<s>[INST] one of my elder sister was suffering from renal cell carcinoma .Four months before doctors completed nephrectomy of her right kidney.A completion of nephrectomy one oncologist completed 20 radiotherapy course. Now it is showing recurrence of carcinoma near the right kidney.At this moment dr. suggest to eat tab-surafenib 400mg twice daily. we are not rely on this doctor.There is any better treatment for her. cancer still not spread another part of the body. Please suggest. Thanks Rabiul Islam. [/INST] Since you said your sister has recurrence it is important to confirm whether recurrence is confined to local region only or if there is spread to distant parts of the body. If the recurrence is solitary, resection of the lesion would help. Sorafenib is for metastatic disease. Since her disease has come back in just 4 months, you need to understand that she has got aggressive cancer and whatever treatment is offered the responses are short lived </s>