Coprimary effectiveness measures were changes in cognition and global functioning , as assessed using least squares mean changes from baseline ( LSM [ SE ] A ) scores ( last observation carried forward ) on the Severe Impairment Battery ( SIB ; cognition ) and the Clinician 's Interview-Based Impression of Change Plus Caregiver Input scale ( CIBIC + ; global function rating ) overall change score ( mean [ SD ] ) at week 24 .
