Patients were assigned randomly to receive a 0.3-mg / kg bolus of nefopam at the induction of anesthesia followed by a continuous infusion of 0.065 mg/kg/h for 48 hours ( G1 ) , a 0.3-mg / kg bolus of nefopam at the end of surgery followed by a continuous infusion of 0.065 mg/kg/h for 48 hours ( G2 ) , or a placebo ( G3 ) .
