What is one drug that replaced drugs that were first shown to be an anesthetic at the Ether Dome?
Massachusetts General Hospital, Bulfinch Building The Bulfinch Building of the Massachusetts General Hospital is located on the hospital's main campus on Fruit Street in the West End of Boston, Massachusetts. It was designed by architect Charles Bulfinch, and built between 1818 and 1823, with a major expansion in 1844-46. A National Historic Landmark, it is an excellent example of Classical Revival architecture, and a rare surviving example of an early 19th-century public hospital building. The building is home to the Ether Dome, an operating theater which has been separately designated a National Historic Landmark as the site of the first public demonstration of the use of ether as an anesthetic.
Mestilbol Mestilbol (brand name Monomestro or Monomestrol), also known as diethylstilbestrol monomethyl ether, is a synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol. It was developed by Wallace & Tiernan Company, patented in 1940, and introduced for medical use in the 1940s, but is now no longer marketed. Mestilbol was available both as oral tablets and in oil for intramuscular injection. The drug is gradually demethylated in the body into diethylstilbestrol and hence is a prodrug of diethylstilbestrol. Mestilbol is a highly active estrogen, although somewhat less so than diethylstilbestrol, but is longer-lasting in comparison.