<s>[INST] i am an indian female age 48, weight @ 87kg, am on anticoagulation therapy (warfarin & aspirin), history of asthma (on daily symbicot inhalation). Am not wheezing now but having difficulty in breathing frequently, walking, climbing stairs, etc. i had an ecg done days ago, shows enlargement of t wave, is it serious? [/INST] Hello. Thanks for posting at Chat Doctor. I would be able to help you better had you also mentioned why warfarin and esprit have been started in the first place. My guesses are either a heart valve replacement, atrial fibrillation (irregular heart rate) or pulmonary embolism. Since you are regular on your Symbicort and have no wheeze I guess asthma side is controlled. Your symptoms seem to be due to heart issues in view of changes in ECG and previous probable history of heart disease. I recommend you to do a 2d echo to see the pumping function of the heart, any fluid overload, any leak between the valves the functioning of the heart. It will help us definitely in an evaluating the cause of the symptoms. Further action can be decided on site of 2 d echo. Please revert with 2 d echo findings. Wishing you good healthRegards </s>