The collective migration of Eukaryotic cells attracts the attention of physicists as one of non-equilibrium collective phenomena [1]}. In particular, the driving mechanism of the collective migration have been investigated with focus on their various microscopic cell-scale factors, including the chemotaxis [2]}, cytoskeleton contraction[3]}, contact inhibition of locomotion [4]}, cell-substrate adhesion [5]}, and cell–cell adhesion [6]}. The roles of these factors are well explained through theoretical reproduction of the collective migration in a macroscopic scale [7]}, [8]}, [9]}, [10]}, [11]}, [12]}, [13]}, [14]}, [15]}, [16]}, [17]}, [18]}.
The cell–cell adhesion has been secondarily considered as a stabilizer of cell–cell contacts, but it is not direct driving force of the collective cell migration [19]}, [20]}.
Here, we theoretically propose a possibility of the cell-cell adhesion as the driving force from the physics point of view.
