A significant interaction was seen between tumors with normal HER1 , HER2 fluorescent in situ hybridization ( FISH ) , or HER3 levels and the enhanced benefit from epi-CMF versus CMF for RFS ( hazard ratio [ HR ] , 0.36 ; HR for overexpressed HER1 or HER2 FISH or HER3 , 0.92 ; P = .035 ) and for OS ( HR , 0.30 ; HR for overexpressed HER1 or HER2 FISH or HER3 ) , 0.98 ; P = .023 ) .
