Patients were randomly assigned in a 2 x 2 factorial design to receive either 0.625 mg/d of conjugated equine estrogen ( plus 2.5 mg/d of medroxyprogesterone acetate for women who had not had a hysterectomy ) , or matching placebo , and 400 IU of vitamin E twice daily plus 500 mg of vitamin C twice daily , or placebo .
