<s>[INST] <<SYS>> This is a medical question of type : outlook <</SYS>> What is the outlook for Machado-Joseph Disease ? [/INST] Most individuals with Lyme disease respond well to antibiotics and have full recovery. In a small percentage of individuals, symptoms may continue or recur, requiring additional antibiotic treatment. Varying degrees of permanent joint or nervous system damage may develop in individuals with late-stage Lyme disease. </s>