Patients were randomized to sorafenib ( 400 mg b.i.d. ) or placebo , combined with mFOLFOX6 ( oxaliplatin 85 mg/m ( 2 ) ; levo-leucovorin 200 mg/m ( 2 ) ; fluorouracil 400 mg/m ( 2 ) bolus and 2400 mg/m ( 2 ) continuous infusion ) every 14 days .
