<s>[INST] I was on chloroquine for about two years to treat lyme disease and since then I have developed what my dermotologist diagnosed as keratoderma on the soles of my feet. If this is a drug induced disease, (I am otherwise 56 and in excellent health), do I stand a better chance of getting rid of it? No family history of it. [/INST] Hi, Keratoderma is thickening of skin that occurs commonly in palms and soles. This condition can be genetic or can be induced by chronic diseases and use of certain medications. Chloroquine can cause this condition. Keratodermas are not curable, but symptoms can be controlled. Treatment options include regular use of emollients, keratolytics such as salicylic acid or urea and topical/systemic retinoids. Take care. Hope I have answered your question. Let me know if I can assist you further.  </s>