Although the DLVO formalism has been a significantly efficient tool to characterize the macromolecular stability in water solvent, its theoretical framework includes certain approximations [1]}, [2]}, [3]}. The first limitation of the DLVO formalism stems from its inclusion of the attractive vdW forces, and the repulsive double layer forces obtained from the Poisson-Boltzmann (PB) theory in an additive fashion. This additivity assumption limited to low macromolecular charges and high salt concentrations has been relaxed by field-theoretic techniques such as one-loop-level weak-coupling (WC) approaches [4]}, [5]}, [6]}, [7]} and electrostatic strong-coupling theories [8]}, [9]}, [10]}.
