🧬 #ScienceSaturday 🧬

How can we learn from #autoimmune diseases to improve #cancer #immunotherapy? Inherited changes in the PTPN22 gene have been associated with numerous autoimmune diseases. 

🔬 In a recent study by the Gajewski lab, PTPN22 knock out in dendritic cells enhanced their proliferation, activation and ability to present tumor antigens, resulting in enhanced antitumor activity. 

➡️ This work identifies a novel target to potentially improve cancer immunotherapy. 

🔗 Here’s a full link to the study-