"Brain surgery for children whose epilepsy is resistant to drug therapy can produce a fold increase in the odds of being seizurefree after one year and can do it without affecting IQ according to a new Indian study of  patients in The New England Journal of Medicine.  Seventyseven percent of the children were free of seizures at one year after the surgery compared with seven percent in a control group of youngsters who received medical therapy alone while waiting for surgery. Behavior and quality of life also improved.  But surgery also produced serious adverse effects in onethird of the children most frequently a weakness on one side of the body known as hemiparesis. The researchers said that was to be expected and without surgery patients probably would have experienced similar problems as a result of their continuing seizures.  What the study clearly shows is surgery for children produces seizure freedom compared to children not operated on for similar conditions senior author Dr. Manjari Tripathi a professor of neurology and epilepsy at the All India Institute of Medical Sciences in New Delhi told Reuters Health in a telephone interview.  Not only does it reassure us that several surgical procedures are effective she said it demonstrates that surgery should be done as early as possible once it becomes clear that a child is not responding to two antiseizure medications.  About  million people worldwide suffer with epilepsy and drugs cant control the seizures in approximately  percent of the cases.  This is the first randomized study to look at surgical outcome in children said Dr. Donald Schomer director of the Comprehensive Epilepsy Program at Beth Israel Deaconess Medical Center in Boston. He was not involved in the research.  The results are impressive he told Reuters Health by phone. Adults who undergo surgery often suffer from the collective effect of years of uncontrolled seizures. The study in kids shows if you reduce the time from the onset of seizures from the  to  years you see in adults down to four to five years the outcome is much better. Its documentation that these techniques really work.  Although  percent were judged by the Tripathi team to be seizurefree at the end of the study some of those children actually had seizures immediately after surgery. Yet the cases were judged to be a success because the seizures decreased in frequency over time. Ultimately  percent never had a seizure in the year after surgery.  When all seizures were taken into account children who did not have surgery were four times more likely to have a seizure during that year than youngsters in the surgery group the researchers calculated.  Success rates ranged from  percent to  percent depending on the type of surgery used to correct the childs particular brain abnormality.  Surgery improved quality of life and social wellbeing and it didnt affect IQ something that can decline with ongoing seizures. But Dr. Schomer said the children were only followed for one year and that may be too soon to see a noticeable change in the intelligence quotient.  Postsurgery weakness was seen in  of the  patients who had a serious side effect following surgery.  The weakness is significant Dr. Tripathi said. The child may not be able to ambulate by his or herself. But with physical therapy all regain the lower and upper limb function within six months. The only thing that does not improve is the wrist and the fingers. They are left with this minor deficit. But even before surgery some of them have this weakness.  Other side effects depended on the area of the brain that was removed or disconnected from the rest of the brain.  In contrast . percent of the children waiting for surgery had a serious injury as a result of their continuing seizures.  The surgery had a transforming effect on how they get along in life Dr. Tripathi said. Many could go back school earlier or go back to being tutored and get on with their life.  But a major problem facing these children is getting insurance companies to pay for such surgeries said Dr. Schomer of Beth Israel.  Rather than pay  to  on surgery that might cure the problem and prevent further damage to the child insurance companies prefer to demand that more drugs be tried even if the odds of them working in drugresistant cases is small he said.  Studies like this lend credence to the idea that the earlier you do it the better the outcome he said. I hope insurance companies will look at this and realize that early detection and surgery if appropriate will ultimately save them money in the long term.  SOURCE bit.lygVClQv httpbit.lygVClQv The New England Journal of Medicine online October  . Our StandardsThe Thomson Reuters Trust Principles. httpthomsonreuters.comenaboutustrustprinciples.html"