This book follows two people - Ares (aka War & one of the Four Horsemen of the Apocalypse) and Cara, a human with a special gift that allows her to heal animals. 
 At the beginning of the novel, we find out that Reseph (aka Pestilence and another of the Four Horsemen of the Apocalypse) has had his seal broken. This means that he has turned over to his demon nature and is spreading sickness and plagues around the world while the rest of his siblings are waiting around, worrying about when their seals will break and bring hell on earth (because yeah, that would not be a good thing for humankind). 
 In his plot for an impending Apocalypse, Reseph focuses on Ares' seal which involves destroying his agimortus (basically, the thing/person responsible for a seal breaking). 
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