<s>[INST] <<SYS>> This is a medical question of type : frequency <</SYS>> How many people are affected by GM1 gangliosidosis ? [/INST] GM1 gangliosidosis is estimated to occur in 1 in 100,000 to 200,000 newborns. Type I is reported more frequently than the other forms of this condition. Most individuals with type III are of Japanese descent. </s>