<s>[INST] My father has been hospitlaized for breathlessness and bronchial asthma.He has delirium now and the CT scan says he has prominence of sulcal spaces, basal cisterns and verntricles altherosclerotic vessel wall calcification of intracranial arteries what does this mean. He was a chain smoker and quit it many years back but the damage was done and now he has repeated instances of hospitalization for breathlessness. He is diabetic [/INST] Thanks for your question on Chat Doctor. I can understand your concern. I have gone through the CT report you have mentioned. This report is suggestive of brain damage caused by age and smoking. So his delirium is due to brain damage. His breathlessness is due to COPD (chronic obstructive Pulmonary disease) caused by smoking. So give him inhaled bronchodilators (formoterol or albuterol) and inhaled corticosteroid (ICS) (budesonide or fluticasone). Smoking cessation should be done as soon as possible. Hope I have solved your query. I will be happy to help you further. Wishing good health to your father. Thanks. </s>