<s>[INST] My left hand (back of hand) and wrist are aching and burning. When I run my finger along the vain on the back of my hand it hurts. I have a wrist stabilizer and cold pack on it but it still hurts like I jammed the wrist but I have not jammed it or fallen on it. I am on Eliquis 0.5 mg 2x per day for a fib. What signs should I look for of a clot. As far as I know I have been in a normal synus rythum for the last two weeks. [/INST] Hello, I have studied your case with diligence. Wrist pain and burning can be due to ligament injury. I will advise going for MRI and routine blood investigation if swelling does not reduce. Continue ice fomentation, and medication like anti-inflammatory Another probability of carpal tunnel can be considered in which there is swelling over wrist. There is nerve compression near wrist which leads to pain and tingling. Biopsy can be done when some malignancy is suspected, if he has done some blood investigation which lead towards malignancy then biopsy can be done, but before that MRI can be done which will give extent of lesion. Hope this answers your query. If you have additional questions or follow-up queries then please do not hesitate in writing to us. I will be happy to answer your queries. Wishing you good health. Take care. </s>