<s>[INST] pain swelling numbness left lower arm-hand slight color change to lt hand-swelling localized at thumb side of wrist about 2 inches long above wrist--no recent injury or bite--concerned might be blook clot--53 yo male woke up this am with considerable pain in arm-wrist -hand [/INST] Hello, Well to me, it looks like a blood clot only, any severe pain with color changes can be suspected for a blood clot in the vasculature. If such a patient comes to my clinic I would suggest him to have an Immediate scan and also few Blood Investigations without any delay.1) Arterial and Venous Doppler of the Left Upper Limb2) FBS & PLBS3) Hba1C4) PT INR5) Preview with a general surgeon. If you have any Queries further you can get back to me. Hope I have answered your query. Let me know if I can assist you further. </s>