In the present work, we investigate how the cooperativity of the chemoreceptors affects their methylation levels. More precisely, we study the temporal variation of the receptor methylation levels as the cell navigates through spatially varying attractant environment. Our extensive numerical simulations on a detailed theoretical model [1]}, [2]} show that the nature of variation depends sensitively on the level of cooperativity present among the receptors. We explicitly consider two different types (directions) of runs: uphill and downhill. As the names suggest, during an uphill run the local attractant concentration increases along the cell trajectory and during a downhill run it decreases. We monitor the average change in methylation level of a receptor cluster as a function of time during these runs.
