<s>[INST] my mother is 62 year old, diabetic for 25 years, her creatinine is 5.7 and urea is 120. we observe that when creatinine level comes down, her urea level also drops. are these two related ? is dialysis essential ? she is normal and carries her routine activities [/INST] Hello, Yes urea and creatinine levels are related. Both of them are waste products of protein degradation occurring in body. They both are excreted by kidney. So if kidney is not functioning properly, then the levels of creatinine and urea goes above normal levels. That is why we check serum creatinine and urea to indirectly see the functioning of kidney. Normally creatinine should be around 1.0 and urea below 45. She might need dialysis if the levels keep on going higher because if it goes higher it affects functioning of brain, kidney and lungs. So, if you are advised dialysis by your doctor, It's advisable to undergo the procedure. Thank you </s>