In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led inexorably to severe skin ulceration, neurological damage, and death.[citation needed] COUNT 10
QSN1 Who developed Arsphenamine? ANS1 Paul Ehrlich and chemist Alfred Bertheim QSN2 What was the first effective treatment for Syphilis? ANS2 Arsphenamine QSN3 What complications are associated with Syphilis? ANS3 severe skin ulceration, neurological damage, and death QSN4 What is Amphetamine's market name? ANS4 Institute of Experimental Therapy QSN5 Where is the Institute of Experimental Therapy located? ANS5 Berlin QSN6 Bacterial infections could be treated with medicines containing what kind of dye? ANS6 arsenic QSN7 What was the name of the first synthetic bacterial drug? ANS7 arsphenamine QSN8 Arsphenamine became the first treatment for what previously incurable disease? ANS8 syphilis QSN9 In what year was arsphenamine discovered? ANS9 1911 QSN10 What was the commercial name of arsphenamine? ANS10 Salvarsan