Between August 6 , 1986 and September 1 , 1994 , 905 previously untreated children aged younger than 16 years with stage II favorable histology ( FH ) WT ( low-risk [ LR ] ) , stages III to IV FH WT , or stages I to IV clear-cell sarcoma of the kidney ( high-risk [ HR ] ) were randomized after the completion of 6 months of chemotherapy to discontinue ( short ) or continue for 9 additional months ( long ) treatment with chemotherapy regimens that included vincristine and either divided-dose ( standard [ STD ] ) courses ( 5 days ) or single-dose ( pulse-intensive [ PI ] ) treatment with dactinomycin .
