<s>[INST] sir, what does brain Granuloma edema means... is it epilepsy or simply one of the reason for seizure or fits.... [/INST] Hello. Welcome to Chat Doctor. Like elsewhere in the body, brain too can be affected by a granulators reaction, commonly1. Tuberculosis2. Fungal infections3. Sarcoidosis.4. Cysticercosis5. Uncommon causes- cholesterol granulomas, antis related or Wegener granulomatosis can also involve brain. Each of these granulomas have specific morphological clues, pointing out to its etiology. Once, the cause is decided, treatment can be targeted towards that cause. Depending on site in brain and extent of involvement of brain tissue, the clinical features may be seizures, personality changes, simply headache, visual defects- to name a few. Mostly if the granulomas are located in the cerebral cortex (commonly frontal hemisphere), the patient will present as seizures. Hope this helps. </s>