Age difference between subjects is a potential confounding factor in whole brain Jaccard distance, and we plotted the variation of distance vs. age difference in Figure REF . Distance distributions are virtually identical across the HCP subject age range spanning 22-36 years of age, indicating that age difference is not a major confound in this relatively young and healthy HCP cohort where brain morphology is relatively stable. Note that the Jaccard distance was found to increase with age difference in older subjects due to natural aging and neurodegenerative disease in [1]}.
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