A clear dose-dependent pharmacodynamic response in circulating IGF-I levels was observed [ from a predose mean ( SD ) IGF-I SD score of -3.2 ( 1.7 ) to peak plasma concentration of -0.5 ( 1.3 ) , 1.6 ( 1.3 ) , 2.1 ( 0.5 ) , and 4.4 ( 0.9 ) in the four dose groups , respectively ] .
