<s>[INST] Hi, My 3 yr old son suffering from seizure fro last 2 yrs his active seizure after 1 yr of age with fever 2 to3 episodes come seizure with fever after then sezure come without fever after 12 to 20 day repeated more than 1 mints before attach he is crying and jerking hole body & eye & lip blinking. Diagonist: His MRI CT Scan & EEG are normal 30mint EEG 4 time repeated but normal. Treatment: Last 1.5 yrs given - Valparin 200 - 5ml x 2 time, Clobazam 5mg - 5mg x 2time, Last 5 month given : Valparin 200 - 5ml x 2 time, Clobazam 7.5mg per day in night, Levera Syrup: 3ml x 2 time. Last 5 month given : Valparin 200 - 5ml x 2 time, Clobazam 7.5mg per day in night, Zanoxa 150mg (Oxcarbazepine) 1 tab mornig & 1.5 tab in night and Levera Stop. But still no any improvement last year 4-5 month control but stil is not improvement. Please help any one hi is treated in delhi Proff Dr Veena Kalra, Appolo Hospital, Retired proff from AIIMS (Ped. Neurology) Thanks Shashi - 0000 [/INST] His have gone through the detail, and it is a CSE of refractory seizure. EEG test can show false positive or false negative result. I would like to know was the MRI done with epilepsy protocol as standard MRI brain may also show no abnormality. There is one modality called MRI with epilepsy protocol in which emphasis is given to find out the cause of epilepsy like medial temporal epilepsy or conical dysplasia. These condition needs to be treated surgically if not controlled by medication. I would like to add topiramate which is a very good medication particularly for refractory seizures. Thanks and regards </s>