<s>[INST] I had a MRI of my brain w/without contrast which states some foci of nonspecific increased signal in the periventricular and subcortical white matter particularly in the region of the right frontal parietal love but to a lesser extent in the white matter of the left frontal lob and right occipital lobe. What does that mean? [/INST] Hello, Thanks for your queryFirst of all let me explain you that in Neurology Practice the interpretation of MRI should be done in a given clinical context. Only the MRI findings should not make you worried. Further the MRI findings will depend upon the age, gender and the presence /absence of other comorbid medical illness like high blood pressure, diabetes etched findings that you have described could be seen in 1. Ischemic cerebrovascular disease2. Desalinating disease3. Non-specific changes seen in the settings of migraine, Neurofibomatosis and so please donor worry much about the MRI findings only. If you have any symptoms, please discuss with a neurologist and resolve this issueHOPE THIS CLARIFIES YOUR QUERY </s>