<s>[INST] What could cause an acute elevation in platelet levels? Im a 27 year old female. I was recently diagnosed with Hashimotos Disease and 2 days ago I had an initial eval with a Hematologist regarding chronic elevating platelet levels over the past few years. My platelets Monday were around 500. Today I woke up with an unquenchable thirst. I have been drinking water non stop. It feels like my mouth is so dry. After drinking a lot of water I wasnt feeling so good so I took my temp, it kept decreasing, although I never felt cold. When it got down to 95.5 I layed down to try to sleep it off. Woke up with a bad headache and pressure in my chest. I went to an urgent care, they ran labs and everything was normal except for my platelet count which is 656. What could cause it to increase by 100 in 2 days? I do not have diabetes, my blood glucose was checked today to rule it out and it was 74. Im still thirsty and feeling pressure in my chest. Im supposed to follow up with my Endo and Heme/onc but I would like to know whats going on to ease my mind a little bit. Thank you for your help! [/INST] Hi, dairy have gone through your question. I can understand your concern. You may have reactive thrombocytes.  There are many causes of reactive thrombocytes. Infection, anemia, hemorrhage, surgery all can lead to reactive thrombocytes.  So no need to worry. You should go for peripheral smear examination. Consult your doctor and take treatment accordingly. Hope I have answered your question, if you have doubt then I will be happy to answer. Thanks for using Chat Doctor. Wish you a very good health. Don't forget to click, thank you. </s>