<s>[INST] <<SYS>> This is a medical question of type : inheritance <</SYS>> Is Empty sella syndrome inherited ? [/INST] Is empty sella syndrome inherited? Empty sella syndrome (ESS) is typically not inherited. We are aware of one report of familial ESS, occurring in a father and two children. Some researchers believe that a defect present at birth may play a role in the development of the condition, but are unsure whether the defect directly causes ESS or is only a predisposing factor. </s>