There were statistically significant decreases in DAVG ( 4 ) and DAVG ( 24 ) for all doses of TDF compared with placebo , with the greatest effect seen with TDF 300 mg ( DAVG ( 4 ) , -0.62 , P < 0.001 ; DAVG ( 24 ) , -0.58 ; P < 0.001 ; DAVG ( 48 ) , -0.62 ) .
