"Two new DNAbased tests one of them described at a meeting in Philadelphia on Thursday hold the promise of detecting early  and sharply reducing  colon cancer httphealth.nytimes.comhealthguidesdiseasecoloncanceroverview.htmlinlinenytclassifier a disease that afflicts  people a year in the United States and costs an estimated  billion to treat. The new tests could help most people avoid colonoscopies httphealth.nytimes.comhealthguidestestcolonoscopyoverview.htmlinlinenytclassifier which are routinely prescribed for people over age . Instead of screening the entire population doctors could instead refer people for a colonoscopy only if they had tested positive in one of the DNA tests. Unlike colonoscopy in which a seeing tube is threaded up the colon the DNA tests are noninvasive so more people would take them. Both tests could be brought to market within two years. One of the tests developed by Exact Sciences http of Madison Wis. looks in stool samples for the presence of four altered genes that are diagnostic of colon cancer. The test could catch cancerous and precancerous tumors httphealth.nytimes.comhealthguidesdiseasetumoroverview.htmlinlinenytclassifier at an early stage when they are curable and allow doctors to remove them promptly. The other test looks in blood for changes in a single gene called Septin  which is not in the Exact Sciences panel of four genes. The test has been developed by Epigenomics AG http in Germany. Both tests would be less expensive than colonoscopy and potentially more effective. Compliance with colonoscopy is low since people dont want to have one and the overall cost per detection is high because most people are healthy and even colonoscopy misses many tumors in the upper part of the intestine. Exact Sciences now plans to enlist several thousand patients in a prospective trial designed to win the Food and Drug Administrations approval. The trial will be completed in  and the test if approved should be available shortly thereafter. If widely used and regularly this test really does have the opportunity to eliminate colon cancer said Dr. David A. Ahlquist http a colon cancer expert at the Mayo Clinic and an adviser to Exact Sciences. The practical value of the tests depends critically on details like their sensitivity meaning the proportion of tumors that are detected and their specificity meaning how many of the positive results are in fact false alarms. Exact Sciences reported in July that its test was highly sensitive and specific when applied directly to cells taken from tumors. But in the real world the tumor httphealth.nytimes.comhealthguidesdiseasetumoroverview.htmlinlinenytclassifier DNA must be detected in stool samples even though almost all the DNA comes from the bacteria of the gut. Just . percent of the DNA is human and most of this is normal DNA not the altered DNA of tumors. The company reported Thursday at a meeting of the American Association for Cancer Research http that in a trial of  patients the test had detected  percent of adenomas or polyps larger than one centimeter in diameter and  percent of cancers as judged by the colonoscopies also given to the patients. Dr. Ahlquist said he was very pleased with the new results especially the  percent detection rate for precancerous polyps since these are best targets for intervention. Although such a detection rate sounds far from perfect it can be effective if the test is given on a regular schedule. The Pap smear httphealth.nytimes.comhealthguidesspecialtopicpapsmearandtreatmentoverview.htmlinlinenytclassifier detects only  percent of cervical cancers but applied over time it virtually eliminates the disease Dr. Ahlquist said. The specificity of the Exact Sciences test is  percent meaning that  percent of the time the patient will be given a false alarm. This may be acceptable given that the worst that will happen is that the patient will get an unnecessary colonoscopy. With stool tests you need a  percent specificity said Dr. Bert Vogelstein http a cancer httphealth.nytimes.comhealthguidesdiseasecanceroverview.htmlinlinenytclassifier expert at Johns Hopkins University who is also an adviser to the company. Exact Sciences has gotten close to that. Theres a lot of hope for getting a stoolbased test. Promising results for the bloodbased tests were reported this week at a meeting in Barcelona Spain. Epigenomics said its test had a sensitivity of  percent and a specificity of  percent. Proponents of each test note possible weaknesses of the other. Dr. Achim Plum http_Plum a vice president for Epigenomics said that  to  percent of people have small polyps but less than  percent of these ever become cancerous. The colonbased test may pick up too many of these sending far too many people in for colonoscopy. The health economics of such a test make no sense he said. But the bloodbased test may have a similar problem since a positive signal could come from cancers anywhere in the body. If the patient is advised to take a whole body imaging scan more false positives could be generated so you end up doing more harm than good Dr. Vogelstein said. Dr. Plum said that Epigenomics did not see its test as being necessarily in competition with the Exact Sciences test because the bloodbased test would be good alternative for people put off by stool testing."