At baseline , diastolic function was impaired in all patients as indicated by abnormal values for the peak flow of the early filling phase ( E , 55.3 + / - 9.5 mm/sec ) , the ratio of E and the peak flow of the atrial filling phase ( E/A ratio , 0.87 + / - 0.13 ) , the early diastolic velocity obtained by tissue Doppler ( E ' , 5.7 + / - 1.3 cm/sec ) , and the peak atrial filling velocity obtained by tissue Doppler ( A ' , 6.8 + / - 1.4 cm/sec ) , prolonged E deceleration time ( 234 + / - 34 msec ) , and isovolumetric relaxation time ( 121 + / - 15 msec ) .
