<s>[INST] My wife has lost power from her right knee to her ankle In addition she has what her GP diagnosed as Sciatica in her left hip with pain going down her left leg and she was prescribed Lyrica 200mg three times daily ,which is having no effect and she has it three weeks. In addition the problems with her right leg started last July and she is now complaining of hoarsiness in her voice, Are these initial symptoms of Motor Neuron Disease?, [/INST] Hello sir, The diagnosis of sciatica has to be evaluated as what is causing it. It appears to be that she might be having spine problem with disc prolapse so might require evaluation as X-rays and MRI to look for cause. For now as treatment there is need for lifestyle modification including work that involve weight lifting and bending should be avoided, sleeping on firm bed, sitting upright. And please consult orthopaedician for thorough evaluation and treatment will be advice by him. Thank you. </s>