<s>[INST] Hi, I m 8 weeks pregnant and have been constipated for a while now. It was so bad that I decided to use a Biscolax Suppository and it did help. but now I m worried that it might effect my baby. I only used it once...Is it possible to effect my unborn baby?? Please help!!! [/INST] Hello dear, I understand your concern. In my opinion usage of Nicolas suppository once might not cause any problem. Suppositary has local effect and absorption into blood is less. You need not worry. The fetus is safe. And constipation is routinely seen in pregnancy. It needs to be counteracted by taking high fiber diet, adequate fluids up to 3 liters per day and if needed laxatives. Best regards... </s>