<s>[INST] My cousin has a resting pulse of 40-50 bpm and a blood pressure of 110/70 however anytime he sits or stands up, his pulse jumps to 170-180 and blood pressure of 160/130, there is pituitary or thyroid problem and his heart is healthy.  Any explanations? [/INST] Hello, Thanks for writing to Chat Doctor, I am Chat Doctor. Sundenly rise BP from sitting to standard condition is called orthostatic hypertension in which systolic BP increase more than 20 MMH than resting.it can be due to autonomic system problem, pheocromcytoma, DM etc.if u were my patent i would like to take detail history that u have other features like headache or palpitation that point toward pheochromocytoma, </s>