<s>[INST] Hi Doctor, my father has donated his one kidney to my brother on 1992. now he is suffering from some kidney malfunction.His blood creatinine is 3.18, blood urea is 95. Blood pressure comes to 160/85 (he is taking nicardia R 10 2 time a day)Please give your opinion to his further tretment.Thanks. V.K. Chandrakar [/INST] HelloThanks for query. You have not mentioned age of your father in your statement. Your father has donated his kidney to your brother and himself has been detected to have raised Serum Creatinine(3.18)and blood urea 95. Both these findings are suggestive of either early Renal Parenchymal Kidney disease or may be due to chronic back pressure changes in kidney due to Enlarged prostate. Consult qualified Nephrologist/Urologist for clinical assessment and get following basic tests done to confirm the diagnosis, 1) Urine routine and culture.2) Ultrasound scanning of abdomen and pelvis with post void urine residue to rule out Enlarged prostate 3) Serum PSA. Further treatment will depend upon result of these tests and final diagnosis. Chat Doctor.  </s>