<s>[INST] My RA has attacked the synovial fluid in my big toe causing the bone on bone. I had bunion surgery year and a half ago and this has cause a shift and daily discomfort. Can stem cell therapy regenerate the fluid between my toe thus causing my toe to shift back in correct alignment? [/INST] Dear patient There are no studies in literature that supports use of stem cells in rheumatoid arthritis affected toe joints. Also toe deformities cannot be corrected by just replacing synovial fluid and synovial cells. Since rheumatoid arthritis is disease of synovial joints it will affect regenerate cells.  You have undergone realignment surgery and that is helpful in deformity correction.  For pain relief arthrosis is helpful. You need to visit your operating surgeon with report. </s>