<s>[INST] My nephew is in the hospital with Hepatitis C. His conditioning is worsening each day. I know there is a medication that is on the market now, but the cost is $1000 per pill. His most recent symptom is that his testicles have swollen to grapefruit size. Is this one of the symptoms of the infection spreading in his organs? [/INST] Greetings from Chat Doctor. P No I don't think it is a symptom of Hepatitis C spreading to testes.  Due to severe hepatitis it damages the liver and because of the liver damage the protein production gets reduced. If the protein concentration in the blood reduces then it can cause swellings in legs or face or in testes.  I would recommend him to get Serum Albumin levels which will confirm that protein levels are low If at all it is in normal range then an ultrasound Scan of scrotum has to be done. Hope this information was useful to you. Any clarification feel free to ask. Regards. </s>