Before operation , the CD3 + , CD4 + , CD4 + / CD8 + and the activity of NK cells in LIC patients were lower , but CD8 + was higher than that of normal level ( P < 0.01 ) , which indicated that cellular immunity in LIC was in immunosuppressive state , they all further reduced 1 week after operation , particularly CD3 + cell counts , but CD3 + , CD4 + and the activity of NK cells normalized 1 month after operation in CAKF group , and 2 months were needed to normalize in combination therapy group .
