<s>[INST] My wife has been following medicines for last 6 months for depression.Lithosun SRDaxid 50mgOpiprol 50Modalert 200.For last one week her condition is little bit worse.Can anyone help me what to do?My doctor just prescribed to stop all medicines except Lithosun.Is it enough to keep her normal? [/INST] Hello have not mentioned the dosage of without. Moreover, i donor think that presently lithium alone can be sufficient. In my opinion her David should be increased to 75-150 mg daily dose, and stop opinion (as it is not desirable at all in her case). Get the lithium levels done, if it is less than it will be good to increase her lithium dose. Continue monitoring her condition. She should start showing improvement in about a week.  Ask her to take more water and salad. May continue mod alert for some time and when she GES better stop that. Hope this helps you wish you good luck. </s>