<s>[INST] I constantly have leg pain and swelling in my ankle, and knee this only one one side. My ana test was also positive with speckled pattern. I can t seem to stop this constant pain. I only been prescribed ibuprofen till I see a rhemy. PCP thinks its Lupus. [/INST] Hello, I have studied your case with diligence. Yes this can be lupus with reactive arthritis. Rheumatoid arthritis may involve small joints and early morning stiffness in joints, do you have sucChatDoctorplain? Ankylosing spondylitis typically involve spine and hips with other large joint also. There is reduced chest function in this disease. Stiffness in spine is increased do you have such stiffness in spine? NSAIDs, Awards (disease-modifying anti-rheumatic Chat Doctor.  These include methotrexate and sulfasalazine. Hope this answers your query. If you have additional questions or follow-up queries then please do not hesitate in writing to us. I will be happy to answer your queries. Wishing you good health. Take care </s>