<s>[INST] I have a high white blood cell count, 22,000. No fever. No chills. I ve been treated with Rocephin and Levaquin. I am responding favorably however they cannot locate the source of the infection. This is the second bout I ve had in 3 weeks. First time was way worse with difficulty breathing and 101 fever. I ve also had gallbladder removed in Sept along with an ERCP in Dec. Extensive diagnostic exams whicChatDoctore back normal. [/INST] Thanks for posting your query to Chat Doctor. Off course raised WBC count is due to infection, but you should be concerned about this count if remain persistently high .thee may be possibility of some infection inside body. You should undergone 1. Blood culture to microbiology lab to find out if any bacterial pathogen is present in blood .2. Send me the report of your blood count to know which cells are increasing in your blood .as in different kind of infection different cells are increased .3. Peripheral blood film examination to know morphology of blood cell.review me after investigation report .take care. </s>