<s>[INST] I use 15 mg daily dose of Enalapril, 1 baby aspirin and 5-10 mg Zolpidem. I also take chondroitin/MSM/glucosamine combo daily.   I have occasional attacks of low peripheral circulation with cold hands and feet.  Is this the synergistic effect of the drugs I am taking and what would be an optimal drug use. [/INST] Hello and thanks for writing. I can understand your concern and would try to help you in the best way possible. The Chat Doctor.  You are probably having Reynolds phenomenon, I suggest you consult a physician for a diagnostic workup and management plan. You may need additional medications like calcium channel blockers to prevent such episodes.In the meantime avoid cold exposure, keep your hands and toes warm and keep good care of your skin of hands and feet. </s>