Statins are the standard-of-care therapy for reducing low-density lipoprotein cholesterol ( LDL-C ) levels ; however , combination with other lipid-modifying agents may be necessary to normalize lipid profiles in patients with mixed dyslipidemia who , in addition to high LDL-C , also have high triglycerides ( TG ) and low levels of high-density lipoprotein cholesterol ( HDL-C ) .
