<s>[INST] <<SYS>> This is a medical question of type : frequency <</SYS>> How many people are affected by Fabry disease ? [/INST] Fabry disease affects an estimated 1 in 40,000 to 60,000 males. This disorder also occurs in females, although the prevalence is unknown. Milder, late-onset forms of the disorder are probably more common than the classic, severe form. </s>