<s>[INST] Dear Sir i am 25 year old i am suffer low plate count since 2009.I am take so many medicine but my plate late did not increase .last month my plate count felt down under 5000 plate late . Pl z told me how am cure from this deaseas.my Dr. give me advise of to do spleen removing . operation.What can i do [/INST] Hello, Low platelet count occurs due to low platelet production or increased destruction of platelets. An enlarged spleen leads to increased destruction of platelets in peripheral blood. Thus, the cause of decreased platelets in your peripheral blood is enlarged spleen. In such a situation, surgical removal of the spleen helps improve platelet counts in your peripheral blood. Hope I have answered your query. Let me know if I can assist you further. </s>