<s>[INST] Hello, My question is about hypothyroid plus cardiovascular changes. Age 55, hgt 5 7 wgt 163 lb; hypothyroid since age 22 treated with Synthroid only. Recent M.I. with one sided hypertension now, and metabolic syndrome. I ve never felt clinically improved on Synthroid, just marginally, all these years.. still serious fatigued, wgt gain, leg/foot cramps, muscle weakness, dry skin/hair, brain fog moments, generally weak and weary. Could t3 supplement, like Cytomel, help me with these lingering hypo symptoms? Am I looking at high risks, due to heart attack recently? I understand that subclinical hypothyroid can eventually lead to hypertension and even some of these nasty cardiovascular deteriorations. Would like to correct any lingering under treated thyroid deficiency, as I ve modified to heart diet, taking gold standard cardiac meds now also. Thank you. [/INST] Synthroid is safe in heart disease and there is no such evidence of hypertension caused by it. You have to set up your priorities, as you have multiple comorbidities like Diabetes, hypertension, high cholesterol, hypothyroid, overweight and most important recent myocardial infarction. Please keep your antiplatelet as the first and foremost priority and then continue statins, levothyroxine, beta blocker and ACE inhibitor if any and lifestyle modifications. Keep your sugars under control. Diet and Exercise are very, very important part of you disease complex. I am not sure but T 3 is not of much help in your scenario. All the best. </s>