"Standard guidelines for stroke treatment currently recommend clot removal only within six hours of stroke onset. But a milestone study with results published today in the New England Journal of Medicine shows that clot removal up to  hours after stroke led to significantly reduced disability for properly selected patients.    The international multicenter clinical study known as the DAWN trial randomly assigned  stroke victims who arrived at the hospital within six to  hours to either endovascular clot removal therapy known as thrombectomy or to standard medical therapy.    Thrombectomy involves a catheter placed in the femoral artery and snaked up the aorta and into the cerebral arteries where the clot that is blocking the artery and causing the neurological symptoms is retrieved.    Almost half of the patients . percent who had clot removal showed a considerable decrease in disability meaning they were independent in activities of daily living  days after treatment. Only . percent of the medication group had a similar decrease. There was no difference in mortality or other safety endpoints between the two groups.    These findings could impact countless stroke patients all over the world who often arrive at the hospital after the current sixhour treatment window has closed says coprincipal investigator Raul Nogueira MD professor of neurology neurosurgery and radiology at Emory University School of Medicine and director of neuroendovascular service at the Marcus Stroke  Neuroscience Center at Grady Memorial Hospital.    When the irreversibly damaged brain area affected by the stroke is small we see that clot removal can make a significant positive difference even if performed outside the sixhour window says coprincipal investigator Tudor Jovin MD director of the University of Pittsburgh Medical Center Stroke Institute. However this does not diminish urgency with which patients must be rushed to the ER in the event of a stroke. The mantra time is brain still holds true.    To select patients for the trial the researchers used a new approach which used brain imaging and clinical criteria as opposed to just time alone.    Looking at the physiological state of the brain and evaluating the extent of tissue damage and other clinical factors seems to be a better way to decide if thrombectomy will benefit patients as opposed to adhering to a rigid time window says Nogueira.    The researchers planned to enroll a maximum of  patients over the course of the study period. However a preplanned interim review of the treatment effectiveness after  patients were enrolled in the trial led the independent Data Safety Monitoring Board overseeing the study to recommend early termination of the trial based on predefined criteria demonstrating that clot removal provided significant clinical benefit in the studied patients.    Our research and clinical teams are immensely proud of these breakthrough findings which are so profound they will likely result in a paradigm shift that will not be seen again for many years in the field of stroke therapeutics says Michael Frankel MD professor of neurology Emory University School of Medicine chief of neurology and director of the Marcus Stroke and Neuroscience Center for the Grady Health System.    According to Frankel the Emory neuroscience team was a major contributor to the DAWN trial working at Grady Memorial Hospital the second leading site of the trials enrollment.    The DAWN trial included trial locations in the United States Spain France Australia and Canada. The trial was sponsored by Stryker Corporation a medical technology company that manufactures the clot removal devices used in the study.    The DAWN trial results were presented at the European Stroke Organization Conference in May."