Nevertheless , there was a trend toward worse DFS among patients with the variant allele of MTHFR C677T compared with wild-type , particularly in treatment arm 2 , in which patients with the MTHFR C677T TT genotype had worse overall survival ( hazards ratio , 1.76 ; 95 % confidence interval , 1.06-2 .93 [ P = .03 ] ) and DFS ( hazards ratio , 1.84 ; 95 % confidence interval , 1.12-3 .03 [ P = .02 ] ) compared with those with homozygous wild-type .
