<s>[INST] I have no diabetes or no high blood pressure and do a lot of walking. My microalbumin urine is 381mg/l but my creatinine is 4.2mmol/l. Do I have kidney disease? i am very active normally and but have been using simvastatin to control my cholesterol over last 2 years( around 5.2mmol/l). Thank you [/INST] Hello! Yes, your concern is very true. Raised creatinine level indicates either obstructive myopathy or Medico-renal disease i.e. obstruction to urine outflow or dysfunction of parenchymal (functional tissue) of kidneys. Obstruction can be due to many causes like stones/strictures/growths or pressure on urinary tubes (ureters/urethra) from outside i.e. growths from surrounding structures like rectum/uterus/colon etc. In my clinic, I advise X-ray PUB, ultrasound abdomen & pelvis, urine routine, renal function tests, serum uric acid. Treatment is accordingly. Hope this information is useful to you. Wish you healthy life. Thanks. Regards. </s>