Limitations of state-of-art OR/OM approaches.
Operation Research and Operations Management (OR/OM) methodologies can facilitate drug discovery, biomanufacturing system design and analysis, simulation model calibration [1]}, [2]}, [3]}, sensitivity and uncertainty analyses [4]}, [5]}. Mathematical programming methods [6]}, [7]}, supply chain planning [8]}, Markov decision process and stochastic optimization [9]}, [10]} are developed to guide bioprocess decision making and optimization. However, existing OR/OM methodologies on process modeling, analytics, and optimization are general and they often fail to consider the physics underlying the specifics of drugs as well as the mechanisms activated during bioprocesses. These limitations hinder the application of these methodologies.
