Consecutive 48 men with AMI , not eligible for thrombolytic therapy because of late presentation ( > 12 h ) , were prospectively randomized 2:1 to double-blind ISDN ( mean dose 2.4 + / - 0.9 mg/h ) ( n = 33 ) or placebo ( 0.9 % sodium chloride ) ( n = 15 ) infusion .
