"Even as treatment options for laryngeal cancer seemed to improve survival rates did not. For the most advanced patients  percent survival was the norm whether patients had surgery to totally remove the voice box or alternative treatment with chemotherapy and radiation to try to avoid surgery. But the head and neck oncology team at the University of Michigan Comprehensive Cancer Center came up with a different approach Give patients a single dose of chemotherapy and see who responds to it. The responders can continue with combination chemotherapy and radiation. The nonresponders can be referred immediately for surgery.  After a decade of using this approach researchers are reporting exceptional survival rates nearing  percent even for the most advanced patients. The team published their outcomes in JAMA Otolaryngology  Head and Neck Surgery. In trying to match the biology of the tumor to the treatment all of the patients get better outcomes says study author Gregory T. Wolf M.D. professor and chair emeritus of otolaryngology  head and neck surgery at Michigan Medicine.  This approach allows us to enhance quality of life for all of our patients. Many patients can spare their voice box by having chemotherapy and radiation. But thats only good if the treatment works. For patients who must go on to receive surgery by selecting them up front we can spare them the complications that may occur when the voice box is removed following multiple cycles of chemotherapy with radiation adds study author Francis Worden M.D. professor of hematologyoncology. The Michigan Medicine team first tested the idea in . They found that patients whose tumor shrunk by more than half after one round of chemotherapy were more likely to do well with chemotherapy and radiation and have an excellent chance of saving their voice box. If the tumor did not respond after that first dose patients would likely fail on the chemotherapy and would do better going straight to surgery. In a clinical trial they saw diseasespecific survival rates of  percent in patients with advanced disease. This was unheard of. And it wasnt just those who responded to the chemotherapy. The nonresponders who were immediately referred for surgery had better outcomes too. We adopted the treatment approach and started offering it to all our laryngeal cancer patients Wolf says. As part of a Specialized Program of Research Excellence or SPORE grant the team was already maintaining longterm followup data on patients. Wolf suggested they look back and see if they were still maintaining such strong outcomes with this approach. The results surprised even him. Over  years  stage  and  laryngeal cancer patients were treated at Michigan Medicine with about half receiving the induction chemotherapy. The remainder elected to proceed straight to surgery or chemoradiation without the induction dose. Average disease specific survival at five years for the induction chemotherapy patients was  percent  equivalent to the results in patients with early stage disease and significantly better than the  percent survival for patients who had chemoradiation without the induction strategy. This adds ammunition to the idea that we need to pick individual therapies more carefully. Both chemoradiation and surgery are difficult treatments with their share of challenging longterm effects. But if we tailor treatments to the individual biology of the tumor and characteristics of the patient well get the best results Wolf says. The study did find lower functional preservation of the larynx in the induction chemotherapy group compared to those who elected chemoradiation. Twothirds of the induction group achieved organ preservation while more than threequarters of the chemoradiation patients did.  Wolf notes however that chemoradiation often severely damages the larynx which may cause problems with eating or swallowing years later.  The induction approach can be done anywhere but requires intense collaboration among surgeons medical oncologists and radiation oncologists. All three must be involved to assess the patient and refer to the appropriate therapy. Even that single dose of chemotherapy can be debilitating and toxic for some patients. Wolf hopes future research will reveal a way to tailor treatment without the need for the induction chemotherapy. Additional authors Emily Bellile M.S. Avraham Eisbruch M.D. Susan Urba M.D. Carol R. Bradford M.D. Lisa Peterson M.S. Mark E. Prince M.D. Theodoros N. Teknos M.D. Douglas B. Chepeha M.D. Norman D. Hogikyan M.D. Scott A. McLean M.D. Jeffrey Moyer M.D. Jeremy M.G. Taylor Ph.D. Francis P. Worden M.D. Funding National Cancer Institute grants P CA and P CA and the Sinabaldo and Diane Tozzi Research Fund Disclosure None Reference JAMA Otolaryngology  Head and Neck Surgery doi.jamaoto.. published online Feb.   Resources  University of Michigan Comprehensive Cancer Center http  Michigan Medicine Cancer AnswerLine   Michigan Health Lab http"