However , the IN route induced significantly higher rates for de novo development of CD8 + T cells that respond by cytokine secretion to peptide-pulsed targets ( six [ 85.7 % ] of seven IN patients v two [ 33 % ] of six ID patients v none [ 0 % ] of six IV patients ; P = .005 ) and de novo DTH ( seven [ 87.5 % ] of eight IN patients v two [ 33.3 % ] of six ID patients v one [ 14.3 % ] of seven IV patients ; P = .01 ) compared with other routes .
