Plasma fibrinogen , fibrin gel structure [ permeability coefficient ( Ks ) and fiber mass/length ratio ( mu ) ] , prothrombin fragment 1 +2 ( F1 +2 ) antigen , plasminogen activator inhibitor-1 ( PAI-1 ) activity and tissue plasminogen activator ( tPA ) antigen were analysed before randomization ( baseline value ) , and at the end of the treatment period .
