<s>[INST] My Husband has red itching blister-like rash or pimples or nodes, what ever you call them -on both legs below the knees and above the ankles. They have a liquid center from time to time and bleed when he itches them. what could this be? The dermatologist said type of psoriosis and prescribed a cream that did nothing.Do you have any ideas what it could be and how to get rid of it. [/INST] Hello, Itchy blister on the legs and knees may be due to atomic eczema. Take care of your hygiene. Have regular showers, wash your clothes bed covers frequently in hot water. After shower keep your skin moisturized, Chat Doctor.  You can apply corticosteroid creams like Renovate N in the area affected. Do Not scratch. Sometimes, a course of antifungals are also effective if you have a tendency of fungal infection elsewhere in the body. If sexually active with multiple partners you can get an STD test done to stay on the safer side. Hope I have answered your question. Let me know if I can assist you further.  </s>