"Although effective for the treatment of diabetes exercise is sometimes difficult for overweight or elderly people. A new wearable medical device developed by Kumamoto University has been found to effect visceral fat loss and improve blood glucose sugar. The current study reports clinical trial results for optimal use frequency. Type  diabetes is a disease of systemic organ failure due to chronic hyperglycemia and inflammation from the accumulation of excess visceral fat. Metabolic disorders such as hyperglycemia attenuate stress resistance in the human body and exacerbate insulin resistance. The ability of insulin to lower blood sugar levels is reduced and insulin secretion is decreased. The heat shock response HSR is activated as a response to stress in the human body but its function decreased in those with type  diabetes. A research team from Kumamoto University Japan has found that by restoring the function of HSP the main protein of HSR improved glucoserelated abnormalities. The team found that a suitable combination of mild electrical stimulation MES with heat shock HS activated HSP more efficiently.  The researchers developed a belttype medical device that uses a special type of rubber to transmit MES and HS at the same time. They then performed a clinical trial of MES  HS on  obese men suffering from type  diabetes. Results showed a decrease fasting glucose levels a loss of visceral fat improve insulin resistance and a significant . improvement in glycated hemoglobin HbAc values. About half of all subjects . achieved less than . HbAc which is a treatment goal for diabetes. The first trial showed that activation of the HSR produced a large therapeutic effect. In the researchers next clinical trial  obese patients with type  diabetes from both genders were given a week treatment with the beltshaped MESHS medical device. Trial subjects received treatments for  minutes each time and were separated into three groups of   and  treatments per week. This determined the most effective treatment frequency. The reduction in the visceral fat area was . sq. cm in the  treatment per week group . sq. cm in the  per week group and . sq. cm in the  per week group. Declines in HbAc were . . and . in the   and  treatmentperweek groups respectively. Improvements in chronic inflammation fatty liver markers renal function and lipid profile were also shown. Furthermore adding the MESHS treatment to a DPP inhibitor which is the most often used therapeutic drug for diabetes in Japan showed an even stronger blood glucose improvement. This device is very easy to use since it simply attaches to the abdomen and it has a lowimpact on the patient. One can expect the effects to be similar to exercise therapy said Dr. Tatsuya Kondo who lead the research. Even in patients who have difficulty exercising such as those who are overweight elderly or have some form of disability this device can be expected to provide acceptable treatment in addition to conventional diabetic medical care. This research was posted online in the nature.com journal Scientific Reports on October th .  CITATION  T. Kondo R. Goto K. Ono S. Kitano M. A. Suico M. Sato M. Igata J. Kawashima H. Motoshima T. Matsumura H. Kai and E. Araki Activation of heat shock response to treat obese subjects with type  diabetes a prospective frequencyescalating randomized openlabel triplearm trial Scientific Reports vol.  p.  .  DOI .srep"