<s>[INST] sir i have a white little raised line on lower lip vermillion border.it has been ther since 10 years.i have taken flucanozole and applied miconazole but no use.it reduces but when i leave the medicine it retrieves back again.what is it and is this could be treated [/INST] Hello, I can understand your concern. As you are having this line on your lip for about 10 years, and you have already tried antifungal agents, it does not seem like a fungal infection. White line on the lip can be due to charities which can occur due to deficiency of Vitamin B12, iron deficiency anemia or allergy to some substance that you are exposed to on routine basis. I would recommend you to start having Vitamin B12 supplements and iron supplements along with including leafy vegetables in your diet. You can also take antihistamine such as Loratadine 10 mg (Forfeits) once a day for about a week to 10 days to combat an allergic reaction, if present. You should give it a month to reduce in size and intensity or disappear completely. If it does not respond to these supplements, I would advise you to go for a biopsy of the lesion as 10 years is a very long time to have a persistent painless lesion on the lip and confirmed diagnosis is necessary. You can visit an oral and maxillofacial surgeon for the biopsy. I hope this information helps you. Thank you for choosing Chat Doctor. Take care. Best, </s>