From a biological perspective, it’s well established that changes in neuroplasticity occur lifelong through many age-specific processes [1]}, ultimately affecting cerebral network maturation [2]}, [3]} and controllability [4]}.
Likewise, brain lesions could impact brain organizational properties in an age-dependent manner. In this direction, two seemingly contradictory explanations have emerged: first, “early plasticity”, arguing for the greater flexibility of the immature brain, and associated good recovery and outcome [5]}, [6]}; and secondly, “early vulnerability” referring to the young brain's unique susceptibility and subsequent poor outcome [7]}, [8]}, [9]}.
