<s>[INST] I am Mtf i have been taking 100 mg spirolactone and 4 mg of Estrodial for 6 weeks now, i noticed recently for about the last 2 weeks that the Spiro which i take in the morning with food i believe is causing me lower back to hurt? Could this be the Spiro or something else. I drink lots of water, no coffee or soda. I also watch my carb intake as i am also a controlled type 2 diabetic. Any idea what could be going on? [/INST] Hi sir/madam, Thanks for your question on Chat Doctor.there could be few possible reasons for the backache, it could be the exacerbation of previous problem you have. Secondly it could be due to the fact that you are on diuretics like resemble and spironolactone which can lead to backache secondary to electrolyte disturbance and deny Chat Doctor. Basically the muscle of the back produce this backache.I would suggest that you do inform this to your doctor and have an evaluation in order to find out what exactly is causing the backache and then have appropriate treatment. Hope this was helpful. Have a healthy day. </s>