<s>[INST] Hi, i am having dermographism . most of the time associated with hot and cold rashes. Have taken antihiatamines and mast cell stablissers like olopatadine. But it gives me only timely relief But I want a permanent cure. Please help me out. Even i can take alternate medicine. [/INST] HAI, This is a condition of hypersensitivity of the skin which is a peculiar characteristic of your body constitution. It is due to the presence of weak membranes of a cell in the body called mast cells which contains the histamines responsible for allergic reactions. When slightest pressure exerted on the skin, mast cells release histamine to take trail of area where pressure was applied. Since the defect lies in the cellular level, I suggest a treatment plan that would require regular follow-ups for more than a couple of months. Since it is a type of urticaria rash, Utica urns 30 can be thought of. It helps reduce the hypersensitivity of the skin. Hope the answer helped, Wish you good health. </s>