<s>[INST] My husband was just put on the HCTZ to help lower his blood pressure and creatine level. I found out there are possible side effects with his asthma medication. He takes Symbicort twice a day, a rescue inhaler (albuterol) and a nebulizer that also uses the albuterol treatment (as needed). The other medication he takes is cyclobenzaprine for his back. I want to find out if there are any major problems that we should look out for? [/INST] Hello! Thank you for asking on Chat Doctor! Regarding your concern, I would explain that, your statement is true regarding concomitant use of HCTZ and Symbicort and Albuterol. In fact there exists a risk of hypokalemia, as there is a synergistic effect of these Chat Doctor.  Nevertheless, no dangerous complications are seen usually in clinical practice. It is cautions to monitor periodically potassium blood level. Regarding HCTZ and Cyclobenzaprine no any significant interactions is found. Hope to have been helpful to you. Greetings!  </s>