At baseline and at 1 year , body composition was assessed by dual photon x-ray absorptiometry scans ; body fat distribution was measured by computed tomographic scans at the L4/L5 vertebral disk space ; insulin sensitivity was measured by euglycemic hyperinsulinemic clamp ; interleukin-6 ( IL-6 ) , leptin , and adiponectin were measured by enzyme-linked immunosorbent assay ; and c-reactive protein ( CRP ) was measured by radioimmunoassay .
