The absence ( deletion [ D ] ) of a 287-bp marker in the ACE gene is associated with greater myocardial ACE levels and exercise-related LV growth than is its presence ( insertion [ I ] ) , an effect potentially mediated through either increased activity of the cellular growth factor angiotensin II on the angiotensin type 1 ( AT ( 1 ) ) receptor or increased degradation of growth-inhibiting kinins .
