At 6 and 12 months of therapy , carvedilol plus standard treatment was associated with significant decreases from baseline in SOD ( 2516 [ 126 ] and 2550 [ 118 ] , respectively , vs 2781 [ 116 ] U/g Hb ; both , P < 0.001 ) and GR ( 4.7 [ 0.3 ] and 4.1 [ 0.2 ] , respectively , vs 5.3 [ 0.2 ] micromol NADPH/min/g Hb ; P < 0.05 and P < 0.001 ) and increased CAT ( 16.9 [ 1.0 ] and 16.4 [ 0.7 ] , respectively , vs 12.7 [ 0.9 ] U/g Hb ; both , P < 0.001 ) .
