Notwithstanding a comparable improvement in metabolic control , 8-iso-PGF ( 2alpha ) ( M from 708 + / - 32 to 589 + / - 45 pg/mg cr , p < 0.001 ; G from 646 + / - 80 to 665 + / - 79 , pg/mg cr , p = ns ) and 11-dehydro-thromboxane B ( 2 ) ( M from 2190 + / - 196 to 1753 + / - 150 pg/mg cr , p < 0.05 ; G from 2048 + / - 202 to 1923 + / - 223 , pg/mg cr , p = ns ) urinary excretion decreased after metformin but not after gliclazide treatment .
