<s>[INST] my father is diabetic and hypertensive. He is taking tripride, olmezest AM, and minipress XL for its treatment. since few months he has pitting edema over both legs below ankle. is this edema is sideeffect of these drugs. what shall i do now? do i have to change the drug? [/INST] Hi, Yes, Trip ride is associated with edema of the legs. Trip ride contains glimepiride, metformin, and pioglitazone and commonly prescribed for the treatment of diabetes mellitus. Pioglitazone is known to cause edema of the limbs, thinning of the bones, upper respiratory tract infection, and headache. You should consult your fathers doctor for an alternate effective but a safer combination of medicines to control his blood sugar. Hope I have answered your question. Let me know if I can assist you further.  </s>