<s>[INST] Hi im female an have severe irritation from my anus to my clitoris. My GP has already prescribed canaestan which had no effect whatsoever.  He then suggested Daktacort and Nystaform-HC which I understand are both hydrocortisone type creams.  These tended to cause stinging which I couldnt put up with.I am extremely clean and wash regularly - have also tried E45 and Sudocream but nothing seems to help.  The main irritation tends to be during the evening and night (which I assume could be due to sweating) but it has become unbearable and Im afraid of eventual skin breakdown.  Can you help please? [/INST] Hi, It seems that you might be having yeast infection giving all problems. Along with local application you might require one course of oral antifungal medicine like Fluconazole 150 mg once in a week for four weeks. There is another possibility of having worm infestation like thread worm which also might cause itching and irritation on the part. Go for stool test for ova and cyst and if you require go for one anti-helminth medicine course like Albendazole. Ok and take care. </s>