<s>[INST] DOC, MY WIFE HAD FEVER N WAS TOLD HER CREATINE LEVEL WAS VERY HIGH.SHE HAD TREATMENT IN HOSPITAL N NOW UNDER MEDICATION FOR ABOUT A YEAR  BUT HER CREATINE LEVEL IS NOT GOING DOWN TO NORMAL AND DOCTOR SAYS HER BLOOD IS VERY LOW.HOW TO BRING DOWN HER CREATINE LEVEL TO NORMAL? [/INST] HI, THANK YOU FOR POSTING YOUR QUERY ON Chat Doctor.AS PER YOUR CLINICAL HISTORY YOUR WIFE COULD MOST LIKELY HAVE "ACUTE KIDNEY INJURY ON CHRONIC RENAL FAILURE.THIS CAN Present WITH ELEVATED CREATININE LEVELS, CAUSES INCLUDE CHRONIC PYELONEPHRITIS OR RENAL STONES. G.F.R ESTIMATION CAN HELP TO GRADE THE DISEASE.RENAL ULTRASOUND CAN GIVE ACCURATE MORPHOLOGY OF KIDNEY DETAILS.TREATMENT INCLUDES REPEATED SESSIONS OF HEMODIALYSIS WILL HELP.ANTIBIOTICS CAN BE ALSO USED.CONSULT YOUR NEPHROLOGIST FOR FURTHER ASSISTANCE.THANK YOU.TAKE CARE. </s>