<s>[INST] my wife came up and told me she was Hep. b positive and wanted me test, and she does not know how she got it.. I went to a doctors and got checked up and i came up negative in fact, i am immune can t get hep b ever. So my question is how can she get it if there is no foul play? to add we have not had sexual intercourse without condoms.... [/INST] History to hear your problem. Your wife hep B positive, and you are negative. More ever you are saying you are immune.It's very unlikely to spread from your wife as you are immune. There are so many ways for spread. Blood and blood product transfusion, contact of infected persons secretions into open cut or abraded skin / mucosa, sexual relation, from mother to baby & very rarely from sweat. So your wife might have got any of those above ways. Better to keep low viral load to reduce her infectivity.evaluate hep B viral serology to know acute or chronic and to know viral load. If high viral load better to take treatment with lamivudine / interferon. Thank Vasundhara </s>