<s>[INST] Relative increase in renal parenchymal echogenicity which may relate to normal variance (40%) or early, non specific medical renal disease (60%). Please correlate.  Low density (uric acid, oxalate, xanthine or matrix) calculi both kidneys, non obstructing at present. What does this mean? [/INST] Hi and welcome to Chat Doctor. Thank you for your query. I am Chat Doctor, I understand your concerns and I will try to help you as much as I can. This may indicate some interstitial kidney disorder and if there are symptoms and signs of kidneys failure, you should OD biopsy to confirm possible diagnosis. Also, CT scan would be advisable for better visualization of kidney parenchymal. I hope I have answered you query. If you have any further questions you can contact us in every time. Kindly regards. Wish you a good health. Chat Doctor.  </s>