<s>[INST] hello doctor, My father is 62. he is having liver problem and is taking medicines. He is non- alcoholic. we got his hepatitis C test done and it was negative. We recently had his LFT done. His report was Bilurbin1.20, Conjugated Bilurbin - 0.70, Unconjugated Bilurbin - 0.50, Total Protien - 6.70, Alumbin - 3.60, Globolin - 3.10, A/g ratio - 1.16, SGOT -67, SGPT - 81 Alkaline Phosphate -134. From last few months his SGOT and SGPt has increased earlier it was normat SGOT 58 and SGPT 63. No one in our family had this genentic disease. doctor has further advice to go for ANA and ASMA and Coesophonal level test. is it really require. kindly suggest and is there any risk facto if SGOT and SGPT level goes higher [/INST] Dear FriendWelcome to Chat Doctor. I am Chat Doctor. I advise you to get also Hepatitis B testing. If it comes negative, you should get ANA, ASIA, to rule out Auto immune hepatitis. However, in autoimmune hepatitis, Serum Globulin levels are raised. Also, get an ultrasound of liver to see for size and echo texture of liver. Based on the available details, this is my best advice for you. You should discuss with your doctor and share my opinion, I am sure he/she will agree to my opinion. Good Luck. </s>