"A study led by McMaster University researchers has found that contrary to recent reports flu nasal sprays provide similar protection against influenza as standard flu shots. Published today in the scientific journal Annals of Internal Medicine the study shows that the nose spray had a similar effect to the standard flu shot. Previous recommendations from the Centers for Disease Controls Advisory Committee on Immunization Practices ACIP had previously called for nasal sprays or live attenuated influenza vaccine LAIV not be used during the  flu season.  Dr. Mark Loeb lead author of the study says his teams findings challenge the ACIPs recommendations towards flu shots or inactivated vaccines. Our study is the first blinded randomized controlled trial to compare the direct and indirect effect of the live vaccine versus the inactivated vaccine said Loeb a professor in McMasters Department of Pathology and Molecular Medicine. Our results are important because in previous years the live vaccine had first been preferred for children. In fact as late as June  the live vaccine was preferred. Then subsequently it was no longer preferred and now not recommended at all. Our trial showed no difference between the two in protecting entire communities. For the study Loebs team conducted a threeyear trial in a Hutterite colony where people live communally and are relatively isolated from cities and towns to determine whether vaccinating children and adolescents with the flu nasal spray provided better direct and community protection than the standard flu shot.  The researchers randomly assigned  children in  Hutterite colonies in Alberta and Saskatchewan Canada to receive either the nasal spray vaccine or the flu shot and also followed  community members who did not receive a flu vaccine.  Average vaccine coverage among children in the nasal spray group was . per cent versus . per cent in the flu shot group.  The original intention of the study was to show that nasal spray vaccines would provide better protection than flu shots but Loeb says the conclusions of the study are now especially important given the ACIPs recommendations. The ACIPs decision was an unprecedented decision in influenza vaccine policymaking for children. Our study challenges previous studies because our results show conclusively that the vaccines show similar protection when both direct and indirect effects are taken into account. Loeb says his team will continue to study herd immunity with different vaccine formulations by vaccinating children. They are also looking at the effect of repeated vaccination of children.  This study was funded by the Canadian Institutes for Health Research. A downloadable photo of Dr. Mark Loeb is available here httpadobe.lybhVxEM To book an interview please contact Veronica McGuire"