S-flurbiprofen produced almost complete ( > 99 % vs baseline ) inhibition of thromboxane B2 ( TXB2 ) in serum in all volunteers and significant inhibition of prostaglandin E2 ( PGE2 ) generation in blister fluid , but there was a considerable inter-individual variation in the response ranging from -78 to +190 % change from control PGE2 AUC .
