<s>[INST] I have severe thigh and calf muscle pain. The muscles in my legs thigh and calf s fatigue out. I can feel the thigh muscles having what feels like they are contracting, holding, then releasing on their own. It is very painful...any idea what this might be? Thank you [/INST] Hi, thank-you for providing the brief history of you. As you have issue with the thigh and leg muscles I think this may be connected to the lumbar spine pinch nerve. As many a time the symptoms of lumbar spine disc degenerative changes start with small symptoms like itching, burning, tingling, pulling pain etc. With simple physical therapy like therapeutic ultrasound therapy and TENS therapy the pain can be reduced. Exercise in later stages will help improve the coordination between the muscle groups As muscle has an abnormal contraction and pain it may be totally due to nerve pathology and needs physical therapy. Regards Jay In Chat Doctor.  </s>