Twenty consecutive non-diabetic patients were randomized to receive conventional anesthesia ( CA ) or conventional anesthesia plus isoflurane ( ISO ) ( added to the inspired oxygen before starting cardiopulmonary bypass ) ; 40 consecutive diabetic patients in chronic treatment with oral glibenclamide were randomized to conventional anesthesia ( G-CA ) , conventional anesthesia plus isoflurane ( G-ISO ) , conventional anesthesia after shifting to insulin ( I-CA ) or conventional anesthesia plus isoflurane after shifting to insulin ( I-ISO ) .
