Compared with placebo , ER metoprolol significantly reduced systolic blood pressure ( SBP ) at the 1.0 and 2.0 mg/kg dose ( P = .027 and P = .049 , respectively ) , reduced diastolic blood pressure ( DBP ) at the 2.0 mg/kg dose ( P = .017 ) , and showed a statistically significant dose response relationship for the placebo-corrected change in DBP from baseline .
