Likewise the changes in renal handling of sodium and water in response to ET-1 infusion were unaffected by pretreatment with placebo or isradipine , e.g. sodium excretion ( -44.6 % versus -40.8 % ) , urine flow rate ( -49.8 % versus -38.9 % ) and clearance of lithium ( -32.0 % versus -29.1 % ) .
