<s>[INST] My Grandmother died in 1943 @ 29 yrs old during a hospital stay of 16 days. The Death Cert identified the following. Immediate Cause of Death: Uremia Due to chronic Glomerulonephritis....Major findings of an operation identifed sub acute appendicitis and hydrops of gall bladder. Can you pls put this in context for a layman? [/INST] Hi, There are many causes of chronic glomerularnephritis1. Rapidly progressive glomerulonephritis or crescent glomerulonephritis2. Focal segmental glomerulosclerosis3. Membranous nephropathy4. Membranoproliferative glomerulonephritis5. IGA nephropathy6. Poststreptococcal glomerulonephritis7. Lupus nephritis In 1943, the medical research was still under progress and many of the causes were unknown. So your grandmother might have had one of the above causes for a while before she had appendicitis and gall bladder HY Chat Doctor.  Her kidney condition led to complications during surgery and death. It is very difficult to say which of the above conditions she had as in those days kidney biopsy was not done regularly and microscopes were also still under development. The actual pathological picture was still not identifiable. </s>