In the PPA group , the 0.33-mg / kg dose resulted in insignificant changes in peak systolic BP ( +5.4 mm Hg , p = 0.260 ) , peak diastolic BP ( -1.6 mm Hg , p = 0.622 ) , peak pulse ( -2.2 beats/min , p = 0.12 ) , peak Borg ( RPE = -0.10 ( p = 0.823 ) , time to exhaustion ( -16.9 s , p = 0.287 ) , and VO2max ( +0.50 ml/kg/min , p = 0.71 ) .
