<s>[INST] Hi I want some help with hot flushs and all that goes with it, depression , sleeping , gaining weight, mood swings, Iam 67 and have been going through this for about twenty five years. I had cancer of the lining of the womb and have been told that I can not have hormone replacement , is there anything I can do.Valda [/INST] Hi thanks for using Chat Doctor In your there may be multiple reason like hormone imbalance after menopause or metastatic change in thyroid gland or may be due to certain Chat Doctor.  You should get your thyroid profile done to rule out hypothyroidism and consult a physician for further query. If it is due to hypothyroidism then you would improve with thyroxine hormone otherwise you can go for antidepressants. Thanks </s>