( CNN ) -- A charter bus bound for a casino overturned on an interstate highway in Los Angeles County on Thursday morning , injuring 46 people , officials said . Most of the injuries were minor to moderate , Saul Gomez of the California Highway Patrol told CNN . Several trauma patients were airlifted by helicopter . `` Luckily , none are life-threatening , and the situation has stabilized for now , '' Gomez said . Witnesses were still being interviewed , and it was too early to ascertain a cause of the wreck , he said . The bus , which was on its side off of Interstate 210 near Irwindale , had traversed four lanes before coming to rest . The stretch of highway is popular with tour buses headed to casinos . The wreck occurred at about 10 a.m. ( 1 p.m . ET ) The crash happened on eastbound I-210 near the intersection with Interstate 605 , nearly 20 miles northeast of downtown Los Angeles . By early afternoon , one eastbound lane of I-210 was open . Medical helicopters landed on the highway to transport victims , and numerous emergency personnel were tending to people at the side of the highway , video from CNN affiliate KCAL showed . Girls injured when bus overturns in Kansas . Pasadena 's Huntington Hospital had three patients , including an 86-year-old man with chest injuries and rib fractures , hospital spokesman Kevin Andrus said . Three hospitals in the Citrus Valley Health Partners system had a total of 20 patients , all of whom were listed in mild to moderate conditions , spokeswoman Annette Macias said . CNN 's Phil Gast contributed to this report .
Vehicle was headed for a California casino . The driver of the vehicle is in custody and has been charged with felony vehicular manslaughter. Accident occurs near city of Irwindale ; bus ends up on its side .