<s>[INST] Respectable Dr. Very recently after my check up doctor advised me to take Istamet 50 mg/ 500 Mg morining and evening.Just want to make sure, there is any side effect from this medicine.Many thanks for your valuable information With best regards XXXX YYYY@YYYY [/INST] Hi, I can understand your concern regarding safety of the prescribed medication. Stamen is a combination of two medicines sitagliptin (50 mg) and Metformin (500 mg) commonly prescribed to treat type 2 diabetes mellitus. Generally it is well tolerated by most of our patients, however it may cause stomach upset, vomiting, diarrhea, cramps, hypoglycemia (low blood sugar) and rarely a serious condition called lactic acidosis. Continue taking it as prescribed and report any side effects. Hope I have answered your query. Let me know if I can assist you further.  </s>