<s>[INST] My Father (60Yrs) old is suffering CA colon from 2005 and opt RT Hemicolectomy on 04/21/2005 after six Chemo .he was well.again 2010 he suffering pain & got Ca colon & again surgery on anastomosis site on 07/10/10. Now again four chemo completed & again biopsy report showing adenocereionoma with ulceration. so please reply me whether he need another surgery to remove infection. [/INST] Hi and welcome to Chat Doctor, thank you for your query. You said that there was verified adenocarcinoma again, not infection and in this case he needs surgery definitely unless there are some contraindications such as liver metastases or other site metastases. So always when there is evidence of recurrence of malignant disease, it should be removed surgically followed by chemo. Wish you good health. Regards </s>