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 SAINTS 45, PANTHERS 17 
 
 At New Orleans, _ Drew Brees threw for 389 yards and five touchdowns as New Orleans set a slew of NFL and club records. The Colts may have been the big winners, though. Indianapolis locked up the top pick in April's NFL draft, setting the stage to select Stanford quarterback Andrew Luck. There's also questions about Indy coach Jim Caldwell's future. Instead, owner Jim Irsay will have the choice to draft Luck and give the team a young quarterback to join four-time MVP Peyton Manning. Tennessee got some early help when the Jets lost in Miami. But they can't be satisfied after entering the year with Super Bowl aspirations. It's the first time since 2007 that Philadelphia didn't qualify for the postseason and just the fourth time in coach Andy Reid's 13 seasons.
– The New England Patriots overcame a 21-point deficit today with 49 unanswered points to rock the Buffalo Bills 49-21, the AP reports. The win earned the Pats home-field advantage and the AFC's top seed. Tom Brady threw for 338 yards and finished with the second-most passing yards in NFL history, 5,235—behind only Drew Brees, who threw for 5,486 this year with the New Orleans Saints. More NFL action, from USA Today: The Miami Dolphins knocked the New York Jets out of playoff contention with a 19-17 win, burying coach Rex Ryan's pledge to win the Super Bowl this year. The Jets reached the AFC championship game each of the past two years. The Atlanta Falcons scored a team-record 42 first-half points against the Tampa Bay Buccaneers and cruised to a 45-24 victory, securing the No. 5 seed in the NFC playoffs. The San Diego Chargers ended the Oakland Raiders' playoff hopes with a 38-26 victory. The Raiders' 8-year playoff drought continues. The Baltimore Ravens clinched the No. 2 seed in the AFC and a first-round bye by holding off the Cincinnati Bengals, 24-16. Backup quarterback Matt Flynn set Green Bay Packer records with 480 yards passing and 6 touchdowns, out-dueling Detroit Lions QB Matthew Stafford in a 45-41 victory. Stafford threw for 520 yards and 5 touchdowns. The Houston Texans botched a 2-point conversion and saw their rally fall short against the Tennessee Titans in a 23-22 loss. The New Orleans Saints set several club and NFL records in a 45-17 rout of the Carolina Panthers. Drew Brees threw for 389 yards and 5 touchdowns. The San Francisco 49ers locked up the NFC's No. 2 seed and a first-round bye with a 34-27 victory over the St. Louis Rams. Michael Vick tossed three TDs as the Philadelphia Eagles thrashed the Washington Redskins, 34-10, in a fourth straight victory. The Indianapolis Colts secured the top 2012 NFL draft pick by losing to the Jacksonville Jaguars, 19-13. Hello quarterback controversy? Maybe so, if the Colts draft Andrew Luck, USA Today reports. Click here for more NFL updates.