<s>[INST] My 17 year old daughter was diagnosed with POTS in January (after 5 years of incorrect diagnosis). She is currently taking midodrine 3x daily for the fatigue and joint pain. The cardiologist we are currently seeing feels she may also have mast cell instability, since her allergies to foods are becoming more severe. I cannot find much information on this. Do I go back to the immunologist? Is it diagnosable and treatable? [/INST] Thanks for your question on Chat Doctor. I can understand your daughter s situation and problem. Yes, Mast cell instability is curable if treated early. If left untreated it can give rise to life-threatening allergies (anaphylaxis) and blood cancer (leukemia or lymphoma). And her severe food allergy is also due to Mast cell instability. So better to consult immunologist and allergist for appropriate treatment. Early treatment is having good outcomes. Hope I have solved your query. Wishing good health to your daughter. Thanks. </s>