What is one drug that replaced drugs that were first shown to be an anesthetic at the Ether Dome?
Massachusetts General Hospital, Bulfinch Building The Bulfinch Building of the Massachusetts General Hospital is located on the hospital's main campus on Fruit Street in the West End of Boston, Massachusetts. It was designed by architect Charles Bulfinch, and built between 1818 and 1823, with a major expansion in 1844-46. A National Historic Landmark, it is an excellent example of Classical Revival architecture, and a rare surviving example of an early 19th-century public hospital building. The building is home to the Ether Dome, an operating theater which has been separately designated a National Historic Landmark as the site of the first public demonstration of the use of ether as an anesthetic.
Aminoestradiol Aminoestradiol (AE), also known as 17β-aminoestradiol (17βAE) or as 17β-aminoestra-1,3,5(10)-trien-3-ol, is a synthetic, steroidal estrogen and a 17β-aminoestrogen with anticoagulant effects that was never marketed. It is an analogue of estradiol in which the C17β hydroxyl group has been replaced with an amine group. AE has profoundly reduced estrogenic potency compared to estradiol; its EC for activation of the ERα was found to be 1.82 μM, whereas that of estradiol was 2.14 nM (relative potency 0.12 for AE versus 100 for estradiol, or roughly a 1,000-fold difference). It binds with low relative affinity to both the ERα and ERβ and has estrogenic activity that is greatly mediated through the ERβ and to a lesser extent through the ERα.