Dazzling Mirage was a Nigerian film that tells a story about what inherited blood disorder?
Dazzling Mirage Dazzling Mirage is a 2014 Nigerian drama film, produced and directed by Tunde Kelani; it stars Kemi "Lala" Akindoju, Kunle Afolayan, Bimbo Manuel, Yomi Fash Lanso, Taiwo Ajai-Lycett and Seun Akindele. It also features special appearances from Adewale Ayuba, Sean Tizzle, Tunde Babalola and Steve Sodiya. The film is an adaptation of a novel of the same name by Olayinka Abimbola Egbokhare, adapted to screen by Ade Solanke. It tells the story of a young sickle-cell patient and the various social and emotional challenges she is faced with.
Hypophosphatasia Hypophosphatasia (also called deficiency of alkaline phosphatase or phosphoethanolaminuria) is a rare, and sometimes fatal, metabolic bone disease. Clinical symptoms are heterogeneous, ranging from the rapidly fatal, perinatal variant, with profound skeletal hypomineralization and respiratory compromise, to a milder, progressive osteomalacia later in life. Tissue non-specific alkaline phosphatase (TNSALP) deficiency in osteoblasts and chondrocytes impairs bone mineralization, leading to rickets or osteomalacia. The pathognomonic finding is subnormal serum activity of the TNSALP enzyme, which is caused by one of 200 genetic mutations identified to date, in the gene encoding TNSALP. Genetic inheritance is autosomal recessive for the perinatal and infantile forms but either autosomal recessive or autosomal dominant in the milder forms. The prevalence of hypophosphatasia is not known; one study estimated the live birth incidence of severe forms to be 1:100,000.