<s>[INST] I am considering taking a supplement called Accel. It has 50 mg of ubiquinol in liquid form plus vitamin E (tocotrinols) in a gel tablet. It is marketed online by Dr. Al Sears via a company called PRIMAL FORCE. (not a trust inspiring name!) I have Parkinson s Disease and when I asked my nuerologist he said a recently completed clinical trial did not bear out the theory that CoQ10 helped with Parkinson s symptoms. In spite of this disappointing news, there seem to be other benefits that might make me feel better i.e. energy, cardio-vascular health, and lower cholesterol, etc. I would be interested in your opinion. Edith Dzubay [/INST] Hi.EDITH, thanks for writing.I have understood your concerns.the Parkinson disease is a neurodegenerative disease, in which the dopamine containing neurons in the basal ganglia region of the brain gradually degenerate over time.there are hypotheses about the oxidative stress as an etiology of the disease.so further research proposed the possible role of antioxidant medications in prevention and treatment of Parkinson disease. Variety of agents have been identified, and many trials have been done, but none have shown any promising results. So there use is still a debate. Our clinical experience also have negative opinion.for the Parkinson disease in the initial stage when the symptoms are mild, at that time their use can be beneficial for delaying the degeneration but at severe stage they are of no benefit.if there are documented benefits over other systems of the body then you can give it a try.[most of the studies shows that benefits are unreliable]don't expect that it will help you in your Parkinson.I hope this information will be helpful to you.best of luck.wish you a good health. </s>