<s>[INST] My 8 yr old son has an ASO level of 1600 and DNase level of 667. We are suspecting PANDAS due to his extreme behavior over the last few weeks, seems to have been triggered by trip to Disney with some family members. He has Strep this past winter along with a fever of close to 105. Please advise. [/INST] Welcome to Chat Doctor. I appreciate your concern for your son. Also known as Childhood neuropsychiatric syn Chat Doctor.  Onset of symptoms from age 3 years to puberty2. Presence of obsessive-compulsive disorder, Attention Deficit Hyperactive Disorder symptoms, or oppositional behaviors3.  Abrupt onset and or symptoms vary in intensity4. Neurological abnormalities, including motor hyperactivity, or abnormal movements, such as involuntary jerky movements), other combinations of neuropsychiatric symptoms, such as anxiety, emotional lability, bed-wetting, or temper tantrums, personality changes and deterioration in math skills and handwriting5. History of A beta-hemolytic streptococcal infection (the bacteria that causes strep throat) either by culture or other evidence of infection, such as scarlet fever or by laboratory test evidence (High AS & DNAs titles). Hope this answers your query. Best regards. </s>