<s>[INST] <<SYS>> This is a medical question of type : outlook <</SYS>> What is the outlook for Von Hippel-Lindau Disease (VHL) ? [/INST] The prognosis for individuals with VHL depends on then number, location, and complications of the tumors. Untreated, VHL may result in blindness and/or permanent brain damage. With early detection and treatment the prognosis is significantly improved. Death is usually caused by complications of brain tumors or kidney cancer. </s>