<s>[INST] My Doctor prescribed me with Janet XR 100/1000 mg once daily as a new Diabetic treatment, however the previous treatment of Metforming XR 1000mg and Glyburide 5mg was working fine. Since changing my sugar has skyrocketed. Can I take Glyburide with Janet XR to try to bring my sugar back to normality 113 avg. before Janet XR now 199 avg. (insane) [/INST] Hello, you need to give some time for Janet XR to work. If you start taking glyceride 5 mg with Janet XR then there are more chances that you may have episode of low blood sugar if you are not aware of sugar levels. Consult your doctor for this, and he may prescribe you other additive medications like alpha glucoside inhibitors like Carbone or foliose, which decreases glucose absorption in the body without causing hypoglycemia. </s>