<s>[INST] <<SYS>> This is a medical question of type : causes <</SYS>> What causes Von Hippel-Lindau disease ? [/INST] What causes Von Hippel-Lindau disease? Von Hippel-Lindau (VHL) disease is caused by a mutation in the VHL gene. This gene is a tumor suppressor gene, which helps to control cell growth. Mutations in the VHL gene lead to a lack of regulation of cell growth and survival, allowing cells to grow and divide uncontrollably, forming the tumors that are associated with VHL disease. </s>