"This is cancer therapy at its most aggressive a treatment patients liken to being filleted disemboweled and then bathed in hot poison. The therapy which couples extensive abdominal surgery with blasts of heated chemotherapy to the abdominal cavity and its organs was once a niche procedure used mainly against rare cancers of the appendix. Most academic medical centers shunned it. More recently as competition for patients and treatments intensifies an increasing number of the nations leading medical centers has been offering the costly  and controversial  therapy to patients with the more common colorectal or ovarian cancers. And some hospitals are even publicizing the treatment http as a hot chemo bath. To critics the therapy is merely the latest example of one that catches on with little evidence that it really works. Were practicing this technique that has almost no basis in science said Dr. David P. Ryan clinical director of the Massachusetts General Hospital Cancer Center. But to some patients the procedure however grueling and invasive represents their best hope for survival Its throwing everything but the kitchen sink at cancer said Gloria Borges a yearold Los Angeles lawyer who had her colon cancer treated with what she called the pick it out pour it in procedure. If it were our motherfathersisterbrotherchildbest friend what price would we put on the additional daysweeksmonthsyears of Life... For hours on a recent morning at the University of California San Diego Dr. Andrew Lowy painstakingly performed the therapy on a patient. After slicing the mans belly wide open he thrust his gloved hands deep inside and examined various organs looking for tumors. He then lifted the small intestine out of the body to sift it through his fingers. As he found tumors he snipped them out. You can see how this is coming off like wallpaper Dr. Lowy said as he stripped out part of the lining of the mans abdominal cavity. After about two hours of poking and cutting Dr. Lowy began the socalled shake and bake. The machine pumped heated chemotherapy directly into the abdominal cavity for  minutes while nurses gently jiggled the mans bloated belly to disperse the drug to every nook and cranny. The treatment is formally called cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy or Hipec. Recent converts include University Hospitals Case Medical Center in Cleveland Montefiore Medical Center in the Bronx and even Massachusetts General. The Memorial SloanKettering Cancer Center is looking at it according to people in the field. Advocates predict that the number of procedures could grow to  a year from about  now. The therapy has even been featured on an episode of the TV series Greys Anatomy. But Dr. Ryan a gastrointestinal oncologist suggested in an interview that the procedure was being extended to colorectal cancer because you cant make a living doing this procedure in appendix cancer patients. He debated the procedure http_session_presentations_viewconfIDtrackIDsessionID publicly at the recent annual meeting of the American Society of Clinical Oncology. While some patients did seem to live much longer than expected he said that they had been carefully selected and might have fared well even without the therapy. Proponents say that if cancer has spread into the abdominal cavity but not elsewhere then lives can be prolonged by removing all the visible tumor and killing whats missed with Hipec. By contrast said Dr. Paul Sugarbaker a surgeon at Washington Hospital Center and the leading proponent of Hipec there are no longterm survivors with systemic chemotherapy  zero. Dr. Sugarbaker who opposed Dr. Ryan in the debate said that it has long been known that cancerous cells are unable to withstand as much heat as healthy cells. And putting the chemotherapy on top of tumors should be more effective than systematically delivering it through the bloodstream. One randomized trial httpjco.ascopubs.orgcontent.full done more than a decade ago involving  patients in the Netherlands did show a striking benefit. The median survival of those getting surgery and Hipec plus intravenous chemotherapy was . months almost double the . months for those getting only the intravenous chemotherapy. But  percent who got the surgery and Hipec died from the treatment itself. And critics say that since that trial was conducted new drugs have come to market that allow patients with metastatic colorectal cancer to live two years with intravenous chemotherapy alone. A new trial in the United States has been temporarily suspended so that researchers can find a way to recruit patients. After nearly a year only one patient had enrolled because people were reluctant to chance winding up in the control group according to one of the investigators. While proponents contend that the risk of dying from the surgery has been reduced since the Dutch trial the procedure still lasts eight hours or more and full recovery can take three to six months. Its maximally invasive said Dr. Sugarbaker who often removes the spare parts  organs a patient can live without like the spleen the gall bladder the ovaries and the uterus. The cost of the surgery and Hipec including hospitalization ranges from  to more than  doctors said. While Medicare and insurers generally pay for the operation the heated treatment may not be covered. But doctors added it may be if it is described merely as chemotherapy. Some patients like Ms. Borges who is a fitness devotee recover well and say the procedure staved off a death sentence. But Dr. Alan Venook a colon cancer specialist at the University of California San Francisco said that a couple of patients referred by him had died miserable deaths. One lost much of her abdominal wall to infection and just died in misery. Another risk is that the surgery may be done unnecessarily. CT scans cannot pick up many of the small tumors so it is often unclear how much cancer is inside until the patient is opened. In June Dr. Lowy sliced open a woman and saw to his horror that she had more tumors than he could remove. Taking out only some would not improve her chances of survival so he closed the incision and she is now starting intravenous chemotherapy. Things with the male patient Andy S. went better. A yearold father of two from near San Francisco Mr. S. agreed to let a reporter observe the surgery but asked that his full name not be published because he did not want his cancer history to surface through Web searches. Mr. S. had abdominal pain eventually diagnosed as appendicitis. But the appendix was found to be cancerous. Such cancers typically spew mucus containing tumor cells into the abdominal cavity. So he signed up for surgery and Hipec with Dr. Lowy. Ive had to say my goodbyes to everybody Mr. S. said the day before the operation. I had to talk to my priest. I had to do all these things I never thought Id have to do at . I wouldnt wish it on my worst enemy but I have to go through with it. Dr. Lowy explored the entire cavity from the diaphragm to the pelvis. He found mucus in several spots that he sopped up with a cloth and also tiny tumors the size of a pencil eraser that had implanted in several spots. He snipped those out and sewed up the wounds. He removed the right side of the mans colon and the omentum a fatty structure. Then two Yshaped tubes hooked to the Hipec machine were inserted into the abdominal cavity one to deliver the chemotherapy and the other to bring the drug back to the machine to be reheated. The incision was sewn up around the tubes so the chemotherapy would not leak. The mans belly was filled with three liters of saline fluid and the chemotherapy a generic drug called mitomycin C heated to  degrees Celsius or nearly  degrees Fahrenheit. Any hotter could have caused injuries. Bloated with liquid the mans torso resembled a water bed. After  minutes the fluid was drained and the incision reopened for a final check before the patient was stitched up. The procedure took six hours. We got all of the visible disease and he didnt have a lot of visible disease Dr. Lowy said with satisfaction. Mr. S. left the hospital eight days later happy to have undergone the treatment. I want to have the best chance I can have to never see this again he said."