<s>[INST] Hello DR. GRIEF: MY ANKLES ARE SWELLING. IT NEVER HAPPENED BEFOR I STARTED A TEMP JOB, WHERE I SIT DOWN FOR MOST OF THE DAY. I DON T EAT ALOT OF SALT, HOWEVER, I DO TAKE A WATERPILL EVERYDAY, AND I VE BEEN TAKING IT FOR ABOUT 5 YEARS. IT S HYDROCHLOROTHIAZIDE 25 MG. WHY IS THIS HAPPENING? [/INST] Hi, Thanks for your question. After going through your question, I can understand your concern. For better opinion I want to know-Your age and gender. - why are you taking water pill. - Is there any diabetes, heart disease, Blood pressure or cholesterol problem. - Habits like smoking, alcohol. - Associated symptoms like fever, change in color of skin over feet, breathing difficulties. There may be following causes for swelling in your case - - Prolonged sitting. But other causes related to heart, Kidney, Liver disease need to be ruled out. Following investigation may help in diagnosis - - ECG, 2DEcho. - Complete Blood Count. - Renal function test. - Liver function test. - Urine examination including urinary protein. Depending upon clinical examination and above test results appreciate management can be planned. Hope this helps you, if so do vote as helpful. </s>