"This new drug could be a game changer for future treatment of asthma  Professor Chris Brightling NIHR Senior Research Fellow at the University of Leicester The first new asthma pill for nearly  years has the power to significantly reduce the severity of the condition a study led by the University of Leicester has found. The research was funded by Novartis Pharmaceuticals National Institute for Health Research NIHR and the EU AirPROM and is described by the lead researcher as a game changer for future treatment of asthma. Three people die every day because of asthma attacks and research shows that two thirds of asthma deaths are preventable according to Asthma UK. Fevipiprant QAW significantly decreased the symptoms of asthma improved lung function reduced inflammation and repaired the lining of airways. The drug is currently being evaluated in late stage clinical trials for efficacy in patients with severe asthma according to ClinTrials.gov.  A total of  people took part in the research. One group was given mg of the drug twice a day for  weeks and the other participants were assigned to a placebo group. Fevipiprant and the placebo were added to the medications the participants were already taking. The study was designed primarily to examine the effects on inflammation in the airway by measuring the sputum eosinophil count.  The sputum eosinophil is an inflammation measurement of a white blood cell that increases in asthma and is used to assess the severity of this condition.  People who do not have asthma have a percentage of less than one and those with moderatetosevere asthma typically have a reading of about five per cent. The rate in people with moderatetosevere asthma taking the medication was reduced from an average of . percent to . percent over  weeks according to the study published today in the prestigious The Lancet Respiratory Medicine journal. Professor Christopher Brightling who is a NIHR Senior Research Fellow and Clinical Professor in Respiratory Medicine at the University of Leicester led the study at the NIHR Respiratory Biomedical Research Unit which is based at the Glenfield Hospital in Leicester. Professor Brightling said A unique feature of this study was how it included measurements of symptoms lung function using breathing tests sampling of the airway wall and CT scans of the chest to give a complete picture of how the new drug works.  Most treatments might improve some of these features of disease but with Fevipiprant improvements were seen with all of the types of tests. We already know that using treatments to target eosinophilic airway inflammation can substantially reduce asthma attacks.  This new treatment Fevipiprant could likewise help to stop preventable asthma attacks reduce hospital admissions and improve daytoday symptoms making it a game changer for future treatment. Gaye Stokes from Grantham in Lincolnshire has had severe asthma for  years. She took part in the trial and was part of the Fevipiprant group. The yearold said I knew straight away that I had been given the drug. I felt like a completely different person. I had more get up and go I was less wheezy and for the first time in years I felt really really well.  For me it felt like a complete wonder drug and I cant wait for it to be available because I really think it could make a huge difference to me. After the  week trial and Gaye stopped receiving the drug she said her health started to go downhill again very quickly.  Professor Brightling added that the latest advance underpinned the work of the Leicester Precision Medicine Institute a Centre of Excellence that coalesces and aligns the research missions of the University of Leicester and the NHS in Leicester.  Future treatment of human disease will increasingly move from a one size fits all approach to one of tailoring the treatment to the individual patient.  Asthma is a longterm condition that affects the airways. When a person with asthma comes into contact with something that irritates their sensitive airways it causes the body to react in several ways which can include wheezing coughing and can make breathing more difficult.  The NIHR Leicester Respiratory Biomedical Research Unit  a partnership between the University of Leicester and Leicesters Hospitals  focuses on promoting the development of new and effective therapies for the treatment of respiratory diseases including severe asthma and chronic obstructive pulmonary disease COPD. AirPROM stands for Airway Disease Predicting Outcomes through Patient Specific Computational Modelling.  This is the technical name for the five year Europewide EU funded project which aimed to produce computer and physical models of the whole human airway system for people with asthma and chronic obstructive pulmonary disease COPD.  AirPROM has demonstrated how an integrated approach involving modelling measurement and clinical validation can accelerate the development of new therapies and improve existing methods.  AirPROM is led by the University of Leicester and coordinated by Professor Brightling. If media wish to link to the paper once its published they can use the following link which will go live when the embargo lifts http"