Steady-state plasma levels of total estrone and total delta8,9-DHE measured on day 14 over a 24-hour period showed minor fluctuations and a similar time to maximum concentration ( Tmax ) : mean Tmax of total estrone = 7.94 and 8.36 hours for 0.3-mg and 1.25-mg tablets , respectively ; mean Tmax of total delta8,9-DHE = 7.08 and 8.36 hours for 0.3-mg and 1.25-mg tablets , respectively .
