"A multiple sclerosis drug usually reserved for people in the late stages of the disease seems to offer longterm remission in newly diagnosed patients researchers report.  Because of serious side effects the drug  Lemtrada alemtuzumab  is approved in the United States only for patients who have failed other treatments. But the authors of a new study believe giving it early may slow and even reverse some diseaserelated disability.  The expectation in MS has always been to try to slow down the progression of the disease. Now we can tell our patients that a significant number can actually improve by reversing their disability said lead researcher Dr. Gavin Giovannoni. He is a neurology professor at Queen Mary University of London in England. The treatment is not without its downsides however. Because of the potential for side effects people who received this treatment have to undergo monthly blood and urine tests for four years after the last dose Giovannoni said. Giovannoni described Lemtrada as an immune system rebooter. First it depletes the immune system then it allows it to recover he explained. During the time when the immune system is depleted there is a risk of infection over eight to  weeks including herpes infections he said. Also when the immune system rebuilds itself a significant number of people about  percent will develop another autoimmune disease Giovannoni said. These include Graves disease a thyroid disorder and a bleedingbruising disorder called idiopathic thrombocytopenic purpura ITP which occurs in about  percent of patients he noted. But these diseases can be treated so its not like MS. Its kind of trading in your MS for another autoimmune disease Giovannoni said. Still one MS specialist who reviewed the new study said patients need to be cautious about taking the drug. Lemtrada is not for every patient with MS and the decision to use it should be carefully considered said Dr. Dhanashri Miskin an attending neurologist at Lenox Hill Hospital in New York City. Although the safety profile is generally manageable for the right patient risks probably outweigh benefits in patients with mild or early stage disease Miskin said. The decision to start Lemtrada should be made in the context of the risks including infusionassociated reactions infections and autoimmune adverse events she said. Although alemtuzumab Lemtrada treatment is associated with safety risks those risks are manageable in most patients Miskin said. The new trial of more than  patients with relapsingremitting MS was funded by Sanofi Genzyme and Bayer HealthCare Pharmaceuticals the drugs makers. MS occurs when the immune system mistakenly attacks the protective sheath around nerve fibers in the brain and spinal cord. People can suffer muscle weakness numbness vision problems and difficulty with balance and coordination. Relapsingremitting MS is the most common type with symptoms suddenly worsening and then going into remission. For this study Giovannoni and colleagues treated  patients with relapsingremitting MS who had not responded to at least one other MS drug. Lemtrada was given to  patients while  received another drug interferon betaa. The researchers assessed disability levels at the start of the study and every three months for two years. By the studys end nearly  percent of those given Lemtrada had improved by at least one point on a point disability test versus about  percent of those receiving interferon the researchers found. Moreover patients receiving Lemtrada were . times more likely to have their thinking skills improve compared to those given interferon. And they were more than twice as likely to see improvement in their ability to move without tremor or clumsiness the findings showed. The findings held after researchers adjusted the results to make sure the gains werent led by those recovering from relapses. Giovannoni believes the drug could offer real relief from MS symptoms. Not only does alemtuzumab improve disability but most patients go into longterm remission of at least five to eight years he said. Some patients have been going  years without any evidence of disease activity he said. According to Bruce Bebo executive vice president for research at the National Multiple Sclerosis Society Restoring lost function is a significant unmet need for people living with MS.  This study examines previous findings related to the reversal of some disability in those receiving alemtuzumab he said. I am encouraged by these results and urge others to pursue potentially restorative approaches to treatment Bebo said.  Giovannoni pointed out that most of the drugs benefits are obtained early in the disease. If you really want this drug to have a big impact you should use it as early as possible. In the European Union its recommended for early use he noted. The report was published online Oct.  in the journal Neurology. More information For more about multiple sclerosis visit the National Multiple Sclerosis Society http SOURCES Gavin Giovannoni M.D. Ph.D. professor neurology Queen Mary University of London U.K. Dhanashri Miskin M.D. attending neurologist Lenox Hill Hospital New York City Bruce Bebo Ph.D. executive vice president research National Multiple Sclerosis Society Oct.   Neurology online"