<s>[INST] i am 30 year old, married for 5 years now. trying to conceive from ldast 2 years.diagnosed with PCOS 2 yrs back . but no cysts in the ovaries. with symtoms irregular periods, acne, abdomen fat, hair loss and unwaned hair. besides this i had a miscarriage last year. I exercise regularly with no refined carbs, high protein and fiber and lots of fruits,vegetables and nuts. and also i used clomid for 9 months with no success. all the symptoms were subsided during clomid use and again came back after stopped using it. please help me on this problem and to conceive and have successful pregnancy. [/INST] Hello, It is quite possible that you may not be ovulating even after taking CLOSED. In such cases, the dose of CLOSED is increased, and it can be increased up to 250 mg. You must also check for prolactin levels in blood as hyperprolactenemia can result in situation where CLOSED doesn't act. Other methods for improved ovulation chances are. Regular exercises and reduction of weight. It is said that a mere reduction of weight by 10% can help achieve ovulation. Use of Chat Doctor. It helps in reduction of insulin resistance and achieving ovulation. Please consult your doctor and discuss it in detail. Thanks </s>