<s>[INST] my dad was dignosed with adenocarcinoma of colon cancer dukes c stage two years back.we successfully underwent sigmiodscopy.later on he was advised folfox therapy and avastin( k-ras mutation). after 6 doses itself he responded well by giving a clean report and CEA-3.for the next 6 chemos his dose was reduced.after 3 months he had reoccurence in lungs.nothing in the colon was found though.the doctor gave xeloda and irinotecan,avastin..5Fu however was skipped.he didnt even cheked the CEA once in 6 doses.after 6 doses his cea rosed to 80.we got back to oxilaplatin and xeloda and avastin.but till that time the disease progressed in his pelvic area.now his limbs are swollen and suddenly he started breathlessness.also the reason behind it is low HB and RBC.since he had hematuria cos of a small tumour near the bladder which we removed by scopy,now his brathing is ok and right from the day he got admiited he is on NIV.docs now say there is nothing much to do.his lungs are fully gone.i dont belive this completely.his pelvic nodes are iliac nodes and a laproscopy surgeon says he can easily remove them.now the lung remains the major concern.what do u suggest? [/INST] Hello, As per my clinical experience, the substantial amount of breathlessness is due to micrometastases involving bronchi and alveoli. In our clinic, after thorough counseling of the patient and relatives, I recommend the only symptomatic mode of treatment rather than giving extensive eradicate measures which are not going to be 100% result oriented at this stage of metastasis. Hope I have answered your query. Let me know if I can assist you further. </s>