After both 5 weeks and 1 year , significant and dose-dependent differences were seen with total symptom scores on nasal challenge ( P < .0001 ) , with titrated skin prick testing with cat dander extract at 5 weeks ( P = .014 ) and 1 year ( P < .0001 ) , and with cat-specific IgG4 measurement at 5 weeks ( P = .004 ) and 1 year ( P = .003 ) .
