<s>[INST] Hi - i have sciatica with pain going down my right leg when it occurs! i did a mantoux test that says i have Mycobacterium TB of the spine. Have been taking pyrazinamide-rifampicin-isoniazid-ethambutol for about 6months now!! Please, any suggestions to ease the leg cramps and sciatica?? Thanks, Aminu, nigeria. [/INST] Hi Amino, thanks for asking from Chat Doctor. I can understand your concern. You are suffering from Potts spine (TB of spine). You are already taking 4 first line anti-tubercular therapy, which is ideal treatment of Potts spine. The therapy is long, around 9 to 15 months. There is no standard treatment guidelines. The duration can be decided based on your physician decision and your symptoms. Now coming to your symptoms, leg cramps and sciatica. These symptoms are most probably due to compression and collapse of vertebrae, collection of pus in spinal canal and compression of nerves. To get relief, you should-Avoid any kind of weight-bearing- Avoid flexion and extension at spine-Wear back supporting belt like thoracolumbar corset.- For pain relief, you can take tablet pregabalin after proper prescription. Usual adult is 75 to 150 mg twice a day. If still no relief, you can take tablet amitriptyline after proper prescription.- For cramps, do physiotherapy and take tablet baclofen after proper prescription.- Also increase your protein and calcium intake for strengthening bones. If still no relief and symptoms worsen, repeat MRI spine to rule out any progressively increasing compression of spinal cord or nerves. Sometimes surgery (less than 10% cases) may be needed to relieve pressure symptoms. Hope it will help you. If still in doubt, do let me know. Thanks. Take care. Chat Doctor.  </s>