<s>[INST] Hi i m 29yr old Male 100kg 5.7ft, few days back i started to having dark yellow urine, i started to worry i got my LFT checked following were the result bilirubin 0.8mg/dl ALT 110 AST 61 and ALP 253 and also checked for HEP A,B,C all were negative i m not a drinker but i do smoke. i also checked with the doctor he done ultrasound check on my liver, kidney, pancreas all were fine with no problem, i am still worried why is my ALT and AST level high. For the past 2 year i was talking orlistat for weight management than my alt was around 50-70 but when i stopped last month due to FDA warning that it may cause liver failure. Than my alt level came to normal level after discounting orlistat but now my alt is much higher when i was taking orlistat. could u suggest what could be the reason and what other test should i take. i also took test for UTI which was also clear. Thanks [/INST] Thank you for posting query. Increase in the level of liver enzymes(AST, ALT) reflect an INJURY to the Liver. Medically, the condition is known as "Hepatitis". It maybe caused by viral infection, alcohol, certain Chat Doctor.  As most of your test negative, kindly get following done also:1. Serum iron and ferritin level2. Serum copper 3. Autoimmune profile (ANA, anti DSNA)advice:abstinence from "Alcohol and  </s>