<s>[INST] Yes please. I had Euflexxa injections in my left knee on 7/8, 7/15 and 7/25 was the last of three. I flew to Dallas TX from Philadelphia PA on 7/31. There was a connection flight both there and on the return so a total of four fights. I returned home 8/4. My left leg is swollen in the calf and ankle area. I am not feeling any hot spots. It is just the left leg. Should I be concerned about this? Would the injection be ok to fly so soon after? [/INST] Dear patient Intro articular euglena injections will not lead to swelling in ankle and calf. This is because joint cavity is not connected to intramuscular planes. Swelling might be frequent air travel which might lead to deep vein thrombosis, or it might be dependent edema. Is dorsiflexion of foot is leading to calf pain ? If yes than its deep vein thrombosis.  I would like to advise Doppler ultrasound of left leg to confirm diagnosis.  Visit radiology center nearby you and get it done.  If its normal do not worry. If report us abnormal you need to consult expert vascular surgeon nearby you. All the best. </s>