<s>[INST] Hello - My mother was diagnosed with autoimmune cholangiopathy in 2005.  She began her treatment with prednisone and responded positively to it and was then take off of the prednisone.  After being take off, her liver levels elevated again and was put back on steroids and is now on Urso and Imuran for the rest of her life.  Since 2008 she has been experiencing sporadic nausea which has become increasingly debilitating this last month.  Can you please give me a prognosis for autoimmune choloangiopathy in patients who are being treated for it? [/INST] Hi and welcome to Chat Doctor. Thanks for the query. If there is as good response on treatment then it should not reduce lifetime but some complications such as liver cirrhosis may occur. In case of cirrhosis, liver transplant may be required, but this usually happens in late stages of the disease after20-30 years. Today's therapy is very efficient, and you can hope for normal life. I hope I have answered your question. Wish you good health. Regards </s>