Nariman Bomanshaw Mehta, was an Indian-born American organic chemist and pharmacologist who designed, synthesized, and patented which organic compound, medication primarily used as an antidepressant and smoking cessation aid?
Bupropion Bupropion is a medication primarily used as an antidepressant and smoking cessation aid. It is marketed as Wellbutrin and Zyban among other trade names. It is one of the most frequently prescribed antidepressants in the United States and Canada, although in many countries this is an off-label use. It is an effective antidepressant on its own, but is also popular as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. Bupropion is taken in tablet form and is available only by prescription in most countries.
RS-102221 RS-102221 is a drug developed by Hoffmann–La Roche, which was one of the first compounds discovered that acts as a potent and selective antagonist at the serotonin 5-HT receptor, with around 100x selectivity over the closely related 5-HT and 5-HT receptors. It has anxiolytic effects in animal studies, increases the effectiveness of SSRI antidepressants, and shows a complex interaction with cocaine, increasing some effects but decreasing others, reflecting a role for the 5-HT receptor in regulation of the dopamine signalling system in the brain.