Both brinzolamide and timolol significantly decreased IOP at 12 weeks , by a mean of 2.0 mm Hg and mean 2.7 mm Hg , respectively , and were more effective than latanoprost alone ( P < 0.01 ) , but there were no significant differences between the drugs and no significant differences in corneal endothelial cell density and blood pressure before and after addition of either drug .
