In response to similar increases in nicotine serum levels , FMD values declined from 10.2 + / - 4.4 % to 6.7 + / - 4.0 % after the spray ( mean difference : -3.6 + / - 2.0 % , 95 % confidence interval : -4.6 ; -2.5 , p < 0.0001 ) and from 9.4 + / - 3.8 % to 4.3 + / - 2.8 % after the cigarette ( -5.1 + / - 2.6 % , -6.5 ; -3.7 , p < 0.0001 ) .
