"kalo a privatelyheld pharmaceutical company today announced that EVZIO naloxone HCl injection Autoinjectors have been reported to help save more than  lives. EVZIO was the first naloxone product specifically designed FDA approved and labeled for the emergency treatment of opioid overdose by individuals without medical training. EVZIO is an intelligent Autoinjection system that provides simple onthespot voice and visual guidance.  In Baltimore we believe that naloxone should be a part of everyones medicine cabinet and everyones first aid kit. If we dont save lives today there is no chance for a better tomorrow said Baltimore City Health Commissioner Dr. Leana Wen. Having EVZIO available in Baltimore is helping us do everything possible to help prevent opioid overdose deaths in our community and across the country. The opioid epidemic is killing  people each day the equivalent of a fully loaded  airplane crashing each and every week. We cant stand by and hope that things change on their own said Spencer Williamson President and CEO of kalo. By empowering more patients to have access to this potentially lifesaving medicine we believe that EVZIO will help reduce the burden of opioid overdose in the United States. Since October  we have received reports that EVZIO Autoinjectors have helped save an average of  lives per week.   People at an overdose scene may be very emotional so it really helps that EVZIO has audio instructions on how to administer this potentially lifesaving medication said Laurie Fugitt RN BSN cofounder of Georgia Overdose Prevention. It has already helped save many many lives in Georgia.  The CabellHuntington Health Department is pleased to have EVZIO in our community said Dr. Michael Kilkenny Physician Director of the CabellHuntington Health Department in Huntington West Virginia. Following initial deployment of EVZIO on February  we had a confirmed life saved on February th. Our community is in a crisis as a result of opioid overdoses and EVZIO has provided an outstanding tool to help combat the harmful effects and death resulting from heroin and opioid use. The Sarasota County Sheriffs Office SCSO has found the naloxone Autoinjector to be an outstanding addition to our first responder capabilities said Captain Charlie Thorpe. Deputies now have instant access to this potentially lifesaving tool since our field deployment in December . Opioid overdoses continue to plague communities nationwide. The SCSO recognizes this effective medical intervention as another way to help combat the opioid overdose threat to our community. About OpioidInduced Respiratory Depression OIRD and Overdose Opioid emergencies such as an accidental overdose are a growing public health epidemic. On average  people die from opioids including prescription opioid analgesics and heroin everyday in the United States most occur outside of medical settings such as in a home. Approximately  opioid overdose emergency department visits occur each year. Many communities throughout the United States are facing a devastating heroin epidemic. Additionally there are nearly two times the number of prescription opioidrelated deaths as compared to heroinrelated deaths. On average  children five years old and younger are admitted to emergency departments each year due to accidental opioid exposure. Lifethreatening opioid emergencies result in respiratory andor central nervous system depression. OpioidInduced Respiratory Depression OIRD is the most important serious adverse effect of opioids as it can be immediately lifethreatening. In addition to the risk of an opioid overdose associated with an opioid use disorder there may be an increased risk of lifethreatening OIRD even when patients take a prescribed dose of an opioid as directed. For example taking high doses of opioids taking an opioid in combination with other drugs e.g. benzodiazepines or alcohol or if there is a history of certain medical conditions e.g. COPD severe asthma places individuals at significantly higher risk for lifethreatening OIRD. Seconds count when a lifethreatening OIRD event occurs. Without rapid intervention brain injury or death can occur in as little as  minutes. Most lifethreatening OIRD emergencies occur in the home and are witnessed by family and friends who may be in the best position to intervene quickly.  Naloxone is an opioid antagonist that displaces opioids from the receptors in the brain temporarily reversing the lifethreatening breathing problems that can occur during an opioid emergency. About EVZIO EVVzeeoh EVZIO naloxone HCl injection Autoinjector is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose as manifested by respiratory andor central nervous system depression. EVZIO is intended for immediate administration as emergency therapy in settings where opioids may be present. EVZIO is not a substitute for emergency medical care. EVZIO is an intelligent Autoinjection system that provides simple onthespot voice and visual guidance. EVZIO is small easytocarry and easytouse to help patients and caregivers keep it on hand so they can take fast confident action administering EVZIO during an opioid emergency. Results averaged across two adequate and wellcontrolled usability studies demonstrate more than  of users can correctly administer EVZIO without training and  with training. Each EVZIO prefilled singleuse handheld Autoinjector delivers a single . mg dose of naloxone. Each EVZIO prescription comes with two Autoinjectors and a Trainer. For more information on EVZIO including full Prescribing Information visit  http EVZIO IMPORTANT SAFETY INFORMATION EVZIO is contraindicated in patients known to be hypersensitive to naloxone hydrochloride or to any of the ingredients in EVZIO. The following warnings and precautions should be taken when administering EVZIO  Due to the duration of action keep the patient under continued surveillance and repeated doses of naloxone should be administered as necessary while awaiting emergency medical assistance.   Additional supportive andor resuscitative measures may be helpful while awaiting emergency medical assistance.   Reversal of respiratory depression by partial agonists or mixed agonistsantagonists such as buprenorphine and pentazocine may be incomplete.   Use in patients who are opioid dependent may precipitate acute abstinence syndrome.   Patients with preexisting cardiac disease or patients who have received medications with potential adverse cardiovascular effects should be monitored in an appropriate healthcare setting.   In neonates opioid withdrawal may be lifethreatening if not recognized and properly treated. The following adverse reactions have been identified during use of naloxone hydrochloride in the postoperative setting hypotension hypertension ventricular tachycardia and fibrillation dyspnea pulmonary edema and cardiac arrest. Death coma and encephalopathy have been reported as sequelae of these events. Excessive doses of naloxone hydrochloride in postoperative patients have resulted in significant reversal of analgesia and have caused agitation. Abrupt reversal of opioid effects in persons who were physically dependent on opioids has precipitated signs and symptoms of opioid withdrawal including body aches fever sweating runny nose sneezing piloerection yawning weakness shivering or trembling nervousness restlessness or irritability diarrhea nausea or vomiting abdominal cramps increased blood pressure and tachycardia. In the neonate opioid withdrawal signs and symptoms also included convulsions excessive crying and hyperactive reflexes. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit  http or call FDA. For full Prescribing Information visit httpevzio.compdfsEvzio PI.PDF httpevzio.compdfsEvzioPI.PDF.  About kalo kuhLAYoh Kalo is a pharmaceutical company dedicated to building innovative solutions for serious and lifethreatening medical conditions. Our mission is to provide innovative solutions that empower patients to confidently take control of their medical conditions. We believe patients and caregivers are the experts on how their medical condition impacts their lives and are an integral part of our product development process. Each kalo product combines an established drug with an innovative delivery platform with the goal of achieving superiority and cost effectiveness. Kalo is a privatelyheld company headquartered in Richmond Virginia. For more information visit  http  Centers for Disease Control and Prevention. Increase in Drug and Opioid Overdose DeathsUnited States . http_cidmma_w.  Accessed .  World Health Organization. Community Management of Opioid Overdose. Geneva Switzerland WHO .  Yokell et al. Presentation of Prescription and Nonprescription Opioid Overdoses to US Emergency Departments. JAMA Int. Med.  .  Burghardt L et al. Adult Prescription Drug Use and Pediatric Medication Exposures and Poisonings. Pediatrics.  .  Food and Drug Administration. FDA Blueprint for Prescriber Education for ExtendedRelease and LongActing Opioid Analgesics .  Zedler B Xie L Wang L et al. Risk factors for serious prescription opioidrelated toxicity or overdose among Veterans Health Administration patients. Pain Med.  .  Bohnert A Valenstein M Bair MJ et al. Association between Opioid Prescribing Patterns and Opioid OverdoseRelated Deaths.  .  Gudin JA Mogali S Jones JD Comer SD. Risks Management and Monitoring of Combination Opioid Benzodiazepines andor Alcohol Use. Postgrad Med J.  .  Caplan LR Hurst JW Chimowitz MI. Cardiac arrest and other hypoxicischemic insults. In Clinical Neurocardiology. New York NY CRC Press .  World Health Organization. Community Management of Opioid Overdose. Geneva Switzerland WHO .  Straus M Ghitza U Tai B. Preventing deaths from rising opioid overdose in the US  the promise of naloxone antidote in communitybased naloxone takehome programs. Subst Abuse Rehabil. .  EVZIO Naloxone Hydrochloride Injection Autoinjector Data on File. Richmond VA Kaleo Inc. Contact Mark Herzog kalo mark.herzogkaleopharma.com mailtomark.herzogkaleopharma.com   office  Logo  httpphotos.prnewswire.comprnhLOGO  SOURCE kaleo Related Links http"