<s>[INST] Sir , I am 46 years old and have weight of 69 kg. i have a high ESR rate , test reports showing a high ESR is 57 mm at 1st Hour and all other reports are normal. What is this ESR ? How can i reduce this ESR ? Is this ESR will lead to any other diseases? [/INST] Hello ESR or Erythrocyte Sedimentation Rate is normally 2-5 mm in 1st hour. When someone got an infection, it effects on red cells (erythrocyte) and they sediments and this rate is known as ESR, more serious disease(infectious) elevate level. Previously this was a standard parameter for the infectious disease, nowadays most of the doctors call it as irrelevant and don't take it serious. As I mentioned that high ESR means any chronic infectious disease (maybe any e.g. tuberculosis, bronchiectasis, intestinal infection, osteomyelitis etc. This is only example) .ESR high or low don't causes any disease, rather high ESR may be due to some CHRONIC INFECTIOUS DISEASE. So in my opinion consult a physician and get his consultation regarding this as clinical history and physical examination is important. Hope this will help you. </s>