<s>[INST] I took 5 mg amlodipine on Tuesday morning along with my beta blocker Bystolic (all doctor approved). Early Wednesday morning (2am), my blood pressure rose to 213/117 and I felt horrible. I got up and had some juice - got pressure down to 209/ but I was up all night. My doctor wants to switch me to another med and I am afraid. I have taken the beta blocker for years with no problem (I have asthma) . my regular pressure is around 152/ [/INST] Hello there I have read through your question and can understand your concern. You had an episode of hypertensive urgency. Sometimes it can lead to serious end organ damage. It seems Amlodipine and B blocker are unable to control your blood pressure. I would suggest you to track your BP for one week and if it remains on the higher side that is above 140/90 it is preferable to switch to another Chat Doctor.  Diuretics and aldosterone antagonist s can be substituted. I hope that answers your question. If you have any further questions please feel free to write. Thank you for choosing Chat Doctor. </s>