What acute metabolic condition can be defined by the elevation of a yellow compound that occurs in normal catabolic pathway that breaks down heme in vertebrates?
Zieve's syndrome Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged alcohol abuse. It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinaemia (excessive blood lipoprotein), jaundice (elevation of unconjugated bilirubin), and abdominal pain. The underlying cause is liver delipidization. This is distinct from alcoholic hepatitis which, however, may present simultaneously or develop later.
Succinic acid Succinic acid ( ) is a dicarboxylic acid with the chemical formula (CH)(COH). The name derives from Latin "succinum", meaning amber. In living organisms, succinic acid takes the form of an anion, succinate, which has multiple biological roles both as a metabolic intermediate and as a signaling molecule reflecting the cellular metabolic state. Succinate is generated in mitochondria via the tricarboxylic acid cycle (TCA), an ancient energy-yielding process shared by all organisms. Succinate can exit the mitochondrial matrix and function in the cytoplasm as well as the extracellular space, changing gene expression patterns, modulating epigenetic landscape or demonstrating hormone-like signaling. As such, succinate links cellular metabolism to the regulation of cellular function. Dysregulation of succinate synthesis and degradation can lead to pathological conditions, such as malignant transformation, inflammation and tissue injury.