<s>[INST] I have received cortisone injections in both shoulders for severe OA pain for total of 4 shots 3 months apart. (I am not sure if Methylprednisolone but think so.) My last injections were in 07/2015. I cancelled my appt. in 10/15 d/t concerns with side effects one of which is hair loss/thinning. Is this reversible? If possible how long does this stay in my system. I m wondering if/when I will see any possible improvement or at least slowing. [/INST] Hi Dear, Welcome to Chat Doctor. Understanding your concern. As per your query you are wondering if Cortisone injection cause pain in both shoulders. Well there can be many reasons for symptoms you mention in query like cervical spondylosis, tendinitis or angina. It seems to me that the symptoms are not related to cortisone injection. I would suggest you to consult cardiologist to rule out symptoms like angina. Doctor may order ECG, TMT, complete blood profile and check vitals. Doctor may prescribe isosorbide initiate, beta blockers, diuretics and aspirin along with sedatives. Doctor may also refer you to orthopedic surgeon for muscle bone or shoulder joint problem There is also problem or trapezius muscle trigger point or cervical spondylosis. For now apply warm compresses to shoulders and shoulder blades. Hope your concern has been resolved. Get Well Soon. Best Wishes, </s>