While highly effective, the requirement for injection limited the use of norepinephrine[clarification needed] and orally active derivatives were sought. A structurally similar compound, ephedrine, was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Following the work of Henry Dale and George Barger at Burroughs-Wellcome, academic chemist Gordon Alles synthesized amphetamine and tested it in asthma patients in 1929. The drug proved to have only modest anti-asthma effects, but produced sensations of exhilaration and palpitations. Amphetamine was developed by Smith, Kline and French as a nasal decongestant under the trade name Benzedrine Inhaler. Amphetamine was eventually developed for the treatment of narcolepsy, post-encepheletic parkinsonism, and mood elevation in depression and other psychiatric indications. It received approval as a New and Nonofficial Remedy from the American Medical Association for these uses in 1937 and remained in common use for depression until the development of tricyclic antidepressants in the 1960s. COUNT 10
QSN1 Who developed Amphetamine? ANS1 Smith, Kline and French QSN2 Who synthesized Amphetamine for asthma? ANS2 Gordon Alles QSN3 What are common side effects of Amphetamine? ANS3 sensations of exhilaration and palpitations QSN4 When were tricyclic antidepressants developed? ANS4 1960s QSN5 What were some uses for Amphetamine? ANS5 narcolepsy, post-encepheletic parkinsonism, and mood elevation in depression and other psychiatric indications QSN6 Ephedrine was used as an oral medicine for what illness? ANS6 asthma QSN7 In what year was amphetamine first tested on asthma patients? ANS7 1929 QSN8 What was the trade name of amphetamine as a nasal decongestant? ANS8 Benzedrine Inhaler QSN9 In what year did the American Medical Association approve amphetamine for medical use? ANS9 1937 QSN10 In what decade were tricyclic antidepressants created? ANS10 1960s