<s>[INST] <<SYS>> This is a medical question of type : causes <</SYS>> What causes Megalocytic interstitial nephritis ? [/INST] What causes malakoplakia? The cause of malakoplakia is unknown, but is thought to be associated with immunodeficiency or autoimmune disorders, such as hypogammaglobinlinemia, therapies that suppress the immune system, cancer, a chronic debilitating disorder, rheumatoid arthritis, and AIDS. </s>