<s>[INST] <<SYS>> This is a medical question of type : frequency <</SYS>> How many people are affected by SOX2 anophthalmia syndrome ? [/INST] SOX2 anophthalmia syndrome is estimated to affect 1 in 250,000 individuals. About 10 percent to 15 percent of people with anophthalmia in both eyes have SOX2 anophthalmia syndrome. </s>