"The first laser treatments used to treat skin conditions such as benign vascular birthmarks and portwine stains were developed more than  years ago. Since then clinicians and dermatologists have seen a rise in demand for minimally invasive laserbased treatments including tattoo removal. However it is difficult for the laser light which is held at a distance from the skin to be perfectly and selectively absorbed by only the targeted birthmark or tattoo. Now researchers from the University of Missouri have developed instruments that transmit laser light into the tissue through direct contact. The techniques developed by the interdisciplinary team can be used by dermatologists and will reduce safety concerns in laser dermatology by improving laser transmission through surface layers of the skin. Laser techniques come with risks including eye damage. Openair transmission in which the clinician holds the laser at a distance from the patient is typical during normal dermatological procedures and presents a hazard to both the patients and doctors eyes. Paul J.D. Whiteside a doctoral candidate in the MU Division of Food Systems and Bioengineering devised a system that will not only improve the process but will be safer for both clinicians and patients. The system we developed uses ultrasonic pulsation in conjunction with a clinical laser to alter the properties of skin tissues during the procedure Whiteside said. Weve named the technique sonoillumination and were hopeful that the procedure will be available widely in the near future. Whiteside and his team including adviser Heather K. Hunt httpengineering.missouri.edupersonhunth an assistant professor of bioengineering in the MU College of Engineering httpengineering.missouri.edu tested the sonoillumination system on porcine skin tissue samples. Using various amplitudes and pulses the instruments they developed were tested on the samples and showed great promise for the clinical setting. Whiteside presented his technique to clinicians on April   at the annual conference of American Society for Laser Medicine and Surgery ASLMS. Pork skin samples are very close to human skin samples so the initial results we saw are promising for human applications Hunt said. Sonoillumination will be extremely beneficial for clinicians and the ASLMS presentation allowed us to demonstrate the system to the people who actually will be using the technology once its commercialized. Nicholas Golda httpmedicine.missouri.edudermatologygoldan.php associate professor of dermatology and director of dermatology surgery at the MU School of Medicine httpmedicine.missouri.edu echoed the merits of the sonoillumination system and the effect it will have on dermatology. Our goal is to provide patients with safer more effective treatment options that potentially lower the number of treatments needed Golda said. This new technology may also provide physicians with a safer more controllable option for treating patients. The team coauthored the paper Ultrasonic modulation of tissue optical properties in ex vivo porcine skin to improve transmitted transdermal laser intensity which recently was accepted for publication by the societys journal Lasers in Surgery and Medicine. The sonoillumination research was funded in part by a  Fast Track grant from the University of Missouri System. The team is in the planning stages of developing a startup company to commercialize the technique. Products produced by Whiteside and the team highlight the Universitys impact on the states economic development efforts including commercialization of research conducted at Mizzou workforce development and job growth quality of life improvements for residents and attracting corporations and businesses to the state. Over the last five years companies commercializing MU technologies have secured hundreds of millions of dollars in investments and grants to advance their commercialization efforts. In  the Office of Technology Management and Industry Relations reported that Mizzou received . million in revenue from more than  technology licenses. The MU bioengineering department is jointly affiliated with College of Agriculture Food and Natural Resources httpscafnr.missouri.edu CAFNR and the College of Engineering httpengineering.missouri.edu. Editors Note For more information on the patent application for sonoillumination please see https"