<s>[INST] its about my uncle.He is 70 years of age.Doctors and reports are saying that his both kidneys functions has stopped and he is on dialysis process right now.there is a thing printed on the report saying corticomedullary is lost.what would be the effect aftermath, if it is so?what it is supposed to mean in general.thanks a lot.cheers. [/INST] Hello and welcome to Chat Doctor. As a Urologist, I can assure you, poor cortico-medullary differentiation is consistent with chronic kidney disease. This change is noted on an ultrasound scan, in patients with poorly functioning kidneys.  This an early indicator of kidney disease. The most important change is seen with rising level of creatinine, urea, and potassium. The blood pressure may also increase. If you've any doubt, send it as a direct question, for my expert opinion. Chat Doctor.  Manga. </s>