<s>[INST] My freinds dad has Creatine 2.5 last month.....4rm 2008 to 2012 creatine level went from 1.8 to 2.5.....so we consulted Kidney specialist dr......he sugested Keto Alpha & Synprotik 4r kidney.......Synprotik 1----1-----1 & Keto Alpha 2----2------2... after 1 week with low protein diet & above tablet his creatine level went 4rm 2.5 to 4 in 1week...is anything wrong or is it going right. please help me...i am confused & afraid....please help me [/INST] Hi and welcome to Chat Doctor. Stop the dam stuff. Keto amino acids have not been proven to be of any benefit at all, but still widely prescribed in India (no where else in the world can people be fooled like here!!). At the very least it should not cause any harm. However, if the Creatinine has jumped up so quickly, something is wrong here, and it might/ might not be the new medicines that you started. Many medicines can cause a kind of inflammation in kidneys called Interstitial Nephritis which can cause sudden deterioration in kidney function (especially in those with suboptimal kidney function). The cause of deterioration might be something totally different - hence very important to get back to your)or another) nephrologist and get yourself checked out. Bur stops the new medications straight away. Best wishes </s>