<s>[INST] I m 42 years old. my daughter is 3.5 months old, from a donor. my brother, 44, has Kallmann Syndrome and he is infertile. My daughter has a very small head (~38 CM, height 60 CM, weights 5.8 Kg) and also suffers from a slight hypotonomy. she is also alergic tpo milk. My q: 1. what are the odds that she was affected by Kallmann Syndrome ? what is the meaning of size of her head? her front fontanel is still open . thanks [/INST] Allman syn Chat Doctor.  Clinically, it is characterized by its association with anemia or hyperosmia; 85% of the cases are autosomal. The X-linked form (KAL1) is caused by mutations of the KAL1 gene at Xp22.3. This leads to failure of olfactory axons and GnRH-expressing neurons to migrate from their common origin in the olfactory place to the brain. The KAL gene product anosmin-1, an extracellular 95 DA matrix glycoprotein, facilitates neuronal growth and migration. The KAL gene is also expressed in various parts of the brain, facial mesenchyme, and mesonephros and metaphors, thus explaining some associated findings in patients with Allman syn </s>