Well I did not expect this story to break my heart. 
 I was honestly rushing to the end, so I could say I'd finished it and moved on. At the beginning of volume book the epic conflict of the story resolved relatively quickly and quietly. I was expecting a lengthy denouement, acceptable for a long-running series such as this one. Boy was I wrong. The last chapter of this book, in my admittedly very hasty assessment, is what makes this a science-fiction story well-worth completing. 
 Other observations, including spoilers: 
 (view spoiler)[- MAJOR props to Bryan K. Vaughan for keeping up the 'is it science or magic' plotline throughout. The explanation even kind of justified the dream-link stuff. If this is world where there's such a thing as genetic resonance, there's definitely telepathy. 
 - I was totally caught off-guard by three-fifty's death. And y'all, it broke me. And just abruptly ending on Yorick crying, then jumping to 60 years later and explaining everything over clips from all the saddest, inevitably tragic moments of Yorick's horrific life. I need a hug. 
 Though let's be real. If Yorick's life was anything other than tragic the story couldn't be called honest. 
 (hide spoiler)] 
 - Good lord, the art and layout of these books improved dramatically by the end of this series. I was really blown away by the framing of some of these panels.