"For decades research has suggested a link between oral health and inflammatory diseases affecting the entire body  in particular heart attacks and strokes.  The results released today from a randomized trial of a novel plaque identifying toothpaste Plaque HD show statistically significant reductions in dental plaque and inflammation throughout the body. Inflammation throughout the body is accurately measured by high sensitivity Creactive protein hsCRP a sensitive marker for future heart attacks and strokes. These results published today online ahead of print in the American Journal of Medicine with an accompanying editorial by the editorinchief show that Plaque HD produced statistically significant reductions in dental plaque and inflammation throughout the body as measured by hsCRP.  In this trial all randomized subjects were given the same brushing protocol and received a day supply of toothpaste containing either Plaque HD or an identical nonplaque identifying placebo toothpaste. To assess dental plaque all subjects utilized a fluorescein mouth rinse and intraoral photographs were taken under black light imaging. For hsCRP levels were measured by an independent laboratory using an enzyme linked immunosorbent assay.  While the findings on reducing dental plaque extend a previous observation the findings on decreasing inflammation are new and novel said Charles H. Hennekens M.D. Dr.P.H. senior author and first Sir Richard Doll Professor and senior academic advisor to the dean in the Charles E. Schmidt College of Medicine at Florida Atlantic University.  Last month the prestigious New England Journal of Medicine ranked the original manuscript by Hennekens and colleagues on aspirin inflammation and cardiovascular disease published in  as their most influential original report of the last  years. The original research from the landmark Physicians Health Study in which Hennekens was the founding principal investigator was the first to demonstrate that hsCRP predicted future heart attacks and strokes.  In the accompanying editorial titled Can a Toothpaste Reduce Heart Attacks and Strokes Joseph S. Alpert M.D. an internationally renowned cardiologist noted the importance and timeliness of these findings and commented on how his father a dentist had told him even before he went to medical school that dental health may affect heart attacks and strokes.  Plaque HD is the first toothpaste that reveals plaque so that it can be removed with directed brushing. In addition the products proprietary formulation contains unique combinations and concentrations of cleaning agents that weaken the core of the plaque structure to help the subject visualize and more effectively remove the plaque.  This investigator initiated randomized trial was published in collaboration with academic collaborators from the University of Illinois at the Chicago School of Dentistry and the University of Wisconsin School of Medicine and Public Health.  Based on these findings Hennekens and colleagues are drafting an investigator initiated research grant proposal to the National Institutes of Health NIH under the direction of coauthor Patrick E. McBride M.D. M.P.H. professor of medicine and interim associate dean for faculty affairs at the University of Wisconsin School of Medicine and Public Health. This large scale randomized trial will test whether Plaque HD reduces risks of heart attacks and strokes. The trial will be conducted in the Wisconsin Network for Health Research WiNHR and the Wisconsin Research and Education Network WREN both of which McBride directs.  Among the numerous honors and recognition Hennekens has received include the  Fries Prize for Improving Health for his seminal contributions to the treatment and prevention of cardiovascular disease the  Presidential Award from his alma mater Queens College for his distinguished contributions to society and the  honoree of the American Heart Association which he shared with FAUs College of Medicine for reducing premature deaths from heart attacks and strokes. From  to  Science Watch ranked Hennekens as the third most widely cited medical researcher in the world and five of the top  were his former trainees andor fellows. In  Science Heroes ranked Hennekens No.  in the history of the world for having saved more than . million lives.  In  he received the Ochsner Award for reducing premature deaths from cigarettes. In  he was ranked the No.  Top Scientist in the World with an Hindex of .  About Florida Atlantic University  Florida Atlantic University established in  officially opened its doors in  as the fifth public university in Florida. Today the University with an annual economic impact of . billion serves more than  undergraduate and graduate students at sites throughout its sixcounty service region in southeast Florida. FAUs worldclass teaching and research faculty serves students through  colleges the Dorothy F. Schmidt College of Arts and Letters the College of Business the College for Design and Social Inquiry the College of Education the College of Engineering and Computer Science the Graduate College the Harriet L. Wilkes Honors College the Charles E. Schmidt College of Medicine the Christine E. Lynn College of Nursing and the Charles E. Schmidt College of Science. FAU is ranked as a High Research Activity institution by the Carnegie Foundation for the Advancement of Teaching. The University is placing special focus on the rapid development of critical areas that form the basis of its strategic plan Healthy aging biotech coastal and marine issues neuroscience regenerative medicine informatics lifespan and the environment. These areas provide opportunities for faculty and students to build upon FAUs existing strengths in research and scholarship. For more information visit http"