IDPs can be divided into three major archetype sequences [1]}: polar tracts, polyelectrolytes, and polyampholytes. Each type could exhibit ISH depending on its sequence [2]}. For example, it was shown that polyelectrolyte regions are locally stretched due to electrostatic repulsion as opposed to electrostatic bridges in the polyampholyte regime [3]}. Moreover, it was found that IDPs can include collapsed domains due to the hydrophobic interaction [4]}.
