"First marketed in the s as a fertility drug tamoxifen has been hailed as a miracle drug for its ability to prevent and treat breast cancer and despite decades of research scientists have not been able to find anything comparable  until now. In a study published in The Lancet  http Thursday researchers found that a class of inexpensive existing generic called aromatase inhibitors which suppress hormones reduce recurrence rates by  percent as compared with tamoxifen. That confirmed what researchers had believed for several years. But a separate finding about the effect of the drug on death risk was a surprise. The study reported that taking aromatase inhibitors for  years reduced the risk of postmenopausal women with breast cancer dying of their disease by  percent within  years of starting treatment compared with no hormonal treatment. The results were part of the Early Breast Cancer Trialists Collaborative Group a collaboration based at the University of Oxford that collects and analyzes information about randomized clinical trials every few years. Breast cancer and mammograms Study suggests widespread overdiagnosis http Paul Workman professor and chief executive of the Institute of Cancer Research in London said in a statement accompanying the publication of the journal article that the evidence on aromatase inhibitors has been accumulating for well over a decade but it has taken this huge and complex study to make sense of all the data and provide a firm basis for clinical guidelines. It tends to be the discovery of new treatments that grabs the headlines but it is just as important to maximize the benefit patients get from existing treatments through major practicechanging studies like this Workman said. The researchers wrote in the study that a substantial number of the trial participants switched from tamoxifen to aromatase inhibitors after they heard that it could reduce recurrence which affected their results. If this had not happened the benefit of aromatase inhibitors over tamoxifen would probably have been somewhat greater they surmised. A separate analysis by the same group also published in The Lancet http looked at bisphosphonates which are typically used for osteoporosis. Researchers at Sheffield University found that in postmenopausal women during the first  years after diagnosis of breast cancer the drug could reduce the risk of death by  per cent. Using the two drugs together as a onetwo punch may be even more powerful. Richard Gray a professor at the University of Oxford and who served as the lead statistician for both studies said that half of all women with breast cancer are postmenopausal with hormonesensitive tumors and could potentially benefit from both drugs. The drugs are complementary because the main side effect of aromatase inhibitors is an increase in bone loss and fractures while bisphosphonates reduce bone loss and fractures as well as improving survival he said."