What handgun cartridge designed by John Browning in 1905, for use in his prototype Colt semi-automatic pistol, is chambered in a third-generation semi-automatic pistol from Smith & Wesson's 4500 series of handguns?
.45 ACP The .45 ACP (Automatic Colt Pistol), or .45 Auto (11.43×23mm) is a handgun cartridge designed by John Browning in 1905, for use in his prototype Colt semi-automatic pistol. After successful military trials it was adopted, along with the Browning .45 Colt handgun, as the .45 M1911 cartridge. The handgun was designated M1911 pistol.
Grendel P30 The Grendel P30 is a semi-automatic pistol chambered in .22 Winchester Magnum Rimfire. Designed by George Kellgren, it uses a 30-round Zytel magazine and was available with a 5 or 8 inch barrel. A carbine version (R-31) was also offered. It was manufactured from 1990 to 1994.