What handgun cartridge designed by John Browning in 1905, for use in his prototype Colt semi-automatic pistol, is chambered in a third-generation semi-automatic pistol from Smith & Wesson's 4500 series of handguns?
.45 ACP The .45 ACP (Automatic Colt Pistol), or .45 Auto (11.43×23mm) is a handgun cartridge designed by John Browning in 1905, for use in his prototype Colt semi-automatic pistol. After successful military trials it was adopted, along with the Browning .45 Colt handgun, as the .45 M1911 cartridge. The handgun was designated M1911 pistol.
.375 Ruger The .375 Ruger (9.5×65.5mm) is a rimless, standard-length rifle cartridge designed for the hunting of large dangerous game. It is designed to provide an increase in performance over the .375 H&H cartridge, yet to be chambered in a standard length action rifle. The cartridge was designed by Hornady and Ruger in partnership and released commercially in 2007 and chambered in the Ruger Hawkeye African and the Ruger Hawkeye Alaskan rifles.