In view of the difficulty to identify the relevant structural features that are responsible for the occurrence of PE, recent studies have used machine learning approaches to identify a connection between these two quantities [1]}, [2]}, [3]}, [4]}, [5]}. Although these works have demonstrated that this technique is indeed able to predict to some extent the location of PEs, Richard and collaborators has recently shown that the quality of these predictions is not always superior to the one of simple local structural predictors and hence one concludes that at present we are still lacking insight on the relevant quantity that is able to predict PEs [6]}.
