A promising solution to this conundrum is group testing. The Dorfman procedure, the first group testing protocol proposed in 1943 to screen enlisted soldiers for syphilis [1]}, pools multiple samples together and tests each pool using a single test. Samples from a pool testing negative are cleared, while samples from a pool testing positive receive individual followup tests. Especially in low-prevalence settings, group testing can save significant test resources compared to individual testing [2]}.
