<s>[INST] Ive been running my entire life - or for at least the last 55 years.  I was taking Lisinopril 10 mg.  My BP began rising a month ago and my doctor increased the dosage to 40 mg.  I now have difficulty - several times a week - completing my daily 30 minute jogs.  Something better than Lisinopril? [/INST] The better Chat Doctor.  It would be better to change to ARB group which consists of losartan, telmisartan or Alsatian in appropriate dosage as its toreability is better in clinical practice as compared to lisinopril. , a small dose of diuretic chlothalidone 6.25 mg added to the above regime would be ideal. Lastly I would strongly suggest that you get evaluated for other causes of easy tiredness rather than attributing to lisinopril.  Least a treadmill stress test to know your cardiac reserve is justified in your case. Regards  </s>