Our virtual patient is modeled through two ordinary differential equations presented by [1]}. This system is trivially flat with obvious flat outputs. The design of suitable reference trajectories with the corresponding open-loop controls becomes straightforward. A major source of uncertainty, according to [2]}, is the unknown fluctuation of the drug delivery to the tumor, which should be related to actuators faults, i.e., to a classic topic in fault-tolerant control (see, e.g., [3]}). It has been already noticed that model-free control is well-suited for dealing with actuators faults: see [4]} for an academic example and [5]} for a concrete case-study. The loop is therefore closed via model-free control. Let us emphasize the following points:
