<s>[INST] <<SYS>> This is a medical question of type : frequency <</SYS>> How many people are affected by core binding factor acute myeloid leukemia ? [/INST] Acute myeloid leukemia occurs in approximately 3.5 per 100,000 individuals each year. CBF-AML accounts for 12 to 15 percent of acute myeloid leukemia cases in adults. </s>