<s>[INST] My husband was diagnosed with CLL in 2005 and has been in remission for the last 5 years or so.   He seems to be coming out of remission..  He is being treated with IVIG and Retuxin.   Hes running a fever that comes on and then breaks after taking tylenol, but it was 105 today before it broke.   He doesnt seem to have much energy and is frequently short of breath.  Whats going on and what can I do about it? [/INST] Hi, dairy have gone through your question. I can understand your concern. There are high chances of infection in CLL.  He may have some secondary infection.  He should go for x-ray chest also. Furthermore, he needs higher antibiotics and antipyretic to control infection. Consult your doctor and take treatment accordingly. Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using Chat Doctor. Wish you a very good health. </s>