A 2009 Cochrane review concluded that thiazide antihypertensive drugs reduce the risk of death (RR 0.89), stroke (RR 0.63), coronary heart disease (RR 0.84), and cardiovascular events (RR 0.70) in people with high blood pressure. In the ensuring years other classes of antihypertensive drug were developed and found wide acceptance in combination therapy, including loop diuretics (Lasix/furosemide, Hoechst Pharmaceuticals, 1963), beta blockers (ICI Pharmaceuticals, 1964) ACE inhibitors, and angiotensin receptor blockers. ACE inhibitors reduce the risk of new onset kidney disease [RR 0.71] and death [RR 0.84] in diabetic patients, irrespective of whether they have hypertension. COUNT 8
QSN1 What drugs reduce the risk of death and other events in people with high blood pressure? ANS1 thiazide antihypertensive drugs QSN2 Who conducted the review on Thiazide Antihypertensive drugs? ANS2 Cochrane QSN3 What were Thiazide Antihypertensive drugs used with? ANS3 combination therapy QSN4 What do ACE inhibitors do? ANS4 reduce the risk of new onset kidney disease [RR 0.71] and death [RR 0.84] in diabetic patients QSN5 In what year did Cochrane release the report? ANS5 2009 QSN6 What reduces the risk of new onset kidney diseases and death? ANS6 ACE inhibitors QSN7 What type of drugs reduced the risk of strokes and heart disease for people with high blood pressure? ANS7 thiazide antihypertensive drugs QSN8 In what year was thiazide antihypertensive drugs shown to help those with heart problems? ANS8 2009