<s>[INST] I am having anemia , mild spleen enlargement and before one year I fall down , my ligaments became torn in my knee , Then doctors said that it s an inflammation in the synovial fluid on the knee but now There s pain in all joints of both legs ! Is it related to the spleen enlargement and platelets number or what ? [/INST] Hi Dear, Welcome to Chat Doctor. Understanding your concern. As per your query you are wondering if joint pain in leg related to spleen enlargement. Well joint pain is not the symptom of spleen enlargement, spleen enlargement can cause extreme fatigue. But there can be many reasons for joint pain like arthritis, gout and over exertion. I would suggest you to take complete rest, Chat Doctor.  Consult orthopedic surgeon for proper examination. Doctor may order blood test and urine test to confirm the diagnosis. Doctor may prescribe allopurinol, methotrexate or refer you to gastroenterologist if the symptoms are due to spleen. Hope your concern has been resolved. Get Well Soon. Best Wishes, </s>