<s>[INST] hi my son age 8 yrs 4 months is a case of global development delay ( all milestones delayed) and had two episodes of epilepsy one in oct 2013 and second in june 2014. he also has mild Attention defficient and hyperactive he is on velporic acid (200mg TD and sizodone 5mg OD at night and livocartetine 5ml OD. he used to be active all the day as well as eating well . these days i am noticing appetite lossas his usual diet has reduced what could be possible reason and is it due to epilepsy medicine or due to sizodone which he has recently started ?? [/INST] Hi, With such presentations in my clinic, I would first rule out serious conditions with consult of neurologist and euro visualization by MRI of brain. The main cause is a death of neurons, maybe he had severe seizures. Valproic acid usually increases appetite, but sometimes it causes hepatotoxicity, that's why you kindly perform liver function test. Then give him LIV 52 for increasing appetite and hepatoprotection 2 capsule twice a day for 1 month Please let me know if you have further questions before meeting your primary care Doctor. </s>