"Researchers at the Childrens Hospital of Eastern Ontario CHEO looked at the incidence of and risk factors associated with sedationrelated adverse events in pediatric emergency departments as part of a multicentre observational study published today in JAMA Pediatrics. When children and youth present at an emergency department and require an immediate painful procedure it is standard to sedate the patient so they can tolerate the treatment. Procedural sedation is commonly used for painful or uncomfortable procedures like setting fractures repairing lacerations and draining abscesses in emergency departments worldwide. Although sedationrelated serious adverse events occur infrequently recognition and early intervention is necessary to ensure patient safety said Dr. Maala Bhatt lead author director of pediatric emergency research at CHEO and assistant professor at the University of Ottawa. Weve been able to identify sedation medications and practices associated with the best clinical outcomes which is practicechanging. According to the authors this study represents the largest and most robust prospective emergency department procedural sedation cohort to date. It includes children from six emergency departments across Canada sedated with six different medication combinations.  The results of the study show that choice of sedation medication had the biggest impact on the incidence of adverse events and need for significant interventions in response to those events. The incidence of serious adverse events was lowest among patients sedated with ketaminealone and highest among patients sedated with combination drugs ketamine plus propofol or fentanyl.  The overall incidence of adverse events in the study population was .. The most common events were a decrease in oxygen saturation . and vomiting .. Significant interventions in response to an adverse event were rare occurring in only . of children. Two other practices  receiving an opioid prior to sedation and having a laceration repair  were associated with the occurrence of vomiting oxygen desaturation and need for significant interventions.  The low rate of serious adverse events and significant interventions supports the safety of procedural sedation in the hands of emergency department physicians said Dr. Bhatt. While all sedation medications and combination of medications are effective and safe in the hands of experienced providers ketaminealone is associated with the fewest serious adverse events and significant interventions making it a logical choice for providing procedural sedation for children in emergency departments.   Coauthors include Drs. Maala Bhatt David W. Johnson Jason Chan Monica Taljaard Nick Barrowman Ken J. Farion Samina Ali Suzanne Beno Andrew Dixon C. Michelle McTimoney Alexander Sasha Dubrovsky Nadia Sourial and Mark G. Roback for the Sedation Safety Study Group of Pediatric Emergency Research Canada PERC. This study was funded by a Canadian Institutes of Health Research CIHR team grant in Pediatric Emergency Medicine. About the CHEO Research Institute  The CHEO Research Institute coordinates the research activities of the Childrens Hospital of Eastern Ontario CHEO and is affiliated with the University of Ottawa. Its three programs of research include molecular biomedicine health information technology and evidence to practice research. Key themes include cancer diabetes obesity mental health emergency medicine musculoskeletal health electronic health information and privacy and genetics of rare disease. The CHEO Research Institute makes discoveries today for healthier kids tomorrow. For more information visit http"