For the subset of 12 patients ( combination , N = 7 ; zonisamide , N = 5 ) that completed the full 12-week treatment , the mean ( SE ) weight loss was 8.1 ( 1.4 ) kg ( 8.5 % ) for the combination group versus 3.0 ( 0.9 ) kg ( 3.3 % ) for the zonisamide group ( F = 4.6 , df = 4,40 ; p = .004 ) .
