<s>[INST] I am taking humog 450 but still my folicules are not increased. why? [/INST] Hello, Follicular development is judged by the concentration of estrogen, measured in blood or urine. Clinical assessment of the response including pelvic examination and cervical mucus studies should also be performed.  Humor administration should continue until an adequate estrogen level is achieved. Did your doctor prescribed you humor. It is given on the day of the urinary estrogen peak or the day after the plasma 17B -estradiol peak. If the estrogen values are less than either 180 MOL/24 hr. (50ug/24 hr) for tested urinary estrogen or 1100pmol/L (300 pg/ml) for plasma 17B-Oestradiol follicular development may be inadequate. it's better to consult your doctor for the cause of follicular development. Take care </s>