There are several research papers in which they have studied about ischemia in the animals.
[1]}, [2]}, [3]}, [4]}, [5]}, [6]}, [7]}, [8]}. Since it is difficult to get the human data, and hence it is challenging to extend the properties from animals to human. But it can be achieved via computational modeling. Even though many human models have been built
and analyzed via healthy cell data their appropriateness for the ischemia computation is not known. So, it is essential to examine the effect of varying ischemic parameters in the ischemic region. In [9]}, [10]}, [11]}, studies have been done for the global ischemia in human under different ischemic conditions. In [12]}, the authors has discussed the effect of local cardiac ischemia on the electrical activity of the ischemic region and the neighboring healthy region in a human cardiac tissue.
