A three-limbed randomized crossover study in 10 healthy volunteers was completed to determine the ability of a 50 g dose of activated charcoal to reduce the bioavailability of a simulated overdose of acetaminophen ( 12 x 325 mg tablets ) in the presence and absence of a concurrently present anticholinergic drug , atropine ( 0.01 mg/kg I. M. administered 15 min prior to the acetaminophen ingestion ) .
