<s>[INST] my child aged 2.5 years, has been suffering from urine frequency (48 times in 24 hours),painful urination only on night (first he cries then urinate on night sometime he prostrate to urinate ),sunken eyes many times,little weight loss,hands and feet cold, sometime fever,sometime vomting and nausea, for 2 years......urine d/r in first lab has calcium oxalate +,and in second lab test has all was normal,and in third lab test there was a nitrite and bacteria in urine..then we had 2 urine culture test in 15 days that found no bacteria growth...and we had a ultrasound that was also normal....he has been given many antibiotics....such as cefixime,cefpodoxime,azithromycin,ceftriaxone sodium,cefotaxime,amoxil,negram,septran,for about 5 to 7 days...... but he does not recover 25 % as well.... [/INST] Hi, Basically he is having polyuria with signs of deny Chat Doctor. This can not be attributed to urine infection. Painful urination is probably from mucosal irritation caused by frequent voiding. This can not be attributed to urine infection. Here we have to rule out other important conditions like diabetes mellitus, diabetes insipid us, renal tubular acidosis. This need few lab tests like serum electrolytes, urine and serum osmolarity, renal function test, urine sodium & pH. Kindly discuss with a pediatrician. Hope I have answered your question. Let me know if I can assist you further.  </s>