<s>[INST] I HAVE BEEN DIAGNOSED WITH DEGENERATIVE DISC DISEASE WITHOUT OSTEOPOROSIS...WILL THIS BE THE CAUSE OF DIFFICULTY OF STANDING FROM SQUATTING POSITION..AND PRACTICALLY HAVING TO CRAWL TO A NEARBY CHAIR TO HELP ME UP? THERE WAS NO PAIN BUT AFTER I GOT UP. THERE WAS EXTREME WEAKNESS AND WOBBLING OF THE LEGS. WHAT CAN I DO? [/INST] Degenerative disc disease is non-reversible condition in which intervertebral discs get degenerated and symptoms are due to compression of nerve roots exiting from neural foramina. If you have extreme pain, Medicine which can be helpful are:1. Gabapentin2. Pregabalin3. Amytriptyline4. Duloxetine problem is not relieved by medicines, Need to think about surgical option to relieve pressure on nerve roots by- laminectomy, vertebroplasty etc </s>