In the first real-world study of the prescription drug, Kaiser researchers found no new HIV infections among the more than 650 people they followed over nearly three years, beginning just after the drug was approved by the U.S. Food and Drug Administration in 2012. Since then, Kaiser Permanente in San Francisco has been giving the drug to its patients for more than two years with even better results.Doctor Jonathan Volk put Kaiser Permanente patients, at risk for HIV, on the medication. "What's really exciting about HIV prevention in 2015 is that we have options, we have several tools that we can use," Volk said.The study suggests that HIV is very close to being managed like any other chronic disease, such as diabetes or asthma. “The fact we had no new HIV infections is very encouraging, but we still have more to learn about how people are using this medication.” 
 
 ‘At high-risk phases’ 
 
 For study participant Paul Marcelin, a San Francisco Kaiser patient who lives in Alameda, the drug allows him to protect himself while maintaining his relationship with his HIV-positive boyfriend.
– Big news in the fight against HIV: Kaiser Permanente, San Francisco's biggest private insurer, says that over a 32-month period, not a single one of its clients taking Truvada contracted HIV. Truvada is the name of the daily pre-exposure prophylaxis, or PrEP, pill that the CDC recommended for use in at-risk populations earlier this year. The new study followed 657 San Franciscans (all but four of them gay men) who asked their doctors for Truvada, and found that while condom use did decline—a major fear of PrEP critics—no one contracted HIV between mid-2012 and February of this year, the New York Times reports. More than 40% of the subjects said they used fewer condoms after starting Truvada, the San Francisco Chronicle reports, and while half of the subjects got syphilis, gonorrhea, or chlamydia within a year of starting PrEP, the Times notes most sexual infections other than HIV can be cured with antibiotics. And rates of those infections were already climbing among gay men before PrEP came on the market, a doctor notes. This was an observational study of the $50-a-month drug; a clinical trial last year actually gave some participants a placebo instead of Truvada. That study, however, was stopped early—because it became so obvious that Truvada worked that it was unethical to keep some of the subjects on a placebo. This new study "takes it out of the realm of clinical trials and into the real world," one doctor and infectious disease expert says. An AIDS activist echoes that, noting the study "fills in a critical gap by showing that PrEP can prevent infections in a real-world public health program." "This is very reassuring data," adds the lead author of the new study. "It tells us that PrEP works even in a high-risk population." According to ABC 7, the study population also included "injection drug users."