<s>[INST] My husband is in ICU on ventilator with bilateral pneumonia. The antibiotics given (meripenum, targocid, colistin and doxycyclin) is affecting liver and kidneys both making rising trend in blood urea, serum creatinin and all four liver enzymes. Itis now fifteen days and doctors are unable to wean him off the ventilator and he is now very drowsy and can not make efforts. I am bewildered that instead of getting better his conditioN is detoriating. Please advice. Thank you. His blood urea is 247, sr creatinin - 2.5, BUN 26,500. [/INST] Thanks for your question on Chat Doctor. I can understand your concern. Honestly speaking, his reports are not good. He is undergoing MODS (multiple organ damage syn Chat Doctor.  Best treatment for pneumonia is identification of causative organisms and start appropriate antibiotics. So to isolate the organism, you need bronchoscopy and BAD (bronchoalveolar lavage) analysis. This is the last resort to take him out of sepsis. So consult pulmonologist and get done bronchoscopy and BAD analysis. Hope I have solved your query. I will be happy to help you further. Wish you good health. Thanks. </s>