<s>[INST] I am a 27 year old African American female and I live with sickle cell disease. I have a sickle cell crisis between 2 to 5 times a year. I have a three year old son and I had a lot of complications with him but I am ready to have another child. Will me having sickle cell disease and so many crisis can this hinder my chances of conceiving? [/INST] HI, Sickle cell crisis is not known to hinder conception, it may affect maternal health, which may not be ideal for child bearing.  Another thing is, sickle cell being a genetically transmitted condition-its likely to pass same sufferings that you have to your offspring-thus making its life miserable.  From this point of view, I would advise to adopt a child instead, if you must have second child.  Thanks. </s>