Patients in both groups had a significant ( P < 0.05 ) decrease in serum creatinine from baseline ( group A day 4 2.4 + / - 1.2 mg/dL , day 8 1.6 + / - 1.2 mg/dL , and day 15 1.0 + / - 0.4 mg/dL ; group B day 4 2.5 + / - 1.5 mg/dL , day 8 1.8 + / - 0.9 mg/dL , and day 15 1.2 + / - 0.5 mg/dL ) and progressive increase in creatinine clearance ( group A day 4 26.5 + / - 12.8 mL/min and day 15 59.8 + / - 14.2 mL/min ; group B day 4 31.4 + / - 21.4 mL/min and day 15 54.9 + / - 27.5 mL/min , P < 0.05 ) .
