<s>[INST] my wife aged 67 has kidney problem.  last week blood test shows s.creatinine: 2.5 .blood urea : 50. hemoglobin : 9.2. sugar fasting 126 and pp sugar 186. recently since 10 days some blisters have developed on the legs from ankle to the knee. she is obese about 120 kgs.kindly tell us what can be done [/INST] Hi dear user have gone through your question. I can understand your concern. In advanced stage of renal disease there is severe water-sodium retention, wich may cause blisters when the fluid becomes trapped under your skin, but in my opinion your wife is not in End-stage renal disease. My advice is to consult a nephrologist in your area because you need to have an exact diagnosis and treatment for your wives renal condition. She need also to take iron treatment for anemia and a hypocaloric diet because she has morbid obesity. Hope I have answered your question. If you have any further questions I will be happy to help. Thank you for using Chat Doctor. Wish you good health. </s>