<s>[INST] <<SYS>> This is a medical question of type : causes <</SYS>> What causes Lipodermatosclerosis ? [/INST] What causes lipodermatosclerosis? The exact cause of lipodermatosclerosis is unknown; however, it may be related to certain vein abnormalities and/or obesity. Lipodermatosclerosis often occurs in people with venous insufficiency. Approximately two thirds of affected people are obese. </s>