The LPA score was examined first in 12 236 participants with prevalent vascular disease ( 9277 coronary disease cases , and 1326 ischemic stroke and 2011 peripheral vascular disease cases with no history of coronary disease ) and 3687 vascular disease-free controls and , subsequently , in 3251 participants who had incident major vascular events during follow-up ( 2106 coronary disease , 507 ischemic stroke , and 707 peripheral vascular disease events ) .
