Work at whatever feels comfortable to you if you are working with pen and paper. Then scan it as large as you can with as much PPI as you can.

When you scan the drawing, you can scan it at 500% or more and 1200PPI or more... which will allow you to properly size it for larger reproduction than the original drawing.

Of course, enlarging it when scanning may mean you need to clean it up a bit digitally to possibly sharpen it a bit.

What size should I make the line art for a one-sheet poster?

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http://stackoverflow.com/questions/3464580/reverse-engineering-a-hash

I have been notified that I cannot post this information anywhere online and I need this question to be taken down. I have edited the specific information out of it, but the revisions would hold the information.
