"Finding ways to fight the flu just got a tad more ribbeting  that is if you ask some researchers who have turned their attention to frogs. A new study suggests that mucus from the skin of certain frogs can be harnessed to obliterate flu viruses.  Some frog mucus contains antimicrobial peptides which are immune system molecules that can neutralize bacteria viruses and fungi. However the flukilling power of such peptides has been demonstrated only under a microscope and in lab mice. More research is needed to determine just how effective a peptide can be in helping humans beat the flu. We have identified a potentially new treatment for HN human influenza virus which is a peptide that comes from the skin of a frog from southern India said Joshy Jacob httpvaccines.emory.edufacultyjacob_joshy.html an associate professor in the Emory University School of Medicines microbiology and immunology department who led the study. The peptide named urumin specifically targets H flu viruses according to the study published Tuesday in the journal Immunity http This peptide works by directly killing the virus and it is specific for all influenza viruses that have a H type of hemagglutinin Jacob said. Hemagglutinin is a spikeshaped protein found on the surface of flu viruses. For the viruses to make you sick the spikes of hemagglutinin attach to your cells httpspdb.rcsb.orgmotm to infect them.  Influenza A viruses  one of four types https two of which routinely spread in people https  are categorized into subtypes H H H H and H based on their hemagglutinin.  It makes the virus particle fall apart For the study skin secretions were collected from  frogs of the species Hydrophylax bahuvistara httpthreatenedtaxa.orgindex.phpJoTTarticleview which are about the size of a tennis ball and brightly colored. Peptides were then gathered from their secretions. The researchers observed how the peptides interacted with influenza viruses under a microscope and in mice.  In this paper we screened  peptides and the surprise was that four out of  had activity against the virus Jacob said. Out of the four we found one of them urumin was nontoxic to human cells he said. So we tested it against viruses that came from the s until the current ones and it kills all of the Hs. It doesnt touch H. Its very very specific. Currently flu subtypes H and H http are circulating among humans worldwide http_monitoringupdateslatest_update_GIP_surveillanceen including across North America Europe and South Asia according to the World Health Organization http The researchers arent quite sure why urumin only targets H viruses but Jacob said that H viruses might be anatomically similar to an amphibian pathogen that the frog mucus is intended to destroy. If there is a similarity it may explain why H viruses are vulnerable to urumins wrath. The frog makes this peptide for its own survival. It never gets influenza Jacob said adding that the peptide fights the flu virus by destroying an important part of the hemagglutinin. To explain how the peptide works Jacob likened hemagglutinin to a billboard sign. You have the message and then you have the little stem that holds it up. The message can change but the stem is the same and this peptide targets the stem of the hemagglutinin thats why its very efficient he said.   A sidebyside electron microscope image of a flu virus before and after being exposed to the urumin peptide.  The urumin peptide could be a novel treatment since it targets the hemagglutinin unlike current drugs on the market which target other parts of the virus resulting in less impact Jacob said. It just blows it up. It makes the virus particle fall apart he said. Gregory Chinchar a professor in the University of Mississippi Medical Centers department of microbiology and immunology said that he was surprised that the peptide targeted the hemagglutinin on the flu virus. He was not involved in the new study. I dont think people thought that they work that way before Chinchar said about the peptide. They thought that they would be more targeted to membranes but the data looks like they target the H protein specifically and that data looks pretty firm. The history of milking frog skin  It was first discovered that frogs had a special way of warding off bacteria and other pathogens in ancient Russia when live Russian Brown frogs were dropped into milk to keep the milk from going sour according to the American Chemical Society https The milk stayed good just like you refrigerated it Jacob said about the ageold Russian practice.  In  scientists took that particular frog and wanted to know why is it why do these frogs keep milk fresh It turned out that when you shock a frog or when you stimulate them or stress them they secrete these short peptides into their surroundings he said. A majority of the peptides were antibacterial and some of them kill the things that make milk go bad. Those scientists who published their findings in the Journal of Proteome Research httppubs.acs.orgdoiabs.prm found that the peptides were just as effective as some antibiotics in fighting bacteria like Staphylococcus aureus https and Salmonella enterica https which can make humans sick. Separate studies have also shown that various amphibian and fish http antimicrobial peptides httpsacademic.oup.comicbarticleAntimicrobialPeptideDefensesinAmphibianSkin play important roles in protecting the animals against invasive pathogens including viruses. Amphibians especially certain groups of frogs produce and store large amounts of antimicrobial peptides in specialized granular glands in the skin said Louise RollinsSmith associate professor of pathology microbiology and immunology at Vanderbilt University School of Medicine. When the skin is injured or the frog is alarmed they release large amounts of the peptides to protect the skin. RollinsSmith who was not involved in the new study has conducted separate research on whether certain antimicrobial peptides in frogs might hold clues http to preventing HIV transmission https The peptide described in the Immunity report is somewhat unusual because of the apparent specificity RollinsSmith said about how urumin specifically targets H viruses. If further studies show that it has a low level of cytotoxicity and it can protect in other animal models of influenza it could be developed as a potential treatment for influenza she said. Cytoxicity refers to being toxic to cells in the body.  As an amphibian biologist concerned about the loss of amphibian species around the globe it is important to note that they may hold important secrets useful for human medicine and they should be preserved she said. Ferrets are next then possibly humans A challenge to possibly using frog mucus as a flufighting treatment in humans is figuring out how to get the urumin peptide to attach to flu virus cells in the human body Jacob said.  In the new study the peptide was delivered to mice through their noses where flu viruses were also delivered. Join the conversation See the latest news and share your comments with CNN Health on Facebook https and Twitter httpstwitter.comcnnhealth. I need to come up with a strategy to deliver it systemically as well maybe an injectable which goes in the bloodstream and kills influenza viruses Jacob mused. For now Jacob said that his colleagues and he are hoping to duplicate their study findings in ferrets which are often used in influenza virus research https and they hope to secure funding for additional studies. If those studies prove to be successful human testing could be next."