<s>[INST] <<SYS>> This is a medical question of type : causes <</SYS>> What causes Type 1 plasminogen deficiency ? [/INST] What causes plasminogen deficiency, type 1? Plasminogen deficiency, type 1 is caused by a mutation in a gene encoding plasminogen, an enzyme whose function is to dissolve fibrin clots. Fibrin clots form scabs at a wound site. </s>