"For concussion sufferers even those who never lost consciousness physicians may now be able to predict early on who is more likely to continue experiencing symptoms months or years after the headjarring event using a new noninvasive magnetic resonance imaging MRI method devised by a consortium of researchers led by UC San Francisco scientists.  In their new study published online January   in the Journal of Neurotrauma the researchers used a technique called functional MRI fMRI coupled with sophisticated statistical analysis to track activity in the brain networks of  patients aged  to  within the first two weeks of their having experienced concussions. The study revealed telltale patterns of brain activity that six months later were associated with worse performance on behavioral and cognitive tests and were different from patterns seen in healthy control subjects. The fMRI method and analysis developed for the study highlighted abnormal patterns of brain activity that pointed to a higher risk for longterm postconcussive symptoms even among the  study participants who had no evidence of bleeding or bruising in the brain in the immediate aftermath of brain trauma on computed tomography CT or ordinary MRI scans. This is an exploratory proofofconcept study showing that we can identify patients soon after mild brain trauma who may have more persistent symptoms despite no other evidence of injury within the brain said Pratik Mukherjee MD PhD professor of radiology and biomedical imaging at UCSF and the senior author of the study. We may be able to use this information to help guide treatment decisions and counseling of patients early on when it may be more effective. Only subjects who had lost consciousness for less than  minutes were eligible for the study and many study subjects never lost consciousness during their injury.  Scientists refer to concussion as mild traumatic brain injury mTBI but for some patients the harmful sometimes insidious effects are long lasting. Common symptoms in the aftermath of concussion include confusion headache changes in vision or hearing thinking or memory problems fatigue sleep changes and mood changes. Previously there has not been a way to predict whose symptoms will fade or persist following mTBI. Although effective drug treatments for mTBI await discovery rest and counseling are known to be helpful for patients Mukherjee said.  In the new study the researchers focused on wellknown networks of activity that are observed when the brain is in a resting state. We asked subjects to close their eyes to relax and to not focus their attention on anything specific  but also to not fall asleep Mukherjee said.  In comparison to the control subjects who had never experienced TBI mTBI patients displayed less connectivity in frontal areas of the default mode network a set of brain regions that are particularly active in the resting brain. They also exhibited less connectivity within several other networks including those known as the executive control network the frontoparietal network the dorsal attentional network and the orbitofrontal network they showed an increase in connectivity in the visual network. Several of these differences were associated with worse performance months later in cognitive and behavioral tests.  UCSF radiologist Esther Yuh MD PhD associate professor of radiology served as the lead neuroradiologist and also contributed to the analysis for the new study. Postdoctoral fellow and first author Eva Palacios PhD led the data analysis for the fMRI experiments. The study was part of the ongoing Transforming Research and Clinical Knowledge in Traumatic Brain Injury TRACKTBI project through which Mukherjee and study coauthor Geoffrey Manley MD PhD vice chairman of neurological surgery at UCSF and chief of neurosurgery at Zuckerberg San Francisco General Hospital along with collaborators from many other research institutions are leading studies and gathering common data across research sites to more quickly advance TBI research. Additional coauthors include researchers from UCSF the University of Texas at Austin the University of Pittsburgh Medical Center Virginia Commonwealth University the Icahn School of Medicine at Mount Sinai and University Hospital Antwerp Belgium.  The research was funded through project grants from the National Institutes of Health and the Department of Defense.  UC San Francisco UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research graduatelevel education in the life sciences and health professions and excellence in patient care. It includes topranked graduate schools of dentistry medicine nursing and pharmacy a graduate division with nationally renowned programs in basic biomedical translational and population sciences and a preeminent biomedical research enterprise. It also includes UCSF Health which comprises topranked hospitals UCSF Medical Center and UCSF Benioff Childrens Hospitals in San Francisco and Oakland  and other partner and affiliated hospitals and healthcare providers throughout the Bay Area."