Hydrocortisone use was not associated with a reduction in 28-day mortality ( RR 1.17 , 95 % CI 0.92-1 .49 , p = 0.19 ) but was associated with an increase in shock relapse ( RR 2.58 , 95 % CI 1.04-6 .45 , p = 0.03 ) and gastrointestinal bleeding ( RR 3.00 , 95 % CI 1.08-8 .36 , p = 0.02 ) .
