The expression of PHD1 , PHD2 and PHD3 together with HIF-1 and the HIF-inducible genes vascular endothelial cell growth factor ( VEGF ) and carbonic anhydrase IX were assessed by immunohistochemistry using a tissue microarray approach in 211 patients with T2-4 N0-1 breast cancer enrolled in a randomised trial comparing single-agent epirubicin versus epirubicin and tamoxifen as the primary systemic treatment .
