<s>[INST] i take lostartan/hydroclorazide 100/12.5, but the pharmacy gave me 100/25. I wasn t feeling well and realized they gave me the wrong prescription strength. I have a stent in my renal artery. I have been having back pain (kidney since I took the wrong meds. Could this have caused a problem with my kidney [/INST] Hi, Thanks for writing in. Losartan is a AT1 receptor blocker in the kidneys. In pathologic states, AT1 blockade improves the impaired autoregulation induced by chronic abnormal activation of Renal Artery Stenosis. AT1 receptor blockade has experimentally been shown to decrease renal fibrosis. Losartan may also be able to decrease inflammation by decreasing leukocyte proliferation and blocking up regulation of adhesion molecules. Overall benefits are more when taking losartan. It has not caused any problem to you. </s>