"A new type of blood test may help physicians identify which patients with and without evidence of coronary blockages are at risk for heart attacks http and strokes http Even individuals with normal levels of lowdensity lipoprotein LDL known as the socalled bad cholesterol but still at risk seem to be identified according to Mayo Clinic research being presented at the American College of Cardiologys th Annual Scientific Session httpsaccscientificsession.acc.org. The test httpsnewsnetwork.mayoclinic.orgdiscussionmayocliniclaunchesfirstinusbloodtestthatassessesriskofheartattackusingplasmaceramides released commercially by Mayo Medical Laboratories http in August  measures blood concentrations of plasma ceramides a class of lipids that are highly linked to cardiovascular disease processes. The study found that individuals with the highest levels of blood ceramides were found to have a  to times greater risk of having a cardiovascular event compared with those with the lowest ceramide score regardless of their LDL cholesterol level or the presence of a blockage in the hearts arteries. Our research suggests that evaluating ceramide levels in patients who are not at immediate risk for coronary artery disease events may help cardiologists decide who could benefit from proactive and preventive treatment such as statins or lifestyle changes to prevent a serious cardiac event down the road says Jeff Meeusen Ph.D. http a clinical chemist codirector of Cardiovascular Laboratory Medicine at Mayo Clinic and the studys lead author. According to Dr. Meeusen ceramides are different than cholesterol which gathers and causes a clog in the arteries. Ceramides are more active attracting inflammatory cells and promoting clotting. In the study  Mayo Clinic patients who were referred for coronary angiography http to check for possible artery blockages were included and followed prospectively for approximately eighteen years. Patients were similar in age and with regard to blood pressure smoking status and highdensity lipoprotein HDL the good cholesterol excluded were those who had diabetes or a previous heart attack stroke or procedure to open narrowed coronary arteries. Researchers measured four different types of ceramides in the blood at baseline and combined the values into a point scale. Patients were grouped into four risk categories according to their ceramide levels low  intermediate  moderate  and high . Over the eighteen years researchers recorded occurrences of heart attack stroke revascularization and death. Overall . percent of patients had a major cardiovascular event each year. But the risk of having an event became higher as ceramide level increased for each point increase in the ceramide risk score the risk rose by  percent. The rate of events was double among people with the highest ceramide score compared with those with the lowest . vs. . percent respectively. In patients without coronary artery disease following angiography the rate of cardiovascular events was only . percent lower than the average overall. But when researchers examined cardiovascular disease in this population by ceramide scores people with the highest levels of ceramides were four times more likely to have an event compared with those with the lowest . vs. . percent respectively. A similar trend was seen among people with low LDL levels  mgdL typically considered a good LDL target. In this group the rate of heart attack stroke and revascularization and death was . percent among those with a low ceramide score but . percent in people with the highest ceramide levels. There is a need to identify patients at increased risk for cardiovascular events so that we can test strategies to prevent those events. This test seems to provide such information says Allan S. Jaffe M.D. http senior author of the study cardiologist at Mayo Clinic and chair of the Division of Clinical Core Laboratory Services. The trial was funded by Mayo Clinic. The new test is available to health care providers worldwide through Mayo Medical Laboratories which offers laboratory testing and pathology services to more than  health care organizations in more than  countries. Mayo Medical Laboratories collaborated with some of the original researchers who established the role of ceramides in cardiovascular disease and Zora Biosciences Oy a diagnostics discovery company based in Finland to develop and refine the test. The present study is also the first to test its clinical utility in a U.S. population. Coauthors are Leslie Donato Ph.D. Sandra Bryant Grant Spears Peter Berger M.D. and Linnea Baudhuin Ph.D. all of Mayo Clinic."