<s>[INST] I take 50 mg of Larsardon in the mornings and when I exercise around 9 a. m. it reall goes up from about 135/70 when I awake up to 179 or 180 . In the afternoon it drops down to 102 or below . Can I split the pill and take 1/2 in the morning and 1/2 at night so it will be good in the mornings ??  Thanks [/INST] Hi! Of course, you can use separate. Losartan can be used in a single dose or in equal doses a day divided twice (every 12 hours). Its does vary from 25 mg to 100 mg (maximal dose). Losartan takes a few hours to start acting, it does not act immediately after use. I do not know how long have you been taking losartan? It needs at least 3-4 weeks to reach the maximal effect. In addition to your question, I would say that during physical activity the blood pressure is slightly increased, but of course it matters also what type of exercise you do and how much your heart rate goes under training. You should monitor your heart rate during training. I recommend that you stop training the moment you see that your heart rate has increased too much (if you had written you age, I could have told you what is the maximal heart rate you should have while you train). Thank you for using Chat Doctor ! </s>