<s>[INST] <<SYS>> This is a medical question of type : causes <</SYS>> What causes Iridocorneal endothelial syndrome ? [/INST] What causes iridocorneal endothelial (ICE) syndrome? The cause of this disease is unknown. However, it has been theorized that a viral infection, such as Herpes simplex virus (HSV) or Epstein-Barr virus (EBV) may be the trigger that causes the cornea to swell. </s>