When cimetidine was administered with voriconazole , the maximum plasma voriconazole concentration ( Cmax ) and the area under the plasma concentration-time curve of voriconazole ( AUCtau ) was increased by 18.3 % [ 90 % confidence interval ( CI ) 6.0 , 32.0 ] and 22.5 % ( 90 % CI 13.3 , 32.5 ) , respectively .
