<s>[INST] my uncle his age is 67 suffering from parkinsons disease.  he take syndopa diaily 3 dosage after meals from past 1 year.  now doctor added pramitrem 0.5mg. from past 3 days only we are taking syndopa before meals.  Now he is feeling sleepy and he started talking something. can u suggest me the sudden change [/INST] Hello! Welcome on Chat Doctor ! I understand your concern and would explain that Syn dopa is usually taken before meals, because the absorption is really low when taken after meals. So, his symptoms could be related to increased circulating levels of levodopa. Coming to this point, he may need to reduce the doses of syn dopa. You should discuss with his doctor on the above issues. Hope you will find this answer helpful! Best wishes,  </s>