Trimethoprim raised the AUC ( 0 , infinity ) and C ( max ) of repaglinide by 61 % ( range , 30-117 % ; P = 0.0008 ) and 41 % ( P = 0.005 ) , respectively , and prolonged the t ( ( 1/2 ) ) of repaglinide from 0.9 to 1.1 h ( P = 0.001 ) .
