<s>[INST] <<SYS>> This is a medical question of type : frequency <</SYS>> How many people are affected by Charcot-Marie-Tooth disease ? [/INST] Charcot-Marie-Tooth disease is the most common inherited disorder that involves the peripheral nerves, affecting an estimated 150,000 people in the United States. It occurs in populations worldwide with a prevalence of about 1 in 2,500 individuals. </s>