<s>[INST] My daughter has been taking adderal for adult ADHD (30mg twice a day) and she suffers from body pain and anxiety and depression. She was just put on Cymbalta once a day with it and I wondered if there are any negative interactions between the two drugs. [/INST] Hi, I can understand your concerns regarding Adderall (amphetamine) and cymbal ta (duloxetine). Amphetamine and duloxetine do have interactions. Duloxetine has the propensity to increase the likelihood of side effects of amphetamine like tremors and restlessness. There is also a risk of a very rare condition called serotonin syn Chat Doctor.  This condition occurs very rarely but has significant symptoms. It can lead to confusion, nausea, vomiting, palpitations, fever, sweating, tremors, and increase the risk of seizure. Both the medications can be used together though. But in case of the above-mentioned symptoms, please do contact your doctor without any delay. Hope this information was helpful. Best wishes. </s>