Different layouts for different pages is one of the many things that the Panels module can do.  It works alongside your base theme.  The base theme sets up general things, gets your site looking consistent, and gives you the opportunity to customize it.  Panels gives you much greater flexibility for creating different layouts for different parts of your site, than the normal blocks in regions combo gives you.

Really customized themes
From the "Agatha Christie's Marple" TV series, I gather that Miss Marple was involved with a Captain Ainsworth. Are there any references to this also in the books? And it is suggested in "Murder at the Vicarage" that Captain Ainsworth was married. Is that correct? Are there other sources for this?
