<s>[INST] My husband has state 4 prostate cancer.  His bone marrow now has cancer and he has GI bleeding which is draining his blood and platelets.  He has had the AVMs caused by the radiation cauterized but the bleeding does not stop. Id there anywhere else that the doctors should be looking for potential bleeding?  He cannot have chemo until the blood levels remain higher.   YYYY@YYYY [/INST] Hello and welcome to Chat Doctor, You have mentioned that the prostatic cancer has spread to the bone marrow. When the cancer cells start replacing the normal bone marrow, the normal blood cells and platelets are suppressed. Decrease in red blood cells causes anemia, decrease in white blood cells predisposes to infection and decrease in platelets cause spontaneous bleeding from various sites. Bleeding can be controlled by infusion of platelets. Platelet transfusion can increase in number of platelets and thus control bleeding. You can consult your doctor for further management. Thanks and take care Chat Doctor.  </s>