"Botox  known for reducing facial wrinkles  may also prevent irregular heart rhythms when injected into fat surrounding the heart after bypass surgery according to research in the American Heart Association journal Circulation Arrhythmia and Electrophysiology. Botulinum toxin commonly known as Botox is produced by Clostridium botulinum bacteria. When a small amount of Botox is injected into a muscle it blocks nerve signals that tell muscles to contract. Atrial fibrillation also called AFib or AF is a quivering or irregular heartbeat arrhythmia that can lead to blood clots stroke heart failure and other heartrelated complications. About a third of all patients undergoing bypass surgery will develop atrial fibrillation putting them at higher risk for cardiovascular complications said Jonathan S. Steinberg M.D. senior study author and Adjunct Professor of Medicine at the University of Rochester and Director of the Arrhythmia Institute in the Valley Health System in Ridgewood New Jersey. Atrial fibrillation is also always associated with lengthened hospitalization and that means increased healthcare costs. In two Russian hospitals researchers randomly assigned  patients to receive Botox or saline injections. The injections were made in the four major fat pads surrounding the heart. To avoid bias neither patients nor doctors knew whether the injections contained Botox or saline. Researchers found that  In the  days following surgery those who received Botox injections during heart bypass surgery had a  percent chance of developing AF compared to  percent chance in patients who received saline.   One year after surgery none of the patients who received Botox had AF compared to  percent of the patients who received saline.   No complications from the Botox injections were reported. But complications from the bypass surgery were similar in both groups including time in intensive care and on a breathing machine and infection rate. The results must be replicated in larger studies before Botox injections are routinely used to prevent AF after bypass surgery researchers said. If confirmed in heart bypass patients Botox injections could also help prevent AF in people undergoing valve repair or replacement. About half of those patients will develop AF after surgery. This firstinman study has opened a whole new line of thinking and research Steinberg said. In the near future botox injections may become the standard of care for heart bypass and valve patients but were not quite there yet.  Coauthors are Evgeny Pokushalov M.D. Boris Kozlov M.D. Alexander Romanov M.D. Artem Streinikov M.D. Sevda Bayramova M.D. David Sergeevichev Ph.D. Alexander BogachevProkophiev M.D. Sergey Zheleznev M.D. Vladimir Shipulin M.D. Vladimir Lomivorotov M.D. Alexander Karaskov M.D. and Sunny S. Po M.D. Author disclosures are on the manuscript. The Russian State Research Institute of Circulation Pathology and the Siberian Division of Russian Academy of Medical Sciences funded the study. Additional Resources Researcher photo heart graphic and beating heart animation are located in the right column of this release link httpnewsroom.heart.orgnewsbotoxmaypreventirregularheartbeatafterbypasssurgerypreviewddebddecc  About Your Bypass Surgery Brochure http_UCM__Article.jsp  What is Atrial Fibrillation http_.pdf  Follow AHAASA news on Twitter HeartNews http Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the associations policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals foundations and corporations including pharmaceutical device manufacturers and other companies also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at http"