PortalCG uses three database, Pfam[1]}, Protein Data Bank (PDB)[2]} and ChEMBL[3]}. Two applications are demonstrated, COVID-19 polypharmacology and undruggable human proteins, for which known approved drugs are collected from CLUE[4]}, 332 human proteins interacting SARS-CoV-2 are listed in recent publication[5]}, 12,475 undruggable proteins are collected by removing the druggable proteins in Pharos [6]} and Casas's druggable proteins [7]} from human disease associated genes [8]}. Detailed explanation of how each data set is used can be found in Supplemental Materials Methods section.
