<s>[INST] I had a vaginal hysterectomy in Feb. 2014 . I m not the same person since. I have no appetite for life any more. I m on antidepressants and estrogen pills. Nothing is helping. On my days off I don t even want to leave my house. I want my life back. To be the person I once was. I ve gained 15 lbs since . I need some help and advice PLEASE!!?? [/INST] Hi dear, on which anti-depressant you are?what are the symptoms you have?there are many medication nowadays which helps you like SSRI(selective serotonin re uptake inhibitor), SARI(serotonin and nor epinephrine re uptake inhibitor) NASA (nor epinephrine and serotonin antagonist).discuss above medication with your doctor. Are you having thyroid problem?whether you test for thyroid any time? Thank you </s>