"A new drug appears to be effective for shrinking uterine fibroids https and controlling the heavy menstrual bleeding they often cause according to new research from Europe. In one study the drug ulipristal acetate proved to be much more effective than a placebo https for shrinking the nonmalignant uterine tumors. In another ulipristal acetate was found to be as effective as monthly injections of the drug Lupron for reducing heavy bleeding in women with uterine fibroids https Both studies appear in the Feb.  issue of The New England Journal of Medicine. Ulipristal acetate is the active chemical in the emergency contraceptive sold in the U.S. as Ella but the daily doses taken by the fibroid patients in the studies were much smaller than those in the contraceptive. If trials now under way in the U.S. prove positive New Jerseybased Watson Pharmaceuticals Inc. and Swissbased PregLem hope to market ulipristal acetate as a fibroid treatment under the trade name Esmya says Watson spokesman Charlie Mayr.  in  Women Have Fibroid Symptoms Uterine fibroids are the most common indication for the close to  hysterectomies performed each year in the U.S. About  in  women in their childbearing years have symptoms related to fibroids such as heavy periods https and related iron deficiency https abdominal pain https and fertility https problems according to figures from the National Institutes of Health. Surgery is the most common uterine fibroid treatment but many women want a nonsurgical treatment option says researcher Jacques Donnez MD PhD of SaintLuc Catholic University of Louvain in Brussels Belgium. Lupron improves symptoms and shrinks uterine fibroids but it does not make them go away. It works by blocking the production of estrogen https  the hormone that fuels fibroids  and many women who take it develop hot flashes https and other symptoms of menopause https In one of the newly published studies women with excessive bleeding caused by uterine fibroids who took ulipristal acetate for three months had similar improvements in bleeding as patients who got monthly injections of Lupron with significantly fewer side effects. Drug Controlled Bleeding Shrank Fibroids Moderate to severe hot flashes were reported in about  of the women treated with ulipristal acetate and  of women who took Lupron. In another study ulipristal acetate was compared to placebo in fibroid patients with heavy bleeding and anemia https Treatment with the drug for  weeks controlled uterine bleeding in around  of patients. In both studies significant reductions in fibroid size were seen during treatment with ulipristal acetate and for some time after. This was a surprise Donnez says. We know that when patients stop taking leuprolide https acetate their symptoms return quickly but this does not appear to be the case with ulipristal acetate. He says this could mean that the newer drug may help patients avoid surgery entirely. It may be that women can go on and off this drug intermittently taking it for a few months when symptoms return he says. Still Too Many Hysterectomies Elizabeth A. Stewart MD a professor of obstetrics and gynecology at the Mayo Clinic in Rochester Minn. says it remains to be seen if the drug is safe for longterm intermittent use. If it is Stewart agrees that ulipristal acetate could help many patients with symptomatic fibroids avoid surgery. She says there are good alternatives to hysterectomy https for the treatment of fibroids but many patients never hear about them. Fibroid patients need to understand their options so they can at least consider them she tells WebMD. There will still be some women who choose hysterectomy but many others may not."