<s>[INST] liver profile sgpt/alt at 204, six month ago last checkup was at 25 sgot/ast at 80, last checkup was at 23 I am 46. Should i be concerned or what could be wrong to have this spike, lately I have ate lot of durians(a hot tropical fruit). Thank you. [/INST] Welcome to Chat Doctor! I appreciate your concern for the isolated increase in SGPT. Incomplete data like do you have any problem or symptoms that made you to undergo these investigations? Because elevated SGPT level has to be co related to your illness if you have. Durian is a topical fruit cultivated in most of the South Asian countries, it is found to have several benefits. Eaten alone it is unlikely to be harmful. If you have underlying problem like fatty liver or if you take alcohol then you must stop taking alcohol, eat healthy food containing fresh fruits and vegetables as they contain good amount of anti-oxidants which are required to preventing the fatty liver. Take care of your health. </s>