Sanders has pledged to remain in the race until the end, even though his fundraising has slowed considerably and the scale of his political operation has been downsized accordingly. If he still hopes to win the nomination, Sanders would need to win more than 84 percent of the remaining delegates and superdelegates. He looks to California, which awards 172 delegates on June 7, the final day of primary voting, to make his nomination officially secure. As of 11 p.m., Sanders led 52 percent to 48 percent, with 95 percent of precincts reporting, according to The Associated Press. [Cruz unloads on Trump: A ‘narcissist at a level I don’t think this country has ever seen’] 
 
 Trump left nothing to chance. Kasich, who won only his home state of Ohio, is set to announce his departure from the race later Wednesday in Columbus. Clinton holds what her campaign and many analysts argue is an irreversible lead in total delegates. Kasich is fourth in the race for delegates, behind Ted Cruz and Marco Rubio, who have suspended their campaigns. But though he won Indiana, the state's Democratic primary allocates delegates proportionally, so he will barely make a dent in the former secretary of State's delegate lead. Clinton is shy of the Democratic nomination by 182 delegates, according to the AP delegate tracker. (Reuters) 
 
 On the Democratic side, Indiana proved a surprising aberration as Bernie Sanders scored an upset victory over Hillary Clinton, giving the Vermont senator a needed psychological boost and a fresh rationale to soldier on against increasingly difficult odds. ADVERTISEMENT 
 
 At a Tuesday night press conference, the Vermont senator touted the momentum of his campaign while acknowledging that it's an uphill battle for him to clinch the nomination. The Fiorina announcement was overtaken by news that former House speaker John A. Boehner (R-Ohio) had disparaged Cruz as “Lucifer in the flesh.” Cruz won a hard-sought endorsement from Indiana Gov. Kasich will fight for the higher path." Donald Trump, the celebrity mogul whose brash and un­or­tho­dox presidential bid was counted out time and again, became the de facto Republican nominee Tuesday night after a runaway victory in Indiana’s primary forced his two GOP rivals, Ted Cruz and John Kasich, to quit the race. She will be a poor president.” 
 
 Clinton, who campaigned Tuesday in the general election battleground of Ohio, now has her focus squarely on Trump. Trump, who struck a far more somber tone Tuesday than in his rallies, saluted Ted Cruz, his former Republican rival, who suspended his campaign earlier in the night, and shifted his attention instead to his likely opponent in the general election. As Trump claimed the mantle of GOP standard-bearer on Tuesday night, he was uncharacteristically measured. The Republican front-runner addressed supporters at Trump Tower in New York on Tuesday night after his chief Republican rival, Ted Cruz dropped out. After Trump’s landslide April victories in six consecutive Northeast and Mid-Atlantic primaries, Cruz saw Indiana as an essential lifeline. “Ted Cruz — I don’t know if he likes me or he doesn’t like me, but he is one hell of a competitor,” Trump said. He said that while he wasn't sure if Cruz likes him, he praised his former rival as a "smart" and "tough guy" who had an "amazing future" ahead of him. Trump says, "We're going after Hillary Clinton." "I believe we’ll be able to make the case to many of those superdelegates that what is most important is not whether Hillary Clinton or Bernie Sanders is the nominee," Sanders said. The Vermont senator’s victory in the Hoosier State breaks Clinton's recent winning streak. In a statement acknowledging Trump’s status as presumptive nominee, Clinton campaign chairman John Podesta said, “Throughout this campaign, Donald Trump has demonstrated that he’s too divisive and lacks the temperament to lead our nation and the free world. Reince Priebus took to Twitter Tuesday after Ted Cruz ended his bid for the GOP nomination, saying that Donald Trump "will be presumptive @GOP nominee, we need to unite and focus on defeating @HillaryClinton." “We’re going to win big league, believe me,” he said at Trump Tower in New York. [The Fix’s winners and losers from Indiana primary night] 
 
 Republican presidential candidate Donald Trump held a campaign event at Trump Tower in Manhattan, after sweeping the Indiana primary. Sanders traveled the state and spent about $1.5 million in advertising in Indiana against Clinton. But Sanders’s success did not change the overall trajectory of the Democratic race, which remains strongly in the former secretary of state’s favor. The Indiana Democratic primary was too close to call once all the polls closed at 7 p.m. EDT. Their only hope is to block Trump and force a contested convention in which no one arrives with a majority of the delegates. The real estate mogul is now the presumptive GOP nominee after his landslide victory in Indiana prompted Texas Sen. Ted Cruz Ted CruzRepublicans bristle at notion they failed to vet Trump Cruz denies sending tweet urging conservatives to leave GOP Republicans fear for party's future MORE to suspend his campaign. "What is most important is that we do not allow someone like a Donald Trump to become president of the United States." Still, most GOP primary voters say they would probably support Trump, Cruz or Kasich in November.
– The GOP race may be all but over after Tuesday's Donald Trump victory in Indiana, but Bernie Sanders made it clear that the Democratic primaries still matter—and he intends to win them. "I sense some great victories coming, and I think while the path is narrow—and I do not deny that for a moment—I think we can pull off one of the great political upsets in the history of the United States and in fact become the nominee for the Democratic Party," he told supporters at a rally in Kentucky after his surprise win in Indiana, per the Hill. "And once we secure that position, I have absolute confidence that we are gonna defeat Donald Trump in the general election." Sanders won Indiana with 52.5% of the vote to 47.5% for Clinton, according to the Washington Post, but although the win gives him momentum and another reason to stay in the race, the delegates are awarded proportionately, meaning he has only cut Clinton's lead by six. The AP reports that Clinton now has 1,682 pledged delegates to 1,361 for Sanders—but when superdelegates are counted, she has 2,202 delegates on her side, just 181 away from the 2,383 needed to win. Sanders told supporters that he plans to make his case to superdelegates in states that he won, and "what is most important is that we do not allow someone like a Donald Trump to become president of the United States." (John Kasich's campaign says he is now the best hope of stopping Trump.)