" 

 == Is Ciliopathy  as a genetypic cause of phenotypical obesity  worth mentioning in the article? == 

 A few edits ago, I added a single sentence to the obesity article:  ""Obesity is one symptom reported in a newly discovered class of genetic diseases known as ciliopathies"" which I sourced from this journal article:    My edit was removed, perhaps because I wrote poorly. 

 What I was trying to say is that there is now, as of some fairly recent developments in the genetics literature, at least a plausible hypothesis that one potential cause (underlying molecular cause, or underlying genetic cause) for some particular cases of clinically observed obesities is ciliopathy.  Perhaps my use of the word ""symptom"" was a mistake; but I thought that saying ""one potential genotype for the obesity phenotype is ciliopathy"" to be rather too esoteric.  Perhaps the entire sentence needs to be rewritten.  But I do think it is an appropriate addition to the Obesity article. 

 I am in no way saying that all ciliopathies result in obesity.  They obviously do not.  From the last ten years of work in molecular genetics with animals that have the cilia organelle, one thing that is obvious is that ciliopathies manifest in an extremely pleiotropic manner.  But there is a plausible hypothesis that has been put forward in the academic literature relating to a ciliopathic underlying cause for some clinically observed obesities; it has to do with a dysfunction in the molecular signaling pathway (along the cilia and/or basal bodies) that signals fullness, and/or taste, and/or time to move food onward in the large and/or small bowell, etc.  To date, most of the specific ciliopathic genes that have been related to obesity have been studied only in relation to more pleiotropic genetic syndromes such as Alstrom's, MKKS and BBS.  But the ciliopathic root cause, identified in some and implied in others, is encyclopedically interesting. 

 In my view, this newly-discovered connection is worthy of mention in the obesity article.  But I am not well-read on Obesity, so I will let those editors who frequent this article hash it out.  Cheers.   "