<s>[INST] I have 20+ mosquito bites all over my legs from being out on the softball field. I have tried every over the counter topical hydrocortisone cream there is with no relief, along with just about every over the counter antihistamine I can find with no relief.  The bites are now quarter size and unbareabley itchy.  What can I do help the itch and calm and inflammation?? [/INST] Hi, Welcome to Chat Doctor. A short course of steroids by mouth (Tablet prednisolone 5 mg twice daily for a week, then once daily for another week) along with antihistamines will help you. Some individuals will have allergy to Mosquito bites and insect bites. Repeated mosquito bites (even one or two) may lead to the persistence of the problem. Protection to the leg and forearms with full pants and full sleeves in the evening and night hours is the only permanent solution for these individuals. Consult your Dermatologist, he/she will help you in this regard. Wish you a speedy recovery.  Chat Doctor. Morgan </s>