"This could be good news for those trying to prevent preterm labor New research published online in The FASEB Journal http suggests that exposing bitter taste receptors in the uterus to certain substances can stop many unwanted contractions that occur during premature labor.  The biological mechanism of labor initiation remains unknown and a large percentage of preterm pregnancies do not respond well to current medications said Ronghua Zhuge Ph.D. associate professor within the University of Massachusetts Medical Schools Department of Microbiology and Physiological Systems in Worcester Massachusetts. The bitter taste receptors that we have found on uterine muscle could be one more piece of the puzzle to understand the onset of labor both at term and preterm and develop new therapeutics for preterm labor.  Zhuge and colleagues attached strips of human and mouse uterine myometrium tissue also known as smooth muscle to a machine that measured their contraction efforts. The researchers first exposed the tissue to native hormones such as oxytocin and chemical compounds to make it contract mimicking normal or premature labor. They then exposed the tissue to bitter substances. By activating the bitter taste receptors in the uterus the bitter substances relaxed the contracted uterine muscle tissue more completely than the current drugs used to prevent preterm labor in humans. The researchers also found that giving mice bitter substances before they showed any premature contractions prevented them from having early deliveries.   Submit to The FASEB Journal by visiting httpfasebj.msubmit.net and receive monthly highlights by signing up at http The FASEB Journal is published by the Federation of the American Societies for Experimental Biology FASEB. It is the worlds most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top  most influential biomedical journals of the past century. FASEB is composed of  societies with more than  members making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy. Details Kaizhi Zheng Ping Lu Ellen Delpapa Karl Bellve Ruitang Deng Jennifer C. Condon Kevin Fogarty Lawrence M. Lifshitz Tiffany A. Moore Simas Fangxiong Shi and Ronghua Zhuge. Bitter taste receptors as targets for tocolytics in preterm labor therapy. FASEB J. doi.fj.RR  http"