While maximal serum concentrations ( Cmax ) and the area under the data ( AUDtot ) of erythromycin were significantly higher ( Cmax 1.44 mg.l-1 , AUDtot 5.66 mg.h.l-1 ) than those of erythromycylamine ( Cmax 0.29 mg.l-1 , AUDtot 1.96 mg.h.l-1 ) , erythromycylamine had a significantly higher mean residence time ( 21 h ) than erythromycin ( 5.5 h ) .
