After nine weeks of 2 mg oestradiol treatment , there was a significant increase in fibrinolytic potential compared with placebo , as indicated by an increase in fibrinolytic activity ( mean ( SEM ) , 80 ( 9 ) v 54 ( 5 ) mm2 of lysis in the fibrin plate , 2 mg v placebo , p = 0.002 ) and a decrease in t-PA antigen ( 5.8 ( 0.9 ) v 8.4 ( 1.2 ) ng/ml , 2 mg v placebo , p < 0.001 ) .
