<s>[INST] If a tumor has been surgically removed what cell would hormone drug therapy attack. My oncologist is thinking of treating with anastrozole trastuzumab. Cancer has been removed margins are clean however he said it was estrogen dominant. I am a 71 year old woman with diabetis II and I do not like the side effects of these drugs. AS my cancer was 1 and found very early the 4x.1 centimeter tumor was removed without any chemo or radiation therapy. Is there any other drug that would not have these many side effects. Recommended length of time is 5 years on drug. The onka test was 15, very low risk of reoccurence. [/INST] Thanks for query. Any tumor >1 cm in size develops its own blood supply, even if margins are clear tumor cells might have already disseminated. Thus it is always better to go for targeted treatment as you have hormone receptor positive. Coming to on test Women with a score of 17 or smaller. You have a low risk of having cancer return, if you get a hormone treatment like tamoxifen or an aromatize inhibitor Chat Doctor.  With this score, chemotherapy probably won't do much to prevent a recurrence. So my advice to go with your doc. Regards </s>