Based on least square means ratios ( 90 % confidence intervals ) , during darunavir and ketoconazole co-administration , darunavir area under the curve ( AUC ( 12h ) ) , maximum plasma concentration ( C ( max ) ) and minimum plasma concentration ( C ( min ) ) increased by 155 % ( 80 , 261 ) , 78 % ( 28 , 147 ) and 179 % ( 58 , 393 ) , respectively , compared with treatment with darunavir alone .
