<s>[INST] my  nephew is  21years  old...he  was  having  back ache  for  2-3years  now...it  increased  so  much  thAt  he  was  taking  2-3  pain killers  in  a  day...mri  relult  showed  some  shadow  around  spine  area....surgery  was  conducted  in  delhi  hospital...biopsy  result  shws  no  tubesculosis  and  no  tumor....but  tissue  growth  is  there  and  doctors  have  taken  out  50-60.,% of  tissues..patient  is  relieved  but  no  clear  diagnosis  could  be  done...problem  might  reoccur  doctors  have  to  say...what  is  your  opinion [/INST] Hello, Welcome at Chat Doctor. I have read complete details of your question. It looks from your details that you are having backache which is troubling you. If biopsy had not shown any tumor or TB then you should not worry. Such type of pain in your age can also be there due to infection of disc or abnormal posture. There are several other reasons like Schumann disease, previous trauma leading abnormal strain over the vertebrae. At present, you should take care of your posture & should avoid abnormal strain over your back by avoiding abnormal bending. Learn some exercises for your back which does strengthen your back muscles- http://orthoperson.blogspot.in/ Do these exercises only under supervision & recommendation of your orthopedic doctor. Hope this all will help you. With best wishes. </s>