<s>[INST] is there any relation between malaria and nonalcoholic liver cirrhosis?the patient presented with liver cirrhosis and splenomegaly detected on USG. he has a low platelet count, and H/o esophageal varices.also in chidhood he had a H/o repeated attacks of malaria could his present condition be because of malaria? pt is currently 52 yrs oldthank you [/INST] Hi, Welcome to Chat Doctor, The patient is having cirrhosis of liver there are many causes of cirrhosis other than alcohol, like viral hepatitis, Autoimmune, Non-alcoholic steatohepatitis (NASH), Blockage of bile ducts, Budd-Chiari syn Chat Doctor. Malaria as cause of Liver cirrhosis is unlikely. If any such thing is reported in literature we need to search. It is possible that there is viral hepatitis in past and now patient presents as cirrhosis. If no cause is known then it is idiopathic or called cryogenic. His spleen is large due to portal hypertension and platelets are low due to splenomegaly. Hope this information helps you, if any thin more is required you can ask me. Take care. Good Luck. </s>