In post hoc analysis , LSM Delta in SIB score and CIBIC + treatment effect at end point were greater with donepezil 23 mg/d than 10 mg/d in patients with more advanced AD compared with less impaired patients ( SIB , +1.6 [ 0.78 ] vs -1.5 [ 0.88 ] , respectively [ P < 0.001 ] ; CIBIC + , 4.31 [ 1.09 ] vs 4.42 [ 1.10 ] [ P = 0.028 ] ) .
