<s>[INST] <<SYS>> This is a medical question of type : inheritance <</SYS>> Is Smith-Magenis syndrome inherited ? [/INST] Smith-Magenis syndrome is typically not inherited. This condition usually results from a genetic change that occurs during the formation of reproductive cells (eggs or sperm) or in early fetal development. Most often, people with Smith-Magenis syndrome have no history of the condition in their family. </s>