"In a finding that is being widely hailed as the first major prevention breakthrough in the AIDS era researchers have shown that taking a single daily pill containing two HIV drugs can reduce risk of contracting the virus by an average of   and by more than  if the subjects take most of their pills. The study involved nearly  highrisk gay men but experts hope that the results will be applicable to other populations considered at risk for contracting the virus. Several studies are already underway to determine if that is the case. The findings reported online Tuesday in the New England Journal of Medicine come only a few months after an African study showed that a microbicidal gel httplat.msbcHiNw can help protect women from contracting the virus and a little more than a year after a vaccine trial suggested that it may eventually be possible to raise antibodies httplat.msxBeU against the virus. To see all these prevention strategies come together we can begin to see an end to the epidemic said A. Cornelius Baker of the Presidential Advisory Council on HIVAIDS. The National AIDS Strategy introduced by the president in July called for reducing the U.S. epidemic by .  If we can prove this works and get this strategy into the communities we can reach that goal much quicker than we had anticipated and move even further to more goals.   Dr. Anthony S. Fauci director of the National Institute of Allergy and Infectious Diseases which was the major sponsor of the study cautioned however that No single prevention strategy is going to be effective for everyone and it is important to note that the new findings pertain only to  men who have sex with men. Experts agreed however that there is no reason to think that it would not be successful in other groups although it must be tested. The new strategy is called preexposure prophylaxis and that is an approach that has been used successfully in certain other diseases. Malaria or tuberculosis drugs for example are frequently prescribed to people entering areas with high transmission rates. Antiretroviral drugs are also used to prevent transmission of HIV from mothers to infants during and after birth and in an effort to prevent infection after accidental exposure in hospitals and laboratories. The new study called iPrEx was conducted by an international team headed by Dr. Robert M. Grant of the Gladstone Institute of Virology and Immunology at UC San Francisco and Dr. Javier R. Lama of Investigaciones Medicas en Salud in Lima Peru. They enrolled  men and transgender women who have sex with men at  sites in six countries. Half were given a daily dose of Truvada a pill containing the AIDS drugs emtricitabine and tenofovir and half a placebo. Truvada was chosen because it is effective has few side effects and is already used by more than . million people worldwide. Subjects were followed for an average of  months and given counseling about using condoms and safe sex practices. The researchers observed  HIV infections in the group taking Truvada compared to  in the control group taking placebo a reduction of .. The reduction in risk however was very sensitive to how regularly the subjects took the medication. For those who took it on more than  of the days as determined by pill counts and other measures the risk fell by .. For those who took it  or more of the days the risk fell by .. Side effects of the drug were mild and included nausea in the first month small increases in serum creatinine and unintentional weight loss. The subjects will be followed for another  months to monitor for longterm effects. In a separate study now underway the drug is being tested in women. In separate arms of that study researchers are also testing tenofovir only and a gel containing tenofovir. More information is available at the trials official website iPrExNews.com http"