In [1]}, [2]} and [3]}, it has been shown that the Kron reduction approach preserve the network structure of the original CRN. For instance, if the original CRN is detailed-balanced or complex-balanced then the Kron-reduced CRN is again detailed-balanced or complex-balanced, respectively. Another network property that is inherited by the Kron-reduced CRN is the network spectrum interlacing property where the spectrum of weighted Laplacian matrix of the Kron-reduced CRN is interlaced with that of the original CRN as in (REF ). In this sub-section, we revisit this property again for the open CRN that contains inflow and outflow, in which case, the Laplacian matrix has an additional loss term of \(R\) .
