In every human cell about 2 meters of DNA filaments are packed inside a nucleus which is only \(\sim 10\)  micrometers in diameter [1]}. In order to characterise the DNA chromatin degree of spatial organization in the nucleus and its connections with the vital transcription, replication and repair cellular functions, several advanced experimental techniques, such as, just to mention a few, “Hi-C” and super resolution microscopy[2]}, [3]}, [4]}, [5]}, have been developed. Such novel experimental tools proved fundamental in revealing complex chromatin topological features as three-dimensional (3D) conformation at different length scales. At large scales, interactions between active regions were discovered to be the driver of the genome segregation into compartments[6]}; at shorter scales, chromosomes were shown to be partitioned into contiguous regions termed domains, or topologically associating domains (TADs) [7]}, characterised by enriched self-interactions and chromatin loops[8]}.
