"GenomeDx Biosciences today announced that a study featured on the cover of Urology demonstrates that Decipher Prostate Cancer Classifier significantly influenced treatment recommendations following prostate surgery reducing disagreement between urologists and radiation oncologists and has the potential to enhance personalization of patient care. Decipher is a Medicarecovered genomic test capable of predicting tumor aggressiveness in men following prostate surgery. The study titled Impact of a Genomic Classifier of Metastatic Risk on Postprostatectomy Treatment Recommendations by Radiation Oncologists and Urologists http was published in this months issue of Urology.  Conflicting treatment recommendations by different specialists looking at the same disease can be highly confusing for patients and is a problem for the health care system in general said Paul Nguyen M.D. of DanaFarberBrigham and Womens Cancer Center and Harvard Medical School. The Decipher tests tendency to make the two specialties more concordant in their treatment recommendations provides significant value toward standardizing care for patients. The study was designed to evaluate how the Decipher Prostate Cancer Classifier which predicts the risk of metastasis after prostatectomy would impact adjuvant treatment recommendations made by urologists and radiation oncologists. These two specialties often disagree on which patients should receive radiation therapy following surgery and when.  Using clinical information alone observation rather than adjuvant radiation therapy was recommended in  of decisions made by urologists and  of decisions by radiation oncologists P  .. The Decipher test results altered  and  of treatment recommendations made by urologists and radiation oncologists respectively. Decipher results indicating genomic high risk resulted in intensification of treatment whereas genomic low risk resulted in less aggressive recommendations. The Decipher results increased agreement in treatment recommendations between urologists and radiation oncologists as the odds of a recommendation for adjuvant treatment by urologists vs radiation oncologists increased from .  CI .. to .  CI .. after results of the Decipher test were made available. It is notable that while the Decipher test significantly influenced treatment decisions it did not increase the total number of people receiving adjuvant therapy suggesting that it helped ensure that the ones selected for adjuvant therapy are the ones most likely to benefit from it said Doug Dolginow M.D. chief executive officer of GenomeDx. As genomic tests like Decipher become used more routinely in urologic cancer patient care they will have a greater impact on treatment recommendations in clinical practice and allow for better personalization of therapy. The Decipher test used in this study has been previously described in multiple blinded independent validation studies in men at high risk of recurrence at the time of prostatectomy. Researchers found that  of the clinically highrisk men would be reclassified as low risk based on the Decipher test and have only a . risk of metastasis at  years after surgery. In addition the  of the patients with the highest risk based on Decipher had a nearly fold higher risk of distant metastases by  years. The test provided a more accurate and precise estimate of a patients risk of recurrence. Use of this test therefore has the potential to assist clinicians to better direct utilization of secondary therapy after surgery. About Decipher The Decipher Prostate Cancer Classifier is a highly validated and commercially available genomic test for men with intermediate and high risk prostate cancer. Decipher predicts cancer aggressiveness by looking for a unique genomic signature comprised of a validated series of biomarkers associated with metastatic disease. Adding truly unique information to the treatment decisionmaking process Decipher generates a risk result that is completely independent and distinct from PSA Gleason score and other clinical risk factors. Clinical studies from leading cancer centers published in over a dozen medical journals demonstrate that Decipher can accurately predict metastatic disease which men may benefit from radiation therapy following prostate surgery and can lead to significant costsavings for healthcare systems. Decipher was developed in partnership with the Mayo Clinic. Decipher is covered by Medicare and multiple private insurance plans in the US. Learn more at  http and follow Decipher on Twitter DecipherTest http and on Facebook. About GenomeDx Biosciences GenomeDx Biosciences is focused on transforming cancer patient care by putting usable genomic information in the hands of patients and their physicians. GenomeDx is developing and commercializing Decipher a highly validated genomic test for predicting metastatic disease in men with prostate cancer. In partnership with leading medical centers the company has assembled the largest genomic catalogue of prostate cancer tumors in the world representing billions of data points and more than  years of prostate cancer research expertise. Using advanced cloudbased bioinformatics GenomeDx mines the genomic data to develop proprietary tests that address key clinical questions in cancer patient management. GenomeDx has partnered to share genomic data with leading clinicianscientists worldwide to collaboratively enrich the knowledge and understanding of urologic cancers for the goal of improving global cancer patient care. GenomeDx is based in San Diego California and Vancouver British Columbia. Learn more at  http and follow us on Twitter at Twitter GenomeDx http Facebook LinkedIn httpca.linkedin.comcompanygenomedxbiosciencesinc. and YouTube http Media Contact for GenomeDx Biosciences Ian Stone Canale Communications  iancanalecomm.com mailtoiancanalecomm.com SOURCE GenomeDx Biosciences Related Links httpgenomedx.com"