In two multicentre , dose-finding studies of tropisetron in the prevention of cisplatin-induced emesis , cancer patients nave to chemotherapy or who had not vomited previously were randomly assigned to tropisetron 5 , 10 , 20 or 40 mg ( study I , 143 patients ) or 2 or 5 mg ( study II , 74 patients ) , administered as a single intravenous dose over 15 minutes just before the start of chemotherapy .
