In the Background section, I referred to the weight estimation procedure by Jackson et al. [1]}, which satisfies the method of moments while maximizing the ESS, thereby reducing the dispersion of the weights. 2SMAIC is a modular framework and this approach could be used instead of the standard method of moments to estimate the trial assignment odds weights. Different weighting modules could be incorporated to account for missing outcomes [2]}, treatment switching [3]}, [4]} and other forms of non-adherence to the protocol [5]} in the index trial.
