<s>[INST] Recently my doctor tested me for Epstein Barr and I was reactive and levels of 8.1, .60 and 8.1, and my white cell count is 1.78 and my spleen is 100% oversize. What is up with me? Doctor wants to start me on combo shots of B-12 and Lysine (not sure if it is L or D), do you have any ideas? [/INST] Hello, Welcome to Chat Doctor, Enlarge spleen is called as splenomegaly, and it is almost always secondary to other disorders. The most common causes are Myeloproliferative disorders, Lymphoproliferative disorders, Storage diseases, Connective tissue disorder sand infectious diseases (e.g., malaria, Kalamazoo). If splenomegaly is massive the cause is usually CLL, non-Hodgkin lymphoma, CML, polycythemia Vera, myelofibrosis and infectious mononucleosis. There is no specific treatment for infectious mononucleosis. People with this disease will be as active as they want. However, because of the risk of rupturing the spleen, heavy lifting and contact sports should be avoided for 1 month, even if the spleen is not noticeably enlarged. NSAIDs, such as ibuprofen can relieve fever and pain. Some complications, such as severe swelling of the airways, may be treated with corticosteroids. Currently, available antiviral Chat Doctor. Thank you. </s>