<s>[INST] Hi I have been taking omeprazole 20mg tablets last 5 months of my pregnancy for preventing extreme heart burn. I recently has liver function test carried out and my alt levels are 211. Consultant will check Nile acids in blood to rule out oc during pregnancy. Would omeprazole be cause for this high alt reading? If I stop would my liver functions get better? Thank you [/INST] Hello dairy understand your concernOmeprazole on long term use damage the liver and cause increase in the Liver enzyme, ALT. Omeprazole is extensively metabolized by the hepatic P450 system and cause damage to the heart like hepatic necrosis. The mild and asymptomatic elevations in serum aminotransferase that have been observed during omeprazole therapy are usually transient and may resolve even without dose modification.  Clinically apparent liver injury due to omeprazole, however, generally calls for prompt with Chat Doctor.  Severe injury due to omeprazole is uncommon and most cases resolve promptly upon with </s>