<s>[INST] Ankylosing spondylitis diagnosis for past 3 years and taking humira / methotrexate and some other drugs which keep things under control, but today have experienced hand and even body tremors that range from mild to large-- uncontrollable and then I relax more and they subside. I m also aching much more today than usual. Is this with A.S. or should I make an appt. to see my rheumatologist after the weekend? It is the shaking/tremors that are totally new symptoms. thanks [/INST] Hi, Thank you for posting your question here, I will try to answer it to the best of my abilities. Hand and body tremors are something many patients with AS suffer from. But that doesn't mean that it shouldn't be checked by a doctor. He may recommend you see a neurologist as well, to check if everything is okay with your nerves. Once that is done, and we have the results of the tests done, we can start treating you. I hope this answered your question. </s>