"Authors from Lake Erie Research Institute in Pennsylvania report an adjustable foot wrap caused to treat restless legs syndrome RLS is . times more effective than the standard pharmaceutical treatment. The pilot study published today in The Journal of the American Osteopathic Association. The eightweek clinical trial involved  otherwise healthy adults with moderate to severe restless leg syndrome. Researchers studied Clinical Global Impression responses as well as the mean change in the International Restless Leg Syndrome Study Group Study Scale IRLSSGS. A metaanalysis was then used to compare the RLS device with three historic studies of the medication ropinirole and a placebo.  Clinical Global Impression responses indicated significantly greater improvement with the RLS device  percent compared with ropinirole  percent the current standard dopamine therapy for RLS. Additionally change in IRLSSGS score was significantly greater for the RLS device . compared to historic reports for ropinirole versus the placebo  versus . respectively. Patients using the RLS device also reported an  percent decrease in sleep loss. The RLS device was designed to put adjustable targeted pressure on two muscles in the foot known to relax symptoms of RLS the abductor hallucis and the flexor hallucis brevis. Researchers indicate that the pressure produced by the device may also stimulate a dopamine release similar to massage therapy or acupressure. By putting pressure on specific muscles in the feet we are able to create a response in the brain that relaxes the muscles activated during RLS said Phyllis Kuhn MS PhD and the studys lead researcher. Its a near perfect example of the body regulating itself without drugs many of which have the potential for significant adverse side effects. Restless leg syndrome RLS is a neurologic disorder causing unpleasant sensations and an urge to move the legs when at rest. The sleep loss associated with RLS can cause extreme fatigue anxiety and depression. According to the National Institute of Health RLS may affect as many as  percent of the U.S. population with more than nine million experiencing moderate to severe symptoms.  Until recently potent drugs including opioids depressants and dopamine agonists have been used to ease symptoms but each of these is accompanied by negative side effects such as dizziness nausea vomiting and the added risk of addiction. Restless legs syndrome really erodes quality of life because it causes extreme fatigue for many patients. As an osteopathic physician its a challenge to balance the need to restore sleep while preventing additional harm from medication. These results show promise in otherwise healthy individuals for a nonpharmaceutical option that appears to have rather minor temporary adverse effects for some users said Rob Danoff DO an osteopathic family physician and program at Aria Health Care in Philadelphia. Adverse effects were reported by seven patients in the study. The effects included pain  pins and needles sensation  irritability  spasm  and warm feet .   Open access to the full review is available until September   httpjaoa.orgarticle.aspxarticleid. Disclosures Dr Kuhn worked without compensation through Lake Erie Research Institute LERI during the  years of the study of the device and is now receiving compensation for that work. She reports no financial interest in its sales. None of the other study authors reported any conflict of interest or financial disclosure relevant to the topic of this study. More details are available in the published article.  About The Journal of the American Osteopathic Association The Journal of the American Osteopathic Association JAOA is the official scientific publication of the American Osteopathic Association. Edited by Robert Orenstein DO it is the premier scholarly peerreviewed publication of the osteopathic medical profession. The JAOAs mission is to advance medicine through the publication of peerreviewed osteopathic research."