<s>[INST] Every morning when i wake up i have a painful erection. It slowly goes away after i urinate but sometimes that ishard to get started. Its been going on about a month. I have psoreatic arthritis in my knees and have been taking Humira. Could the Humira be causing it? [/INST] Hello, There is no such side effect of Humor causing such a symptom. If you are taking certain antidepressants, it can cause ED or painful erection.  Sometimes, when there is UTI, it can cause painful erections. You are suggested to visit a GP, get physically examined.  You will have to get Urinalysis (R/E & C/S) done. Furthermore, you may have to get some blood tests done. If sexually active, get STD tests done. Get assessed & treated at the earliest. Hope I have answered your query. Let me know if I can assist you further. Take care Chat Doctor.  </s>