Adjusted mean AUC of change from baseline in HAQ-DI was also significantly lower in patients initially randomized to tocilizumab-MTX 4 mg/kg ( -287.5 ; p < 0.0001 ) or 8 mg/kg ( -320.8 ; p < 0.0001 ) than in patients initially randomized to placebo-MTX ( -139.4 ) .
