<s>[INST] <<SYS>> This is a medical question of type : frequency <</SYS>> How many people are affected by isolated Duane retraction syndrome ? [/INST] Isolated Duane retraction syndrome affects an estimated 1 in 1,000 people worldwide. This condition accounts for 1 percent to 5 percent of all cases of abnormal eye alignment (strabismus). For unknown reasons, isolated Duane syndrome affects females more often than males. </s>