<s>[INST] I just started Bupropion 150mg sr today. I only took one today as directed- take 1 tablet daily for 3 days then take one tablet twice a day . I do believe I had a headache before I took the medicine but after I took my first tablet for the first day my headache has gotten much much worse to the point where it almost feels like a migraine... can this be caused by the new medication I m on? [/INST] Hi, Yes, it may cause headache as its side effect. Bupropion is an atypical antidepressant commonly prescribed for the treatment of depression, smoking addiction and other conditions. Its common side effects include Chat Doctor.  Ask your doctor for its dose adjustment or an alternate effective but a safer medicine. Hope I have answered your query. Let me know if I can assist you further. Take care  </s>