HD patients in stage I to IIIA with a large mediastinal mass , E stage , or massive spleen involvement were treated with two double cycles of alternating cyclophosphamide , vincristine , procarbazine , and prednisone ( COPP ) plus doxorubicin , bleomycin , vinblastine , and dacarbazine ( ABVD ) followed by EF irradiation in two successive trials ( HD1 and HD5 ) .
