No statistically significant difference was found in the objective response rate to CPT-11 ( p = 0.45 ) ; partial response ( PR ) was 23.3 % for group A patients and 33.3 % for group B. Following documented progression and second line treatment there was a significant difference between the response rate in group A ( 23.3 % ) and group B where no patients were found to respond to second-line treatment with 5-FU/LV ( p = 0.024 ) .
