<s>[INST] yes, my liver enzymes were quite high 450 272. had ultrasound told had gallstone which ruled out liver issue. Then had MRI which shows lesion in bile duct area. Now scheduled for a Endoscopic Retrograde Cholangiopancreatographyll and Endoscopic Ultrasound. never drank, never smoke, no meds. whats wrong with me [/INST] Hi, Thanks for your question. After going through your question, there is possibility of cholangitis which caused rise in liver enzymes. Liver synthesizes bile which is Chat Doctor. Any obstruction to common bile duct causes back pressure and leakage of bile in liver tissue which leads to hepatitis (Inflammation of liver) which causes raised liver enzymes.ERCP (Endoscopic Retrograde Cholangiopancreatography) is an endoscopic invasive procedure by which we can determine type of lesion in bile duct and if required can relieve obstruction by putting stent in common bile duct thereby maintain bile flow and relieve back pressure and bile leakage and revert changes of hepatitis. Endoscopic ultrasound is a less procedure help in knowing the nature of lesion, but we cannot intervene if required. Hope I have answered your question. Do vote as helpful if found helpful. </s>