<s>[INST] sir, my younger brother had typhoid 1 month back.he took medicines for that and his temperature came to normal for 3 days but now again he developed fever...And when his widal test was done in the report it was shownS.typhi "O" WAS 1:320 WHAT SHOULD WE DO NOW? [/INST] Thanks for posting you query to Chat Doctor .what was the O title during last episode of typhoid as it will help in correlation of severity and nature of relapse or new infection. However you should first undergo investigation for Blood culture and sensitivity testing to microbiology lab as it will give you sensitive antibiotic for infecting organism.presently you can be started empirical treatment withe 1. Tablet Ciprofloxacin 500 mg two times a day orally.2. Injection Ceftriaxone 1 gm 12 holy intravenously .3. Paracetamol 750 mg for fever .4. Pentoprazole 40 mg orally in the morning to protect gastritis.5. Multivitamin supplements. Treatment should be taken under guidance of clinician.mentioned doses are for adult and dose can be adjusted according to age if required .hope you are satisfied with my answer.  Feel free to communicate if any query.regards, Chat Doctor.  </s>