Protein conformational processes, which include folding and conformational transitions, are essential to innumerable cellular functions [1]}, and a key goal of computer simulations is to quantify such processes [2]}, [3]}, [4]}. Characterizing the “mechanisms” (pathways) of such processes, the series of conformational states through which a system transits during the process of interest, is at the heart of the biomolecular simulation enterprise.
