<s>[INST] My wife aged 26 years of age had cholestectomy on 9th Jun 2010. She had been discharged on 11th Jun 2010. But now after 5 days of surgery, she had itching problems particularly in arms and back. before surgery, all tests were normal.Please suggest. She had no other chronic problems before surgery. The surgeon has prescribed Nimusulide,Oflaxcin and Rantidine after surgery for 4 days. Presently she in not taking any medicines.Please suggest. [/INST] Hi there, There are two reasons for itching after surgery. The most common reason is a reaction to the pain medications, as opioid based pain medications such as nor co, Vicodin and percent can cause itching.  I would recommend, if she's not having pain issues, for her to stop pain medications. The second thing that can cause itching after gallbladder surgery is an injury to the common bile duct, which causes an increase in bilirubin leading to jaundice and can lead to itching. If she cuts the pain medication and is still having pain issues and itching, she should undergo an ultrasound to evaluate her common bile duct. I hope this answers your questions. Please feel free to contact me should you have any further questions. </s>