Analysis of the area under the plasma concentration versus time curve ( AUC ) , the maximum observed concentration ( Cmax ( obs ) ) and the time of the maximum observed concentration ( Tmax ( obs ) ) for Z-360 , gemcitabine and 2,2-difluorodeoxyuridine ( dFdU ) , could not exclude an effect on the systemic exposure to Z-360 , gemcitabine and dFdU when co-administration of Z-360 and gemcitabine was compared with single agent administration .
