<s>[INST] I had been prescribed percecet for injuries in past ( last time about year ago )with no problem.  I have just fractured fibula and Ortho prescribed generic for me (oxycodone- acetaminophen 5-325).  Tried to take twice.  One time when hadnt eaten reaction was severe - felt really weird - like I couldnt breathe, nauseous, light headed, heart doing something weird.  I tried taking it once again before bed; but couldnt sleep after, felt again like heart was racing a bit.  I take wellbutrim twice a day.  Depakote three times a day.  And Aderall in morning.  All are generic.  Thanks Bonnie [/INST] Respected Bonnie, hi I evaluated your query thoroughly. Dear it's your body is not tolerating oxycodone-acetaminophen to certain extent giving rise to your said symptoms. So simply you have to avoid it as your body is sensitive to certain molecules. In rest of the medicines you have no problem, so you can continue with it. Hope this clears your query. Thanks for using Chat Doctor and taking time to read my answer. RegardsTake nearby Dear. Wishing you a happy healthy life ahead. </s>