<s>[INST] The gap between the paracetamol and meftal 250 ...my daughter is 10 yrs old and having high fever up to 104...my doc advised us to give paracetamol....if fever is still high we should give meftal 250... She has fever even after giving meftal 250....can I give paracetamol.... [/INST] Dear user thank you for your question about that as high grade fever 104 considered very dangerous and may have severe effects and the solution is very simple.....paracetamol and metal are good antipyretic, and you need not increase dose of antipyretic Chat Doctor. .....but very important step required before all of this.....this step is doing cold compresses...making cold compresses and put him under mild cold running water fora time if 10-15 minutes until grade of fever reach 101-102 then give him antipyretic....antipyretic have excellent effect in lowering moderate fever ...but if fever is high antipyretic have limited effect and fever may remain high even if you increased the dose .simple cold compresses should not ignored...it will help you a lot...lastly treatment of the cause of infection is the main........hope that helps you... </s>