What is one drug that replaced drugs that were first shown to be an anesthetic at the Ether Dome?
Massachusetts General Hospital, Bulfinch Building The Bulfinch Building of the Massachusetts General Hospital is located on the hospital's main campus on Fruit Street in the West End of Boston, Massachusetts. It was designed by architect Charles Bulfinch, and built between 1818 and 1823, with a major expansion in 1844-46. A National Historic Landmark, it is an excellent example of Classical Revival architecture, and a rare surviving example of an early 19th-century public hospital building. The building is home to the Ether Dome, an operating theater which has been separately designated a National Historic Landmark as the site of the first public demonstration of the use of ether as an anesthetic.
Pramocaine Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.