This multi-centre , randomized , double-blind , placebo-controlled trial compared the efficacy and safety of valdecoxib 10 mg ( n = 209 ) , 20 mg ( n = 212 ) or 40 mg once daily ( q.d. ) ( n = 221 ) with naproxen 500 mg b.i.d. ( n = 226 ) or placebo ( n = 222 ) , in treating the signs and symptoms of RA .
