<s>[INST] <<SYS>> This is a medical question of type : inheritance <</SYS>> Is Waldenstrm macroglobulinemia inherited ? [/INST] Waldenstrm macroglobulinemia is usually not inherited, and most affected people have no history of the disorder in their family. The condition usually arises from mutations that are acquired during a person's lifetime (somatic mutations), which are not inherited.  Some families seem to have a predisposition to the condition. Approximately 20 percent of people with Waldenstrm macroglobulinemia have a family member with the condition or another disorder involving abnormal B cells. </s>