combining native MS with top-down MS allows the structural characterization of the capsid’s proteins.

#### Recommended products

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[Acclaim SEC-1000 Size Exclusion Chromatography 4.6x300mm HPLC Columns](/order/catalog/product/079724)[Vanquish Horizon UHPLC System](/order/catalog/product/IQLAAAGABHFAPUMZZZ)[Vanquish Flex UHPLC System](/order/catalog/product/IQLAAAGABHFAPUMBHV)[Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS System](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/q-exactive-orbitrap-mass-spectrometers/q-exactive-uhmr.html)[Protein analysis mass spectrometry software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis.html?open=proteinanalysis)[![Nanospray Flex Ion Sources](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/gen/gen-nanospray-flex-ion-sources-150x150.jpg)](/order/catalog/product/ES071)[![Acclaim SEC-1000 Size Exclusion Chromatography 4.6x300mm HPLC Columns](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-acclaim-sec1000-hplc-columns-270x195.jpg)](/order/catalog/product/079724)[![Vanquish Horizon UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-Vanquish-Horizon-UHPLC-270x195.jpg)](/order/catalog/product/IQLAAAGABHFAPUMZZZ)[![Vanquish Flex UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-vanquish-flex-quaternary-270x195.jpg)](/order/catalog/product/IQLAAAGABHFAPUMBHV)[![Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-q-exactive-uhmr-vanquish-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/q-exactive-orbitrap-mass-spectrometers/q-exactive-uhmr.html)[![Protein analysis mass spectrometry software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Communities/omics/hdi/hdi-multi-omics-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis.html?open=proteinanalysis)

[Hydrogen deuterium exchange mass spectrometry (HDX-MS)](#hdxms)

[Hydrogen deuterium exchange mass spectrometry (HDX-MS)](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/protein-structure-analysis-mass-spectrometry/hydrogen-deuterium-exchange-hdx-protein-structure-ms.html)

A major focus of structural virology is to obtain an understanding of the construction and structural basis for stability of the protein capsids that encapsulate the viral genomic information. HDX-MS can be used to measure local conformational dynamics and to gain insight into the mechanisms of assembly and capsid maturation for viruses.

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[Top](#top)

* * *

## Pathogen biology

Understand viral host interactions (virus-host cell interaction) and keep your lab positioned to respond rapidly. Studies are necessary to gain information about interaction events that are critical for different stages of a viral infection and to identify which host proteins are targeted by viral proteins during infection. This type of study can help understand the mechanisms involved in the progression of the virus life cycle or in the inhibition of host defenses.

* * *

### Virus-host cell interaction mass spectrometry workflows

[Affinity purification MS (AP-MS)](#apms)

[Affinity purification MS (AP-MS)](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/protein-structure-analysis-mass-spectrometry/affinity-mass-spectrometry.html)

The focus of virus-host interaction studies is to discover protein interaction events critical for different stages of a viral infection. AP-MS workflows can be used to examine specific protein-protein interactions within protein complexes, or to look at protein complexes more globally at the interactome level. Incorporating quantitative MS (LFQ, TMT) with affinity purification enables researchers to examine protein-protein interactions under different conditions (across different stages of viral infection), thereby providing a much more dynamic view. AP-MS can also be used to examine posttranslational modifications (PTMs) and the role they play in facilitating protein-protein interactions.

#### Recommended products

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[Native MS](#nativems2)

[Native MS](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/protein-structure-analysis-mass-spectrometry/native-mass-spectrometry.html)

Insights into virus-host cell protein complexes, like subunit stoichiometry, subunit identification, biomolecule binding, protein complex topology and protein dynamics can be obtained with native MS. The capabilities of native MS can be further expanded when combined with other techniques like limited proteolysis to infer protein interactions.

#### Recommended products

[Nanospray Flex Ion Sources](/order/catalog/product/ES071)

[Acclaim SEC-1000 Size Exclusion Chromatography 4.6x300mm HPLC Columns](/order/catalog/product/079724)[Vanquish Horizon UHPLC System](/order/catalog/product/IQLAAAGABHFAPUMZZZ)[Vanquish Flex UHPLC System](/order/catalog/product/IQLAAAGABHFAPUMBHV)[Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS System](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/q-exactive-orbitrap-mass-spectrometers/q-exactive-uhmr.html)[Protein analysis mass spectrometry software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis.html?open=proteinanalysis)[![Nanospray Flex Ion Sources](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/gen/gen-nanospray-flex-ion-sources-150x150.jpg)](/order/catalog/product/ES071)[![Acclaim SEC-1000 Size Exclusion Chromatography 4.6x300mm HPLC Columns](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-acclaim-sec1000-hplc-columns-270x195.jpg)](/order/catalog/product/079724)[![Vanquish Horizon UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-Vanquish-Horizon-UHPLC-270x195.jpg)](/order/catalog/product/IQLAAAGABHFAPUMZZZ)[![Vanquish Flex UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-vanquish-flex-quaternary-270x195.jpg)](/order/catalog/product/IQLAAAGABHFAPUMBHV)[![Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-q-exactive-uhmr-vanquish-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/q-exactive-orbitrap-mass-spectrometers/q-exactive-uhmr.html)[![Protein analysis mass spectrometry software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Communities/omics/hdi/hdi-multi-omics-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis.html?open=proteinanalysis)

[Crosslinking MS](#crosslinkingms)

[Crosslinking MS](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/protein-structure-analysis-mass-spectrometry/crosslinking-mass-spectrometry.html)

Virus-host cell protein interactions are intermolecular interactions occurring between virus proteins and host cell receptors. Unfortunately, these interactions tend to be transient, occurring for a brief period. Crosslinking MS (XL-MS) can monitor transient interactions to help distinguish between direct and indirect protein-protein interactions. XL-MS can help identify host cell surface proteins involved in interaction. It can be used to examine protein interaction topologies between a virus and host cell proteins, map interaction sites between the virus and host, as well as the precise residues involved in binding. XL-MS can help elucidate protein structures or complexes involved in host-cell interaction.

#### Recommended products

[Disuccinmidyl sulfoxide (DSSO) & Disuccinimidyl dibutyric urea (DSBU) reagents](/us/en/home/life-science/protein-biology/protein-labeling-crosslinking/protein-crosslinking.html)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[EASY-Spray C18 LC Column](/order/catalog/product/ES806A)[FAIMS Pro Duo interface](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/field-asymmetric-ion-mobility-spectrometry-faims.html)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![Disuccinmidyl sulfoxide (DSSO) & Disuccinimidyl dibutyric urea (DSBU) reagents](/content/dam/LifeTech/global/life-sciences/images/protein-crosslinking-showcase.jpg)](/us/en/home/life-science/protein-biology/protein-labeling-crosslinking/protein-crosslinking.html)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![EASY-Spray C18 LC Column](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES806A)[![FAIMS Pro Interface](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-orbitrap-exploris-faims-easy-nlc-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/field-asymmetric-ion-mobility-spectrometry-faims.html)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

[TMT quantitation](#tmtquantitation)

[TMT quantitation](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry/tmt-quantitation.html)

Virus-host cell interactions are not static but a dynamic process. Quantitative techniques like TMT can be used to observe this dynamic process. As part of AP-MS or XL-MS, TMT workflows can be used to examine the protein-protein interaction occurring during virus infection, measuring changes in levels of interactions or binding affinities. TMT quantitation workflows provide multiplexing capabilities for relative quantitative proteomics analysis, allowing concurrent MS analysis of multiple samples derived from cells, tissues or biological fluids.

#### Recommended products

[Tandem Mass Tag (TMT) Systems](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/tandem-mass-tag-systems.html)[Pierce High pH Reversed-Phase Peptide Fractionation Kit](/order/catalog/product/84868)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[EASY-Spray C18 LC Column](/order/catalog/product/ES806A)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![Tandem Mass Tag (TMT) Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Communities/omics/hdi/hdi-A44520-tmtpro-16plex-270x195.jpg)](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/tandem-mass-tag-systems.html)[![Pierce High pH Reversed-Phase Peptide Fractionation Kit](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Sample-Prep/hdi/hdi-Pierce-High-pH-Reversed-Phase-Peptide-Fractionation-Kit-540x390.jpg)](/order/catalog/product/84868)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![EASY-Spray C18 LC Column](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES806A)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

[Top](#top)

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## Host immune response

A comprehensive product portfolio and custom options are needed for detection of important immunological markers, including host immunity, immune system response and system defense against viral infections. The immune system is the defense system against viral infections; studying molecular characterization of the immune response to viruses is necessary in development of treatments to quell viral replication and propagation and to alleviate symptoms of viral disease.

### Lifecyle of the host immune system

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### Host immune response mass spectrometry workflows

[Bottom-up proteomics](#bottomupproteomics)

[Bottom-up proteomics](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/proteomics-mass-spectrometry-workflows/bottom-up-proteomics.html)

Peptide antigens bind to molecules encoded by the major histocompatibility complex (MHC) and are presented on the cell surface form the targets of T lymphocytes. This critical arm of the adaptive immune system facilitates the eradication of virus-infected cells as well as the production of antibodies. Identifying these peptide antigens is critical to the development of new vaccines. Bottom-up proteomics workflows are the mainstay for proteomics and are used to identify as many protein components in a biological sample as possible.

#### Recommended products

[Cell Lysis and Fractionation](/us/en/home/life-science/protein-biology/protein-purification-isolation/cell-lysis-fractionation.html)[Protein Digestion](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/sample-prep-mass-spectrometry/protein-digestion-mass-spectrometry.html)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[EASY-Spray C18 LC Column](/order/catalog/product/ES806A)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![Cell Lysis and Fractionation](/content/dam/LifeTech/Images/integration/89839-Lyso-Enrichment-Kit-230.jpg)](/us/en/home/life-science/protein-biology/protein-purification-isolation/cell-lysis-fractionation.html)[![Protein Digestion](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-protein-digestion-270x195.jpg)](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/sample-prep-mass-spectrometry/protein-digestion-mass-spectrometry.html)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![EASY-Spray C18 LC Column](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES806A)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

[Quantitative proteomics (TMT, SILAC, & label-free quantitation)](#quantitativeproteomics)

[Quantitative proteomics](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry.html)

Quantitative proteomics can help identify distinct immune response profiles induced by viral infection. This is done by characterizing immune response proteins and identifying immune system pathways involved in response to viral infection. Quantitative proteomics workflows allow system-wide identification and quantification of proteins from discovery to targeted applications, detecting and quantifying thousands of proteins in a single experiment across multiple conditions with dynamics and insights, which can lead to deeper levels of understanding about how biological processes behave.

* * *

[TMT quantitation](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry/tmt-quantitation.html)

These workflows provide multiplexing capabilities for relative quantitative proteomics analysis, allowing concurrent MS analysis of multiple samples derived from cells, tissues or biological fluids.

#### Recommended products

[Tandem Mass Tag (TMT) Systems](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/tandem-mass-tag-systems.html)[Pierce High pH Reversed-Phase Peptide Fractionation Kit](/order/catalog/product/84868)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[EASY-Spray C18 LC Column](/order/catalog/product/ES806A)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![Tandem Mass Tag (TMT) Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Communities/omics/hdi/hdi-A44520-tmtpro-16plex-270x195.jpg)](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/tandem-mass-tag-systems.html)[![Pierce High pH Reversed-Phase Peptide Fractionation Kit](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Sample-Prep/hdi/hdi-Pierce-High-pH-Reversed-Phase-Peptide-Fractionation-Kit-540x390.jpg)](/order/catalog/product/84868)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![EASY-Spray C18 LC Column](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES806A)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

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[SILAC quantitation](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry/silac-quantitation.html)

These workflows identify and quantify relative changes in complex protein samples with a technique that can handle both labeled and unlabeled samples while detecting changes for both low-abundance proteins and posttranslational modifications such as in phosphorylation or glycosylation.

#### Recommended products

[SILAC Metabolic Labeling Systems](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/silac-metabolic-labeling-systems.html)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[EASY-Spray C18 LC Column](/order/catalog/product/ES806A)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![SILAC Metabolic Labeling Systems](/content/dam/LifeTech/global/life-sciences/protein-biology/mass-spec/SILAC-Kit-DMEM-showcase-230x195px.jpg)](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/silac-metabolic-labeling-systems.html)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![EASY-Spray C18 LC Column](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES806A)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

* * *

[Label-free quantitation](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry/label-free-quantitation.html)

These workflows allow relative quantitation of protein samples from any origin with unlimited sample comparisons and peptide identification with any fragmentation method.

#### Recommended products

[Pierce Peptide Retention Time Calibration Mixture](/order/catalog/product/TS-88321)[HeavyPeptide AQUA Custom Synthesis Service](/us/en/home/life-science/protein-biology/peptides-proteins/custom-peptide-synthesis-services/heavypeptide-aqua-custom-synthesis-service.html)[EASY-Spray HPLC Columns](/order/catalog/product/ES803A)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[Orbitrap Exploris 480 Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-480-mass-spectrometers.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![Pierce Peptide Retention Time Calibration Mixture](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/gen/gen-pierce-peptide-retention-time-calibration-mixture-150x150.jpg)](/order/catalog/product/TS-88321)[![HeavyPeptide AQUA Custom Synthesis Service](/content/dam/LifeTech/global/life-sciences/images/heavypeptide-aqua-showcase.jpg)](/us/en/home/life-science/protein-biology/peptides-proteins/custom-peptide-synthesis-services/heavypeptide-aqua-custom-synthesis-service.html)[![EASY-Spray HPLC Columns](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES803A)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![Orbitrap Exploris 480 Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-exploris-480-ms-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-480-mass-spectrometers.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

[Targeted quantitation (PRM, SRM & SureQuant)](#targetedquantitation)

[HRAM protein quantitation with parallel reaction monitoring (PRM)](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry.html?open=targeted#targeted)

These workflows can detect all target product ions in parallel using one, concerted high-resolution, accurate-mass (HRAM) analysis; it’s ideally suited for analyzing and quantifying large numbers of samples.

#### Recommended products

[Pierce Peptide Retention Time Calibration Mixture](/order/catalog/product/TS-88321)[HeavyPeptide AQUA Custom Synthesis Service](/us/en/home/life-science/protein-biology/peptides-proteins/custom-peptide-synthesis-services/heavypeptide-aqua-custom-synthesis-service.html)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[Orbitrap Exploris 480 Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-480-mass-spectrometers.html)[TraceFinder Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)[![Pierce Peptide Retention Time Calibration Mixture](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/gen/gen-pierce-peptide-retention-time-calibration-mixture-150x150.jpg)](/order/catalog/product/TS-88321)[![HeavyPeptide AQUA Custom Synthesis Service](/content/dam/LifeTech/global/life-sciences/images/heavypeptide-aqua-showcase.jpg)](/us/en/home/life-science/protein-biology/peptides-proteins/custom-peptide-synthesis-services/heavypeptide-aqua-custom-synthesis-service.html)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![Orbitrap Exploris 480 Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-exploris-480-ms-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-480-mass-spectrometers.html)[![TraceFinder Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-tracefinder-software-icon-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)

* * *

[Targeted quantitation with selected reaction monitoring (SRM)](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry.html?open=targeted#targeted)

These workflows utilize a triple quadrupole mass spectrometer for more routine, targeted quantitation and analysis of large numbers of samples.

#### Recommended products

[Pierce Peptide Retention Time Calibration Mixture](/order/catalog/product/TS-88321)[HeavyPeptide AQUA Custom Synthesis Service](/us/en/home/life-science/protein-biology/peptides-proteins/custom-peptide-synthesis-services/heavypeptide-aqua-custom-synthesis-service.html)[Vanquish Horizon UHPLC System](/order/catalog/product/IQLAAAGABHFAPUMZZZ)[FAIMS Pro Duo\
\
interface](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/field-asymmetric-ion-mobility-spectrometry-faims.html)[![Pierce Peptide Retention Time Calibration Mixture](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/gen/gen-pierce-peptide-retention-time-calibration-mixture-150x150.jpg)](/order/catalog/product/TS-88321)[![HeavyPeptide AQUA Custom Synthesis Service](/content/dam/LifeTech/global/life-sciences/images/heavypeptide-aqua-showcase.jpg)](/us/en/home/life-science/protein-biology/peptides-proteins/custom-peptide-synthesis-services/heavypeptide-aqua-custom-synthesis-service.html)[![Vanquish Horizon UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-Vanquish-Horizon-UHPLC-270x195.jpg)](/order/catalog/product/IQLAAAGABHFAPUMZZZ)[![FAIMS Pro Interface](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-orbitrap-exploris-faims-easy-nlc-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/field-asymmetric-ion-mobility-spectrometry-faims.html)[TSQ Altis Triple Quadrupole Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/triple-quadrupole-lc-ms/tsq-altis-triple-quadrupole-ms.html)[Skyline Software](https://skyline.ms/project/home/software/Skyline/begin.view)[TraceFinder Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)[![TSQ Altis Triple Quadrupole Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-tsq-altis-tq-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/triple-quadrupole-lc-ms/tsq-altis-triple-quadrupole-ms.html)[![Skyline Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/metabolomics-lipidomics/hdi/hdi-skyline-software-270x195.jpg)](https://skyline.ms/project/home/software/Skyline/begin.view)[![TraceFinder Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-tracefinder-software-icon-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)

* * *

[SureQuant targeted quantitation](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry/surequant-targeted-quantitation.html)

The SureQuant IS targeted quantitation workflow delivers a complete assay from sample preparation to monitoring and quantitation of hundreds of target peptides in complex matrices with easy setup, high selectivity, quantitative accuracy, precision and specificity.

Click to enlarge

[Learn more](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry/surequant-targeted-quantitation.html)

[Posttranslational modification (PTM)](#Posttranslationalmodification)

[Posttranslational modification (PTM)//Phosphoproteomics](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/proteomics-mass-spectrometry-workflows/phosphoproteomics.html)

PTMs such as phosphorylation and polyubiquitination regulate innate inflammatory responses due to infection. Studies have also shown that PTMs such as methylation, acetylation, SUMOylation, and succinylation are involved in the regulation of innate immunity and inflammation. MS can be used to characterize these PTMs. Phosphoproteomics (Posttranslational modification-PTM) workflows enable large-scale study of protein phosphorylation and phosphopeptides, furthering scientific understanding of the influence this important PTM has on biological processes and human health.

#### Recommended products

[Tandem Mass Tag (TMT) Systems](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/tandem-mass-tag-systems.html)[High-Select Fe-NTA Phosphopeptide Enrichment Kit](/order/catalog/product/A32992)[Pierce High pH Reversed-Phase Peptide Fractionation Kit](/order/catalog/product/84868)[Vanquish Neo UHPLC System](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[![Tandem Mass Tag (TMT) Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Communities/omics/hdi/hdi-A44520-tmtpro-16plex-270x195.jpg)](/us/en/home/life-science/protein-biology/protein-mass-spectrometry-analysis/protein-quantitation-mass-spectrometry/tandem-mass-tag-systems.html)[![High-Select Fe-NTA Phosphopeptide Enrichment Kit](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Communities/omics/hdi/hdi-high-select-fenta-kit-230x195.jpg)](/order/catalog/product/A32992)[![Pierce High pH Reversed-Phase Peptide Fractionation Kit](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Sample-Prep/hdi/hdi-Pierce-High-pH-Reversed-Phase-Peptide-Fractionation-Kit-540x390.jpg)](/order/catalog/product/84868)[![Vanquish Neo UHPLC System](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/hdi/vanquish-neo-230x195.png)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-neo-uhplc-system.html)[EASY-Spray C18 LC Column](/order/catalog/product/ES806A)[Orbitrap Eclipse Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[Proteome Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)[![EASY-Spray C18 LC Column](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/General/gen-easy-spray-hplc-columns-150x150.jpg)](/order/catalog/product/ES806A)[![Orbitrap Eclipse Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-orbitrap-eclipse-ms-front-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html)[![Proteome Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-proteome-discoverer-software-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/proteome-discoverer-software.html)

[Metabolomics](#hostimmunemetabolomics)

[Metabolomics](/us/en/home/industrial/mass-spectrometry/metabolomics-lipidomics.html)

Mass spectrometry characterization and quantitation of metabolites can yield important insights into how the immune system functions.

* * *

Structure elucidation in untargeted metabolomics


These workflows are designed for small-molecule identification and can solve the most complex metabolomic challenges.

#### Recommended products

[Vanquish UHPLC Systems](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[Orbitrap IQ-X Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-iq-x.html)[AcquireX Intelligent Data Acquisition Workflow](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[Compound Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[mzCloud HRAM MSn Spectral Library](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)[Mass Frontier Spectral Interpretation Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/mass-frontier-spectral-interpretation-software.html)[![Vanquish UHPLC Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-vanquish-close-270x195.jpg)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[![Orbitrap IQ-X Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/hdi/orbitrap-iql-230x195.png)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-iq-x.html)[![AcquireX Intelligent Data Acquisition Workflow](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/newsletters/mz-cloud/hdi-orbitrap-idx-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[![Compound Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-compound-discoverer-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[![mzCloud HRAM MSn Spectral Library](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-mzcloud-logo-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)[![Mass Frontier Spectral Interpretation Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-mass-frontier-icon-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/mass-frontier-spectral-interpretation-software.html)

* * *

Semi-targeted metabolomics


These workflows enable researchers to detect metabolites of interest while simultaneously discovering unknowns.

#### Recommended products

[Vanquish UHPLC Systems](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[Orbitrap Exploris 240 Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-240-mass-spectrometers.html)[AcquireX Intelligent Data Acquisition Workflow](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[TraceFinder Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)[Compound Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[mzCloud HRAM MSn Spectral Library](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)[![Vanquish UHPLC Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-vanquish-close-270x195.jpg)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[![Orbitrap Exploris 240 Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-Orbitrap-Exploris-240-FAIMS-540x390.png)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-240-mass-spectrometers.html)[![AcquireX Intelligent Data Acquisition Workflow](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/newsletters/mz-cloud/hdi-orbitrap-idx-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[![TraceFinder Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-tracefinder-software-icon-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)[![Compound Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-compound-discoverer-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[![mzCloud HRAM MSn Spectral Library](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-mzcloud-logo-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)

[Top](#top)

* * *

## Translational research

[Translational proteomics](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/proteomics-mass-spectrometry-workflows/translational-proteomics.html) using mass spectrometry is helping to deliver standardization, rapid response and reproducibility for large-scale studies which can lead to the discovery of potentially clinically-relevant protein biomarkers for the development of disease diagnostics, detection tools, tests, treatments and practices that improve human health.

* * *

[Quantitative proteomics](#transresearchquantitativeproteomics)

[Quantitative proteomics](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry.html) techniques can be used to distinguish and predict mild to severe types of disease progression, assisting with development of appropriate medical treatments and resources at earlier stages, which can have a big impact on mortality-survival rate.

[Learn more](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry.html)

[Metabolomics](#transresearchmetabolomics)

[Metabolomics](/us/en/home/industrial/mass-spectrometry/metabolomics-lipidomics.html)

Mass spectrometry characterization and quantitation of metabolites can yield important insights into how the immune system functions.

* * *

Structure elucidation in untargeted metabolomics


These workflows are designed for small-molecule identification and can solve the most complex metabolomic challenges.

#### Recommended products

[Vanquish UHPLC Systems](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[Orbitrap IQ-X Tribrid Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-iq-x.html)[AcquireX Intelligent Data Acquisition Workflow](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[Compound Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[mzCloud HRAM MSn Spectral Library](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)[Mass Frontier Spectral Interpretation Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/mass-frontier-spectral-interpretation-software.html)[![Vanquish UHPLC Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-vanquish-close-270x195.jpg)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[![Orbitrap IQ-X Tribrid Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/hdi/orbitrap-iql-230x195.png)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-iq-x.html)[![AcquireX Intelligent Data Acquisition Workflow](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/newsletters/mz-cloud/hdi-orbitrap-idx-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[![Compound Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-compound-discoverer-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[![mzCloud HRAM MSn Spectral Library](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-mzcloud-logo-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)[![Mass Frontier Spectral Interpretation Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-mass-frontier-icon-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/mass-frontier-spectral-interpretation-software.html)

* * *

Semi-targeted metabolomics


These workflows enable researchers to detect metabolites of interest while simultaneously discovering unknowns.

#### Recommended products

[Vanquish UHPLC Systems](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[Orbitrap Exploris 240 Mass Spectrometer](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-240-mass-spectrometers.html)[AcquireX Intelligent Data Acquisition Workflow](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[TraceFinder Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)[Compound Discoverer Software](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[mzCloud HRAM MSn Spectral Library](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)[![Vanquish UHPLC Systems](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Chromatography/Liquid-Chromatography/hdi/hdi-vanquish-close-270x195.jpg)](/us/en/home/industrial/chromatography/liquid-chromatography-lc/hplc-uhplc-systems/vanquish-uhplc-systems.html)[![Orbitrap Exploris 240 Mass Spectrometer](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-Orbitrap-Exploris-240-FAIMS-540x390.png)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers/orbitrap-exploris-240-mass-spectrometers.html)[![AcquireX Intelligent Data Acquisition Workflow](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/newsletters/mz-cloud/hdi-orbitrap-idx-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/acquirex-intelligent-data-acquisition-workflow.html)[![TraceFinder Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/hdi/hdi-tracefinder-software-icon-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/lc-ms-data-acquisition-software/tracefinder-software.html)[![Compound Discoverer Software](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-compound-discoverer-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/multi-omics-data-analysis/compound-discoverer-software.html)[![mzCloud HRAM MSn Spectral Library](/content/dam/LifeTech/Thermo-Scientific/CMD/Marketing-Images/Mass-Spectrometry/lcms/hdi/hdi-mzcloud-logo-270x195.jpg)](/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-software/mass-spectral-libraries/mzcloud-mass-spectral-library.html)

[Top](#top)

* * *

## Virus detection

Support research and development of alternative and/or complementary testing assays to the conventional RT-PCR based methods to help address issues with capacity and where there are shortages in necessary testing supplies.

Proteomics mass spectrometry applications and workflows can be used to determine relative and absolute abundance of peptides unique to the viral proteins of interest in large sample sets and then selected for targeted quantitative analysis, allowing profiling of hundreds of targets in a single experiment.

[Learn more](/us/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/quantitative-proteomics-mass-spectrometry.html?open=targeted#targeted)

* * *

## Explore all of our SARS-CoV-2 (COVID-19) research tools and solutions

From viral research and epidemiological studies to potential vaccine development, our comprehensive portfolio of products is here to help. As you work to understand the SARS-CoV-2 coronavirus, to rapidly identify future treatment options and develop possible vaccine targets, don't worry about having the supplies and instrument support you need. We're here to help you advance your research.

[Learn more](/us/en/home/clinical/public-health/coronavirus-sars-cov-2-research-solutions.html)

## Brochure: Go beyond To gain new biological insights

Thermo Fisher Scientific offers a complete portfolio of tools and technologies to enable virus research, supporting collaboration and the acceleration of lifesaving discoveries. And we continue to pursue advancements that deliver confidence and rigor in the results.

[Learn more](https://assets.thermofisher.com/TFS-Assets/CMD/brochures/br-000018-virus-research-solution-br000018-en.pdf)

## White Paper: An Urgent Need for Expanded Virus Research

Mass spectrometry offers many approaches to gain insights into viral behavior by studying intact viral particles, their surfaces and binding characteristics, their protein compositions, and their impacts on the biochemical pathways of host cells upon infection.

Download the white paper to read about all the MS-based approaches that enable researchers to develop strategies to better tackle virus studies.

[Open paper](https://assets.thermofisher.com/TFS-Assets/CMD/Reference-Materials/wp-65880-expanded-virus-research-wp65880-en.pdf)

* * *

These devices are for General Laboratory Use Only, and are not used for clinical diagnosis or in diagnostic procedures.

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