<s>[INST] My sisters both kidneys are smaller in size. around 8. Doctor says CMD practically lost. creatinine is 2.8. ESR is also high. B.P. is now 150/100. She is only 30 years old. Mother of one girl child of 4 years of age. Is she curable??? what is her actual problem? Where can i do her treatment? - Mahua Das, Kolkata -Cell no.0000email id:  YYYY@YYYY [/INST] Hi, I had gone through your question and understand your concerns. First thing I want to tell you is function of the kidney once lost is lost we cannot revert the function back, but we need to maintain the remaining function without loss. For the stage of kidney disease she is having transplantation is the permanent solution. She is still in early stages but due to hypertension the situation may go worse in the future. So early treatment is necessary. She does not need dialysis at this point, but we will manage her with medication. If she is my patient I will manage her medically after seeing necessary investigations like -renal function test-serum electrolytes-phosphate-calcium-pth-urine analysis Hope this answers your query. Chat Doctor.  </s>