The most common drug-related nonhematologic toxicities observed were grade 1 to 2 diarrhea ( 250 mg , 65 % ; 500 mg , 56 % ) , fatigue ( 250 mg , 29 % ; 500 mg , 33 % ) , and grade 1 to 2 skin rash ( 250 mg , 24 % ; 500 mg , 39 % ) .
