<s>[INST] In the last year I have taken in combination and separately Deanxit, Zoloft and Atacand. But I have stopped all now since two months. can these be a cause for lasting ejaculation problems? I cannot easily orgasm during sex...usually only through masturbation after my partner has climaxed. I can acheive acceptable and long lasting erections but seem to lack feeling. Either tactile on my penis or sensuelle sexuelle emotion mit my partner. What do you think? [/INST] Degree understand your concerns went through your details. There are many potential causes of DE, including psychological hang-ups, chronic health conditions, and reactions to medications. Relationship stress, poor communication, and anger can make DE worse. Disappointment in sexual realities with a partner compared to sexual fantasies can also result in DE. Often, men with this problem can ejaculate during masturbation, but not during stimulation with a partner. Medications such as antidepressants, antipsychotics, high blood pressure medications, diuretics, and alcohol can all cause DE. In that sense, Zoloft could be a cause. But you should talk to your psychiatrist. If you require more of my help in this aspect, please use this URL. http://goo.gl/aYW2pR. Make sure that you include every minute details possible. Hope this answers your query. Available for further clarifications. Good luck. </s>