"Two new studies have documented the value of the BioZorb marker in improving the treatment of women who have breast cancer http The first study a peerreviewed article appearing in the World Journal of Surgery httplink.springer.comarticle.Fsy outlines how the threedimensional bioabsorbable marker provides more accurate targeting of the cancer tumor bed for radiation treatment when implanted during surgery.   Breast surgeon Michael J. Cross lead author of the World Journal of Surgery study holds BioZorb a novel marker implanted in the tumor bed during breast cancer surgery.  The article reports that the device provides clear visualization of the surgical site where the tumor was removed thereby improving communication between the surgeon and radiation oncologist. The study also noted that the device provides a helpful guide for posttreatment mammograms and other longterm followup to check for any cancer recurrence in these patients. A second study presented at the American Society for Radiation Oncology ASTRO  annual conference describes the extra utility that BioZorb can provide by significantly reducing the amount of normal breast and surrounding tissues that are exposed to radiation treatment. The World Journal of Surgery article by lead author breast surgeon Michael J. Cross concluded that the D marker is an effective method for delineating the tumor bed with a significant utility for RT radiation therapy planning.  In the course of this threeyear study Dr. Cross and colleagues also documented a favorable shift toward use of hypofractionated radiation treatment a shorter form of radiation associated with a substantial reduction in treatment costs. Through our experience with this marker weve observed that its use results in less radiation dose to the patient compared to whole breast radiation plus a better overall cosmetic outcome said Dr. Cross a nationally known breast surgeon at Breast Treatment Associates in Fayetteville Ark. We were also pleased to note in our research that there were no devicerelated complications in this group of patients and that none of them had a recurrence of cancer. The BioZorb device is placed during lumpectomy surgery http which removes the cancer and preserves the breast. It is the first and only device that identifies in a reliable way the D region where the tumor was removed. It is particularly effective because by suturing the implant to the tumor bed the surgeon can more precisely indicate to the radiation oncologist where the cancer was located. Dr. Cross notes that because of the markers unique configuration it can also assist with reconstructing the surgical region during the healing process. The implantable marker consists of a framework made of a bioabsorbable material that holds six titanium clips. The framework slowly dissolves in the body over the course of a year or more. The tiny marker clips stay in place so the surgical site can be viewed for longterm monitoring such as mammograms.  As part of the research for the World Journal of Surgery study  patients with earlystage breast cancer were prospectively implanted with the marker during reconstructive lumpectomy a method of oncoplastic surgery to remove the cancer while reconstructing the remaining breast to improve cosmetic outcomes. The average age of women in the study was  years.  The authors concluded that the marker was helpful for several different types of physicians involved in the care of women with breast cancer surgeons radiation oncologists who plan and oversee radiation treatment and radiologists who follow women after breast cancer treatment. The article also noted that there was a shift during the threeyear course of the study toward increasing use of hypofractionated radiation methods. These methods decrease the time it takes for patients to complete radiation treatment  and are estimated to cut the cost of treatment by approximately . The authors said use of the marker facilitated their shift toward these shorter courses of radiotherapy. Use of the marker allowed physicians to be more confident in their targeting and rely less on ambiguous planning targets such as the seroma and surrounding tissue changes. Seroma is a collection of fluid that builds up in the area of tissue injury after surgery.  While seromas have customarily been targeted for radiation treatment they do not always reflect where the cancer was and can overestimate the size of the target areas in need of radiation. By more precisely marking the tumor bed the article said BioZorb can reduce the amount of healthy tissue that would otherwise receive unnecessary radiation.  The second recent study presented at the  annual ASTRO conference in Boston described a collaborative approach between a radiation oncologist and breast surgeon. They studied the question of whether the marker could better identify the true lumpectomy cavity and thereby reduce the amount of tissue that is irradiated.  The authors  radiation oncologist William Hall M.D. and breast surgeon Cary Kaufman M.D.  combined their analysis of  cases in which BioZorb was used.  They concluded that the tissue marker could significantly reduce radiation of healthy breast tissue an average of  reduction as well as avoid irradiating inadvertent seromas that are more common with oncoplastic procedures. By providing better targeting they said the marker could also play a role in facilitating the use of external beam partial breast irradiation http_HallCollaborativeContouring.pdf. The process of delivering radiation treatment is substantially streamlined by having the D marker in place said Dr. Hall. The marker tells us where the tumor was and helps us determine appropriate forms of treatment whether with partial breast irradiation or standard whole breast irradiation and a boost dose at the end of the treatment process. Dr. Hall is a radiation oncologist in the Department of Radiation Oncology at PeaceHealth St. Joseph Medical Center Bellingham Wash. Dr. Kaufman is Medical Director of the Bellingham Regional Breast Center and past chairman of the National Accreditation Program for Breast Centers.  Resources  Infographic http_Infographic.jpg on BioZorb   How the marker http works  About Focal Therapeutics  Focal Therapeutics is a medical device company based in Aliso Viejo Calif. The companys BioZorb marker is a proprietary bioabsorbable device that provides radiographic marking of soft tissue sites. The BioZorb device is placed at the time of surgical removal of tissue such as during breast surgery and the devices threedimensional array of marker clips has unique clinical utility for patient imaging. BioZorb has received k clearance from the U.S. Food and Drug Administration. The device is available in a range of sizes to accommodate a variety of clinical situations. For more information about the company call U.S.  or email infofocaltherapeutics.com mailtoinfofocaltherapeutics.com. Contact Liz Dowling Dowling  Dennis Public Relations Tel.  Lizdowlingdennis.net mailtoLizdowlingdennis.net Photo httpphotos.prnewswire.comprnh  SOURCE Focal Therapeutics"