"Robert Bush has multiple sclerosis MS which sapped his ability to walk five years ago. Joseph McGlynn suffered a stroke that seriously impaired his left side also five years ago. Using technology designed by Case Western Reserve University and the Advanced Platform Technology and Functional Electrical Stimulation centers at the Louis Stokes Cleveland Veterans Affairs Medical Center the two men got their feet back under them. Two studies published in the American Journal of Physical Medicine and Rehabilitation show that functional electrical stimulation FES significantly helped McGlynn and Bush to effectively walk at the medical center. I went in there and I could barely take two steps said Bush  who researchers believe is the worlds first MS patient to testdrive an implanted FES system. The proofoffeasibility test lasted  days. At the end said Bush of Columbus Ohio I was walking down the hallway. To me it was monumental. A video of him walking with and without the system can be found at httpsyoutu.beJYaKkdRYs. McGlynn  of North Royalton Ohio could walk with a cane but not easily. With the technology switched on he covered far more ground and his pace was twice as fast during his week study.  Its helped with balance and confidence said McGlynn who used to tread a lot of stairs maintaining equipment at a steel plant. Im confident now that I can walk without stumbling and falling. A video of him walking with and without aid of the system can be found here httpsyoutu.beCYqFSFQLM. Nathan Makowski an investigator at the Cleveland FES Center created by Case Western Reserve and the Cleveland VA said that FES technology has been used primarily for therapy in stroke patients in the past. This though is a more longterm assistive system he said.  Addressing needs  The researchers hope these studies will lay the foundation for implanted systems that restore some independence to people with MS or who have suffered a stroke.  Their numbers are substantial. The National Multiple Sclerosis Society estimates that more than . million people have the disease worldwide. Surveys have found that  percent suffer gait impairment within  years of diagnosis and  percent report they are unable to walk twice a week. Other research has found that  million to  million people live with stroke nationally and nearly  percent require assistance to walk.  In both cases there is a disconnect between the brain and muscles said Stephen Selkirk MD a neurologist at the VAs Spinal Cord Injury Division and assistant professor of neurology at Case Western Reserve School of Medicine. This system replaces the lost connection. The system includes implanted electrodes that tie into nerves that control muscles collectively called hip and knee flexors and ankle dorsoflexors. In healthy people the muscles work in seamless coordination each step they take.  When Bush or McGlynn walks he pushes a button on an external controller which sends signals to a pulse generator which then sends electrical pulses to the electrodes. The pulses stimulate the nerves which in turn stimulate the muscles in both of Bushs legs and McGlynns left leg. Both guys were taking steps the first time we turned the systems on said Ron Triolo a professor of orthopaedics and biomedical engineering at Case Western Reserve and executive director of the Advanced Platform Technology APT Center. When Robert Bush took a step it wasnt pretty but we saw the potential. In each patient the pulses are sent in a pattern that is close to how normal muscles work said Rudi Kobetic a principal investigator at the Stokes Cleveland VA and APT Center. We try to time the pattern to stimulation so that its integrated with their ability. Similar to regular physical therapy we can see results. Significant improvement Both men gained strength and endurance through repeated use of the systems and finetuning by the researchers. Bush went from the two steps to consistently walking more than  yards during the trial. In that time he used a walker to help maintain his balance. When they turned it on the first time I was surprised how well it worked said Bush who had to give up his construction career due to the disease. I lifted my knee like I was highstepping. Once we got it finetuned and I got walking I thought it was amazing. I still think its amazing. McGlynns gait became noticeably more symmetrical and energetic the researchers said. His gait without the system was about  yards per minute with the system  yards per minute. Training with the system improved McGlynns speed when it was turned off to  yards per minute indicating therapeutic benefit. Distance is a challenge he said. Initially he could walk  yards but improved to  yardsnearly a mileat the faster gait. I work up a good sweat and that makes me feel good he said. Due to his improvements the research team is developing a system that McGlynn can use at home and outside.  Ill be able to walk for exercise and hopefully be able to walk into church and into a restaurant McGlynn said. When Bushs trial ended surgeons removed his implanted electrodes. The researchers are seeking funding to fit him with a permanent FES system in a clinical trial. In the meantime Bush is now back to using a wheelchair but working to maintain his strength and flexibility repeatedly standing and sitting while holding onto a rail or standing for long periods of time. Im keeping things ready for when they get the green light he said.  Other researchers who contributed to the two studies are the APT Centers Lisa Lombardo physical therapist Kevin Foglyano biomedical engineer and Gilles Pinault MD a surgeon and codirector of the center."