<s>[INST] Hi.  Im a research scientist, and Im doing a query to find out if a systemic Clostridium infection could show up with a symptom of acute acne?  Im not thinking C. tetani or perfringens, but maybe a commensal organism that isnt usually associated with serious illness? [/INST] Hello, I understand your concern. I am Chat Doctor, infectious diseases specialist, answering your query. In my opinion you should go ahead in such pathway. There are evidence of anaerobic bacteria causing acne. As clostridium species are anaerobic one, it may involve in acne. If you do some research you can found some evidence and which can be helpful for man kind.  I will be happy to answer your further concern, you can ask me on bit.ly/ Chat Doctor.  Thank you. ChatDoctorInfectious diseases specialist. </s>