By the end of the fourth week , there was a 67 % improvement of total effective rate ( TER ) with THH compared with a 28 % improvement with placebo by per-protocol analysis ( ( 2 ) = 10.68 , p = 0.0011 ) , while by intention-to-treat analysis , 63 % and 24 % improvements of TER were respectively observed in the therapeutic group and the control group ( ( 2 ) = 11.36 , p = 0.001 ) .
