Overall , sulfadoxine/pyrimethamine plus amodiaquine reduced the rate of subsequent treatments for malaria by 54 % ( 95 % CI 36-66 , p < 0.0001 ) compared with sulfadoxine / pyrimethamine alone and by 37 % ( 12-54 , p = 0.007 ) compared with sulfadoxine/pyrimethamine plus artesunate .
