Estimated mean peak plasma concentration of rimantadine after i.v. administration was 2.0 micrograms/ml , volume of distribution ( mean + / - SD ) at steady-state ( Vdss ) was 7.1 + / - 1.7 L/kg , plasma clearance after i.v. administration was 51 + / - 7 ml/min/kg , and beta-phase half-life was 2.0 + / - 0.4 hours .
