Squirrel Girl brings some well-needed good intentioned irreverence to the Marvel Universe. If that makes you uncomfortable, look at the gif again. 
 Doreen Green is Squirrel Girl, the surprise juggernaut of justice in the MU. She defeated Dr. Doom as a high school freshmen, and went on to stagger the likes of Thanos, M.O.D.O.K., and others. How? A good mix of powers, a sarcastic squirrel sidekick, and a world that never plays too seriously. 
 Now she's in college, and with a monthly book, she's going to crash into a whole lot more established characters. They have no idea what they're in for. 
 There's two ways to write Squirrel Girl. One is to make her a bit of badass lightness in the otherwise dark modern Marvel Universe, such as when she was the Avenger's nanny and Wolverine's ex-lover (or something). 
 That was perfectly cromulent, and she was cool in Fear Itself. The other way is to assume the whole MU is just that crazy, and I love that even more. 
 One great comedy element is the surprisingly omnipresent words of Deadpool. Whenever an established Marvel character appears, Doreen whips out one of "Deadpool's Guide to Supervillains" cards, giving me early 90's nostalgia. 
 One problem with funny superhero books is that they're often written as simple gags with little respect for a character's history. The creative team here love the history of the Marvel Universe and they are absolutely going to make fun of it. 
 Luckily enough, Doreen never comes across as too perfect, considering she is much less capable at her college and social life than she is at saving the world. Also, inside this book also lurks one of the most hilarious insightful observations about Galactus's behavior I've ever read, and I won't spoil that here. Read Squirrel Girl. Your Marvel Universe will be just a little bit brighter.