"Necator americanus the New World hookworm is as long and thin as a vermicelli noodle. It will slip under your skin and travel through the blood to your trachea where you will swallow it and give it a free ride to your small intestine. Upon arrival it will open its tiny jaw dig its teeth into your intestinal wall and begin to drink your blood. And it could be the key to making millions of people healthier. Writing in the journal Science Translational Medicine on Wednesday scientists report that a protein produced by hookworms eases the symptoms of asthma in mice  and could one day be made into a pill to treat humans. The study is the latest from a surprising field of research into the potentially positive sides of parasites one of the most maligned groups in the animal kingdom. It began years ago when a gastroenterology surgeon approached parasitologist Alex Loukas httpsresearch.jcu.edu.auportfolioalex.loukas one of the senior authors on the new study. The doctor wanted to know whether there might be a connection between the dramatic success of deworming programs around the world and the rise of immune system problems like asthma and celiac disease. If you look at the data that comes in from immunological studies . . . where you remove the parasites thats where you see the highest incidence of autoimmune diseases and allergies said Severine Navarro httpsresearch.jcu.edu.auportfolioseverine.navarro the papers lead author and a senior research fellow in Loukass lab at James Cook University in Australia. Dear Science Why do we get allergies Whats the point of a runny nose https_term.bcb  Many parasites have evolved the ability to hide from their hosts immune systems. When a hookworm crawls into a human it secretes chemicals that turn off the immune alarm bells and repair the tissue around it. It limits its consumption of blood to a few drops a day and doesnt leave its offspring scattered all over its hosts gut. Instead it thoughtfully plants them in the hosts poop to ensure an orderly exit from the body. Like a very conscientious cat burglar the hookworm knows its best served by not making a mess. Its almost symbiotic Navarro said because in order for it to survive and thrive it needs its host to be happy and healthy. Perhaps the adaptations that help the parasites stay hidden also benefit their host by reining in overactive immune systems. Thinking that they might be onto something the researchers found  adults with celiac disease  a serious genetic disorder that causes an autoimmune response to gluten  who volunteered to have doctors infect them with a slimy slithery hookworm. It was important that the participants be adults because even relatively benign parasites can cause serious problems for children pregnant women and others. Navarro also warned people with autoimmune disorders that they should not attempt to infect themselves with a hookworm no matter how debilitating their illness might be. Parasites are no joke. For the dozen trial https participants the hookworm did improve their tolerance of gluten. It was an intriguing result but its difficult to scale that kind of study. Only so many people are willing to have a parasite put inside them for science. And because of the risks associated with parasites going around infecting people isnt a viable treatment option. Dear Science How many germs are actually on a toilet seat  and should I care httpwpo.stzEH  So Navarro and her colleagues isolated the active ingredient in hookworm spit  a compound called AIP  and injected it into asthmatic mice on a daily basis for five days. The animals asthma systems substantially declined and their airways became measurably less inflamed. These benefits persisted for  weeks after the mice stopped getting the treatment  I dont even know how much that is in mouse years Navarro said. The researchers also noticed that AIP seemed to have a calming effect on the bodys dendritic cells http  a part of the immune system responsible for processing threats. It is basically rewiring the cells in that tissue into promoting very efficient regulatory T cells Navarro said describing the cells that help modulate the immune system. This suggests that AIP might also help humans since dendritic cells have the same function in us that they do in mice. Navarro said their next step is a phase one clinical trial which would test the effectiveness of an AIP pill. Should that work it has the potential to help the  million people around the world who suffer from asthma. The compound might also be used to treat other autoimmune disorders like celiac disease inflammatory bowel disease and multiple sclerosis. This study would also suggest that humans lost something when we rid ourselves of the microbes and parasites that had evolved alongside us for tens of thousands of years. Theres a major school of thought that says that these parasites should be encountered early in life to contribute to the education of the immune system Navarro said. She wouldnt go so far as to call parasites good. Deworming campaigns and other public health efforts unquestionably have protected countless people from anemia malnutrition developmental disorders and potentially deadly infections. But what we need is to find whats good in them she said and try to restore that missing component."