Total isoflavones showed a breast adipose/glandular tissue distribution of 40:60 , and their mean ( + / - SEM ) derived 17beta-estradiol equivalents toward estrogen receptor beta were 21 + / - 4-fold and 40 + / - 10-fold higher than the 17beta-estradiol concentrations in adipose ( 0.283 + / - 0.089 pmol/g , P < 0.001 ) and glandular ( 0.246 + / - 0.091 pmol/g , P = 0.001 ) fractions , respectively .
