<s>[INST] I am diagnosed with bipolor disorder, mixed with anxiety disorder. I m 64 years old. I ve tried everything. Mood stabilizers (anti-convulsives) give me interolable side effects. SSRIs only work for a short time. I am now taking buspar with works for anxiety and rage but does nothing for depression. Is there anything else that could help? I just started Cymbalta with bad side effects that are worsening. [/INST] Hi. I understand your concern. Bipolar depression can be treated with anti-depressant and mood stabilizer. Here is the combination which will help in bipolar depression. Fluoxetine and olanzapine. This combination is approved by US FDA for bipolar depression. Aquitaine is also US FDA approved medicine for bipolar depression. ECT means electroconvulsive therapy is also useful in resistant cases. Consult your treating psychiatrist for further assistance. Say thank you if you are helped. Wish you a very good health. Thank you. </s>