The 300-mL volume of grapefruit juice decreased the mean area under the plasma drug concentration-time curve ( AUC ) and the peak plasma drug concentration of fexofenadine to 58 % ( P < .001 ) and 53 % ( P < .001 ) , respectively , of those with the corresponding volume of water , and 1200 mL grapefruit juice reduced these parameters to 36 % ( P < .001 ) and 33 % ( P < .001 ) , respectively , of those with the corresponding volume of water .
