Darunavir AUC ( 12h ) , C ( max ) and C ( min ) increased by 42 % ( 23 , 65 ) , 21 % ( 4 , 40 ) and 73 % ( 39 , 114 ) , respectively , during darunavir/ritonavir and ketoconazole co-administration , relative to darunavir/ritonavir treatment .
