"Ebselen works like lithium in mouse study   Standard treatment lithium discovered  years ago   Scientists say new drug could have fewer side effects  By Kate Kelland  LONDON Jan  Reuters  A drug for bipolar disorder that works like lithium  the most common and effective treatment  but without lithiums sideeffects has been identified by British researchers in tests on mice.  Scientists say the drug ebselen may be a swift answer to longsought after better medications for patients with the manic depressive disorder since it is already known to be safe.  If the drug could be repurposed and licensed for the treatment of bipolar disorder it could reduce the unpleasant side effects of weight gain thirst and potential kidney damage that patients risk when taking lithium.  Ebselen is an experimental drug that has been tested in people for other conditions and does not have problematic side effects like lithium does said Grant Churchill of the department of pharmacology at Britains Oxford University.  Bipolar disorder effects around  percent of the population worldwide and sufferers can experience moods that swing from one extreme to another and have periods of depression and mania lasting several weeks or longer. These high and low phases are often so extreme they interfere with everyday life and work.  Sponsored In a telephone interview Churchill said that in tests his team found that mice who were made manic with small doses of amphetamines were able to be calmed again with ebselen.  In mice ebselen works like lithium Churchill said. Now we urgently need to see if it works like lithium in people.  Some  years after it was first discovered lithium  a mood stabiliser that can protect against both depression and mania and reduce the risk of suicide  remains the most effective longterm treatment.  But it is very toxic  at only twice the right dose it could kill a patient Churchill said  and its adverse sideeffects mean many people stop taking the drug and relapse into episodes of mania and depression.  Churchill worked with Sridhar Vasudevan to filter through a library of existing drugs  the U.S. National Institutes of Health Clinical Collection  that are considered safe but do not currently have a proven use.  They screened the library for any drugs that blocked an enzyme that is key to lithiums success and found ebselen was a possible lithium mimic.  This is one of the first handful of examples of drug repurposing where a new use has been found for an existing drug Vasudevan said.  Ebselen is an antioxidant originally developed up to late stage or phase III clinical trials by the Japanese firm Daiichi Sankyo for the treatment of stroke but which never reached market and is now out of patent.  Vasudevan said his study reported in the journal Nature Communications showed ebselen had the same or similar action as lithium in the brains of mice blocking the same enzyme.  The researchers are a now starting a small study in healthy human volunteers to look for effects on brain function. If that shows ebselen has similar effects to lithium they plan to move to second stage trial in bipolar patients. Editing by Pravin Char Our StandardsThe Thomson Reuters Trust Principles. httpthomsonreuters.comenaboutustrustprinciples.html"