<s>[INST] my dad is suffering from Parkinson syndrome. he had been taking t syndopa plus125 and now his physician has told him take syndopa CR 125.Is there any difference in the dosage. can i if there s any treatment to cure this disease. kindly help. he has one side shivering of hands and leg. stiffness, atomach upset frequently, lose of weight. [/INST] Hello, Unfortunately, there is no cure for PARKINSON DISEASE (not referred to as syn Chat Doctor.  The CR version of the Syn dopa is merely a designation that the medication is CONTROLLED RELEASE and therefore, theoretically it has to be dosed LESS FREQUENTLY.  If your fathers tremors are not being quieted with this medication then, you should take him to see a NEUROLOGIST or a PARKINSONOLOGIST for the most updated treatments available.  There is also a SURGICAL approach called DEEP BRAIN STIMULATION. However, more knowledge on how well your father responds to regular doses of his syn dopa are necessary. Hope I have answered your query. Let me know if I can assist you further. Take care  </s>