Antiretroviral-naive HIV-infected participants enrolled in a long-term randomized clinical trial of 3 different initial ART strategies -- protease inhibitor ( PI ) , nonnucleoside reverse transcriptase inhibitor ( NNRTI ) , or PI plus NNRTI-based combinations -- with a median follow-up of 5 years , were compared by gender and race for 14 categories of grade 4 adverse events , discontinuation of initial antiretroviral regimen , and all-cause mortality .
