<s>[INST] I am a 52yr old female i havean under active thyroid , fatty live , overactive bladder, cervical arthritis with a trapped nerve , b12 deficiency,  restless leg syndrome and some years ago i had an aneurysm in the right side of my head .recently i have been in great pain with the bone in my left arm blood test last week revealed the my esr was very high could this have to do with any of the above .THANK YOU [/INST] Hi.understood your concern. First, thyroid hormone is a very important hormone involved in various functions in the body. Decreased levels of thyroid hormone may lead to obesity which may intern result in the development of many diseases such as fatty liver disease and arthritis. Secondly, B12 deficient may lead to neuropathy. High ESR indicates that you're suffering from a chronic disease. you're advised to visit treating physician at earliest and take advise. Thyroid hormone and B12 supplements maybe ingested immediately, though dosage should be advised by the treating physician hope to answer your concern. Regards Chat Doctor.  </s>