<s>[INST] Hey. Myself and my children have thalassemia. One of my daughter s hemoglobin count remains around 93 this is normal for us. I had to have 10 units of blood during each of my pregnancies. This is something my daughter expects when she gets pregnant. This is were my questions comes. She is very serious about a man. This man s mother and sister has scoliosis. He seems fine BUT, can he be tested for this? If he doesn t have it can his child? And, are there addition dangers for them to have children together? [/INST] Scoliosis is believed to be caused by a combination between GENETIC as well as ENVIRONMENTAL factors including medical conditions that may trigger or favor the development of the disease such as cerebral palsy, Mar fans Syn Chat Doctor.  There are no genetic biomarkers available yet or approved by the FDA for testing individuals with or without clinical evidence of scoliosis.  There is a genetic test currently being looked at but not approved for adolescents diagnosed WITH scoliosis in order to predict future progression of curvature....but nothing for people who are not clinically diagnosed to predict the probability of offspring having the problem. Since I stated above that scoliosis is believed to be a COMBINATION of genetic predispositions and environmental factors there is no verifiable or certain way to predict the outcome of having child </s>